CY2010017I2 - Νεα πρωτεϊνη και μεθοδος παρασκευης αυτης - Google Patents
Νεα πρωτεϊνη και μεθοδος παρασκευης αυτηςInfo
- Publication number
- CY2010017I2 CY2010017I2 CY2010017C CY2010017C CY2010017I2 CY 2010017 I2 CY2010017 I2 CY 2010017I2 CY 2010017 C CY2010017 C CY 2010017C CY 2010017 C CY2010017 C CY 2010017C CY 2010017 I2 CY2010017 I2 CY 2010017I2
- Authority
- CY
- Cyprus
- Prior art keywords
- preparing
- new protein
- protein
- new
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30 CD40 or CD95
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9780897 | 1997-04-15 | ||
| JP15143497 | 1997-06-09 | ||
| JP21789797 | 1997-08-12 | ||
| JP22480397 | 1997-08-21 | ||
| JP33224197 | 1997-12-02 | ||
| PCT/JP1998/001728 WO1998046644A1 (fr) | 1997-04-15 | 1998-04-15 | Nouvelle proteine et methode de production associee |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CY2010017I1 CY2010017I1 (el) | 2011-02-02 |
| CY2010017I2 true CY2010017I2 (el) | 2012-01-25 |
Family
ID=27525882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY2010017C CY2010017I2 (el) | 1997-04-15 | 2010-11-30 | Νεα πρωτεϊνη και μεθοδος παρασκευης αυτης |
Country Status (21)
| Country | Link |
|---|---|
| US (7) | US7527790B2 (enExample) |
| EP (3) | EP1657255B1 (enExample) |
| JP (7) | JP3523650B2 (enExample) |
| KR (1) | KR100496063B1 (enExample) |
| CN (1) | CN1138786C (enExample) |
| AT (1) | ATE328006T1 (enExample) |
| AU (1) | AU735355B2 (enExample) |
| CA (2) | CA2781623A1 (enExample) |
| CY (1) | CY2010017I2 (enExample) |
| DE (2) | DE122010000049I1 (enExample) |
| DK (1) | DK0911342T4 (enExample) |
| ES (1) | ES2263204T5 (enExample) |
| FR (1) | FR10C0048I2 (enExample) |
| HU (3) | HU229841B1 (enExample) |
| IL (1) | IL127115A (enExample) |
| LU (1) | LU91759I2 (enExample) |
| NO (2) | NO322632B1 (enExample) |
| NZ (1) | NZ332995A (enExample) |
| PT (1) | PT911342E (enExample) |
| RU (1) | RU2238949C2 (enExample) |
| WO (1) | WO1998046644A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| US20050147611A1 (en) * | 1995-12-22 | 2005-07-07 | Amgen Inc. | Combination therapy for conditions leading to bone loss |
| US7632922B1 (en) * | 1995-12-22 | 2009-12-15 | Amgen, Inc. | Osteoprotegerin |
| ATE399861T1 (de) * | 1996-12-13 | 2008-07-15 | Schering Corp | Oberflächenantigene aus säugern |
| US6017729A (en) | 1996-12-23 | 2000-01-25 | Immunex Corporation | Receptor activator of NF-κB |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| CA2781623A1 (en) | 1997-04-15 | 1998-10-22 | Daiichi Sankyo Company, Limited | Novel protein binding to osteoclastogenesis inhibitory factor and process for producing the same |
| ID23855A (id) * | 1997-04-16 | 2000-05-25 | Amgen Inc | Protein pengikat osteoprotegerin dan reseptor |
| US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
| AU2011202547B2 (en) * | 1997-04-16 | 2014-08-28 | Amgen Inc. | Osteoprotegerin binding proteins and receptors |
| US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| ES2317694T3 (es) * | 1998-05-14 | 2009-04-16 | Immunex Corporation | Metodo para inhibir la actividad osteoclastica. |
| EP1127578A4 (en) | 1998-10-28 | 2004-12-15 | Sankyo Co | MEDICINE FOR BONE METABOLIC DEVIATIONS |
| AUPQ314799A0 (en) * | 1999-09-29 | 1999-10-21 | University Of Western Australia, The | Bone cell factor |
| MXPA02008144A (es) † | 2000-02-23 | 2002-11-29 | Amgen Inc | Agentes de enlace selectivos antagonistas de la proteina de enlace de osteoprotegerina. |
| US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
| WO2002024896A2 (en) | 2000-09-22 | 2002-03-28 | Immunex Corporation | Screening assays for agonists or antagonists of receptor activat or of nf-kb |
| WO2002062990A1 (fr) * | 2001-02-07 | 2002-08-15 | Sankyo Company, Limited | Anticorps et utilisation de cet anticorps |
| WO2002079256A1 (fr) * | 2001-03-26 | 2002-10-10 | Sankyo Company, Limited | Anticorps et son utilisation |
| EP1377610A2 (en) | 2001-04-03 | 2004-01-07 | Société des Produits Nestlé S.A. | Osteoprotegerin in milk |
| NO345566B1 (no) | 2001-06-26 | 2021-04-19 | Amgen Inc | OPGL bindende antistoff, farmasøytisk sammensetning samt anvendelse derav |
| CA2481074A1 (en) | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
| MXPA05006147A (es) * | 2002-12-10 | 2005-08-26 | Schering Plough Ltd | Ligando del activador del receptor de nf-kb de canino, y metodos para preparar y usar el mismo. |
| US20050009097A1 (en) * | 2003-03-31 | 2005-01-13 | Better Marc D. | Human engineered antibodies to Ep-CAM |
| JP2007521232A (ja) | 2003-08-08 | 2007-08-02 | アブジェニックス・インコーポレーテッド | 副甲状腺ホルモン(pth)に対する抗体およびその使用 |
| US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| BRPI0506726B8 (pt) | 2004-01-07 | 2021-05-25 | Chiron Corp | anticorpo monoclonal específico para m-csf e usos deste |
| TWI359026B (en) * | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
| RU2324425C2 (ru) * | 2005-08-30 | 2008-05-20 | Государственное образовательное учреждение "Институт усовершенствования врачей" Министерства здравоохранения и социального развития | Способ профилактики рождения больных остеопетрозом детей |
| TW200736277A (en) | 2005-11-14 | 2007-10-01 | Amgen Inc | RANKL antibody-PTH/PTHrP chimeric molecules |
| US8168181B2 (en) * | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| CN101384733A (zh) * | 2006-02-13 | 2009-03-11 | 奥尔加·奥尔纳茨基 | 通过元素分析实施的基因表达检测 |
| EP2020445B1 (en) | 2006-05-12 | 2013-01-02 | Keio University | Detection of inflammatory disease and composition for prevention or treatment of inflammatory disease |
| WO2008044379A1 (fr) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Modèle animal de perte osseuse |
| WO2008044797A1 (fr) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Animal modèle d'ostéopénie |
| AU2007305855A1 (en) | 2006-10-11 | 2008-04-17 | Oriental Yeast Co., Ltd. | Agent containing fused protein of soluble RANKL with epitope tag |
| EP2165716B1 (en) | 2007-06-05 | 2014-11-12 | Oriental Yeast Co., Ltd. | Novel bone mass increasing agent |
| CN108130327A (zh) | 2007-10-11 | 2018-06-08 | 第三共株式会社 | 靶向破骨细胞相关蛋白Siglec-15的抗体 |
| EP2320945A4 (en) * | 2008-07-30 | 2013-02-27 | Emergent Biosolutions Inc | STABLE MILZBRANDIMPFSTOFFFORMULIERUNGEN |
| EP2343087B1 (en) | 2008-09-30 | 2018-07-18 | Oriental Yeast Co., Ltd. | Novel inducer of chondrocyte proliferation and differentiation |
| US20120018338A1 (en) * | 2009-03-30 | 2012-01-26 | Hoffman-La Roche Inc. | Method for avoiding glass fogging |
| US8575316B2 (en) | 2009-04-09 | 2013-11-05 | Daiichi Sankyo Company, Limited | Anti-Siglec-15 antibody |
| WO2011017294A1 (en) * | 2009-08-07 | 2011-02-10 | Schering Corporation | Human anti-rankl antibodies |
| EP2434285A1 (en) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Breast cancer diagnostics |
| EP2433644A1 (en) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Breast cancer therapeutics |
| BR112013008255A2 (pt) | 2010-10-05 | 2018-09-25 | Daiichi Sankyo Co Ltd | anticorpo isolado ou um fragmento funcional do mesmo, uso de um anticorpo isolado ou de um fragmento funcional do mesmo, composição farmacêutica, polinucleotídeo, vetor, célula transformada, e, método para produzir anticorpo |
| US20130280260A1 (en) * | 2010-10-13 | 2013-10-24 | Tokyo Women's Medical University | Osteoclastogenesis inhibitor containing anti-vdac antibody |
| WO2012133914A1 (ja) | 2011-03-31 | 2012-10-04 | オリエンタル酵母工業株式会社 | Ranklアンタゴニストを含む癌免疫増強剤 |
| EP2827879B1 (en) | 2012-03-21 | 2019-05-08 | Dana-Farber Cancer Institute, Inc. | Isolation and use of human lymphoid organ-derived suppressive stromal cells |
| HK1204657A1 (en) | 2012-03-30 | 2015-11-27 | Daiichi Sankyo Company, Limited | Anti-siglec15 antibody with modified cdr |
| EP2875051B1 (en) | 2012-07-19 | 2019-02-20 | Daiichi Sankyo Company, Limited | Anti-siglec-15 antibodies |
| US10246513B2 (en) | 2013-08-07 | 2019-04-02 | Rigshospitalet Copenhagen University Hospital | Antibodies, compounds and derivatives thereof for use in the treatment of male infertility |
| WO2015100344A1 (en) | 2013-12-27 | 2015-07-02 | Emergent Product Development Gaithersburg Inc. | Temperature stable vaccine formulations |
| RU2747929C2 (ru) * | 2016-09-13 | 2021-05-17 | ИэндЭС ХЕЛТКЕАР КО., ЛТД. | Моноклональное антитело, специфически связывающееся с тиоредоксином-1, и его применение |
| CN108410990B (zh) * | 2018-05-30 | 2021-07-06 | 中国医学科学院北京协和医院 | Igfbp3在制备诊断i型神经纤维瘤合并脊柱畸形病产品中的应用 |
| CN111205354B (zh) * | 2020-01-22 | 2021-01-22 | 天津科技大学 | 一种提高异源蛋白分泌量的信号肽突变体及其构建方法与用途 |
| CN111333709B (zh) * | 2020-03-17 | 2023-09-08 | 吉林大学 | 旋毛虫肌幼虫期丝氨酸蛋白酶抑制剂的b细胞表位多肽、杂交瘤细胞株、单克隆抗体及应用 |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4710457A (en) * | 1983-06-29 | 1987-12-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibody for human hematopoietic glycoproteins and method |
| US4710473A (en) | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
| WO1986000922A1 (en) | 1984-07-30 | 1986-02-13 | The Salk Institute For Biological Studies | Retroviral gene transfer vectors |
| US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| US5846534A (en) * | 1988-02-12 | 1998-12-08 | British Technology Group Limited | Antibodies to the antigen campath-1 |
| US6027729A (en) * | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
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1998
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- 1998-04-15 KR KR10-2003-7009671A patent/KR100496063B1/ko not_active Expired - Lifetime
- 1998-04-15 DE DE122010000049C patent/DE122010000049I1/de active Pending
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- 1998-04-15 WO PCT/JP1998/001728 patent/WO1998046644A1/ja not_active Ceased
- 1998-04-15 DE DE69834699T patent/DE69834699T3/de not_active Expired - Lifetime
- 1998-04-15 HU HU0800628A patent/HU229841B1/hu unknown
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- 1998-12-14 NO NO19985848A patent/NO322632B1/no not_active IP Right Cessation
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2002
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