JP2003530074A5 - - Google Patents
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- JP2003530074A5 JP2003530074A5 JP2001513369A JP2001513369A JP2003530074A5 JP 2003530074 A5 JP2003530074 A5 JP 2003530074A5 JP 2001513369 A JP2001513369 A JP 2001513369A JP 2001513369 A JP2001513369 A JP 2001513369A JP 2003530074 A5 JP2003530074 A5 JP 2003530074A5
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- JP
- Japan
- Prior art keywords
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- epitopes
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- Prior art date
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- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 52
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 52
- 210000003719 b-lymphocyte Anatomy 0.000 description 29
- 210000004027 cell Anatomy 0.000 description 21
- 108091006116 chimeric peptides Proteins 0.000 description 13
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 150000001413 amino acids Chemical class 0.000 description 7
- 230000028993 immune response Effects 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
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- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- 239000002077 nanosphere Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- -1 including Substances 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 description 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 description 1
- 108010086377 HLA-A3 Antigen Proteins 0.000 description 1
- 108010061486 HLA-B27 Antigen Proteins 0.000 description 1
- 102000012153 HLA-B27 Antigen Human genes 0.000 description 1
- 108010091938 HLA-B7 Antigen Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
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- 230000002611 ovarian Effects 0.000 description 1
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- 229920000642 polymer Polymers 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14686999P | 1999-08-03 | 1999-08-03 | |
| US60/146,869 | 1999-08-03 | ||
| PCT/US2000/021222 WO2001008636A2 (en) | 1999-08-03 | 2000-08-03 | Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003530074A JP2003530074A (ja) | 2003-10-14 |
| JP2003530074A5 true JP2003530074A5 (https=) | 2007-10-04 |
| JP4658423B2 JP4658423B2 (ja) | 2011-03-23 |
Family
ID=22519334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001513369A Expired - Fee Related JP4658423B2 (ja) | 1999-08-03 | 2000-08-03 | Ｈｅｒ−２タンパク質に対する免疫反応性を増強するためのポリペプチドおよびポリヌクレオチド |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US7060284B1 (https=) |
| EP (1) | EP1246597B1 (https=) |
| JP (1) | JP4658423B2 (https=) |
| AU (1) | AU6620300A (https=) |
| WO (1) | WO2001008636A2 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE235890T1 (de) | 1997-01-30 | 2003-04-15 | Chiron Corp | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
| US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US20060052321A1 (en) | 2002-04-05 | 2006-03-09 | Raitano Arthur B | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
| US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| EP1246597B1 (en) | 1999-08-03 | 2015-01-14 | The Ohio State University | Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein |
| CA2405290C (en) | 2000-04-13 | 2011-06-21 | Bio Life Science Forschungs Und Entwicklungsgesellschaft Mbh | Vaccine against cancerous diseases |
| EP1236740B1 (de) * | 2001-02-28 | 2012-07-18 | Bio Life Science Forschungs- und Entwicklungsges.m.b.H. | Vakzine gegen Krebserkrankungen, die mit dem HER-2/neu Onkogen assoziiert sind |
| JP4608210B2 (ja) | 2001-05-31 | 2011-01-12 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | キメラアルファウイルスレプリコン粒子 |
| WO2003005952A2 (en) * | 2001-07-10 | 2003-01-23 | Corixa Corporation | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| AU2003268345A1 (en) * | 2002-09-24 | 2004-04-19 | The Burnham Institute | Novel agents that modulate eph receptor activity |
| AU2002951853A0 (en) * | 2002-10-04 | 2002-10-24 | Commonwealth Scientific And Industrial Research Organisation | Crystal structure of erbb2 and uses thereof |
| WO2005007694A1 (ja) * | 2003-07-16 | 2005-01-27 | Green Peptide Co., Ltd. | ＨＥＲ２／ｎｅｕペプチドおよびその治療上の用途 |
| JP5015601B2 (ja) | 2003-10-21 | 2012-08-29 | セダーズ−シナイ メディカル センター | 中枢神経系の癌を含む癌の処置のための系および方法 |
| CA2555274A1 (en) * | 2004-02-05 | 2005-08-25 | The Ohio State University Research Foundation | Chimeric vegf peptides |
| WO2006002422A2 (en) | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| CA2583113C (en) | 2004-10-05 | 2015-11-10 | Diversa Corporation | Compositions comprising an antigen and a promiscuous t-cell epitope |
| CN100381460C (zh) * | 2004-11-30 | 2008-04-16 | 北京市肿瘤防治研究所 | Her-2模拟抗原表位及含有该表位的肽 |
| US20060264897A1 (en) * | 2005-01-24 | 2006-11-23 | Neurosystec Corporation | Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues |
| JP2008528614A (ja) | 2005-01-27 | 2008-07-31 | ザ・バーンハム・インスティテュート | ＥｐｈＢ受容体結合ペプチド |
| AU2006261342B2 (en) * | 2005-06-15 | 2012-02-02 | The Ohio State University Research Foundation | Her-2 peptides |
| CA2626253A1 (en) | 2005-10-18 | 2007-04-26 | Novartis Vaccines And Diagnostics, Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
| ES2536426T3 (es) | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
| EP2049568A2 (en) | 2006-04-07 | 2009-04-22 | Københavns Universitet | Erbb receptor-derived peptide fragments |
| ES2348312T3 (es) * | 2006-04-13 | 2010-12-02 | Bio Life Science Forschungs- Und Entwicklungsges.M.B.H. | Vacuna her-2/neu a base de múltiples péptidos. |
| US8267905B2 (en) * | 2006-05-01 | 2012-09-18 | Neurosystec Corporation | Apparatus and method for delivery of therapeutic and other types of agents |
| US7803148B2 (en) | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
| JP2010511595A (ja) * | 2006-07-31 | 2010-04-15 | ニューロシステック コーポレイション | 遊離塩基ガシクリジンナノ粒子 |
| US7972602B2 (en) * | 2006-08-11 | 2011-07-05 | Dendreon Corporation | Promiscuous HER-2/Neu CD4 T cell epitopes |
| CA2700573C (en) | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| CA2700436C (en) | 2006-09-28 | 2017-04-18 | John S. Yu | Cancer vaccines and vaccination methods |
| HRP20140102T1 (hr) * | 2007-06-01 | 2014-03-28 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Cjepivo za prevenciju relapsa raka dojke |
| EP2262480B1 (en) | 2008-03-04 | 2018-02-14 | Liquidia Technologies, Inc. | Immunomodulator particles |
| PL2328923T3 (pl) | 2008-09-02 | 2016-06-30 | Cedars Sinai Medical Center | Epitopy CD133 |
| US20100234283A1 (en) | 2009-02-04 | 2010-09-16 | The Ohio State University Research Foundation | Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use |
| EP2292258A1 (en) * | 2009-08-18 | 2011-03-09 | Pevion Biotech Ltd. | Multiepitope vaccine for Her2/neu-associated cancers |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| US8895017B2 (en) | 2010-06-07 | 2014-11-25 | Pfizer Inc. | HER-2 peptides and vaccines |
| GB201019467D0 (en) * | 2010-11-17 | 2010-12-29 | Biotecnol Sa | Therapeutic agent |
| ES2662333T3 (es) | 2013-02-14 | 2018-04-06 | Immunocellular Therapeutics Ltd. | Vacunas contra el cáncer y métodos de vacunación |
| US10221230B2 (en) | 2013-02-25 | 2019-03-05 | Ohio State Innovation Foundation | HER-1, HER-3 and IGF-1R compositions and uses thereof |
| WO2014136814A1 (ja) * | 2013-03-08 | 2014-09-12 | 大鵬薬品工業株式会社 | 新規ｃｔｌエピトープ５連結ペプチド |
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| DK3122375T3 (da) | 2014-03-28 | 2021-05-25 | Univ Washington Through Its Center For Commercialization | Vacciner mod bryst- og ovariecancer |
| CN105884885A (zh) * | 2015-02-15 | 2016-08-24 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的水合盐及其制备方法和含有该盐的药物制品 |
| RU2726411C2 (ru) * | 2015-04-17 | 2020-07-14 | Биолайф Сайенс Клд Лимитед | Вакцинная композиция и ее применения |
| WO2018116074A1 (en) | 2016-12-19 | 2018-06-28 | Kabiri Mona | Chimeric peptides against htlv-1 |
| SG11201911430PA (en) | 2017-07-04 | 2020-01-30 | Curevac Ag | Novel nucleic acid molecules |
| US20220233568A1 (en) | 2017-10-19 | 2022-07-28 | Curevac Ag | Novel artificial nucleic acid molecules |
| CN109748952B (zh) * | 2018-05-02 | 2020-09-15 | 中国药科大学 | 辅助性表位肽及其应用 |
| TW202039534A (zh) | 2018-12-14 | 2020-11-01 | 美商美國禮來大藥廠 | KRAS變體mRNA分子 |
| WO2025088088A1 (en) | 2023-10-27 | 2025-05-01 | CureVac SE | Rna composition for improving cell therapy |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク，インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| DE69031120T2 (de) | 1989-05-19 | 1998-01-15 | Genentech, Inc., South San Francisco, Calif. | Her2 extrazellulare domäne |
| WO1991011719A1 (en) | 1990-01-26 | 1991-08-08 | Washington Research Foundation | Immune reactivity to expressed activated oncogenes for diagnosis and treatment of malignancy |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| DE69333588T2 (de) | 1992-09-28 | 2005-08-04 | Wyeth Holdings Corp. | Verfahren zur verstärkung zellularer immunantworten |
| AU679902B2 (en) * | 1992-09-30 | 1997-07-17 | Ohio State University Research Foundation, The | Vaccines and antigenic conjugates |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| US5869445A (en) | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
| US6410022B1 (en) | 1995-05-01 | 2002-06-25 | Avant Immunotherapeutics, Inc. | Modulation of cholesteryl ester transfer protein (CETP) activity |
| WO1997038011A1 (en) * | 1996-04-03 | 1997-10-16 | Pepresearch A/S | Non-dendritic backbone peptide carrier |
| KR20060079258A (ko) * | 1996-10-18 | 2006-07-05 | 제넨테크, 인크. | 항-ＥｒｂＢ２ 항체 |
| ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| DE60040981D1 (de) * | 1999-05-14 | 2009-01-15 | Genentech Inc | BEHANDLUNG MIT ANTI-ErbB2 ANTIKÖRPERN |
| EP1246597B1 (en) | 1999-08-03 | 2015-01-14 | The Ohio State University | Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein |
| US20030235594A1 (en) | 1999-09-14 | 2003-12-25 | Antigen Express, Inc. | Ii-Key/antigenic epitope hybrid peptide vaccines |
| EP1366153A2 (en) | 2000-08-14 | 2003-12-03 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of her-2/neu-associated malignancies |
| AU2006261342B2 (en) | 2005-06-15 | 2012-02-02 | The Ohio State University Research Foundation | Her-2 peptides |
-
2000
- 2000-08-03 EP EP00953823.2A patent/EP1246597B1/en not_active Expired - Lifetime
- 2000-08-03 US US09/632,036 patent/US7060284B1/en not_active Expired - Fee Related
- 2000-08-03 AU AU66203/00A patent/AU6620300A/en not_active Abandoned
- 2000-08-03 JP JP2001513369A patent/JP4658423B2/ja not_active Expired - Fee Related
- 2000-08-03 WO PCT/US2000/021222 patent/WO2001008636A2/en not_active Ceased
-
2006
- 2006-06-09 US US11/423,194 patent/US7666430B2/en not_active Expired - Fee Related
-
2010
- 2010-01-06 US US12/683,114 patent/US8110657B2/en not_active Expired - Fee Related
-
2012
- 2012-02-06 US US13/366,546 patent/US20120201841A1/en not_active Abandoned
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