ATE315930T1 - Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform - Google Patents

Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform

Info

Publication number
ATE315930T1
ATE315930T1 AT01937808T AT01937808T ATE315930T1 AT E315930 T1 ATE315930 T1 AT E315930T1 AT 01937808 T AT01937808 T AT 01937808T AT 01937808 T AT01937808 T AT 01937808T AT E315930 T1 ATE315930 T1 AT E315930T1
Authority
AT
Austria
Prior art keywords
toxic
drug
dosage form
core
potent
Prior art date
Application number
AT01937808T
Other languages
English (en)
Inventor
Francis C Payumo
Chen-Chao Wang
Jill K Sherwood
Michael J Cima
Christopher M Gaylo
Donald C Monkhouse
Jaedeok Yoo
Original Assignee
Therics Inc
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therics Inc, Massachusetts Inst Technology filed Critical Therics Inc
Application granted granted Critical
Publication of ATE315930T1 publication Critical patent/ATE315930T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01937808T 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform ATE315930T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20589600P 2000-05-18 2000-05-18

Publications (1)

Publication Number Publication Date
ATE315930T1 true ATE315930T1 (de) 2006-02-15

Family

ID=22764098

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01937808T ATE315930T1 (de) 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform

Country Status (9)

Country Link
US (2) US7276252B2 (de)
EP (1) EP1286663B1 (de)
JP (2) JP5178982B2 (de)
AT (1) ATE315930T1 (de)
AU (1) AU2001263506A1 (de)
CA (1) CA2408956C (de)
DE (1) DE60116758T2 (de)
ES (1) ES2257412T3 (de)
WO (1) WO2001087272A2 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6518330B2 (en) * 2001-02-13 2003-02-11 Board Of Trustees Of University Of Illinois Multifunctional autonomically healing composite material
CA2464653C (en) * 2001-10-29 2011-10-18 Therics, Inc. System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
US20030099708A1 (en) * 2001-10-29 2003-05-29 Therics, Inc Printing or dispensing a suspension such as three-dimensional printing of dosage forms
EP1439945B1 (de) * 2001-10-29 2006-04-12 Therics, Inc. System und verfahren zum uniaxialen pressen eines gegenstandes wie eine drei-dimensional gedruckte dosierungsform
AU2003232078A1 (en) * 2002-05-06 2003-11-17 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
JP2006528185A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005009365A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009368A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US8758820B2 (en) * 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
AU2004270170B2 (en) * 2003-08-29 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
CA2538064C (en) * 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US20050087902A1 (en) * 2003-10-28 2005-04-28 Isaac Farr Alginate-based materials, methods of application thereof, and systems for using the alginate-based materials
CA2550983C (en) * 2003-12-24 2013-09-17 Advancis Pharmaceutical Corporation Enhanced absorption of modified release dosage forms
US7566747B2 (en) * 2004-05-07 2009-07-28 The Board Of Trustees Of The University Of Illinois Wax particles for protection of activators, and multifunctional autonomically healing composite materials
TWI547431B (zh) * 2004-06-09 2016-09-01 史密斯克萊美占公司 生產藥物之裝置及方法
US20060002594A1 (en) * 2004-06-09 2006-01-05 Clarke Allan J Method for producing a pharmaceutical product
JPWO2006004069A1 (ja) * 2004-07-01 2008-04-24 日本碍子株式会社 微小カプセルおよびその製造方法
AU2005269981A1 (en) * 2004-07-02 2006-02-09 Bonck, John A Tablet for pulsed delivery
ES2555152T3 (es) * 2004-11-26 2015-12-29 Aprecia Pharmaceuticals Co. Formas de dosificación impresas en tres dimensiones
US7829000B2 (en) * 2005-02-25 2010-11-09 Hewlett-Packard Development Company, L.P. Core-shell solid freeform fabrication
US7612152B2 (en) * 2005-05-06 2009-11-03 The Board Of Trustees Of The University Of Illinois Self-healing polymers
US7914776B2 (en) * 2005-10-07 2011-03-29 Adolor Corporation Solid dispersions of opioid antagonists
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US7723405B2 (en) * 2006-01-05 2010-05-25 The Board Of Trustees Of The University Of Illinois Self-healing coating system
GB0608402D0 (en) * 2006-04-28 2006-06-07 Diurnal Ltd Thyroid treatment
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US7569625B2 (en) * 2006-06-02 2009-08-04 The Board Of Trustees Of The University Of Illinois Self-healing elastomer system
CN103169984B (zh) 2006-07-25 2016-08-03 利普生技术有限公司 N末端聚唾液酸化
US20080107725A1 (en) * 2006-10-13 2008-05-08 Albano Antonio A Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers
US20080299391A1 (en) * 2007-05-31 2008-12-04 White Scott R Capsules, methods for making capsules, and self-healing composites including the same
WO2009007969A2 (en) * 2007-07-09 2009-01-15 Colint Ltd. Portable hydration apparatus
US20090181254A1 (en) * 2008-01-15 2009-07-16 The Board Of Trustees Of The University Of Illinois Multi-capsule system and its use for encapsulating active agents
JP2011074015A (ja) * 2009-09-30 2011-04-14 Tomita Pharmaceutical Co Ltd 固形製剤及びその製造方法
DE102010051743B4 (de) 2010-11-19 2022-09-01 C. Miethke Gmbh & Co. Kg Programmierbares Hydrocephalusventil
TWI566787B (zh) * 2011-05-25 2017-01-21 Taiho Pharmaceutical Co Ltd Contains tegafur, gemcopyrimidine, otiorasilide potassium tablets (b)
US9381154B2 (en) * 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
CN102551927A (zh) * 2011-11-29 2012-07-11 上海大学 嵌入式分级释药三维支架及其制备方法
US8888480B2 (en) 2012-09-05 2014-11-18 Aprecia Pharmaceuticals Company Three-dimensional printing system and equipment assembly
ES2873825T3 (es) 2012-09-05 2021-11-04 Aprecia Pharmaceuticals LLC Sistema de impresión tridimensional y conjunto de equipo
US20140099351A1 (en) 2012-10-04 2014-04-10 Axxia Pharmaceuticals, Llc Process for making controlled release medical implant products
EP2968181B1 (de) * 2013-03-15 2019-10-16 Aprecia Pharmaceuticals LLC Schnell zerfallende darreichungsform von topiramat
WO2014143935A1 (en) * 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Company Rapidly dispersible dosage form of oxcarbazepine
CA2906029C (en) 2013-03-15 2017-09-05 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
JP6233996B2 (ja) 2013-08-16 2017-11-22 ザ エクスワン カンパニー ３次元印刷される金属鋳造用鋳型及び同鋳型の製造方法
US20160243621A1 (en) 2013-10-17 2016-08-25 The Exone Company Three-Dimensional Printed Hot Isostatic Pressing Containers and Processes for Making Same
ES2745763T3 (es) 2013-12-23 2020-03-03 The Exone Co Métodos y sistemas para la impresión en tres dimensiones utilizando múltiples fluidos aglutinantes
EP3086922B1 (de) 2013-12-23 2022-03-09 The Exone Company Verfahren zum dreidimensionalen drucken unter verwendung eines mehrkomponentigen konstruktionspulvers
US10188739B2 (en) 2014-02-27 2019-01-29 Xenetic Biosciences, Inc. Compositions and methods for administering insulin or insulin-like protein to the brain
EP3148730A1 (de) 2014-05-29 2017-04-05 The Exone Company Verfahren zur herstellung von superlegierungsartikeln auf nickelbasis durch dreidimensionales drucken
WO2016011098A2 (en) 2014-07-17 2016-01-21 The Exone Company Methods and apparatuses for curing three-dimensional printed articles
US9854828B2 (en) 2014-09-29 2018-01-02 William Langeland Method, system and apparatus for creating 3D-printed edible objects
US20180001551A1 (en) 2014-12-03 2018-01-04 The Exone Company Process for Making Densified Carbon Articles by Three Dimensional Printing
KR20180014778A (ko) 2015-06-03 2018-02-09 트리아스텍 인코포레이티드 제형 및 이의 용도
AU2016310470A1 (en) 2015-08-21 2018-02-22 Aprecia Pharmaceuticals LLC Three-dimensional printing system and equipment assembly
WO2017070612A1 (en) 2015-10-23 2017-04-27 Lyndra, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
CN108697649A (zh) 2015-12-08 2018-10-23 林德拉有限公司 用于胃驻留系统的几何构型
JP6878417B2 (ja) * 2016-02-17 2021-05-26 トリアステック インコーポレイテッド 剤形およびそれらの使用
KR101965283B1 (ko) 2016-05-05 2019-04-03 트리아스텍 인코포레이티드 제어 방출 제형
US10765658B2 (en) 2016-06-22 2020-09-08 Mastix LLC Oral compositions delivering therapeutically effective amounts of cannabinoids
GB201612853D0 (en) 2016-07-25 2016-09-07 Univ Central Lancashire Solid dosage form production
CN110022861A (zh) 2016-09-30 2019-07-16 林德拉有限公司 用于金刚烷类药物缓释的胃驻留系统
GB201620066D0 (en) 2016-11-28 2017-01-11 Ucl Business Plc Solid Pharmaceutical dosage formulations and processes
US11602502B2 (en) 2017-02-24 2023-03-14 Hewlett-Packard Development Company, L.P. Three-dimensional (3D) printing a pharmaceutical tablet
GR1009361B (el) 2017-05-11 2018-09-17 Κωνσταντινος Ηλια Θεοδοσοπουλος Συστημα παραγωγης μεσω τρισδιαστατης εκτυπωσης, δισκιων, κοκκιων και καψουλων
EP3635045A1 (de) 2017-05-26 2020-04-15 Infinite Material Solutions, LLC Wasserlösliche polymerzusammensetzungen
US11571391B2 (en) 2018-01-09 2023-02-07 Triastek, Inc. Oral drug dosage forms compromising a fixed-dose of an ADHD non-stimulant and an ADHD stimulant
US10350822B1 (en) 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof
DE102018107585B3 (de) * 2018-03-29 2019-03-28 Universität Rostock Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen
IT201800004265A1 (it) 2018-04-06 2019-10-06 Apparato e metodo per la produzione automatizzata di forme di dosaggio personalizzabili.
BR112021006668A2 (pt) 2018-10-15 2021-07-06 Aprecia Pharmaceuticals LLC método e sistema para formar uma forma de dosagem dentro de uma embalagem
US20220057417A1 (en) * 2019-01-07 2022-02-24 Aphria Germany Gmbh Method for qualitative and/or quantitative detection of substances contained in a hemp plant and kit for use therein
US11724486B2 (en) 2019-07-09 2023-08-15 Kyndryl, Inc. Printing customized medication based on current user data and medical records of the user
GB201913972D0 (en) 2019-09-27 2019-11-13 Univ Ulster Pharmaceutical Delivery Device and method of manufacture
EP4171518A1 (de) 2020-06-26 2023-05-03 Aprecia Pharmaceuticals LLC Schnell im mund dispergierbare tabletten mit einem inneren hohlraum
CN116507321A (zh) 2020-10-30 2023-07-28 南京三迭纪医药科技有限公司 胃滞留药物剂型
GB2608846A (en) * 2021-07-14 2023-01-18 Quay Pharmaceuticals Ltd Method and apparatus for additive manufacturing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801203A (en) * 1951-03-22 1957-07-30 Byk Gulden Lomberg Chem Fab X-ray method of digestive enzyme diagnosis using protected core of contrast agent
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5082669A (en) 1989-07-20 1992-01-21 Dainippon Pharmaceutical Co., Ltd. Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked
US5215989A (en) 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5314696A (en) * 1991-06-27 1994-05-24 Paulos Manley A Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor
CA2147862A1 (en) * 1992-11-05 1994-05-11 Robert E. Dempski Drug delivery device
US6280771B1 (en) * 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
ZA949929B (en) * 1993-12-23 1995-08-23 Akzo Nobel Nv Sugar-coated pharmaceutical dosage unit.
JPH07223970A (ja) * 1994-02-10 1995-08-22 Tanabe Seiyaku Co Ltd 消化管内適所放出製剤
AU689250B2 (en) * 1994-04-22 1998-03-26 Astellas Pharma Inc. Colon-specific drug release system
US5597829A (en) * 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5783212A (en) * 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
WO1998036739A1 (en) * 1997-02-20 1998-08-27 Therics, Inc. Dosage forms exhibiting multiphasic release kinetics and methods of manufacture thereof
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US6294199B1 (en) * 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin

Also Published As

Publication number Publication date
CA2408956C (en) 2011-07-12
JP5178982B2 (ja) 2013-04-10
EP1286663B1 (de) 2006-01-18
WO2001087272A2 (en) 2001-11-22
JP2003533470A (ja) 2003-11-11
US20060110443A1 (en) 2006-05-25
AU2001263506A1 (en) 2001-11-26
CA2408956A1 (en) 2001-11-22
US20020015728A1 (en) 2002-02-07
DE60116758T2 (de) 2006-11-02
JP2012082224A (ja) 2012-04-26
ES2257412T3 (es) 2006-08-01
WO2001087272A3 (en) 2002-04-18
DE60116758D1 (de) 2006-04-06
EP1286663A2 (de) 2003-03-05
US7276252B2 (en) 2007-10-02
US7875290B2 (en) 2011-01-25

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