JP2004500904A5 - - Google Patents

Info

Publication number

JP2004500904A5

JP2004500904A5 JP2001515000A JP2001515000A JP2004500904A5 JP 2004500904 A5 JP2004500904 A5 JP 2004500904A5 JP 2001515000 A JP2001515000 A JP 2001515000A JP 2001515000 A JP2001515000 A JP 2001515000A JP 2004500904 A5 JP2004500904 A5 JP 2004500904A5

Authority

JP

Japan

Prior art keywords

dose

drug delivery

cartridge

delivery pen

lead screw

Prior art date

2000-07-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000012377 drug delivery Methods 0.000 description 45
• 239000003814 drug Substances 0.000 description 19
• 229940079593 drug Drugs 0.000 description 18
• 230000007246 mechanism Effects 0.000 description 18
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 14
• 102000004877 Insulin Human genes 0.000 description 7
• 108090001061 Insulin Proteins 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• 229940125396 insulin Drugs 0.000 description 7
• 239000012530 fluid Substances 0.000 description 5
• 206010012601 diabetes mellitus Diseases 0.000 description 2
• 238000001647 drug administration Methods 0.000 description 2
• 238000001802 infusion Methods 0.000 description 2
• 229940122254 Intermediate acting insulin Drugs 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 238000002483 medication Methods 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 230000007306 turnover Effects 0.000 description 1