JP2004505912A5 - - Google Patents
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- Publication number
- JP2004505912A5 JP2004505912A5 JP2002517052A JP2002517052A JP2004505912A5 JP 2004505912 A5 JP2004505912 A5 JP 2004505912A5 JP 2002517052 A JP2002517052 A JP 2002517052A JP 2002517052 A JP2002517052 A JP 2002517052A JP 2004505912 A5 JP2004505912 A5 JP 2004505912A5
- Authority
- JP
- Japan
- Prior art keywords
- guanidine
- nitrobenzylideneamino
- composition according
- guanidine acetate
- acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 22
- 229940002612 prodrug Drugs 0.000 description 9
- 239000000651 prodrug Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 6
- 208000022531 anorexia Diseases 0.000 description 4
- 206010061428 decreased appetite Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 201000001441 melanoma Diseases 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000004378 Melanocortin Receptors Human genes 0.000 description 2
- 108090000950 Melanocortin Receptors Proteins 0.000 description 2
- 108010008364 Melanocortins Proteins 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 201000001880 Sexual dysfunction Diseases 0.000 description 2
- 206010040829 Skin discolouration Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 208000030381 cutaneous melanoma Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 239000002865 melanocortin Substances 0.000 description 2
- -1 methoxy, hydroxy Chemical group 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 210000000578 peripheral nerve Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 231100000872 sexual dysfunction Toxicity 0.000 description 2
- 230000036299 sexual function Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 201000003708 skin melanoma Diseases 0.000 description 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 2
- UEYMVLYFTKJDHE-UHFFFAOYSA-N 2-[(2,3,4-trimethoxyphenyl)methylideneamino]guanidine;hydrochloride Chemical compound Cl.COC1=CC=C(C=NNC(N)=N)C(OC)=C1OC UEYMVLYFTKJDHE-UHFFFAOYSA-N 0.000 description 1
- WHSMHQQGLVVQJZ-UHFFFAOYSA-N 2-[(2,3-dimethoxy-5-nitrophenyl)methylideneamino]guanidine;hydrochloride Chemical compound Cl.COC1=CC([N+]([O-])=O)=CC(C=NNC(N)=N)=C1OC WHSMHQQGLVVQJZ-UHFFFAOYSA-N 0.000 description 1
- HDLADIYRGZTSTC-UHFFFAOYSA-N 2-[(2-hydroxy-4-methoxy-5-nitrophenyl)methylideneamino]guanidine Chemical compound COC1=CC(O)=C(C=NNC(N)=N)C=C1[N+]([O-])=O HDLADIYRGZTSTC-UHFFFAOYSA-N 0.000 description 1
- ZPPQPYVAWOBQSX-UHFFFAOYSA-N 2-[(3-bromo-2,6-dinitrophenyl)methylideneamino]guanidine hydrochloride Chemical compound Cl.NC(=N)NN=CC1=C([N+]([O-])=O)C=CC(Br)=C1[N+]([O-])=O ZPPQPYVAWOBQSX-UHFFFAOYSA-N 0.000 description 1
- QZPYZNYEFBAJQK-UHFFFAOYSA-N 2-[(3-chloro-4-methoxy-5-nitrophenyl)methylideneamino]guanidine Chemical compound COC1=C(Cl)C=C(C=NNC(N)=N)C=C1[N+]([O-])=O QZPYZNYEFBAJQK-UHFFFAOYSA-N 0.000 description 1
- FBQIPMYAOJAAAR-UHFFFAOYSA-N 2-[(3-iodophenyl)methylideneamino]guanidine;hydrochloride Chemical compound Cl.NC(=N)NN=CC1=CC=CC(I)=C1 FBQIPMYAOJAAAR-UHFFFAOYSA-N 0.000 description 1
- UTPLZJPUVNVQNQ-UHFFFAOYSA-N 2-[(5-bromo-2-hydroxy-3-nitrophenyl)methylideneamino]guanidine hydrochloride Chemical compound Cl.NC(=N)NN=CC1=CC(Br)=CC([N+]([O-])=O)=C1O UTPLZJPUVNVQNQ-UHFFFAOYSA-N 0.000 description 1
- WSNKYMRJFVHMND-UHFFFAOYSA-N 2-[(5-bromo-2-methoxy-3-nitrophenyl)methylideneamino]guanidine;hydrochloride Chemical compound Cl.COC1=C(C=NNC(N)=N)C=C(Br)C=C1[N+]([O-])=O WSNKYMRJFVHMND-UHFFFAOYSA-N 0.000 description 1
- TVSCNSTYGZWZMS-UHFFFAOYSA-N 2-[(diaminomethylidenehydrazinylidene)methyl]benzenesulfonic acid;hydrochloride Chemical compound Cl.NC(=N)NN=CC1=CC=CC=C1S(O)(=O)=O TVSCNSTYGZWZMS-UHFFFAOYSA-N 0.000 description 1
- FZGICYVEFPCIJR-UHFFFAOYSA-N CC(O)=O.COc1cc(O)c(C=NNC(N)=N)c(OC)c1 Chemical compound CC(O)=O.COc1cc(O)c(C=NNC(N)=N)c(OC)c1 FZGICYVEFPCIJR-UHFFFAOYSA-N 0.000 description 1
- NKTPTBRFGPRMNV-UHFFFAOYSA-N CC(O)=O.COc1ccc(C=NNC(N)=N)c(O)c1 Chemical compound CC(O)=O.COc1ccc(C=NNC(N)=N)c(O)c1 NKTPTBRFGPRMNV-UHFFFAOYSA-N 0.000 description 1
- WXUSRYRMPVIFSJ-UHFFFAOYSA-N Cl.CC1=CC(O)=C(C=NNC(N)=N)C=C1[N+]([O-])=O Chemical compound Cl.CC1=CC(O)=C(C=NNC(N)=N)C=C1[N+]([O-])=O WXUSRYRMPVIFSJ-UHFFFAOYSA-N 0.000 description 1
- WYIQRGNHAFDUJB-UHFFFAOYSA-N Cl.COC1=CC([N+]([O-])=O)=CC(C=NNC(N)=N)=C1O Chemical compound Cl.COC1=CC([N+]([O-])=O)=CC(C=NNC(N)=N)=C1O WYIQRGNHAFDUJB-UHFFFAOYSA-N 0.000 description 1
- GOKZZNWSZZAMPR-UHFFFAOYSA-N Cl.COC1=CC=C([N+]([O-])=O)C(C=NNC(N)=N)=C1[N+]([O-])=O Chemical compound Cl.COC1=CC=C([N+]([O-])=O)C(C=NNC(N)=N)=C1[N+]([O-])=O GOKZZNWSZZAMPR-UHFFFAOYSA-N 0.000 description 1
- NNSCTDFNTPTKDH-UHFFFAOYSA-N Cl.NC(=N)NN=CC1=C(Cl)C=CC([N+]([O-])=O)=C1[N+]([O-])=O Chemical compound Cl.NC(=N)NN=CC1=C(Cl)C=CC([N+]([O-])=O)=C1[N+]([O-])=O NNSCTDFNTPTKDH-UHFFFAOYSA-N 0.000 description 1
- JVNDWFBBXAJJMP-UHFFFAOYSA-N acetic acid 2-[(3,5-dinitrophenyl)methylideneamino]guanidine dihydrate Chemical compound O.O.CC(O)=O.NC(=N)NN=Cc1cc(cc(c1)[N+]([O-])=O)[N+]([O-])=O JVNDWFBBXAJJMP-UHFFFAOYSA-N 0.000 description 1
- HXTUKJJBEGTJPF-UHFFFAOYSA-N acetic acid;2-[(2,3-difluorophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=CC(F)=C1F HXTUKJJBEGTJPF-UHFFFAOYSA-N 0.000 description 1
- PQYJMHHAGLHLAW-UHFFFAOYSA-N acetic acid;2-[(2,3-dimethoxy-5,6-dinitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=CC([N+]([O-])=O)=C([N+]([O-])=O)C(C=NN=C(N)N)=C1OC PQYJMHHAGLHLAW-UHFFFAOYSA-N 0.000 description 1
- XUHYROIDEFAERS-UHFFFAOYSA-N acetic acid;2-[(2,3-dimethoxy-5-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=CC([N+]([O-])=O)=CC(C=NN=C(N)N)=C1OC XUHYROIDEFAERS-UHFFFAOYSA-N 0.000 description 1
- MHJUAHCGSDHUCN-UHFFFAOYSA-N acetic acid;2-[(2,4-dimethoxy-5-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=CC(OC)=C([N+]([O-])=O)C=C1C=NN=C(N)N MHJUAHCGSDHUCN-UHFFFAOYSA-N 0.000 description 1
- AYGPUXPCAFIMIG-UHFFFAOYSA-N acetic acid;2-[(2-bromo-4-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C([N+]([O-])=O)C=C1Br AYGPUXPCAFIMIG-UHFFFAOYSA-N 0.000 description 1
- QDGQJMCEAHTZKE-UHFFFAOYSA-N acetic acid;2-[(2-bromo-5-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC([N+]([O-])=O)=CC=C1Br QDGQJMCEAHTZKE-UHFFFAOYSA-N 0.000 description 1
- YQHLHWOPFVZJAT-UHFFFAOYSA-N acetic acid;2-[(2-fluoro-5-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC([N+]([O-])=O)=CC=C1F YQHLHWOPFVZJAT-UHFFFAOYSA-N 0.000 description 1
- GWMVDBKCYKUESY-UHFFFAOYSA-N acetic acid;2-[(2-iodophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=CC=C1I GWMVDBKCYKUESY-UHFFFAOYSA-N 0.000 description 1
- YKUUEEAVWUIRHZ-UHFFFAOYSA-N acetic acid;2-[(3,4-difluorophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C(F)C(F)=C1 YKUUEEAVWUIRHZ-UHFFFAOYSA-N 0.000 description 1
- BIBSTXHVXAUVSG-UHFFFAOYSA-N acetic acid;2-[(3,5-dichloro-2-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC(Cl)=CC(Cl)=C1[N+]([O-])=O BIBSTXHVXAUVSG-UHFFFAOYSA-N 0.000 description 1
- BGMARYPSDDQNRG-UHFFFAOYSA-N acetic acid;2-[(3,5-dichloro-4-methoxyphenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=C(Cl)C=C(C=NN=C(N)N)C=C1Cl BGMARYPSDDQNRG-UHFFFAOYSA-N 0.000 description 1
- MTEYXIZIIAMIRC-UHFFFAOYSA-N acetic acid;2-[(3,6-dichloro-2-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=C(Cl)C=CC(Cl)=C1[N+]([O-])=O MTEYXIZIIAMIRC-UHFFFAOYSA-N 0.000 description 1
- LDDRALBTDIPTAT-UHFFFAOYSA-N acetic acid;2-[(3-bromo-4-fluorophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C(F)C(Br)=C1 LDDRALBTDIPTAT-UHFFFAOYSA-N 0.000 description 1
- WBGNGAZJSTVCGF-UHFFFAOYSA-N acetic acid;2-[(3-bromo-4-methoxy-5-methylphenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=C(C)C=C(C=NN=C(N)N)C=C1Br WBGNGAZJSTVCGF-UHFFFAOYSA-N 0.000 description 1
- WXKJDNXETFDYLD-UHFFFAOYSA-N acetic acid;2-[(3-chloro-4-fluorophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C(F)C(Cl)=C1 WXKJDNXETFDYLD-UHFFFAOYSA-N 0.000 description 1
- QXHRYVVURDNEBE-UHFFFAOYSA-N acetic acid;2-[(3-hydroxy-4-methyl-2-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.CC1=CC=C(C=NN=C(N)N)C([N+]([O-])=O)=C1O QXHRYVVURDNEBE-UHFFFAOYSA-N 0.000 description 1
- RHSRSSZJWYTEOM-UHFFFAOYSA-N acetic acid;2-[(4-bromo-2-fluoro-5-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC([N+]([O-])=O)=C(Br)C=C1F RHSRSSZJWYTEOM-UHFFFAOYSA-N 0.000 description 1
- UUIQJIHFDPBYAR-UHFFFAOYSA-N acetic acid;2-[(4-bromo-2-fluorophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C(Br)C=C1F UUIQJIHFDPBYAR-UHFFFAOYSA-N 0.000 description 1
- ULXODIFGXWJDAE-UHFFFAOYSA-N acetic acid;2-[(4-bromo-3-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C(Br)C([N+]([O-])=O)=C1 ULXODIFGXWJDAE-UHFFFAOYSA-N 0.000 description 1
- WAQPKHNUTDJSKY-UHFFFAOYSA-N acetic acid;2-[(4-chloro-2-methoxy-5-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=CC(Cl)=C([N+]([O-])=O)C=C1C=NN=C(N)N WAQPKHNUTDJSKY-UHFFFAOYSA-N 0.000 description 1
- MOPSPQWIEOJJIG-UHFFFAOYSA-N acetic acid;2-[(4-chloro-3-fluorophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C(Cl)C(F)=C1 MOPSPQWIEOJJIG-UHFFFAOYSA-N 0.000 description 1
- IMFGNFNOWZDLKV-UHFFFAOYSA-N acetic acid;2-[(4-fluoro-3-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.NC(N)=NN=CC1=CC=C(F)C([N+]([O-])=O)=C1 IMFGNFNOWZDLKV-UHFFFAOYSA-N 0.000 description 1
- OYRPZHBFIZLANB-UHFFFAOYSA-N acetic acid;2-[(4-methoxy-3-nitrophenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=CC=C(C=NN=C(N)N)C=C1[N+]([O-])=O OYRPZHBFIZLANB-UHFFFAOYSA-N 0.000 description 1
- GHHRHXOHRDBWHA-UHFFFAOYSA-N acetic acid;2-[(5-bromo-2,4-dimethoxyphenyl)methylideneamino]guanidine Chemical compound CC(O)=O.COC1=CC(OC)=C(C=NN=C(N)N)C=C1Br GHHRHXOHRDBWHA-UHFFFAOYSA-N 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0019357A GB0019357D0 (en) | 2000-08-07 | 2000-08-07 | Novel phenyl guanidines |
| GB0019357.3 | 2000-08-07 | ||
| PCT/GB2001/003534 WO2002011715A2 (en) | 2000-08-07 | 2001-08-07 | The use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148414A Division JP5683396B2 (ja) | 2000-08-07 | 2011-07-04 | ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004505912A JP2004505912A (ja) | 2004-02-26 |
| JP2004505912A5 true JP2004505912A5 (cg-RX-API-DMAC7.html) | 2007-08-30 |
| JP5654190B2 JP5654190B2 (ja) | 2015-01-14 |
Family
ID=9897134
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002517052A Expired - Fee Related JP5654190B2 (ja) | 2000-08-07 | 2001-08-07 | ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用 |
| JP2011148414A Expired - Fee Related JP5683396B2 (ja) | 2000-08-07 | 2011-07-04 | ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148414A Expired - Fee Related JP5683396B2 (ja) | 2000-08-07 | 2011-07-04 | ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US20040024060A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1313461A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5654190B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100929363B1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2001276522A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0113053A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2417098A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0019357D0 (cg-RX-API-DMAC7.html) |
| IL (2) | IL154272A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA03001072A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002011715A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200300829B (cg-RX-API-DMAC7.html) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001269092A1 (en) * | 2000-06-27 | 2002-01-08 | Axxima Pharmaceuticals Ag | Inhibitors of hepatitis b virus infection |
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| GB0119172D0 (en) * | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| AU2002336638A1 (en) * | 2001-10-12 | 2003-04-28 | Cornell Research Foundation, Inc. | Reversing or preventing premature vascular senescence |
| AU2003219914A1 (en) * | 2002-02-25 | 2003-09-09 | Chiron Corporation | Intranasal administration of mc4-r agonists |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7547693B2 (en) | 2003-09-22 | 2009-06-16 | Banyu Pharmaceutical Co. Ltd. | Piperidine derivative |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| KR101397913B1 (ko) | 2005-05-30 | 2014-05-26 | 엠에스디 가부시키가이샤 | 신규 피페리딘 유도체 |
| JPWO2007018248A1 (ja) | 2005-08-10 | 2009-02-19 | 萬有製薬株式会社 | ピリドン化合物 |
| JPWO2007024004A1 (ja) | 2005-08-24 | 2009-03-05 | 萬有製薬株式会社 | フェニルピリドン誘導体 |
| JPWO2007029847A1 (ja) | 2005-09-07 | 2009-03-19 | 萬有製薬株式会社 | 二環性芳香族置換ピリドン誘導体 |
| CA2624030A1 (en) | 2005-09-29 | 2007-04-12 | Tianying Jian | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| KR20080059233A (ko) | 2005-10-21 | 2008-06-26 | 노파르티스 아게 | 레닌 억제제, 및 항이상지질혈증제 및/또는 항비만제의조합물 |
| EP1944301A4 (en) | 2005-10-27 | 2012-01-04 | Msd Kk | NEW BENZOXATHIIN DERIVATIVES |
| WO2007055418A1 (ja) | 2005-11-10 | 2007-05-18 | Banyu Pharmaceutical Co., Ltd. | アザ置換スピロ誘導体 |
| DE602007014363D1 (de) | 2006-06-09 | 2011-06-16 | Action Pharma As | Phenylpyrrolaminoguanidinderivate |
| CA2664113C (en) | 2006-09-22 | 2013-05-28 | Merck & Co., Inc. | Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer |
| AU2007301126A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| GB0623381D0 (en) * | 2006-11-23 | 2007-01-03 | Acure Pharma Ab | Use of a compound as VEGF inhibitor |
| GB0624987D0 (en) * | 2006-12-14 | 2007-01-24 | Acure Pharma Ab | Novel aminoguanidines as melanocortin receptor ligands |
| EP2474523B1 (en) | 2006-12-26 | 2020-04-08 | Lantheus Medical Imaging, Inc. | Ligands for imaging cardiac innervation |
| EP2145884B1 (en) | 2007-04-02 | 2014-08-06 | Msd K.K. | Indoledione derivative |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2559319T3 (es) | 2007-06-04 | 2016-02-11 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US8442179B2 (en) * | 2007-10-19 | 2013-05-14 | The Boeing Company | Method and apparatus for tagging and identifying a target |
| WO2009111037A2 (en) * | 2008-03-04 | 2009-09-11 | Indigene Pharmaceuticals Inc. | Compositions and methods for treating nos-associated diseases |
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2000
- 2000-08-07 GB GB0019357A patent/GB0019357D0/en not_active Ceased
-
2001
- 2001-08-07 BR BR0113053A patent/BR0113053A/pt not_active Application Discontinuation
- 2001-08-07 EP EP20010954176 patent/EP1313461A2/en not_active Withdrawn
- 2001-08-07 CA CA 2417098 patent/CA2417098A1/en not_active Abandoned
- 2001-08-07 KR KR20037001846A patent/KR100929363B1/ko not_active Expired - Fee Related
- 2001-08-07 WO PCT/GB2001/003534 patent/WO2002011715A2/en not_active Ceased
- 2001-08-07 MX MXPA03001072A patent/MXPA03001072A/es active IP Right Grant
- 2001-08-07 IL IL15427201A patent/IL154272A0/xx unknown
- 2001-08-07 JP JP2002517052A patent/JP5654190B2/ja not_active Expired - Fee Related
- 2001-08-07 AU AU2001276522A patent/AU2001276522A1/en not_active Abandoned
- 2001-08-07 US US10/343,325 patent/US20040024060A1/en not_active Abandoned
-
2003
- 2003-01-30 ZA ZA200300829A patent/ZA200300829B/xx unknown
- 2003-02-03 IL IL15427203A patent/IL154272A/en not_active IP Right Cessation
-
2006
- 2006-12-15 US US11/639,190 patent/US8148429B2/en not_active Expired - Fee Related
-
2007
- 2007-05-16 US US11/798,669 patent/US20070231267A1/en not_active Abandoned
-
2010
- 2010-09-28 US US12/892,402 patent/US8309609B2/en not_active Expired - Fee Related
-
2011
- 2011-07-04 JP JP2011148414A patent/JP5683396B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-21 US US13/426,096 patent/US8410174B2/en not_active Expired - Fee Related
-
2013
- 2013-03-14 US US13/803,555 patent/US9227927B2/en not_active Expired - Fee Related
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