JP2004505024A - 生物学的物質用の保存及び貯蔵媒体 - Google Patents
生物学的物質用の保存及び貯蔵媒体 Download PDFInfo
- Publication number
- JP2004505024A JP2004505024A JP2002515080A JP2002515080A JP2004505024A JP 2004505024 A JP2004505024 A JP 2004505024A JP 2002515080 A JP2002515080 A JP 2002515080A JP 2002515080 A JP2002515080 A JP 2002515080A JP 2004505024 A JP2004505024 A JP 2004505024A
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- polyhydroxy compound
- trehalose
- medium
- storage medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012620 biological material Substances 0.000 title claims abstract description 68
- 239000000203 mixture Substances 0.000 claims abstract description 154
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 105
- 150000001875 compounds Chemical class 0.000 claims abstract description 84
- 238000000034 method Methods 0.000 claims abstract description 63
- 239000003223 protective agent Substances 0.000 claims abstract description 52
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 23
- 239000007864 aqueous solution Substances 0.000 claims abstract description 16
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 75
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 75
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 75
- 239000000126 substance Substances 0.000 claims description 25
- 238000004108 freeze drying Methods 0.000 claims description 24
- 229910019142 PO4 Inorganic materials 0.000 claims description 18
- 239000010452 phosphate Substances 0.000 claims description 18
- 229940085991 phosphate ion Drugs 0.000 claims description 16
- 238000007710 freezing Methods 0.000 claims description 14
- 230000008014 freezing Effects 0.000 claims description 14
- 102000004190 Enzymes Human genes 0.000 claims description 11
- 108090000790 Enzymes Proteins 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 239000012080 ambient air Substances 0.000 claims description 7
- 150000004676 glycans Chemical class 0.000 claims description 7
- 150000002772 monosaccharides Chemical class 0.000 claims description 7
- 229920001282 polysaccharide Polymers 0.000 claims description 7
- 239000005017 polysaccharide Substances 0.000 claims description 7
- 238000004321 preservation Methods 0.000 claims description 7
- 238000007605 air drying Methods 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 150000002016 disaccharides Chemical class 0.000 claims description 5
- 239000002253 acid Substances 0.000 abstract description 2
- 150000002500 ions Chemical class 0.000 abstract description 2
- 239000002609 medium Substances 0.000 description 69
- 239000000523 sample Substances 0.000 description 61
- 210000004027 cell Anatomy 0.000 description 41
- 230000000694 effects Effects 0.000 description 24
- 239000000243 solution Substances 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 238000001035 drying Methods 0.000 description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 10
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 10
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 10
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 9
- 235000019345 sodium thiosulphate Nutrition 0.000 description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 8
- 229930006000 Sucrose Natural products 0.000 description 8
- 239000005720 sucrose Substances 0.000 description 8
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 description 7
- 230000000977 initiatory effect Effects 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000008057 potassium phosphate buffer Substances 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 239000002577 cryoprotective agent Substances 0.000 description 5
- 229940093916 potassium phosphate Drugs 0.000 description 5
- 229910000160 potassium phosphate Inorganic materials 0.000 description 5
- 235000011009 potassium phosphates Nutrition 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 230000009477 glass transition Effects 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000002731 protein assay Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003349 gelling agent Substances 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 2
- 230000008723 osmotic stress Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 159000000001 potassium salts Chemical class 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000008247 solid mixture Substances 0.000 description 2
- 239000013077 target material Substances 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108030001720 Bontoxilysin Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
- 108010028690 Fish Proteins Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 238000003109 Karl Fischer titration Methods 0.000 description 1
- 239000004201 L-cysteine Substances 0.000 description 1
- 235000013878 L-cysteine Nutrition 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000192001 Pediococcus Species 0.000 description 1
- 102000001105 Phosphofructokinases Human genes 0.000 description 1
- 108010069341 Phosphofructokinases Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000009604 anaerobic growth Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 231100001103 botulinum neurotoxin Toxicity 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 229920003064 carboxyethyl cellulose Polymers 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 229940111685 dibasic potassium phosphate Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- -1 lipid vesicles Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 229940111688 monobasic potassium phosphate Drugs 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/625,735 US6653062B1 (en) | 2000-07-26 | 2000-07-26 | Preservation and storage medium for biological materials |
| PCT/US2001/014939 WO2002009515A1 (en) | 2000-07-26 | 2001-05-09 | Preservation and storage medium for biological materials |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007241092A Division JP4889602B2 (ja) | 2000-07-26 | 2007-09-18 | 生物学的物質用の保存及び貯蔵媒体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505024A true JP2004505024A (ja) | 2004-02-19 |
| JP2004505024A5 JP2004505024A5 (enExample) | 2005-07-07 |
Family
ID=24507345
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002515080A Pending JP2004505024A (ja) | 2000-07-26 | 2001-05-09 | 生物学的物質用の保存及び貯蔵媒体 |
| JP2007241092A Expired - Lifetime JP4889602B2 (ja) | 2000-07-26 | 2007-09-18 | 生物学的物質用の保存及び貯蔵媒体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007241092A Expired - Lifetime JP4889602B2 (ja) | 2000-07-26 | 2007-09-18 | 生物学的物質用の保存及び貯蔵媒体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6653062B1 (enExample) |
| EP (1) | EP1303184B1 (enExample) |
| JP (2) | JP2004505024A (enExample) |
| KR (1) | KR100771388B1 (enExample) |
| CN (1) | CN1444442A (enExample) |
| AT (1) | ATE338458T1 (enExample) |
| AU (2) | AU2001268057B2 (enExample) |
| BR (1) | BRPI0112638B1 (enExample) |
| CA (1) | CA2412330C (enExample) |
| DE (1) | DE60122896T2 (enExample) |
| DK (1) | DK1303184T3 (enExample) |
| ES (1) | ES2273854T3 (enExample) |
| MX (1) | MXPA03000251A (enExample) |
| PT (1) | PT1303184E (enExample) |
| WO (1) | WO2002009515A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022539077A (ja) * | 2019-06-26 | 2022-09-07 | トラヴェール セラピューティクス スウィツァランド ゲーエムベーハー | ホモシスチン尿症を処置するための酵素療法のためのｐｅｇ化シスタチオニンベータ合成酵素 |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7569342B2 (en) | 1997-12-10 | 2009-08-04 | Sierra Molecular Corp. | Removal of molecular assay interferences |
| US20080064108A1 (en) * | 1997-12-10 | 2008-03-13 | Tony Baker | Urine Preservation System |
| US6214054B1 (en) | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| AU2003268033A1 (en) * | 2002-07-26 | 2004-02-16 | The General Hospital Corporation | Systems and methods for cell preservation |
| JPWO2004076602A1 (ja) * | 2003-02-27 | 2006-06-08 | 株式会社林原生物化学研究所 | 脂質膜を構成している脂質の分解抑制方法及びその用途 |
| FR2861546B1 (fr) * | 2003-10-31 | 2006-05-26 | Bruno Eto | Procede de production et de conservation des produits dits "milieux physiologiques" et des produits obtenus selon ce procede |
| ES2396689T3 (es) | 2003-12-11 | 2013-02-25 | Isto Technologies Inc. | Sistema de cartílago particulado |
| WO2005113147A2 (en) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20060051731A1 (en) * | 2004-08-12 | 2006-03-09 | David Ho | Processes for preparing lyophilized platelets |
| CN101072506B (zh) | 2004-08-12 | 2010-05-12 | 塞尔菲乐有限公司 | 制备冻干血小板的方法、包括冻干血小板的组合物和使用方法 |
| US20060035383A1 (en) * | 2004-08-12 | 2006-02-16 | David Ho | Dry platelet preparations for use in diagnostics |
| US7811558B2 (en) * | 2004-08-12 | 2010-10-12 | Cellphire, Inc. | Use of stabilized platelets as hemostatic agent |
| MY142987A (en) * | 2005-06-08 | 2011-02-14 | Hayashibara Biochem Lab | Solution for tissue adhesion prevention and method for tissue adhesion prevention |
| EP1916964A4 (en) | 2005-08-26 | 2015-11-04 | Zimmer Inc | IMPLANTS AND METHODS FOR THE REPAIR, REPLACEMENT AND TREATMENT OF JOINT DISEASES |
| US8168206B1 (en) | 2005-10-06 | 2012-05-01 | Allergan, Inc. | Animal protein-free pharmaceutical compositions |
| US8137677B2 (en) * | 2005-10-06 | 2012-03-20 | Allergan, Inc. | Non-protein stabilized clostridial toxin pharmaceutical compositions |
| WO2007079147A2 (en) | 2005-12-28 | 2007-07-12 | Advanced Bionutrition Corporation | A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| US8007992B2 (en) | 2006-10-27 | 2011-08-30 | Edwards Lifesciences Corporation | Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C1-C3 alcohol |
| US8097403B2 (en) * | 2006-12-14 | 2012-01-17 | Cellphire, Inc. | Freeze-dried platelets, method of making and method of use as a diagnostic agent |
| EP2117354B1 (en) | 2006-12-18 | 2018-08-08 | Advanced BioNutrition Corp. | A dry food product containing live probiotic |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| AU2008240191B2 (en) | 2007-04-12 | 2013-09-19 | Zimmer, Inc. | Compositions and methods for tissue repair |
| US9101691B2 (en) | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
| US20090081785A1 (en) | 2007-09-24 | 2009-03-26 | Hememics Biotechnologies, Inc. | Desiccated Biologics And Methods Of Preparing The Same |
| US20090090022A1 (en) * | 2007-10-09 | 2009-04-09 | Hememics Biotechnologies, Inc. | Desiccation Chamber and Methods for Drying Biological Materials |
| DE102007052281A1 (de) * | 2007-11-02 | 2009-05-07 | Zenteris Gmbh | Einschritt-Multiplex-Immuntest |
| US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
| US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| US8735054B1 (en) | 2008-01-04 | 2014-05-27 | Lifecell Corporation | Acellular tissue matrix preservation solution |
| US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US9150318B1 (en) | 2009-01-02 | 2015-10-06 | Lifecell Corporation | Method for sterilizing an acellular tissue matrix |
| WO2010111565A2 (en) | 2009-03-27 | 2010-09-30 | Advanced Bionutrition Corporation | Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish |
| HRP20160598T4 (hr) | 2009-05-01 | 2019-06-28 | Uas Laboratories Llc | Bakterijski sastavi za prevenciju i liječenje degenerativne bolesti |
| EP2435554B1 (en) | 2009-05-26 | 2017-07-26 | Advanced Bionutrition Corporation | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
| EP2451398B1 (en) | 2009-07-10 | 2015-10-28 | Kirk Promotion LTD. | Hip joint device |
| CN107087706A (zh) | 2009-08-14 | 2017-08-25 | 杜邦营养生物科学有限公司 | 具有增强稳定性和生存力的包被的脱水微生物 |
| US11864553B2 (en) | 2009-10-23 | 2024-01-09 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| US20110110975A1 (en) * | 2009-11-06 | 2011-05-12 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| US20110183311A1 (en) * | 2010-01-27 | 2011-07-28 | David Ho | Dry platelet preparations for use in diagnostics |
| PL2529004T3 (pl) | 2010-01-28 | 2017-12-29 | Advanced Bionutrition Corporation | Sucha szklista kompozycja zawierająca bioaktywny materiał |
| US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
| EP2547760A4 (en) | 2010-02-17 | 2014-01-01 | Hememics Biotechnologies Inc | PRESERVATION SOLUTIONS FOR BIOLOGICS AND RELATED METHODS |
| US8679404B2 (en) | 2010-03-05 | 2014-03-25 | Edwards Lifesciences Corporation | Dry prosthetic heart valve packaging system |
| BR122014006876B1 (pt) | 2010-03-23 | 2020-09-29 | Edwards Lifesciences Corporation | Método para preparar material de membrana de tecido bioprotético |
| US8906601B2 (en) | 2010-06-17 | 2014-12-09 | Edwardss Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
| CN102946916B (zh) | 2010-06-17 | 2015-03-18 | 爱德华兹生命科学公司 | 通过化学修饰抗原性碳水化合物稳定生物假体组织的方法 |
| EP2598660B1 (en) | 2010-07-26 | 2017-03-15 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| WO2012018639A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| AR082682A1 (es) | 2010-08-13 | 2012-12-26 | Advanced Bionutrition Corp | Composicion estabilizadora de almacenamiento en seco para materiales biologicos |
| US9351829B2 (en) | 2010-11-17 | 2016-05-31 | Edwards Lifesciences Corporation | Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability |
| US9498317B2 (en) | 2010-12-16 | 2016-11-22 | Edwards Lifesciences Corporation | Prosthetic heart valve delivery systems and packaging |
| US8512679B2 (en) * | 2011-03-04 | 2013-08-20 | Elwha Llc | Glassy compositions |
| EP3662750A1 (en) | 2011-04-07 | 2020-06-10 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
| US9956281B2 (en) | 2011-05-04 | 2018-05-01 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| CN107233569B (zh) | 2011-10-25 | 2021-08-31 | 普罗西纳生物科学有限公司 | 抗体制剂和方法 |
| EP2807177B1 (en) | 2012-01-27 | 2019-11-13 | The Regents of The University of California | Stabilization of biomolecules using sugar polymers |
| FR2992861B1 (fr) | 2012-07-09 | 2014-10-17 | Probionov | Utilisation de thiosulfate pour potentialiser l'effet anti-pathogene des lactobacilles |
| CN103027032B (zh) * | 2012-09-29 | 2014-09-17 | 浙江大学 | 一种鼠李糖脂作为细胞低温或超低温保存的保护剂应用 |
| US10238771B2 (en) | 2012-11-08 | 2019-03-26 | Edwards Lifesciences Corporation | Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system |
| US9725703B2 (en) | 2012-12-20 | 2017-08-08 | Biomatrica, Inc. | Formulations and methods for stabilizing PCR reagents |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| TWI453179B (zh) * | 2013-02-19 | 2014-09-21 | Chunghwa Picture Tubes Ltd | 顆粒狀肥料及其製造方法 |
| CN103564617A (zh) * | 2013-09-18 | 2014-02-12 | 黄雨诗 | 一种动植物体微冰晶冷冻保鲜助冻剂及使用方法 |
| US9615922B2 (en) | 2013-09-30 | 2017-04-11 | Edwards Lifesciences Corporation | Method and apparatus for preparing a contoured biological tissue |
| US10959839B2 (en) | 2013-10-08 | 2021-03-30 | Edwards Lifesciences Corporation | Method for directing cellular migration patterns on a biological tissue |
| AU2014368594B2 (en) * | 2013-12-19 | 2020-03-05 | Janssen Vaccines & Prevention B.V. | Improved formulations for virosomes |
| ES2786373T3 (es) | 2014-06-10 | 2020-10-09 | Biomatrica Inc | Estabilización de trombocitos a temperaturas ambiente |
| US12558395B2 (en) | 2015-07-29 | 2026-02-24 | Advanced Bionutrition Corp. | Stable dry probiotic compositions for special dietary uses |
| MY194231A (en) | 2015-07-29 | 2022-11-23 | Advanced Bionutrition Corp | Stable dry probiotic compositions for special dietary uses |
| EA039591B1 (ru) | 2015-10-30 | 2022-02-15 | Кабусики Кайся Якулт Хонса | Способ получения осушенных микробных клеток |
| FI3998067T3 (fi) | 2015-11-09 | 2024-10-31 | Univ Colorado Regents | Koostumukset ja menetelmät homokystinurian hoitoon |
| AU2016365214B2 (en) | 2015-12-04 | 2021-02-25 | Advanced Bionutrition Corp. | Stable dry compositions having no or little sugars |
| KR20250047404A (ko) | 2015-12-08 | 2025-04-03 | 바이오매트리카 인코포레이티드 | 적혈구 침강 속도의 감소 |
| KR102480965B1 (ko) | 2016-09-13 | 2022-12-26 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
| HUE065794T2 (hu) | 2017-01-19 | 2024-06-28 | Int N&H Denmark Aps | Szárított mikroorganizmus segédanyaggal |
| CA3062547A1 (en) | 2017-05-31 | 2018-12-06 | Edwards Lifesciences Corporation | Collagen fibers and articles formed therefrom |
| WO2019014576A1 (en) | 2017-07-14 | 2019-01-17 | The University Of Chicago | LYOPHILIZED FORMULATIONS COMPRISING NANOPARTICLES AND METHODS OF LYOPHILIZATION |
| EP3743124B1 (en) | 2018-01-23 | 2024-05-08 | Edwards Lifesciences Corporation | Method for pre-stretching implantable biocompatible materials, and materials and devices produced thereby |
| CN109260517B (zh) * | 2018-09-19 | 2020-10-30 | 杭州启明医疗器械股份有限公司 | 一种可预装干燥生物心脏瓣膜及其制备方法 |
| CA3116158A1 (en) | 2018-11-01 | 2020-05-07 | Edwards Lifesciences Corporation | Transcatheter pulmonic regenerative valve |
| CA3121200A1 (en) | 2018-11-30 | 2020-06-04 | Cellphire, Inc. | Platelets as delivery agents |
| WO2020112963A1 (en) | 2018-11-30 | 2020-06-04 | Cellphire, Inc. | Platelets as delivery agents |
| IT201900006056A1 (it) * | 2019-04-18 | 2020-10-18 | Probiotical Spa | Procedimento per la preparazione di una biomassa di cellule di batteri liofilizzate stabili e determinazione della loro stabilità mediante un metodo citofluorimetrico |
| IT201900006066A1 (it) * | 2019-04-18 | 2020-10-18 | Probiotical Spa | Uso di un metodo citofluorimetrico per valutare la stabilità e vitalità di una biomassa di cellule di batteri liofilizzate |
| IL322149A (en) | 2019-05-03 | 2025-09-01 | Cellphire Inc | Materials and methods for manufacturing blood products |
| CN114450066A (zh) | 2019-08-16 | 2022-05-06 | 塞尔菲乐有限公司 | 作为抗血小板剂逆转剂的血栓小体 |
| EP3965841A1 (en) | 2019-12-09 | 2022-03-16 | Edwards Lifesciences Corporation | Bioprosthetic tissue preparation |
| CA3170196A1 (en) | 2020-02-04 | 2021-08-12 | Cellphire, Inc. | Anti-fibrinolytic loaded platelets |
| US12453805B2 (en) | 2020-09-24 | 2025-10-28 | Everest Medical Innovation GmbH | Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery |
| US12426594B2 (en) | 2020-09-24 | 2025-09-30 | Everest Medical Innovation GmbH | Cryoprotective compositions and methods for protection of a surgical site during cryosurgery |
| US20240066073A1 (en) * | 2020-10-06 | 2024-02-29 | Danisco Us Inc. | Readily dispersible shelf-stable microbial granules |
| TW202245814A (zh) | 2021-02-17 | 2022-12-01 | 美商賽菲爾公司 | 用於治療抗血小板誘導的凝血病之凍乾血小板衍生物組成物 |
| WO2024233577A1 (en) | 2023-05-11 | 2024-11-14 | Vetstem, Inc. | Platelet-rich plasma compositions, preparation, and uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62221697A (ja) * | 1986-03-13 | 1987-09-29 | ザ ユニバ−シイテイ オブ サウスウエスタン ルイジアナ | タン白の凍結保護方法 |
| JPH05292943A (ja) * | 1992-04-23 | 1993-11-09 | Nakano Vinegar Co Ltd | 微生物の保存方法 |
| JPH0640801A (ja) * | 1992-07-24 | 1994-02-15 | Morishita Roussel Kk | 移植臓器用溶液 |
| JPH08109136A (ja) * | 1994-02-22 | 1996-04-30 | Nippon Telegr & Teleph Corp <Ntt> | 血球、幹細胞、および血小板の凍結乾燥生成物およびその製造方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| FR2529787B1 (fr) * | 1982-07-09 | 1985-08-02 | Rgl Transfusion Sanguine Centr | Solution protectrice pour la conservation de cellules fonctionnelles |
| FR2542617B2 (fr) | 1982-07-09 | 1986-06-06 | Rgl Transfusion Sanguine Centr | Solution protectrice pour la conservation de cellules fonctionnelles |
| JPS6197229A (ja) | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| US4857319A (en) | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
| JPH0779694B2 (ja) * | 1985-07-09 | 1995-08-30 | カドラント バイオリソ−シズ リミテツド | 蛋白質および同類品の保護 |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| GB8715238D0 (en) | 1987-06-29 | 1987-08-05 | Quadrant Bioresources Ltd | Food process |
| GB8801338D0 (en) | 1988-01-21 | 1988-02-17 | Quadrant Bioresources Ltd | Preservation of viruses |
| US5045446A (en) | 1988-08-26 | 1991-09-03 | Cryopharm Corporation | Lyophilization of cells |
| US5171661A (en) | 1988-05-18 | 1992-12-15 | Cryopharm Corporation | Medium for lyophilization of erythrocytes |
| US5252496A (en) | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| US5621094A (en) | 1990-05-14 | 1997-04-15 | Quadrant Holdings Cambridge Limited | Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sugar alcohol |
| US5314595A (en) | 1992-04-03 | 1994-05-24 | United States Biochemical Corporation | Electrophoresis of nucleic acid fragments |
| DE69333924T2 (de) * | 1992-05-29 | 2006-08-17 | University Of North Carolina At Chapel Hill | Im immobilisierten Zustand getrocknete pharmazeutisch verträgliche menschliche Blutplättchen |
| GB9215587D0 (en) * | 1992-07-22 | 1992-09-02 | Field Group Ltd | Cartons |
| AU685784B2 (en) | 1993-02-23 | 1998-01-29 | Genentech Inc. | Excipient stabilization of polypeptides treated with organic solvents |
| JP3125610B2 (ja) * | 1993-12-24 | 2001-01-22 | 和光純薬工業株式会社 | Ｌ−メチオニン γ−リアーゼの安定化法 |
| GB9401447D0 (en) * | 1994-01-26 | 1994-03-23 | Ciba Geigy Ag | Pharmaceutical compositions |
| DE4405426A1 (de) * | 1994-02-21 | 1995-08-24 | Boehringer Mannheim Gmbh | Pharmazeutisches Präparat enthaltend Plasminogenaktivator (t-PA) oder dessen Derivate |
| US5955448A (en) | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
| FR2719479B1 (fr) | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
| US5512547A (en) | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| US5556771A (en) | 1995-02-10 | 1996-09-17 | Gen-Probe Incorporated | Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification |
| US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
| DE69628007T2 (de) | 1995-06-07 | 2003-11-27 | Elan Drug Delivery Ltd., Ruddington | Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen |
| US5690963A (en) * | 1995-06-30 | 1997-11-25 | The United States Of America As Represented By The Secretary Of The Navy | Freeze dried red blood cells |
| JP2930908B2 (ja) * | 1995-07-19 | 1999-08-09 | 川澄化学工業株式会社 | 血小板保存液 |
| US5736313A (en) * | 1995-10-20 | 1998-04-07 | The United States Of America As Represented By The Secretary Of The Navy | Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing |
| US5827741A (en) | 1996-11-19 | 1998-10-27 | The Regents Of The University Of California | Cryopreservation of human adult and fetal pancreatic cells and human platelets |
| US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| WO1998034478A1 (en) * | 1997-02-07 | 1998-08-13 | Quadrant Holdings Cambridge Limited | Methods and compositions for producing dried, storage-stable platelets |
| GB9705588D0 (en) | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
| AU2945199A (en) | 1998-03-18 | 1999-10-11 | Ronai, Peter | Amorphous glasses for stabilising sensitive products |
| WO2001030141A1 (en) * | 1999-10-22 | 2001-05-03 | Quadrant Healthcare (Uk) Limited | Platelet stabilisation |
| CA2397362A1 (en) | 2000-02-10 | 2001-08-16 | The Regents Of The University Of California | Therapeutic platelets and methods |
| US6770478B2 (en) | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
| US20020076445A1 (en) | 2000-02-10 | 2002-06-20 | Crowe John H. | Eukaryotic cells and method for preserving cells |
-
2000
- 2000-07-26 US US09/625,735 patent/US6653062B1/en not_active Expired - Lifetime
-
2001
- 2001-05-09 AT AT01945951T patent/ATE338458T1/de not_active IP Right Cessation
- 2001-05-09 WO PCT/US2001/014939 patent/WO2002009515A1/en not_active Ceased
- 2001-05-09 ES ES01945951T patent/ES2273854T3/es not_active Expired - Lifetime
- 2001-05-09 AU AU2001268057A patent/AU2001268057B2/en not_active Expired
- 2001-05-09 CA CA002412330A patent/CA2412330C/en not_active Expired - Lifetime
- 2001-05-09 AU AU6805701A patent/AU6805701A/xx active Pending
- 2001-05-09 DE DE60122896T patent/DE60122896T2/de not_active Expired - Lifetime
- 2001-05-09 DK DK01945951T patent/DK1303184T3/da active
- 2001-05-09 BR BRPI0112638-5A patent/BRPI0112638B1/pt not_active IP Right Cessation
- 2001-05-09 KR KR1020037000995A patent/KR100771388B1/ko not_active Expired - Lifetime
- 2001-05-09 JP JP2002515080A patent/JP2004505024A/ja active Pending
- 2001-05-09 MX MXPA03000251A patent/MXPA03000251A/es active IP Right Grant
- 2001-05-09 PT PT01945951T patent/PT1303184E/pt unknown
- 2001-05-09 CN CN01813325A patent/CN1444442A/zh active Pending
- 2001-05-09 EP EP01945951A patent/EP1303184B1/en not_active Expired - Lifetime
-
2003
- 2003-09-05 US US10/657,017 patent/US6919172B2/en not_active Expired - Lifetime
-
2004
- 2004-03-12 US US10/799,462 patent/US7169606B2/en not_active Expired - Fee Related
-
2007
- 2007-09-18 JP JP2007241092A patent/JP4889602B2/ja not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62221697A (ja) * | 1986-03-13 | 1987-09-29 | ザ ユニバ−シイテイ オブ サウスウエスタン ルイジアナ | タン白の凍結保護方法 |
| JPH05292943A (ja) * | 1992-04-23 | 1993-11-09 | Nakano Vinegar Co Ltd | 微生物の保存方法 |
| JPH0640801A (ja) * | 1992-07-24 | 1994-02-15 | Morishita Roussel Kk | 移植臓器用溶液 |
| JPH08109136A (ja) * | 1994-02-22 | 1996-04-30 | Nippon Telegr & Teleph Corp <Ntt> | 血球、幹細胞、および血小板の凍結乾燥生成物およびその製造方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022539077A (ja) * | 2019-06-26 | 2022-09-07 | トラヴェール セラピューティクス スウィツァランド ゲーエムベーハー | ホモシスチン尿症を処置するための酵素療法のためのｐｅｇ化シスタチオニンベータ合成酵素 |
Also Published As
| Publication number | Publication date |
|---|---|
| US6653062B1 (en) | 2003-11-25 |
| JP4889602B2 (ja) | 2012-03-07 |
| MXPA03000251A (es) | 2003-06-06 |
| ATE338458T1 (de) | 2006-09-15 |
| BRPI0112638B1 (pt) | 2015-05-26 |
| WO2002009515B1 (en) | 2002-06-27 |
| DE60122896D1 (de) | 2006-10-19 |
| WO2002009515A1 (en) | 2002-02-07 |
| DK1303184T3 (da) | 2007-01-08 |
| CN1444442A (zh) | 2003-09-24 |
| US20040209236A1 (en) | 2004-10-21 |
| BR0112638A (pt) | 2003-06-24 |
| EP1303184A1 (en) | 2003-04-23 |
| AU2001268057B2 (en) | 2005-06-09 |
| CA2412330A1 (en) | 2002-02-07 |
| EP1303184B1 (en) | 2006-09-06 |
| DE60122896T2 (de) | 2007-04-05 |
| US20040043374A1 (en) | 2004-03-04 |
| JP2008044953A (ja) | 2008-02-28 |
| ES2273854T3 (es) | 2007-05-16 |
| KR100771388B1 (ko) | 2007-10-31 |
| US6919172B2 (en) | 2005-07-19 |
| KR20030031561A (ko) | 2003-04-21 |
| CA2412330C (en) | 2009-02-10 |
| PT1303184E (pt) | 2007-01-31 |
| AU6805701A (en) | 2002-02-13 |
| US7169606B2 (en) | 2007-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4889602B2 (ja) | 生物学的物質用の保存及び貯蔵媒体 | |
| AU2001268057A1 (en) | Preservation and storage medium for biological materials | |
| AU650045B2 (en) | Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions | |
| US5736313A (en) | Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing | |
| US6060233A (en) | Methods for the lyophilization of platelets, platelet membranes or erythrocytes | |
| JP3068836B2 (ja) | 物質の貯蔵 | |
| EP0483329B1 (en) | Novel lyophilized and reconstituted cell compositions | |
| US6221575B1 (en) | Methods for producing dried storage-stable platelets and compositions obtained thereby | |
| KR100777349B1 (ko) | 민감한 생물학적 물질의 보존방법 | |
| US5690963A (en) | Freeze dried red blood cells | |
| JPH07507443A (ja) | 細胞および細胞様物質を凍結する方法 | |
| US8628960B2 (en) | Desiccated biologics and methods of preparing the same | |
| EP0594651B1 (en) | Dried blood cells and method of preparation | |
| US6040132A (en) | Methods for the lyophilization of living biological materials | |
| JPH08509374A (ja) | 生存可能な細菌 | |
| Spargo et al. | Freeze Dried Platelets. | |
| Spargo | Freeze Dried Red Blood Cells and Platelets. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20061004 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20061016 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070116 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070123 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070416 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20070521 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070918 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071114 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071114 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20080116 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20080502 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100702 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100707 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110524 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110530 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110824 |