CN1222917A - 新型蛋白质及其制备方法 - Google Patents
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- CN1222917A CN1222917A CN199898800477A CN98800477A CN1222917A CN 1222917 A CN1222917 A CN 1222917A CN 199898800477 A CN199898800477 A CN 199898800477A CN 98800477 A CN98800477 A CN 98800477A CN 1222917 A CN1222917 A CN 1222917A
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- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
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- 230000009870 specific binding Effects 0.000 description 1
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- 230000009182 swimming Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 125000004035 thiopropyl group Chemical group [H]SC([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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- 150000003704 vitamin D3 derivatives Chemical class 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Abstract
Description
抗体名 | 抗原 | |||
hsOBM | hOBM | msOBM | mOBM | |
H-OBM1 | + | + | - | - |
H-OBM2 | + | + | - | - |
H-OBM3 | + | + | - | - |
H-OBM4 | + | + | - | - |
H-OBM5 | + | + | - | - |
H-OBM6 | + | + | - | - |
H-OBM7 | + | + | - | - |
H-OBM8 | + | + | - | - |
H-OBM9 | + | + | + | + |
H-OBM10 | + | + | - | - |
H-OBM11 | + | + | - | - |
H-OBM12 | + | + | - | - |
H-OBM13 | + | + | + | + |
H-OBM14 | + | + | - | - |
抗体名 | IgG1 | IgG2a | IgG2b | IgG3 | IgA | κ |
H-OBM8 | - | + | - | - | - | + |
H-OBM9 | + | - | - | - | - | + |
H-OBM10 | + | - | - | - | - | + |
H-OBM11 | + | - | - | - | - | + |
H-OBM12 | - | - | + | - | - | + |
H-OBM13 | + | - | - | - | - | + |
H-OBM14 | + | - | - | - | - | + |
抗体名 | 亚型 | 抗原 | 解离常数Kd(M) |
H-OBM1 | IgG1(κ) | hsOBM | 1×10-11<Kd<1×1010 |
H-OBM4 | IgG1(κ) | hsOBM | 1×10-11<Kd<1×10-10 |
H-OBM9 | IgG1(κ) | hsOBM | 1×10-9<Kd<1×10-8 |
H-OBM9 | IgG1(κ) | msOBM | 1×10-8<Kd<1×10-7 |
抗体添加量(ng/ml) | TRAP阳性多核细胞数 | |
兔抗小鼠OBM/sOBM多克隆抗体 | 小鼠抗人OBM/sOBM单克隆抗体(H-OBM9) | |
0 | 1155±53 | 1059±45 |
10 | 510±24 | 650±25 |
100 | 10±3 | 15±4 |
Claims (64)
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP97808/97 | 1997-04-15 | ||
JP97808/1997 | 1997-04-15 | ||
JP9780897 | 1997-04-15 | ||
JP15143497 | 1997-06-09 | ||
JP151434/1997 | 1997-06-09 | ||
JP151434/97 | 1997-06-09 | ||
JP21897/1997 | 1997-08-12 | ||
JP217897/97 | 1997-08-12 | ||
JP21789797 | 1997-08-12 | ||
JP22480397 | 1997-08-21 | ||
JP224803/97 | 1997-08-21 | ||
JP224803/1997 | 1997-08-21 | ||
JP33224/1997 | 1997-12-02 | ||
JP332241/97 | 1997-12-02 | ||
JP33224197 | 1997-12-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1222917A true CN1222917A (zh) | 1999-07-14 |
CN1138786C CN1138786C (zh) | 2004-02-18 |
Family
ID=27525882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB988004771A Expired - Lifetime CN1138786C (zh) | 1997-04-15 | 1998-04-15 | 识别破骨细胞形成抑制因子结合蛋白的抗体及制备和用途 |
Country Status (21)
Country | Link |
---|---|
US (7) | US7527790B2 (zh) |
EP (3) | EP1657255B1 (zh) |
JP (7) | JP3523650B2 (zh) |
KR (1) | KR100496063B1 (zh) |
CN (1) | CN1138786C (zh) |
AT (1) | ATE328006T1 (zh) |
AU (1) | AU735355B2 (zh) |
CA (2) | CA2257247C (zh) |
CY (1) | CY2010017I2 (zh) |
DE (2) | DE122010000049I1 (zh) |
DK (1) | DK0911342T4 (zh) |
ES (1) | ES2263204T5 (zh) |
FR (1) | FR10C0048I2 (zh) |
HU (3) | HU229476B1 (zh) |
IL (1) | IL127115A (zh) |
LU (1) | LU91759I2 (zh) |
NO (2) | NO322632B1 (zh) |
NZ (1) | NZ332995A (zh) |
PT (1) | PT911342E (zh) |
RU (1) | RU2238949C2 (zh) |
WO (1) | WO1998046644A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1942581B (zh) * | 2004-02-12 | 2010-09-08 | 三共株式会社 | 针对破骨细胞相关蛋白质的抗体 |
CN103990122B (zh) * | 1997-04-16 | 2017-01-04 | 安姆根有限公司 | osteoprotegerin 结合蛋白和受体 |
CN108410990A (zh) * | 2018-05-30 | 2018-08-17 | 中国医学科学院北京协和医院 | Igfbp3在制备诊断i型神经纤维瘤合并脊柱畸形病产品中的应用 |
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US7632922B1 (en) * | 1995-12-22 | 2009-12-15 | Amgen, Inc. | Osteoprotegerin |
CA2274801C (en) * | 1996-12-13 | 2014-02-04 | Schering Corporation | Mammalian cell surface antigens; related reagents |
AU713473B2 (en) | 1996-12-23 | 1999-12-02 | Immunex Corporation | Receptor activator of NF-kappa B, receptor is member of TNF receptor superfamily |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
KR100496063B1 (ko) | 1997-04-15 | 2005-06-21 | 산쿄 가부시키가이샤 | 신규단백질 및 그 제조방법 |
RO128635A2 (ro) * | 1997-04-16 | 2013-07-30 | Amgen Inc. | Anticorp sau fragment al acestuia care se leagă la opgbp şi utilizarea acestuia, utilizarea unei forme solubile de odar, şi metodă de identificare a unui compus care descreşte activitatea opgbp |
US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
AU2011202547B2 (en) * | 1997-04-16 | 2014-08-28 | Amgen Inc. | Osteoprotegerin binding proteins and receptors |
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IL142557A0 (en) | 1998-10-28 | 2002-03-10 | Snow Brand Milk Products Co Ltd | Remedies for bone metabolic errors |
AUPQ314799A0 (en) * | 1999-09-29 | 1999-10-21 | University Of Western Australia, The | Bone cell factor |
US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
DK2105449T3 (da) † | 2000-02-23 | 2019-10-07 | Amgen Inc | Antagonistiske selektive bindemidler af osteoprotegerinbindende protein |
CA2423052C (en) | 2000-09-22 | 2011-07-12 | Immunex Corporation | Screening assays for agonists or antagonists of receptor activator of nf-kb |
WO2002062990A1 (fr) * | 2001-02-07 | 2002-08-15 | Sankyo Company, Limited | Anticorps et utilisation de cet anticorps |
WO2002079256A1 (fr) * | 2001-03-26 | 2002-10-10 | Sankyo Company, Limited | Anticorps et son utilisation |
CN1500096A (zh) | 2001-04-03 | 2004-05-26 | �Ʒ� | 乳中的osteoprotegerin |
CN1547486A (zh) | 2001-06-26 | 2004-11-17 | 抗opgl抗体 | |
EP1494714A4 (en) | 2002-04-05 | 2008-03-05 | Amgen Inc | HUMAN ANTI-OPGL NEUTRALIZING ANTIBODIES AS SELECTIVE OPGL PATH HEMMER |
AU2003297833A1 (en) * | 2002-12-10 | 2004-06-30 | Schering-Plough Ltd. | Canine rankl and methods for preparing and using the same |
US20050009097A1 (en) * | 2003-03-31 | 2005-01-13 | Better Marc D. | Human engineered antibodies to Ep-CAM |
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CN1838968A (zh) | 2003-08-08 | 2006-09-27 | 艾伯吉尼斯公司 | 针对甲状旁腺激素(pth)之抗体和其用途 |
AR045563A1 (es) * | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
HUE026132T2 (en) | 2004-01-07 | 2016-05-30 | Novartis Vaccines & Diagnostics Inc | M-CSF-specific monoclonal antibody and its uses |
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EP2083073B1 (en) | 2006-10-11 | 2013-09-04 | Oriental Yeast Co., Ltd. | Reagent containing fused protein of soluble rankl with epitope tag |
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Cited By (4)
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CN103990122B (zh) * | 1997-04-16 | 2017-01-04 | 安姆根有限公司 | osteoprotegerin 结合蛋白和受体 |
CN1942581B (zh) * | 2004-02-12 | 2010-09-08 | 三共株式会社 | 针对破骨细胞相关蛋白质的抗体 |
CN108410990A (zh) * | 2018-05-30 | 2018-08-17 | 中国医学科学院北京协和医院 | Igfbp3在制备诊断i型神经纤维瘤合并脊柱畸形病产品中的应用 |
CN108410990B (zh) * | 2018-05-30 | 2021-07-06 | 中国医学科学院北京协和医院 | Igfbp3在制备诊断i型神经纤维瘤合并脊柱畸形病产品中的应用 |
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