JP2003522165A - Ｐｄｅ４アイソザイムの阻害剤として有用なピリミジンカルボキサミド - Google Patents

Ｐｄｅ４アイソザイムの阻害剤として有用なピリミジンカルボキサミド

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Publication number
JP2003522165A
JP2003522165A JP2001557857A JP2001557857A JP2003522165A JP 2003522165 A JP2003522165 A JP 2003522165A JP 2001557857 A JP2001557857 A JP 2001557857A JP 2001557857 A JP2001557857 A JP 2001557857A JP 2003522165 A JP2003522165 A JP 2003522165A
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Japan
Prior art keywords
formula
group
disease
pyrimidin
carboxamide
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Pending
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JP2001557857A
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English (en)
Japanese (ja)
Inventor
チャンバース，ロバート・ジェームズ
マギー，トーマス・ヴィクター
マーファット，アンソニー
Original Assignee
ファイザー・プロダクツ・インク
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Publication of JP2003522165A publication Critical patent/JP2003522165A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
JP2001557857A 2000-01-31 2001-01-30 Ｐｄｅ４アイソザイムの阻害剤として有用なピリミジンカルボキサミド Pending JP2003522165A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17928200P 2000-01-31 2000-01-31
US60/179,282 2000-01-31
PCT/IB2001/000125 WO2001057025A1 (en) 2000-01-31 2001-01-30 Pyrimidine carboxamides useful as inhibitors of pde4 isozymes

Publications (1)

Publication Number Publication Date
JP2003522165A true JP2003522165A (ja) 2003-07-22

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US (1) US6740655B2 (enExample)
EP (1) EP1252157B1 (enExample)
JP (1) JP2003522165A (enExample)
KR (1) KR20020071029A (enExample)
CN (1) CN1404480A (enExample)
AP (1) AP2002002590A0 (enExample)
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ES (1) ES2223772T3 (enExample)
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TR (1) TR200402292T4 (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008515910A (ja) * 2004-10-08 2008-05-15 アボット・ラボラトリーズ 薬物の塩およびその結晶形
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