PT1252157E - Carboxamidas de pirimidina uteis como inibidores de isozimas pde4 - Google Patents

Carboxamidas de pirimidina uteis como inibidores de isozimas pde4

Info

Publication number
PT1252157E
PT1252157E PT01901334T PT01901334T PT1252157E PT 1252157 E PT1252157 E PT 1252157E PT 01901334 T PT01901334 T PT 01901334T PT 01901334 T PT01901334 T PT 01901334T PT 1252157 E PT1252157 E PT 1252157E
Authority
PT
Portugal
Prior art keywords
isozimas
chronic
pyrimidine carboxamides
useful
inhibitors pde4
Prior art date
Application number
PT01901334T
Other languages
English (en)
Inventor
Robert James Chambers
Thomas Victor Magee
Anthony Marfat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PT1252157E publication Critical patent/PT1252157E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
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  • Hospice & Palliative Care (AREA)
PT01901334T 2000-01-31 2001-01-30 Carboxamidas de pirimidina uteis como inibidores de isozimas pde4 PT1252157E (pt)

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US17928200P 2000-01-31 2000-01-31

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PT1252157E true PT1252157E (pt) 2004-10-29

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US (1) US6740655B2 (pt)
EP (1) EP1252157B1 (pt)
JP (1) JP2003522165A (pt)
KR (1) KR20020071029A (pt)
CN (1) CN1404480A (pt)
AP (1) AP2002002590A0 (pt)
AR (1) AR027336A1 (pt)
AT (1) ATE269860T1 (pt)
AU (1) AU2700301A (pt)
BG (1) BG106868A (pt)
BR (1) BR0107934A (pt)
CA (1) CA2396458C (pt)
CO (1) CO5271669A1 (pt)
CR (1) CR6714A (pt)
CZ (1) CZ20022413A3 (pt)
DE (1) DE60103976T2 (pt)
DK (1) DK1252157T3 (pt)
DZ (1) DZ3406A1 (pt)
EA (1) EA005028B1 (pt)
EE (1) EE200200426A (pt)
ES (1) ES2223772T3 (pt)
GE (1) GEP20043385B (pt)
GT (1) GT200100023A (pt)
HK (1) HK1054232A1 (pt)
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NO (1) NO20023614L (pt)
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OA (1) OA12170A (pt)
PA (1) PA8511301A1 (pt)
PE (1) PE20011059A1 (pt)
PL (1) PL357555A1 (pt)
PT (1) PT1252157E (pt)
SK (1) SK10342002A3 (pt)
SV (1) SV2001000298A (pt)
TN (1) TNSN01019A1 (pt)
TR (1) TR200402292T4 (pt)
UY (1) UY26570A1 (pt)
WO (1) WO2001057025A1 (pt)
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ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
DE60019167T2 (de) * 1999-12-24 2006-05-11 Glaxo Group Ltd., Greenford Pharmazeutische aerosol formulierung enthaltend salmeterol und fluticason
DE10110772A1 (de) * 2001-03-07 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren
US7776315B2 (en) 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
YU39503A (sh) * 2000-11-22 2006-05-25 F. Hoffmann-La Roche Ag. Derivati pirimidina
DE60113731T2 (de) 2001-01-31 2006-06-29 Pfizer Products Inc., Groton Als inhibitoren von pde4-isozymen geeignete etherderivate
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