JP2003533470A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003533470A5 JP2003533470A5 JP2001583741A JP2001583741A JP2003533470A5 JP 2003533470 A5 JP2003533470 A5 JP 2003533470A5 JP 2001583741 A JP2001583741 A JP 2001583741A JP 2001583741 A JP2001583741 A JP 2001583741A JP 2003533470 A5 JP2003533470 A5 JP 2003533470A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical dosage
- dosage form
- region
- toxic
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 description 32
- 239000007788 liquid Substances 0.000 description 18
- 238000000034 method Methods 0.000 description 18
- 239000000843 powder Substances 0.000 description 15
- 230000007704 transition Effects 0.000 description 15
- 239000013543 active substance Substances 0.000 description 14
- 231100000331 toxic Toxicity 0.000 description 13
- 230000002588 toxic effect Effects 0.000 description 13
- 239000000546 pharmaceutical excipient Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 2
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 description 2
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127093 camptothecin Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 2
- 229940050521 gelatin agent Drugs 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229950008325 levothyroxine Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 description 2
- 229950009213 rubitecan Drugs 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 2
- 229940035722 triiodothyronine Drugs 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 101100379079 Emericella variicolor andA gene Proteins 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20589600P | 2000-05-18 | 2000-05-18 | |
| US60/205,896 | 2000-05-18 | ||
| PCT/US2001/040763 WO2001087272A2 (en) | 2000-05-18 | 2001-05-18 | Encapsulating a toxic core within a non-toxic region in an oral dosage form |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012012834A Division JP2012082224A (ja) | 2000-05-18 | 2012-01-25 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003533470A JP2003533470A (ja) | 2003-11-11 |
| JP2003533470A5 true JP2003533470A5 (https=) | 2008-07-17 |
| JP5178982B2 JP5178982B2 (ja) | 2013-04-10 |
Family
ID=22764098
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001583741A Expired - Fee Related JP5178982B2 (ja) | 2000-05-18 | 2001-05-18 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
| JP2012012834A Withdrawn JP2012082224A (ja) | 2000-05-18 | 2012-01-25 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012012834A Withdrawn JP2012082224A (ja) | 2000-05-18 | 2012-01-25 | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7276252B2 (https=) |
| EP (1) | EP1286663B1 (https=) |
| JP (2) | JP5178982B2 (https=) |
| AT (1) | ATE315930T1 (https=) |
| AU (1) | AU2001263506A1 (https=) |
| CA (1) | CA2408956C (https=) |
| DE (1) | DE60116758T2 (https=) |
| ES (1) | ES2257412T3 (https=) |
| WO (1) | WO2001087272A2 (https=) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030118645A1 (en) * | 1998-04-29 | 2003-06-26 | Pather S. Indiran | Pharmaceutical compositions for rectal and vaginal administration |
| US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) * | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6518330B2 (en) * | 2001-02-13 | 2003-02-11 | Board Of Trustees Of University Of Illinois | Multifunctional autonomically healing composite material |
| JP2005509001A (ja) * | 2001-10-29 | 2005-04-07 | セリクス， インコーポレイテッド | 投薬形態の三次元懸濁液プリンティング |
| US7931914B2 (en) * | 2001-10-29 | 2011-04-26 | Massachusetts Institute Of Technology | System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form |
| US7300668B2 (en) * | 2001-10-29 | 2007-11-27 | Massachusetts Institute Of Technology | System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing |
| DE60323482D1 (de) * | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
| CA2533358C (en) * | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| AU2004258953B2 (en) | 2003-07-21 | 2011-02-10 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| WO2005009365A2 (en) * | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8758820B2 (en) * | 2003-08-11 | 2014-06-24 | Shionogi Inc. | Robust pellet |
| JP2007502294A (ja) * | 2003-08-12 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
| US8246996B2 (en) * | 2003-08-29 | 2012-08-21 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| JP2007513869A (ja) * | 2003-09-15 | 2007-05-31 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
| US20050087902A1 (en) * | 2003-10-28 | 2005-04-28 | Isaac Farr | Alginate-based materials, methods of application thereof, and systems for using the alginate-based materials |
| JP2007517039A (ja) * | 2003-12-24 | 2007-06-28 | アドバンシス ファーマスーティカル コーポレイション | 変性放出製剤の吸収増強 |
| US7566747B2 (en) * | 2004-05-07 | 2009-07-28 | The Board Of Trustees Of The University Of Illinois | Wax particles for protection of activators, and multifunctional autonomically healing composite materials |
| TWI356036B (en) * | 2004-06-09 | 2012-01-11 | Smithkline Beecham Corp | Apparatus and method for pharmaceutical production |
| US20060002594A1 (en) * | 2004-06-09 | 2006-01-05 | Clarke Allan J | Method for producing a pharmaceutical product |
| JPWO2006004069A1 (ja) * | 2004-07-01 | 2008-04-24 | 日本碍子株式会社 | 微小カプセルおよびその製造方法 |
| US8715727B2 (en) * | 2004-07-02 | 2014-05-06 | Shionogi Inc. | Tablet for pulsed delivery |
| ES2555152T3 (es) * | 2004-11-26 | 2015-12-29 | Aprecia Pharmaceuticals Co. | Formas de dosificación impresas en tres dimensiones |
| US7829000B2 (en) * | 2005-02-25 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Core-shell solid freeform fabrication |
| US7612152B2 (en) * | 2005-05-06 | 2009-11-03 | The Board Of Trustees Of The University Of Illinois | Self-healing polymers |
| US7914776B2 (en) * | 2005-10-07 | 2011-03-29 | Adolor Corporation | Solid dispersions of opioid antagonists |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) * | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US7723405B2 (en) * | 2006-01-05 | 2010-05-25 | The Board Of Trustees Of The University Of Illinois | Self-healing coating system |
| GB0608402D0 (en) * | 2006-04-28 | 2006-06-07 | Diurnal Ltd | Thyroid treatment |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| US7569625B2 (en) * | 2006-06-02 | 2009-08-04 | The Board Of Trustees Of The University Of Illinois | Self-healing elastomer system |
| WO2008012528A1 (en) | 2006-07-25 | 2008-01-31 | Lipoxen Technologies Limited | N-terminal polysialylation |
| US20080107725A1 (en) * | 2006-10-13 | 2008-05-08 | Albano Antonio A | Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers |
| US20080299391A1 (en) * | 2007-05-31 | 2008-12-04 | White Scott R | Capsules, methods for making capsules, and self-healing composites including the same |
| WO2009007969A2 (en) * | 2007-07-09 | 2009-01-15 | Colint Ltd. | Portable hydration apparatus |
| US20090181254A1 (en) * | 2008-01-15 | 2009-07-16 | The Board Of Trustees Of The University Of Illinois | Multi-capsule system and its use for encapsulating active agents |
| JP2011074015A (ja) * | 2009-09-30 | 2011-04-14 | Tomita Pharmaceutical Co Ltd | 固形製剤及びその製造方法 |
| DE102010051743B4 (de) | 2010-11-19 | 2022-09-01 | C. Miethke Gmbh & Co. Kg | Programmierbares Hydrocephalusventil |
| WO2012161240A1 (ja) * | 2011-05-25 | 2012-11-29 | 大鵬薬品工業株式会社 | テガフール、ギメラシル、オテラシルカリウム含有有核錠 |
| US9381154B2 (en) * | 2011-06-09 | 2016-07-05 | Xerox Corporation | Direct inkjet fabrication of drug delivery devices |
| US8414654B1 (en) * | 2011-11-23 | 2013-04-09 | Amendia, Inc. | Bone implants and method of manufacture |
| CN102551927A (zh) * | 2011-11-29 | 2012-07-11 | 上海大学 | 嵌入式分级释药三维支架及其制备方法 |
| BR112015004530A8 (pt) | 2012-09-05 | 2019-08-27 | Aprecia Pharmaceuticals Co | montagem de equipamento de impressão tridimensional e método para preparação de artigos impressos tridimensionalmente |
| US8888480B2 (en) | 2012-09-05 | 2014-11-18 | Aprecia Pharmaceuticals Company | Three-dimensional printing system and equipment assembly |
| US20140099351A1 (en) | 2012-10-04 | 2014-04-10 | Axxia Pharmaceuticals, Llc | Process for making controlled release medical implant products |
| US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
| ES2761265T3 (es) * | 2013-03-15 | 2020-05-19 | Aprecia Pharmaceuticals LLC | Forma de dosificación de oxcarbazepina rápidamente dispersable |
| JP6466399B2 (ja) | 2013-03-15 | 2019-02-06 | アプレシア・ファーマスーティカルズ・カンパニー | トピラマートの急速分散性の剤形 |
| MX365513B (es) | 2013-03-15 | 2019-06-06 | Aprecia Pharmaceuticals LLC | Forma de dosificacion de dispersion rapida que contiene levetiracetam. |
| KR102171123B1 (ko) | 2013-08-16 | 2020-10-29 | 더 엑스원 컴퍼니 | ３차원 인쇄된 금속 주조용 몰드 및 그를 제조하기 위한 방법 |
| WO2015057761A1 (en) | 2013-10-17 | 2015-04-23 | The Exone Company | Three-dimensional printed hot isostatic pressing containers and processes for making same |
| US11001048B2 (en) | 2013-12-23 | 2021-05-11 | The Exone Company | Method of three-dimensional printing using a multi-component build powder |
| WO2015100086A1 (en) | 2013-12-23 | 2015-07-02 | The Exone Company | Methods and systems for three-dimensional printing utilizing multiple binder fluids |
| WO2015130963A2 (en) | 2014-02-27 | 2015-09-03 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
| US20170120329A1 (en) | 2014-05-29 | 2017-05-04 | The Exone Company | Process for Making Nickel-Based Superalloy Articles by Three-Dimensional Printing |
| US20170203514A1 (en) | 2014-07-17 | 2017-07-20 | The Exone Company | Methods and Apparatuses for Curing Three-Dimensional Printed Articles |
| US9854828B2 (en) | 2014-09-29 | 2018-01-02 | William Langeland | Method, system and apparatus for creating 3D-printed edible objects |
| US20180001551A1 (en) | 2014-12-03 | 2018-01-04 | The Exone Company | Process for Making Densified Carbon Articles by Three Dimensional Printing |
| CA3254279A1 (en) | 2015-06-03 | 2025-03-18 | Triastek, Inc. | PHARMACEUTICAL FORMS AND RELATED USES |
| CN116423825A (zh) | 2015-08-21 | 2023-07-14 | 阿普雷奇亚制药有限责任公司 | 三维打印系统和设备组件 |
| HK1258050A1 (zh) | 2015-10-23 | 2019-11-01 | Lyndra Therapeutics, Inc. | 用於治疗剂缓释的胃驻留系统及其使用方法 |
| EP3386488B1 (en) | 2015-12-08 | 2023-09-06 | Lyndra Therapeutics, Inc. | Geometric configurations for gastric residence systems |
| JP6878417B2 (ja) * | 2016-02-17 | 2021-05-26 | トリアステック インコーポレイテッド | 剤形およびそれらの使用 |
| CA3023278C (en) | 2016-05-05 | 2019-04-30 | Triastek, Inc. | Controlled release dosage form |
| AU2017268840B2 (en) | 2016-05-27 | 2022-02-10 | Nortiva Bio, Inc. | Materials architecture for gastric residence systems |
| US10765658B2 (en) | 2016-06-22 | 2020-09-08 | Mastix LLC | Oral compositions delivering therapeutically effective amounts of cannabinoids |
| GB201612853D0 (en) | 2016-07-25 | 2016-09-07 | Univ Central Lancashire | Solid dosage form production |
| US11576866B2 (en) | 2016-09-30 | 2023-02-14 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| GB201620066D0 (en) * | 2016-11-28 | 2017-01-11 | Ucl Business Plc | Solid Pharmaceutical dosage formulations and processes |
| KR20190107712A (ko) | 2017-01-26 | 2019-09-20 | 트리아스텍 인코포레이티드 | 특정 위장 부위에서의 제어 방출의 투여 형태 |
| WO2018156141A1 (en) | 2017-02-24 | 2018-08-30 | Hewlett-Packard Development Company, L.P. | Three-dimensional (3d) printing a pharmaceutical tablet |
| GR1009361B (el) * | 2017-05-11 | 2018-09-17 | Κωνσταντινος Ηλια Θεοδοσοπουλος | Συστημα παραγωγης μεσω τρισδιαστατης εκτυπωσης, δισκιων, κοκκιων και καψουλων |
| KR102626745B1 (ko) | 2017-05-26 | 2024-01-17 | 인피니트 머티리얼 솔루션즈, 엘엘씨 | 수용성 중합체 조성물 |
| US12023406B2 (en) | 2017-06-09 | 2024-07-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| US10350822B1 (en) | 2018-01-09 | 2019-07-16 | Triastek Inc. | Dosage forms with desired release profiles and methods of designing and making thereof |
| DE102018107585B3 (de) * | 2018-03-29 | 2019-03-28 | Universität Rostock | Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen |
| IT201800004265A1 (it) | 2018-04-06 | 2019-10-06 | Apparato e metodo per la produzione automatizzata di forme di dosaggio personalizzabili. | |
| WO2020081561A1 (en) | 2018-10-15 | 2020-04-23 | Aprecia Pharmaceuticals LLC | Method and system for forming a dosage form within a packaging |
| EP4338722A3 (de) * | 2019-01-07 | 2024-05-29 | LuxCan Innovation S.A. | Vorrichtung und verfahren für die tablettierung einer pulverförmigen, flüssigen, pastösen, verkapselten oder granularen wirkstoffzusammensetzung |
| US11724486B2 (en) | 2019-07-09 | 2023-08-15 | Kyndryl, Inc. | Printing customized medication based on current user data and medical records of the user |
| GB201913972D0 (en) | 2019-09-27 | 2019-11-13 | Univ Ulster | Pharmaceutical Delivery Device and method of manufacture |
| US12371581B2 (en) | 2020-03-25 | 2025-07-29 | Infinite Material Solutions, Llc | High performance water soluble polymer compositions |
| AU2021296908A1 (en) | 2020-06-26 | 2023-02-16 | Aprecia Pharmaceuticals LLC | Rapidly-orodispersible tablets having an interior cavity |
| WO2022089588A1 (zh) | 2020-10-30 | 2022-05-05 | 南京三迭纪医药科技有限公司 | 胃滞留药物剂型 |
| US12251208B2 (en) | 2020-11-30 | 2025-03-18 | International Business Machines Corporation | Time controlled medication |
| GB2608846A (en) * | 2021-07-14 | 2023-01-18 | Quay Pharmaceuticals Ltd | Method and apparatus for additive manufacturing |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2801203A (en) * | 1951-03-22 | 1957-07-30 | Byk Gulden Lomberg Chem Fab | X-ray method of digestive enzyme diagnosis using protected core of contrast agent |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| US5082669A (en) * | 1989-07-20 | 1992-01-21 | Dainippon Pharmaceutical Co., Ltd. | Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked |
| US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
| US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
| WO1994009762A1 (en) | 1992-11-05 | 1994-05-11 | Merck & Co., Inc. | Drug delivery device |
| US6280771B1 (en) * | 1997-02-20 | 2001-08-28 | Therics, Inc. | Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof |
| ZA949929B (en) | 1993-12-23 | 1995-08-23 | Akzo Nobel Nv | Sugar-coated pharmaceutical dosage unit. |
| JPH07223970A (ja) * | 1994-02-10 | 1995-08-22 | Tanabe Seiyaku Co Ltd | 消化管内適所放出製剤 |
| EP0759303B1 (en) * | 1994-04-22 | 2002-10-16 | Yamanouchi Pharmaceutical Co. Ltd. | Colon-specific drug release system |
| US5597829A (en) * | 1994-05-09 | 1997-01-28 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of camptothecin and methods for uses thereof |
| US5783212A (en) * | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| WO1998036739A1 (en) * | 1997-02-20 | 1998-08-27 | Therics, Inc. | Dosage forms exhibiting multiphasic release kinetics and methods of manufacture thereof |
| US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US6294199B1 (en) * | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
-
2001
- 2001-05-18 CA CA2408956A patent/CA2408956C/en not_active Expired - Fee Related
- 2001-05-18 AT AT01937808T patent/ATE315930T1/de not_active IP Right Cessation
- 2001-05-18 JP JP2001583741A patent/JP5178982B2/ja not_active Expired - Fee Related
- 2001-05-18 EP EP01937808A patent/EP1286663B1/en not_active Expired - Lifetime
- 2001-05-18 AU AU2001263506A patent/AU2001263506A1/en not_active Abandoned
- 2001-05-18 DE DE60116758T patent/DE60116758T2/de not_active Expired - Lifetime
- 2001-05-18 ES ES01937808T patent/ES2257412T3/es not_active Expired - Lifetime
- 2001-05-18 US US09/861,480 patent/US7276252B2/en not_active Expired - Lifetime
- 2001-05-18 WO PCT/US2001/040763 patent/WO2001087272A2/en not_active Ceased
-
2005
- 2005-10-07 US US11/246,910 patent/US7875290B2/en not_active Expired - Fee Related
-
2012
- 2012-01-25 JP JP2012012834A patent/JP2012082224A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003533470A5 (https=) | ||
| JP5178982B2 (ja) | 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化 | |
| AU660824B2 (en) | Pharmaceutical preparation for intra-airway administration | |
| JP2002538110A5 (https=) | ||
| US6372246B1 (en) | Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals | |
| US20030077297A1 (en) | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents | |
| KR101053558B1 (ko) | 흡착제 및 억제제를 포함하는 내변조성 제형 | |
| JP2002519318A5 (https=) | ||
| JP2011121974A (ja) | シームレスマイクロカプセルを含む固形経口剤形 | |
| WO2004024209A3 (en) | Materials and methods for drug delivery and uptake | |
| JP2009513669A5 (https=) | ||
| JP2007513152A (ja) | 耐湿性容器内のチオトロピウムから構成される医薬製品 | |
| RU96107106A (ru) | Новые гранулы для регулируемого высвобождения и фармацевтические препараты, содержащие такие гранулы | |
| US20200289402A1 (en) | Pouch-type orally dissolving films with high active ingredient concentration | |
| CA2447990A1 (en) | Encapsulation of nanosuspensions in liposomes and microspheres | |
| CN1968670A (zh) | 利用了盒的吸入器 | |
| RU2002112238A (ru) | Перорально распадающаяся композиция, содержащая миртазапин | |
| MX2008016565A (es) | Composiciones farmaceuticas que comprenden una combinacion de piperidinoalcanol y descongestivo. | |
| WO2009006299A2 (en) | Multi-particulate systems | |
| CN103768071A (zh) | 一种治疗糖尿病的口服制剂 | |
| JP2004523536A5 (https=) | ||
| JP3343144B2 (ja) | マイクロカプセル | |
| JPH05261139A (ja) | 医薬品の分包剤 | |
| WO2009063320A3 (es) | Composición farmacéutica sólida de didanosina | |
| JPH07242535A (ja) | 高脂溶性かつ難水溶性薬物の吸収改善経口製剤 |