JP2004041195A5 - - Google Patents
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- Publication number
- JP2004041195A5 JP2004041195A5 JP2003169309A JP2003169309A JP2004041195A5 JP 2004041195 A5 JP2004041195 A5 JP 2004041195A5 JP 2003169309 A JP2003169309 A JP 2003169309A JP 2003169309 A JP2003169309 A JP 2003169309A JP 2004041195 A5 JP2004041195 A5 JP 2004041195A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- protein
- amino acid
- acid sequence
- inhibitory activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 36
- 108090000623 proteins and genes Proteins 0.000 claims 36
- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 230000002401 inhibitory effect Effects 0.000 claims 24
- 210000002997 osteoclast Anatomy 0.000 claims 22
- 230000015572 biosynthetic process Effects 0.000 claims 18
- 238000010494 dissociation reaction Methods 0.000 claims 16
- 230000005593 dissociations Effects 0.000 claims 16
- 208000006386 Bone Resorption Diseases 0.000 claims 14
- 230000024279 bone resorption Effects 0.000 claims 14
- 102000008108 Osteoprotegerin Human genes 0.000 claims 12
- 108010035042 Osteoprotegerin Proteins 0.000 claims 12
- 230000001747 exhibiting effect Effects 0.000 claims 9
- 238000001962 electrophoresis Methods 0.000 claims 8
- 229920002401 polyacrylamide Polymers 0.000 claims 8
- 230000001737 promoting effect Effects 0.000 claims 8
- 210000002536 stromal cell Anatomy 0.000 claims 8
- 230000002159 abnormal effect Effects 0.000 claims 6
- 230000004097 bone metabolism Effects 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 238000003501 co-culture Methods 0.000 claims 4
- 230000004069 differentiation Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000035800 maturation Effects 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 4
- 210000004989 spleen cell Anatomy 0.000 claims 4
- 206010065687 Bone loss Diseases 0.000 claims 2
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 2
- 208000037147 Hypercalcaemia Diseases 0.000 claims 2
- 208000010191 Osteitis Deformans Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 208000027067 Paget disease of bone Diseases 0.000 claims 2
- 208000016738 bone Paget disease Diseases 0.000 claims 2
- 230000000148 hypercalcaemia Effects 0.000 claims 2
- 208000030915 hypercalcemia disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 201000006409 renal osteodystrophy Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003169309A JP3935861B2 (ja) | 1997-04-15 | 2003-06-13 | 新規蛋白質及びその製造方法 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9780897 | 1997-04-15 | ||
| JP15143497 | 1997-06-09 | ||
| JP21789797 | 1997-08-12 | ||
| JP22480397 | 1997-08-21 | ||
| JP33224197 | 1997-12-02 | ||
| JP2003169309A JP3935861B2 (ja) | 1997-04-15 | 2003-06-13 | 新規蛋白質及びその製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54374198A Division JP3523650B2 (ja) | 1997-04-15 | 1998-04-15 | 新規蛋白質及びその製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004381995A Division JP4230993B2 (ja) | 1997-04-15 | 2004-12-28 | 新規蛋白質及びその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004041195A JP2004041195A (ja) | 2004-02-12 |
| JP2004041195A5 true JP2004041195A5 (enExample) | 2005-08-04 |
| JP3935861B2 JP3935861B2 (ja) | 2007-06-27 |
Family
ID=27525882
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54374198A Expired - Lifetime JP3523650B2 (ja) | 1997-04-15 | 1998-04-15 | 新規蛋白質及びその製造方法 |
| JP2003169309A Expired - Lifetime JP3935861B2 (ja) | 1997-04-15 | 2003-06-13 | 新規蛋白質及びその製造方法 |
| JP2004381995A Expired - Lifetime JP4230993B2 (ja) | 1997-04-15 | 2004-12-28 | 新規蛋白質及びその製造方法 |
| JP2008191860A Expired - Lifetime JP4355357B2 (ja) | 1997-04-15 | 2008-07-25 | 新規蛋白質及びその製造方法 |
| JP2008260450A Expired - Lifetime JP4878616B2 (ja) | 1997-04-15 | 2008-10-07 | 新規蛋白質及びその製造方法 |
| JP2011195938A Expired - Lifetime JP5285751B2 (ja) | 1997-04-15 | 2011-09-08 | 新規蛋白質及びその製造方法 |
| JP2013050045A Expired - Lifetime JP5593407B2 (ja) | 1997-04-15 | 2013-03-13 | 新規蛋白質及びその製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54374198A Expired - Lifetime JP3523650B2 (ja) | 1997-04-15 | 1998-04-15 | 新規蛋白質及びその製造方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004381995A Expired - Lifetime JP4230993B2 (ja) | 1997-04-15 | 2004-12-28 | 新規蛋白質及びその製造方法 |
| JP2008191860A Expired - Lifetime JP4355357B2 (ja) | 1997-04-15 | 2008-07-25 | 新規蛋白質及びその製造方法 |
| JP2008260450A Expired - Lifetime JP4878616B2 (ja) | 1997-04-15 | 2008-10-07 | 新規蛋白質及びその製造方法 |
| JP2011195938A Expired - Lifetime JP5285751B2 (ja) | 1997-04-15 | 2011-09-08 | 新規蛋白質及びその製造方法 |
| JP2013050045A Expired - Lifetime JP5593407B2 (ja) | 1997-04-15 | 2013-03-13 | 新規蛋白質及びその製造方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (7) | US7527790B2 (enExample) |
| EP (3) | EP2336168A1 (enExample) |
| JP (7) | JP3523650B2 (enExample) |
| KR (1) | KR100496063B1 (enExample) |
| CN (1) | CN1138786C (enExample) |
| AT (1) | ATE328006T1 (enExample) |
| AU (1) | AU735355B2 (enExample) |
| CA (2) | CA2257247C (enExample) |
| CY (1) | CY2010017I2 (enExample) |
| DE (2) | DE69834699T3 (enExample) |
| DK (1) | DK0911342T4 (enExample) |
| ES (1) | ES2263204T5 (enExample) |
| FR (1) | FR10C0048I2 (enExample) |
| HU (3) | HU229841B1 (enExample) |
| IL (1) | IL127115A (enExample) |
| LU (1) | LU91759I2 (enExample) |
| NO (2) | NO322632B1 (enExample) |
| NZ (1) | NZ332995A (enExample) |
| PT (1) | PT911342E (enExample) |
| RU (1) | RU2238949C2 (enExample) |
| WO (1) | WO1998046644A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| US20050147611A1 (en) * | 1995-12-22 | 2005-07-07 | Amgen Inc. | Combination therapy for conditions leading to bone loss |
| US7632922B1 (en) * | 1995-12-22 | 2009-12-15 | Amgen, Inc. | Osteoprotegerin |
| DK1114864T4 (da) * | 1996-12-13 | 2012-09-03 | Schering Corp | Pattedyrcelleoverfladeantigener samt tilhørende reagenser |
| EP0946725B1 (en) | 1996-12-23 | 2011-01-26 | Immunex Corporation | Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| ATE328006T1 (de) * | 1997-04-15 | 2006-06-15 | Sankyo Co | Neues protein und verfahren zu dessen herstellung |
| SI0975754T2 (sl) * | 1997-04-16 | 2016-04-29 | Amgen Inc., | Vezivni proteini in receptorji osteoprotegerina |
| US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
| AU2011202547B2 (en) * | 1997-04-16 | 2014-08-28 | Amgen Inc. | Osteoprotegerin binding proteins and receptors |
| US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
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| PL222211B1 (pl) | 2001-06-26 | 2016-07-29 | Amgen Fremont Inc | Przeciwciało przeciwko OPGL, kompozycja je zawierająca, jego zastosowanie i sposób jego wytwarzania, sposób wykrywania poziomu OPGL, kompozycja obejmująca polinukleotydy i komórka gosodarza |
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| BR0318454A (pt) | 2003-08-08 | 2006-09-12 | Abgenix Inc | anticorpos dirigidos a hormÈnio da paratireóide (pth) e seus usos |
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| EP2020445B1 (en) | 2006-05-12 | 2013-01-02 | Keio University | Detection of inflammatory disease and composition for prevention or treatment of inflammatory disease |
| US20100105612A1 (en) | 2006-10-11 | 2010-04-29 | Oriental Yeast Co., Ltd. | Agent containing fused protein of soluble rankl with epitope tag |
| WO2008044797A1 (fr) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Animal modèle d'ostéopénie |
| WO2008044379A1 (fr) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Modèle animal de perte osseuse |
| CN101772351B (zh) | 2007-06-05 | 2013-01-02 | 东方酵母工业株式会社 | 新的骨量增加药 |
| RU2475499C2 (ru) | 2007-10-11 | 2013-02-20 | Дайити Санкио Компани, Лимитед | Антитело, направленное на белок siglec-15, связанный с остеокластами |
| US8778359B2 (en) * | 2008-07-30 | 2014-07-15 | Emergent Biosolutions Inc. | Stable anthrax vaccine formulations |
| US9435811B2 (en) | 2008-09-30 | 2016-09-06 | Oriental Yeast Co., Ltd | Inducer of chondrocyte proliferation and differentiation |
| CN102361632A (zh) * | 2009-03-30 | 2012-02-22 | 弗·哈夫曼-拉罗切有限公司 | 避免玻璃雾化的方法 |
| CN106317224B (zh) | 2009-04-09 | 2020-05-12 | 第一三共株式会社 | 抗-Siglec-15抗体 |
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| US20130280260A1 (en) * | 2010-10-13 | 2013-10-24 | Tokyo Women's Medical University | Osteoclastogenesis inhibitor containing anti-vdac antibody |
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| SG11201405966PA (en) | 2012-03-30 | 2014-11-27 | Daiichi Sankyo Co Ltd | Cdr-modified anti-siglec-15 antibody |
| US9493562B2 (en) | 2012-07-19 | 2016-11-15 | Alethia Biotherapeutics Inc. | Anti-Siglec-15 antibodies |
| CN105555291B (zh) | 2013-08-07 | 2021-08-24 | 助育公司 | 用于治疗雄性不育症的抗体、化合物及其衍生物 |
| US10357559B2 (en) | 2013-12-27 | 2019-07-23 | Emergent Product Development Gaithersburg Inc. | Temperature stable vaccine formulations |
| WO2018052153A1 (ko) * | 2016-09-13 | 2018-03-22 | 주식회사 이앤에스헬스케어 | 티오레독신 1에 특이적으로 결합하는 단일클론항체 및 이의 용도 |
| CN108410990B (zh) * | 2018-05-30 | 2021-07-06 | 中国医学科学院北京协和医院 | Igfbp3在制备诊断i型神经纤维瘤合并脊柱畸形病产品中的应用 |
| CN112521466B (zh) * | 2020-01-22 | 2022-06-17 | 天津科技大学 | 一种提高异源蛋白分泌量的信号肽突变体及其用途 |
| CN111333709B (zh) * | 2020-03-17 | 2023-09-08 | 吉林大学 | 旋毛虫肌幼虫期丝氨酸蛋白酶抑制剂的b细胞表位多肽、杂交瘤细胞株、单克隆抗体及应用 |
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| PL222211B1 (pl) * | 2001-06-26 | 2016-07-29 | Amgen Fremont Inc | Przeciwciało przeciwko OPGL, kompozycja je zawierająca, jego zastosowanie i sposób jego wytwarzania, sposób wykrywania poziomu OPGL, kompozycja obejmująca polinukleotydy i komórka gosodarza |
| CA2481074A1 (en) * | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
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1998
- 1998-04-15 AT AT98914034T patent/ATE328006T1/de active
- 1998-04-15 ES ES98914034T patent/ES2263204T5/es not_active Expired - Lifetime
- 1998-04-15 CA CA2257247A patent/CA2257247C/en not_active Expired - Lifetime
- 1998-04-15 KR KR10-2003-7009671A patent/KR100496063B1/ko not_active Expired - Lifetime
- 1998-04-15 CA CA2781623A patent/CA2781623A1/en not_active Abandoned
- 1998-04-15 RU RU99100615/13A patent/RU2238949C2/ru active Protection Beyond IP Right Term
- 1998-04-15 DK DK98914034.8T patent/DK0911342T4/da active
- 1998-04-15 PT PT98914034T patent/PT911342E/pt unknown
- 1998-04-15 HU HU0800628A patent/HU229841B1/hu unknown
- 1998-04-15 NZ NZ332995A patent/NZ332995A/xx not_active IP Right Cessation
- 1998-04-15 DE DE69834699T patent/DE69834699T3/de not_active Expired - Lifetime
- 1998-04-15 HU HU0000717A patent/HU229476B1/hu active Protection Beyond IP Right Term
- 1998-04-15 CN CNB988004771A patent/CN1138786C/zh not_active Expired - Lifetime
- 1998-04-15 IL IL127115A patent/IL127115A/en not_active IP Right Cessation
- 1998-04-15 EP EP20100186133 patent/EP2336168A1/en not_active Withdrawn
- 1998-04-15 AU AU68518/98A patent/AU735355B2/en not_active Expired
- 1998-04-15 JP JP54374198A patent/JP3523650B2/ja not_active Expired - Lifetime
- 1998-04-15 EP EP98914034.8A patent/EP0911342B2/en not_active Expired - Lifetime
- 1998-04-15 DE DE122010000049C patent/DE122010000049I1/de active Pending
- 1998-04-15 EP EP05017241.0A patent/EP1657255B1/en not_active Expired - Lifetime
- 1998-04-15 WO PCT/JP1998/001728 patent/WO1998046644A1/ja not_active Ceased
- 1998-12-14 NO NO19985848A patent/NO322632B1/no not_active IP Right Cessation
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2002
- 2002-06-11 US US10/167,182 patent/US7527790B2/en not_active Expired - Lifetime
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2003
- 2003-06-13 US US10/460,623 patent/US7192718B2/en not_active Expired - Lifetime
- 2003-06-13 JP JP2003169309A patent/JP3935861B2/ja not_active Expired - Lifetime
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2004
- 2004-05-27 US US10/854,300 patent/US7449185B2/en not_active Expired - Fee Related
- 2004-12-28 JP JP2004381995A patent/JP4230993B2/ja not_active Expired - Lifetime
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2005
- 2005-05-24 US US11/135,521 patent/US20050208580A1/en not_active Abandoned
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2006
- 2006-08-31 US US11/513,178 patent/US20080187540A9/en not_active Abandoned
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2008
- 2008-07-25 JP JP2008191860A patent/JP4355357B2/ja not_active Expired - Lifetime
- 2008-10-07 JP JP2008260450A patent/JP4878616B2/ja not_active Expired - Lifetime
- 2008-12-19 US US12/340,327 patent/US20100136011A1/en not_active Abandoned
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2010
- 2010-11-24 LU LU91759C patent/LU91759I2/fr unknown
- 2010-11-25 NO NO2010021C patent/NO2010021I2/no unknown
- 2010-11-25 FR FR10C0048C patent/FR10C0048I2/fr active Active
- 2010-11-30 CY CY2010017C patent/CY2010017I2/el unknown
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2011
- 2011-09-08 JP JP2011195938A patent/JP5285751B2/ja not_active Expired - Lifetime
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2012
- 2012-08-16 US US13/587,791 patent/US20120329671A1/en not_active Abandoned
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2013
- 2013-03-13 JP JP2013050045A patent/JP5593407B2/ja not_active Expired - Lifetime
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2014
- 2014-05-07 HU HUS1400027C patent/HUS1400027I1/hu unknown
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