JP2004267216A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004267216A5 JP2004267216A5 JP2004132989A JP2004132989A JP2004267216A5 JP 2004267216 A5 JP2004267216 A5 JP 2004267216A5 JP 2004132989 A JP2004132989 A JP 2004132989A JP 2004132989 A JP2004132989 A JP 2004132989A JP 2004267216 A5 JP2004267216 A5 JP 2004267216A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- coupled receptor
- polypeptide
- amino acid
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 16
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 239000013598 vector Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229940125425 inverse agonist Drugs 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 239000004031 partial agonist Substances 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Claims (20)
- Ｇタンパク質共役型受容体ポリペプチドをコードする単離されたポリヌクレオチドであって、該ポリヌクレオチドが、以下：
（ａ）配列番号８に示されるアミノ酸配列を含むポリペプチドをコードする配列；あるいは
（ｂ）（ａ）に規定されるアミノ酸配列の１個もしくは数個のアミノ酸の置換、欠失または付加による（ａ）由来のポリペプチドをコードする配列；あるいは
（ｃ）ストリンジェントな条件下で、配列番号７の相補体にハイブリダイズするポリヌクレオチドによってコードされるポリペプチドをコードする配列であって、該ストリンジェントな条件下は、６５℃にて０．１×ＳＳＣ中の洗浄を含む、配列
からなる群より選択されるヌクレオチド配列を含み、
ここで、配列番号８を有するポリペプチドは、Ｇタンパク質共役型受容体の活性を有する、単離されたポリヌクレオチド。 - 請求項１に記載の単離されたポリヌクレオチドであって、該ポリヌクレオチドが、配列番号８に示されるアミノ酸配列を含むポリペプチドをコードするヌクレオチド配列を含む、単離されたポリヌクレオチド。
- ヒトの膵臓から得られる、請求項１または請求項２に記載の単離されたポリヌクレオチド。
- 請求項１〜３のいずれか１項に記載の単離されたポリヌクレオチドであって、前記ヌクレオチド配列が、選択的に、ヒトの膵臓において内因的に発現される、単離されたポリヌクレオチド。
- 請求項４に記載の単離されたポリヌクレオチドであって、前記発現が、ＲＴ−ＰＣＲを実施する工程を包含するプロセスを使用して決定される、単離されたポリヌクレオチド。
- 請求項１〜５のいずれか１項に示される単離されたポリヌクレオチドに相補的な単離されたポリヌクレオチド。
- 請求項１〜５のいずれか１項に記載のポリヌクレオチドを含むベクター。
- 前記ベクターが発現ベクターであり、請求項１〜５のいずれか１項に記載のポリヌクレオチドが作動可能にプロモーターに連結される、請求項７に記載のベクター。
- 請求項７に記載のベクターを含む、組換え宿主細胞。
- 請求項８に記載のベクターを含む、組換え宿主細胞。
- 請求項９に記載の組換え宿主細胞の単離された膜であって、該膜が、請求項１〜５のいずれか１項に記載の単離されたポリヌクレオチドによってコードされるＧタンパク質共役型受容体を含む、単離された膜。
- 以下の工程：
（ａ）請求項８に記載の発現ベクターを宿主細胞にトランスフェクトして、トランスフェクトされた宿主細胞を作製する工程；および
（ｂ）該発現ベクターからＧタンパク質共役型受容体を発現するのに十分な条件下で、該トランスフェクトされた宿主細胞を培養する工程
を包含する、Ｇタンパク質共役型受容体を作製する方法。 - 以下：
（ａ）配列番号８に示されるアミノ酸配列を含む配列；あるいは
（ｂ）（ａ）に規定されるアミノ酸配列の１個もしくは数個のアミノ酸の置換、欠失または付加による（ａ）由来のポリペプチドのアミノ酸配列を含む配列；あるいは
（ｃ）ストリンジェントな条件下で、配列番号７の相補体にハイブリダイズするポリヌクレオチドによってコードされるポリペプチドのアミノ酸配列を含む配列であって、該ストリンジェントな条件は、６５℃にて０．１×ＳＳＣ中の洗浄を含む、配列
からなる群より選択されるアミノ酸配列を含む単離されたＧタンパク質共役型受容体ポリペプチドまたは組換えＧタンパク質共役型受容体ポリペプチドであって、
ここで、配列番号８を有するポリペプチドは、Ｇタンパク質共役型受容体の活性を有する、単離されたＧタンパク質共役型受容体ポリペプチドまたは組換えＧタンパク質共役型受容体ポリペプチド。 - 前記Ｇタンパク質共役型受容体ポリペプチドが、配列番号８に示されるアミノ酸配列を含むアミノ酸配列を含む、請求項１３に記載の単離されたＧタンパク質共役型受容体ポリペプチドまたは組換えＧタンパク質共役型受容体ポリペプチド。
- 以下の工程：
（ａ）候補化合物と、請求項１３〜１４のいずれか１項に記載のＧタンパク質共役型受容体を含む組換え宿主細胞またはその膜とを接触させる工程；および
（ｂ）該Ｇタンパク質共役型受容体を阻害または刺激する該化合物の能力を測定する工程、
を包含する、該Ｇタンパク質共役型受容体を阻害または刺激し得る１種以上の候補化合物を同定する方法。 - 前記組換えＧタンパク質共役型受容体ポリペプチドが、配列番号８に示されるアミノ酸配列を含む、請求項１５に記載の方法。
- 前記方法が、前記Ｇタンパク質共役型受容体のアゴニスト、部分アゴニストまたは逆アゴニストとしての前記候補化合物を同定するためである、請求項１５〜１６のいずれか１項に記載の方法。
- 前記方法が、医薬として前記アゴニスト、部分アゴニストまたは逆アゴニストを処方する工程をさらに包含する、請求項１７に記載の方法。
- 前記宿主細胞が、哺乳動物の宿主細胞である、請求項１５〜１８のいずれか１項に記載の方法。
- 前記宿主細胞が、酵母の宿主細胞である、請求項１５〜１８のいずれか１項に記載の方法。
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10921398P | 1998-11-20 | 1998-11-20 | |
| US12041699P | 1999-02-16 | 1999-02-16 | |
| US12185299P | 1999-02-26 | 1999-02-26 | |
| US12394699P | 1999-03-12 | 1999-03-12 | |
| US12394999P | 1999-03-12 | 1999-03-12 | |
| US13656799P | 1999-05-28 | 1999-05-28 | |
| US13643799P | 1999-05-28 | 1999-05-28 | |
| US13713199P | 1999-05-28 | 1999-05-28 | |
| US13712799P | 1999-05-28 | 1999-05-28 | |
| US13643699P | 1999-05-28 | 1999-05-28 | |
| US13643999P | 1999-05-28 | 1999-05-28 | |
| US14144899P | 1999-06-29 | 1999-06-29 | |
| US15663399P | 1999-09-29 | 1999-09-29 | |
| US15665399P | 1999-09-29 | 1999-09-29 | |
| US15663499P | 1999-09-29 | 1999-09-29 | |
| US15655599P | 1999-09-29 | 1999-09-29 | |
| US15728199P | 1999-10-01 | 1999-10-01 | |
| US15728099P | 1999-10-01 | 1999-10-01 | |
| US15729499P | 1999-10-01 | 1999-10-01 | |
| US15729399P | 1999-10-01 | 1999-10-01 | |
| US15728299P | 1999-10-01 | 1999-10-01 | |
| US41704499A | 1999-10-12 | 1999-10-12 | |
| US41676099A | 1999-10-12 | 1999-10-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584067A Division JP2003534767A (ja) | 1998-11-20 | 1999-10-13 | ヒトオーファンｇタンパク質共役型受容体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007129923A Division JP2007209352A (ja) | 1998-11-20 | 2007-05-15 | ヒトオーファンｇタンパク質共役型受容体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004267216A JP2004267216A (ja) | 2004-09-30 |
| JP2004267216A5 true JP2004267216A5 (ja) | 2007-02-01 |
Family
ID=27586698
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584067A Withdrawn JP2003534767A (ja) | 1998-11-20 | 1999-10-13 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2004132989A Withdrawn JP2004267216A (ja) | 1998-11-20 | 2004-04-28 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2007129923A Pending JP2007209352A (ja) | 1998-11-20 | 2007-05-15 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2008033839A Pending JP2008133300A (ja) | 1998-11-20 | 2008-02-14 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2009159339A Withdrawn JP2009298791A (ja) | 1998-11-20 | 2009-07-03 | ヒトオーファンｇタンパク質共役型受容体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584067A Withdrawn JP2003534767A (ja) | 1998-11-20 | 1999-10-13 | ヒトオーファンｇタンパク質共役型受容体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007129923A Pending JP2007209352A (ja) | 1998-11-20 | 2007-05-15 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2008033839A Pending JP2008133300A (ja) | 1998-11-20 | 2008-02-14 | ヒトオーファンｇタンパク質共役型受容体 |
| JP2009159339A Withdrawn JP2009298791A (ja) | 1998-11-20 | 2009-07-03 | ヒトオーファンｇタンパク質共役型受容体 |
Country Status (13)
| Country | Link |
|---|---|
| EP (8) | EP1780280A1 (ja) |
| JP (5) | JP2003534767A (ja) |
| KR (5) | KR100963367B1 (ja) |
| AT (3) | ATE301673T1 (ja) |
| AU (2) | AU770056B2 (ja) |
| CA (2) | CA2348377C (ja) |
| DK (3) | DK1133559T3 (ja) |
| ES (3) | ES2308759T3 (ja) |
| HK (2) | HK1037675A1 (ja) |
| IL (2) | IL142538A0 (ja) |
| NZ (3) | NZ527622A (ja) |
| PT (3) | PT1584683E (ja) |
| WO (1) | WO2000031258A2 (ja) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2264267T3 (es) * | 1998-03-12 | 2006-12-16 | Astellas Pharma Inc. | Nuevas proteinas de receptores copulados a proteina g. |
| EP1073681A4 (en) * | 1998-04-24 | 2005-01-12 | Smithkline Beecham Corp | CLONING OF A NEW 7-TM RECEPTOR, AXOR-2 |
| US6071722A (en) * | 1998-04-24 | 2000-06-06 | Smithkline Beecham Corporation | Nucleic acids encoding a G-protein coupled 7TM receptor (AXOR-1) |
| WO2000026339A2 (en) * | 1998-11-03 | 2000-05-11 | Smithkline Beecham Corporation | Axor14, a g-protein coupled receptor |
| US20030017528A1 (en) | 1998-11-20 | 2003-01-23 | Ruoping Chen | Human orphan G protein-coupled receptors |
| USRE42190E1 (en) | 1998-11-20 | 2011-03-01 | Arena Pharmaceuticals, Inc. | Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors |
| US7816492B2 (en) | 1998-11-20 | 2010-10-19 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors |
| US6221660B1 (en) | 1999-02-22 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
| EP1157038A4 (en) * | 1999-02-26 | 2005-01-19 | Smithkline Beecham Corp | CLONING OF A P2Y-LIKE 7TM RECEPTOR (AXOR17) |
| US6620615B1 (en) * | 1999-04-23 | 2003-09-16 | Curagen Corporation | G-protein coupled receptor—encoding nucleic acids |
| WO2000078809A1 (en) * | 1999-06-21 | 2000-12-28 | Smithkline Beecham Corporation | Axor16, a g protein coupled receptor |
| CA2378786A1 (en) * | 1999-07-13 | 2001-01-18 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | G-protein coupled receptor and dna sequences thereof |
| CA2381437A1 (en) * | 1999-07-30 | 2001-02-08 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | G-protein coupled receptor and dna sequences thereof |
| EP1207169A4 (en) * | 1999-08-27 | 2003-03-19 | Takeda Chemical Industries Ltd | NOVEL G PROTEIN COUPLED RECEPTOR PROTEIN AND ITS DNA |
| US6998255B1 (en) | 1999-09-24 | 2006-02-14 | Solvay Pharmaceuticals B.V. | Human G-protein coupled receptor |
| GB9923177D0 (en) * | 1999-09-30 | 1999-12-01 | Pfizer Ltd | Novel polypeptide |
| US6204017B1 (en) | 1999-10-07 | 2001-03-20 | Schering Corporation | Polynucleotide encoding a histamine receptor |
| GB9923893D0 (en) * | 1999-10-08 | 1999-12-08 | Pfizer Ltd | Novel polypeptide |
| GB9923890D0 (en) * | 1999-10-08 | 1999-12-08 | Pfizer Ltd | Novel polypeptide |
| GB9924960D0 (en) * | 1999-10-21 | 1999-12-22 | Pfizer Ltd | Novel polypeptide |
| GB9924956D0 (en) * | 1999-10-21 | 1999-12-22 | Pfizer Ltd | Novel polypeptide |
| AU1575601A (en) * | 1999-10-27 | 2001-05-08 | Pharmacia & Upjohn Company | G protein-coupled receptors expressed in brain |
| ATE375390T1 (de) * | 1999-10-29 | 2007-10-15 | Pfizer | G-protein-gekoppelter rezeptor-ähnliche proteine |
| JP2003513629A (ja) * | 1999-11-03 | 2003-04-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 新規なｇｐｃｒ＿ｋｄ５ポリペプチドおよびそのｄｎａ配列 |
| US6461836B1 (en) * | 1999-11-05 | 2002-10-08 | Smithkline Beecham Corporation | Molecular cloning of a 7TM receptor (AxOR34) and screening methods thereof |
| EP1237909A2 (en) * | 1999-11-16 | 2002-09-11 | PHARMACIA & UPJOHN COMPANY | Human g protein-coupled receptors |
| US7029857B1 (en) | 1999-12-17 | 2006-04-18 | H. Lundbeck A/S | Processes for obtaining compounds employing SNORF72 receptors |
| AU2398501A (en) * | 1999-12-20 | 2001-07-03 | Banyu Pharmaceutical Co., Ltd. | Novel guanosine triphosphate-binding protein-coupled receptor protein, bg26 |
| AU2288601A (en) | 1999-12-23 | 2001-07-03 | Millennium Pharmaceuticals, Inc. | P2Y12 receptor |
| AU2230401A (en) * | 1999-12-28 | 2001-07-09 | Helix Research Institute | Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same |
| GB0001700D0 (en) * | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Novel protein |
| KR20020086491A (ko) * | 2000-02-04 | 2002-11-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 스크리닝 방법 |
| AU2001252181A1 (en) * | 2000-03-14 | 2001-09-24 | Bayer Aktiengesellschaft | Regulation of human lipoxin a4 receptor-like protein |
| AU3930201A (en) * | 2000-03-17 | 2001-09-24 | Bayer Aktiengesellschaft | Regulation of human leukotriene B4-like G protein-coupled receptor |
| WO2001070815A1 (fr) * | 2000-03-21 | 2001-09-27 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau recepteur du leucotriene b4 |
| AU2001242800A1 (en) * | 2000-03-28 | 2001-10-08 | Takeda Chemical Industries Ltd. | Novel g protein-coupled receptor protein and dna thereof |
| WO2001073023A1 (fr) * | 2000-03-31 | 2001-10-04 | Helix Research Institute | Nouveau recepteur gprv53 couple a une proteine se liant a la guanosine-triphosphate, gene correspondant et procede de production et d'utilisation associe |
| AU2001248755A1 (en) * | 2000-04-12 | 2001-10-23 | Takeda Chemical Industries Ltd. | Novel g protein-coupled receptor protein and dna thereof |
| EP1178110A1 (en) * | 2000-08-01 | 2002-02-06 | Aventis Pharma Deutschland GmbH | EDG8 receptor for sphingosine 1-phosphate , its preparation and use |
| ES2278755T3 (es) * | 2000-05-18 | 2007-08-16 | Bayer Healthcare Ag | Regulacion del receptor acoplado a proteinas g de tipo dopamina humano. |
| WO2002000719A2 (en) * | 2000-06-23 | 2002-01-03 | Tularik Inc. | Human and mouse g-protein couipled receptors |
| AU2001281862A1 (en) * | 2000-06-26 | 2002-01-08 | Akzo Nobel N.V. | G-protein coupled receptor org10 |
| AU2001281933A1 (en) * | 2000-06-30 | 2002-01-14 | Ingenium Pharmaceuticals Ag | Human g protein-coupled receptor igpcr17, and uses therof |
| WO2002004518A2 (en) * | 2000-07-06 | 2002-01-17 | Bayer Corporation | Human neuropeptide y-like g protein-coupled receptor |
| WO2002012344A2 (en) * | 2000-08-09 | 2002-02-14 | Millennium Pharmaceuticals, Inc. | Methods for using 14266, a human g protein-coupled receptor |
| US6790608B2 (en) | 2000-09-20 | 2004-09-14 | The Regents Of The University Of California | Methods of identifying and ADP-glucose receptor ligand, agonist or antagonist |
| JP3519078B2 (ja) * | 2000-11-01 | 2004-04-12 | 山之内製薬株式会社 | 抗血小板剤スクリーニング方法 |
| JP4178028B2 (ja) * | 2000-11-07 | 2008-11-12 | タケダ ケンブリッジ リミテッド | 受容体 |
| CN1549858A (zh) * | 2000-11-27 | 2004-11-24 | 阿伦纳药品公司 | 内源和非内源型人g蛋白偶联受体 |
| EP1338651B9 (en) | 2000-12-01 | 2007-05-09 | Astellas Pharma Inc. | Method of screening remedy for diabetes |
| WO2002057311A2 (en) * | 2000-12-22 | 2002-07-25 | University Of South Florida | Sphingosine 1-phosphate receptor gene, sppr |
| WO2002052047A2 (en) * | 2000-12-22 | 2002-07-04 | Mergen Ltd. | Methods for identifying g-protein coupled receptors associated with diseases |
| GB0100782D0 (en) * | 2001-01-11 | 2001-02-21 | Glaxo Group Ltd | Assay |
| ES2311601T3 (es) * | 2001-04-25 | 2009-02-16 | Astellas Pharma Inc. | Receptores acoplado a proteina que se une a trifosfato de guanosina place 6002312 y su gen y produccion y uso del mismo. |
| US20030096299A1 (en) | 2001-07-09 | 2003-05-22 | Valerie Wittamer | Natural ligand of G protein coupled receptor ChemR23 and uses thereof |
| US7419658B2 (en) | 2001-07-09 | 2008-09-02 | Euroscreen S.A. | Isolated ligand of ChemerinR |
| US7858755B2 (en) | 2001-07-09 | 2010-12-28 | Euroscreen S.A. | Monoclonal antibodies that bind Chemerin polypeptide |
| US6946244B2 (en) * | 2001-08-07 | 2005-09-20 | Euroscreen, S.A. | Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13) |
| ATE545866T1 (de) | 2002-04-12 | 2012-03-15 | Schering Corp | Liganden von g-protein-gekoppelten rezeptoren und verfahren |
| AU2003261874A1 (en) * | 2002-09-02 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Adrenocortical hormone secretion controller |
| JPWO2004033687A1 (ja) * | 2002-10-11 | 2006-02-09 | アステラス製薬株式会社 | 腎不全治療薬をスクリーニングする方法 |
| US7056685B1 (en) | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
| DE60335827D1 (de) | 2002-12-20 | 2011-03-03 | Merck Sharp & Dohme | 1-(amino)indane als edg-rezeptoragonisten |
| ES2295816T3 (es) | 2003-01-14 | 2008-04-16 | Arena Pharmaceuticals, Inc. | Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia. |
| US7083933B1 (en) | 2003-05-09 | 2006-08-01 | Prosidion Limited | Methods for identification of modulators of OSGPR116 activity |
| US7524638B1 (en) | 2003-06-27 | 2009-04-28 | Osi Pharmaceuticals, Inc. | Methods for identification of modulators of OSGPR114 or OSGPR78 activity, and their use in the treatment of disease |
| CA2531073A1 (en) * | 2003-06-27 | 2005-02-03 | Tanox, Inc. | Human mast cell-expressed membrane protein |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| GB0508990D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| KR101281962B1 (ko) | 2006-04-11 | 2013-07-08 | 아레나 파마슈티칼스, 인크. | 특정 개체에게서 골 질량을 증가시키는 데에 유용한 화합물을 확인하기 위해 ｇｐｒ119 수용체를 사용하는 방법 |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| CN101754962B (zh) | 2007-07-19 | 2013-12-25 | 赛马拜制药公司 | 作为rup3或gpr119受体的激动剂治疗糖尿病和代谢性病症的n-氮杂环状经取代吡咯、吡唑、咪唑、三唑和四唑衍生物 |
| MX2010003117A (es) | 2007-09-20 | 2010-04-01 | Irm Llc | Compuestos y composiciones como moduladores de la actividad de gpr119. |
| EP2108960A1 (en) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| CA2775840C (en) | 2009-10-01 | 2018-02-06 | Metabolex, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
| US8791100B2 (en) | 2010-02-02 | 2014-07-29 | Novartis Ag | Aryl benzylamine compounds |
| AU2011237775A1 (en) | 2010-04-06 | 2012-11-22 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
| CN103037843A (zh) | 2010-06-23 | 2013-04-10 | 麦它波莱克斯股份有限公司 | 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物 |
| CN103539791B (zh) | 2010-09-22 | 2017-01-11 | 艾尼纳制药公司 | Gpr119 受体调节剂和对与其相关的障碍的治疗 |
| US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
| US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
| AU2017305392A1 (en) | 2016-08-03 | 2019-02-21 | Cymabay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| JP2020524181A (ja) | 2017-06-19 | 2020-08-13 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｎａｆｌｄおよびｎａｓｈの治療のための化合物および方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0868510A2 (en) * | 1995-11-15 | 1998-10-07 | Cor Therapeutics, Inc. | P2u2 PURINERGIC RECEPTOR |
| WO1997024929A1 (en) * | 1996-01-11 | 1997-07-17 | Human Genome Sciences, Inc. | Human g-protein coupled receptor |
| WO1998031810A2 (en) * | 1997-01-21 | 1998-07-23 | Schering Corporation | Mammalian chemokines; receptors; reagents; uses |
| US6221627B1 (en) * | 1997-02-24 | 2001-04-24 | Smithkline Beecham Corporation | cDNA clone HDPB130 that encodes a novel human 7-transmembrane receptor |
| US5955303A (en) * | 1997-03-06 | 1999-09-21 | Incyte Pharmaceuticals, Inc. | Human chemokine receptor-like protein |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| US6060272A (en) * | 1997-05-07 | 2000-05-09 | Human Genome Sciences, Inc. | Human G-protein coupled receptors |
| EP0899332A3 (en) * | 1997-08-15 | 2000-07-05 | Smithkline Beecham Corporation | The G-protein coupled receptor HFIAO41 |
| CA2239255A1 (en) * | 1997-10-23 | 1999-04-23 | Smithkline Beecham Corporation | Cdna clone hneaa81 that encodes a human 7-transmembrane receptor |
| US5932445A (en) * | 1997-11-07 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Signal peptide-containing proteins |
| EP1029916B1 (en) * | 1997-11-11 | 2007-05-23 | Ono Pharmaceutical Co., Ltd. | Human lysophosphatidic acid receptor and use thereof |
| US6207412B1 (en) * | 1997-11-13 | 2001-03-27 | The Regents Of The University Of California | Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells |
| JP2002504492A (ja) * | 1998-02-20 | 2002-02-12 | スミスクライン ビーチャム コーポレーション | Ｇタンパク質共役型受容体Ｆｉｓｈｂｏｙ |
| ES2264267T3 (es) * | 1998-03-12 | 2006-12-16 | Astellas Pharma Inc. | Nuevas proteinas de receptores copulados a proteina g. |
| AU3749499A (en) * | 1998-04-16 | 1999-11-01 | Millenium Pharmaceuticals, Inc. | Novel molecules of the bgckr-related protein family and uses thereof |
| EP1073681A4 (en) * | 1998-04-24 | 2005-01-12 | Smithkline Beecham Corp | CLONING OF A NEW 7-TM RECEPTOR, AXOR-2 |
| US6071722A (en) * | 1998-04-24 | 2000-06-06 | Smithkline Beecham Corporation | Nucleic acids encoding a G-protein coupled 7TM receptor (AXOR-1) |
| SE9801455D0 (sv) * | 1998-04-24 | 1998-04-24 | Astra Pharma Inc | New receptor |
| AU5575299A (en) * | 1998-08-19 | 2000-03-14 | Millennium Pharmaceuticals, Inc. | 14274 receptor, a g-protein coupled receptor related to the edg receptor family |
| EP1104465A1 (en) * | 1998-08-20 | 2001-06-06 | Millennium Pharmaceuticals, Inc. | 14400 receptor, a g-protein coupled receptor |
| WO2000011015A1 (en) * | 1998-08-24 | 2000-03-02 | Alphagene, Inc. | Secreted proteins and polynucleotides encoding them |
| WO2000012707A1 (en) * | 1998-09-02 | 2000-03-09 | Millennium Pharmaceuticals, Inc. | 14926 receptor, a novel g-protein coupled receptor |
| CA2348688A1 (en) * | 1998-10-13 | 2000-04-20 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human g protein-coupled receptors |
| WO2000023588A2 (en) * | 1998-10-16 | 2000-04-27 | Millennium Pharmaceuticals, Inc. | G-protein coupled receptors |
| JP2003534765A (ja) * | 1998-11-04 | 2003-11-25 | カイロン コーポレイション | 単離されたｖｓｈｋ−１レセプターポリペプチドおよびそれを使用する方法 |
| ATE342974T1 (de) * | 1998-11-06 | 2006-11-15 | Bayer Healthcare Ag | G-protein-gekoppelter rezeptoren, die holomog zu ebv-induzierter gpcr (ebi-2) sind, verfahren zur identifizierung von ihren entsprechenden liganden |
| US6221660B1 (en) * | 1999-02-22 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
| US6689866B1 (en) * | 1999-03-09 | 2004-02-10 | Curagen Corporation | Polynucleotides and proteins encoded thereby |
| GB9923177D0 (en) * | 1999-09-30 | 1999-12-01 | Pfizer Ltd | Novel polypeptide |
| US6590938B1 (en) * | 1999-09-30 | 2003-07-08 | Conexant Systems, Inc. | DCT domain conversion of a higher definition signal to lower definition signal |
-
1999
- 1999-10-13 KR KR1020087003578A patent/KR100963367B1/ko not_active IP Right Cessation
- 1999-10-13 EP EP07001452A patent/EP1780280A1/en not_active Ceased
- 1999-10-13 KR KR1020077018185A patent/KR100926208B1/ko not_active IP Right Cessation
- 1999-10-13 KR KR1020017006279A patent/KR100765039B1/ko not_active IP Right Cessation
- 1999-10-13 DK DK99972682T patent/DK1133559T3/da active
- 1999-10-13 NZ NZ527622A patent/NZ527622A/en not_active IP Right Cessation
- 1999-10-13 IL IL14253899A patent/IL142538A0/xx unknown
- 1999-10-13 ES ES07008841T patent/ES2308759T3/es not_active Expired - Lifetime
- 1999-10-13 EP EP05005946A patent/EP1580271A3/en not_active Ceased
- 1999-10-13 PT PT05003040T patent/PT1584683E/pt unknown
- 1999-10-13 KR KR1020087003575A patent/KR100926209B1/ko not_active IP Right Cessation
- 1999-10-13 KR KR1020087024998A patent/KR20080104062A/ko not_active Application Discontinuation
- 1999-10-13 WO PCT/US1999/023687 patent/WO2000031258A2/en active Application Filing
- 1999-10-13 CA CA002348377A patent/CA2348377C/en not_active Expired - Fee Related
- 1999-10-13 DK DK05003040T patent/DK1584683T3/da active
- 1999-10-13 EP EP10010658A patent/EP2295574A1/en not_active Withdrawn
- 1999-10-13 EP EP05003040A patent/EP1584683B1/en not_active Expired - Lifetime
- 1999-10-13 AT AT99972682T patent/ATE301673T1/de active
- 1999-10-13 PT PT07008841T patent/PT1849866E/pt unknown
- 1999-10-13 DK DK07008841T patent/DK1849866T3/da active
- 1999-10-13 CA CA002645717A patent/CA2645717A1/en not_active Withdrawn
- 1999-10-13 EP EP10008862A patent/EP2295572A1/en not_active Withdrawn
- 1999-10-13 NZ NZ537625A patent/NZ537625A/en not_active IP Right Cessation
- 1999-10-13 ES ES05003040T patent/ES2289610T3/es not_active Expired - Lifetime
- 1999-10-13 PT PT99972682T patent/PT1133559E/pt unknown
- 1999-10-13 ES ES99972682T patent/ES2243095T3/es not_active Expired - Lifetime
- 1999-10-13 NZ NZ511087A patent/NZ511087A/en not_active IP Right Cessation
- 1999-10-13 AT AT07008841T patent/ATE396400T1/de active
- 1999-10-13 EP EP10010303A patent/EP2295573A1/en not_active Withdrawn
- 1999-10-13 AT AT05003040T patent/ATE366815T1/de active
- 1999-10-13 EP EP99972682A patent/EP1133559B1/en not_active Expired - Lifetime
- 1999-10-13 EP EP07008841A patent/EP1849866B1/en not_active Expired - Lifetime
- 1999-10-13 AU AU37904/00A patent/AU770056B2/en not_active Ceased
- 1999-10-13 JP JP2000584067A patent/JP2003534767A/ja not_active Withdrawn
-
2001
- 2001-04-11 IL IL142538A patent/IL142538A/en not_active IP Right Cessation
- 2001-12-07 HK HK01108607A patent/HK1037675A1/xx not_active IP Right Cessation
-
2004
- 2004-04-28 JP JP2004132989A patent/JP2004267216A/ja not_active Withdrawn
- 2004-05-12 AU AU2004202147A patent/AU2004202147A1/en not_active Abandoned
-
2005
- 2005-12-02 HK HK07112367A patent/HK1103763A1/xx not_active IP Right Cessation
-
2007
- 2007-05-15 JP JP2007129923A patent/JP2007209352A/ja active Pending
-
2008
- 2008-02-14 JP JP2008033839A patent/JP2008133300A/ja active Pending
-
2009
- 2009-07-03 JP JP2009159339A patent/JP2009298791A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004267216A5 (ja) | ||
| Guo et al. | Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor | |
| JP2005052158A5 (ja) | ||
| KR102483242B1 (ko) | Mg53 돌연변이체, 및 그의 제조 방법 및 그의 용도 | |
| JP7427208B2 (ja) | 視覚機能再生剤又は視覚機能低下予防剤 | |
| JPH03155795A (ja) | マウス・インターロイキン―６レセプター蛋白質 | |
| Gu et al. | Identification and characterization of pro-interleukin-16 from mud crab Scylla paramamosain: The first evidence of proinflammatory cytokine in crab species | |
| Yang et al. | Molecular basis of transferrin polymorphism in goldfish (Carassius auratus) | |
| JP2003530821A5 (ja) | ||
| JP2004537284A5 (ja) | ||
| Chondrou et al. | cDNA cloning and phylogenetic analysis of the sixth complement component in rainbow trout | |
| RU2007111137A (ru) | Гонадотропный гормон, полученный из беспозвоночных, и его синтез | |
| WO2000077211A1 (fr) | Genes associes a la pyrexie et proteines vegetales associees a la pyrexie | |
| JP2013502217A5 (ja) | ||
| JP2003514549A5 (ja) | ||
| Papanastasiou et al. | Cloning and phylogenetic analysis of the alpha subunit of the eighth complement component (C8) in rainbow trout | |
| JP2005507245A5 (ja) | ||
| JP2005507651A5 (ja) | ||
| FURUTA et al. | Molecular cloning of m3 muscarinic acetylcholine receptor in rat iris | |
| JP2002065284A5 (ja) | ||
| CN102558342B (zh) | 猪4-1bb受体，编码其的基因及其应用 | |
| Suter et al. | Cloning of the cDNA encoding the porcine p55 tumor necrosis factor receptor | |
| JPWO2009013794A1 (ja) | インスリン分泌誘導剤及び膵臓β細胞増加促進剤 | |
| JP2007306919A5 (ja) | ||
| JP2003525018A5 (ja) |