JP2004523536A5 - - Google Patents

Info

Publication number

JP2004523536A5

JP2004523536A5 JP2002562324A JP2002562324A JP2004523536A5 JP 2004523536 A5 JP2004523536 A5 JP 2004523536A5 JP 2002562324 A JP2002562324 A JP 2002562324A JP 2002562324 A JP2002562324 A JP 2002562324A JP 2004523536 A5 JP2004523536 A5 JP 2004523536A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

bimodal

fraction

coarse

Prior art date

2002-02-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 24
• 230000002902 bimodal effect Effects 0.000 claims 23
• 239000000203 mixture Substances 0.000 claims 7
• 239000004480 active ingredient Substances 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 239000002245 particle Substances 0.000 claims 5
• 229940079593 drug Drugs 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 239000000126 substance Substances 0.000 claims 4
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 3
• 239000002260 anti-inflammatory agent Substances 0.000 claims 3
• 210000004072 lung Anatomy 0.000 claims 3
• 229940124630 bronchodilator Drugs 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 229940112141 dry powder inhaler Drugs 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
• 102000018997 Growth Hormone Human genes 0.000 claims 1
• 108010051696 Growth Hormone Proteins 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 102000014150 Interferons Human genes 0.000 claims 1
• 108010050904 Interferons Proteins 0.000 claims 1
• 108010000817 Leuprolide Proteins 0.000 claims 1
• 102000003982 Parathyroid hormone Human genes 0.000 claims 1
• 108090000445 Parathyroid hormone Proteins 0.000 claims 1
• 238000010521 absorption reaction Methods 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 230000000202 analgesic effect Effects 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 239000011362 coarse particle Substances 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000003246 corticosteroid Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 239000003623 enhancer Substances 0.000 claims 1
• PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
• 229960002428 fentanyl Drugs 0.000 claims 1
• 239000010419 fine particle Substances 0.000 claims 1
• 239000000122 growth hormone Substances 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 229940079322 interferon Drugs 0.000 claims 1
• GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 1
• 229960004338 leuprorelin Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229960005181 morphine Drugs 0.000 claims 1
• 239000006199 nebulizer Substances 0.000 claims 1
• 229960001319 parathyroid hormone Drugs 0.000 claims 1
• 239000000199 parathyroid hormone Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 239000003380 propellant Substances 0.000 claims 1
• 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1