DE602007014363D1 - Phenylpyrrolaminoguanidinderivate - Google Patents
PhenylpyrrolaminoguanidinderivateInfo
- Publication number
- DE602007014363D1 DE602007014363D1 DE602007014363T DE602007014363T DE602007014363D1 DE 602007014363 D1 DE602007014363 D1 DE 602007014363D1 DE 602007014363 T DE602007014363 T DE 602007014363T DE 602007014363 T DE602007014363 T DE 602007014363T DE 602007014363 D1 DE602007014363 D1 DE 602007014363D1
- Authority
- DE
- Germany
- Prior art keywords
- present
- phenyl pyrrole
- aminoguanidine derivatives
- relates
- phenylpyrrolaminoguanidinderivate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Biomedical Technology (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200600780 | 2006-06-09 | ||
| PCT/EP2007/055715 WO2007141343A1 (en) | 2006-06-09 | 2007-06-11 | Phenyl pyrrole aminoguanidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007014363D1 true DE602007014363D1 (de) | 2011-06-16 |
Family
ID=58709169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007014363T Active DE602007014363D1 (de) | 2006-06-09 | 2007-06-11 | Phenylpyrrolaminoguanidinderivate |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8058306B2 (de) |
| EP (2) | EP2348016B1 (de) |
| JP (1) | JP5444523B2 (de) |
| CN (1) | CN101466669B (de) |
| AT (1) | ATE508111T1 (de) |
| AU (1) | AU2007255366B2 (de) |
| CA (1) | CA2688485C (de) |
| CY (1) | CY1117851T1 (de) |
| DE (1) | DE602007014363D1 (de) |
| DK (1) | DK2348016T3 (de) |
| ES (1) | ES2571253T3 (de) |
| HK (1) | HK1160136A1 (de) |
| HU (1) | HUE029016T2 (de) |
| MX (1) | MX2008015454A (de) |
| NZ (1) | NZ573457A (de) |
| PL (1) | PL2348016T3 (de) |
| SI (1) | SI2348016T1 (de) |
| WO (1) | WO2007141343A1 (de) |
| ZA (1) | ZA200810347B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009071101A1 (en) * | 2007-12-07 | 2009-06-11 | Action Pharma A/S | N-modified aminoguanidine derivatives |
| WO2009074157A1 (en) * | 2007-12-13 | 2009-06-18 | Action Pharma A/S | Fully-modified phenyl pyrrole aminoguanidines |
| UA99555C2 (en) | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
| KR102494613B1 (ko) * | 2018-06-22 | 2023-02-06 | 신액트 파마 에이피에스 | 단백뇨의 치료 |
| EP4119140A1 (de) | 2019-05-10 | 2023-01-18 | SynAct Pharma ApS | Kombinationsbehandlung von arthritischen erkrankungen |
| AU2021247480A1 (en) | 2020-03-31 | 2022-10-06 | Synact Pharma Aps | Treatment of symptomatic viral diseases |
| CA3220756A1 (en) | 2021-06-21 | 2022-12-29 | Synact Pharma Aps | Phenyl pyrrole aminoguanidine salts and formulations |
| WO2023218048A1 (en) | 2022-05-12 | 2023-11-16 | Synact Pharma Aps | Resomelagon and its derivatives for the treatment of cardiovascular disease, hypertension and atherosclerosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9604348D0 (sv) | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| AU7464998A (en) | 1997-10-27 | 1999-05-17 | Trega Biosciences, Inc. | Melanocortin receptor ligands and methods of using same |
| EP1076649A4 (de) | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | Isoquinolinverbindung, melanocortinrezeptor-liganden und anwendungsverfahren derselben |
| JP2002517444A (ja) | 1998-06-11 | 2002-06-18 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作動薬としてのスピロピペリジン誘導体 |
| KR100519201B1 (ko) | 1999-03-29 | 2005-10-06 | 더 프록터 앤드 갬블 캄파니 | 멜라노코르틴 수용체 리간드 |
| WO2000074679A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| AU6605800A (en) | 1999-07-16 | 2001-02-05 | Trega Biosciences, Inc. | Melanocortin receptor-3 ligands to treat sexual dysfunction |
| GB0002059D0 (en) | 2000-01-28 | 2000-03-22 | Melacure Therapeutics Ab | Novel aromatic amines |
| AU2001228677A1 (en) | 2000-01-28 | 2001-08-07 | Melacure Therapeutics Ab | Novel melanocortin receptor agonists and antagonists |
| WO2001055107A2 (en) | 2000-01-28 | 2001-08-02 | Melacure Therapeutics Ab | Aromatic amines and amides acting on the melanocortin receptors |
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| US6768024B1 (en) | 2000-08-04 | 2004-07-27 | Lion Bioscience Ag | Triamine derivative melanocortin receptor ligands and methods of using same |
| GB0019359D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| DZ3415A1 (fr) | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
| GB0119172D0 (en) | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
-
2007
- 2007-06-11 JP JP2009513710A patent/JP5444523B2/ja active Active
- 2007-06-11 DE DE602007014363T patent/DE602007014363D1/de active Active
- 2007-06-11 SI SI200731768A patent/SI2348016T1/sl unknown
- 2007-06-11 US US12/304,065 patent/US8058306B2/en active Active
- 2007-06-11 MX MX2008015454A patent/MX2008015454A/es active IP Right Grant
- 2007-06-11 EP EP11164583.4A patent/EP2348016B1/de active Active
- 2007-06-11 CN CN200780021060XA patent/CN101466669B/zh active Active
- 2007-06-11 AT AT07730054T patent/ATE508111T1/de not_active IP Right Cessation
- 2007-06-11 AU AU2007255366A patent/AU2007255366B2/en active Active
- 2007-06-11 CA CA2688485A patent/CA2688485C/en active Active
- 2007-06-11 EP EP07730054A patent/EP2035373B1/de active Active
- 2007-06-11 WO PCT/EP2007/055715 patent/WO2007141343A1/en active Application Filing
- 2007-06-11 PL PL11164583.4T patent/PL2348016T3/pl unknown
- 2007-06-11 HU HUE11164583A patent/HUE029016T2/en unknown
- 2007-06-11 DK DK11164583.4T patent/DK2348016T3/en active
- 2007-06-11 ES ES11164583T patent/ES2571253T3/es active Active
- 2007-06-11 NZ NZ573457A patent/NZ573457A/en unknown
-
2008
- 2008-12-05 ZA ZA200810347A patent/ZA200810347B/xx unknown
-
2012
- 2012-01-26 HK HK12100756.0A patent/HK1160136A1/zh unknown
-
2016
- 2016-05-16 CY CY20161100421T patent/CY1117851T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2571253T3 (es) | 2016-05-24 |
| CY1117851T1 (el) | 2017-05-17 |
| HK1160136A1 (zh) | 2012-08-10 |
| AU2007255366A1 (en) | 2007-12-13 |
| US8058306B2 (en) | 2011-11-15 |
| EP2035373A1 (de) | 2009-03-18 |
| JP2009539809A (ja) | 2009-11-19 |
| WO2007141343A1 (en) | 2007-12-13 |
| CN101466669A (zh) | 2009-06-24 |
| CN101466669B (zh) | 2011-11-30 |
| PL2348016T3 (pl) | 2016-09-30 |
| EP2348016B1 (de) | 2016-02-17 |
| ZA200810347B (en) | 2010-05-26 |
| EP2035373B1 (de) | 2011-05-04 |
| US20110082183A1 (en) | 2011-04-07 |
| CA2688485C (en) | 2016-01-05 |
| HUE029016T2 (en) | 2017-02-28 |
| AU2007255366B2 (en) | 2013-07-18 |
| NZ573457A (en) | 2011-06-30 |
| EP2348016A1 (de) | 2011-07-27 |
| MX2008015454A (es) | 2009-01-30 |
| DK2348016T3 (en) | 2016-05-30 |
| CA2688485A1 (en) | 2007-12-13 |
| ATE508111T1 (de) | 2011-05-15 |
| SI2348016T1 (sl) | 2016-10-28 |
| JP5444523B2 (ja) | 2014-03-19 |
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