JP2003515526A5 - - Google Patents
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- JP2003515526A5 JP2003515526A5 JP2001516885A JP2001516885A JP2003515526A5 JP 2003515526 A5 JP2003515526 A5 JP 2003515526A5 JP 2001516885 A JP2001516885 A JP 2001516885A JP 2001516885 A JP2001516885 A JP 2001516885A JP 2003515526 A5 JP2003515526 A5 JP 2003515526A5
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- Prior art keywords
- formula
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- acid
- compound
- nitroxy
- Prior art date
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- 150000001875 compounds Chemical class 0.000 description 4
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- 229940006015 4-hydroxybutyric acid Drugs 0.000 description 1
- ZETOHPSSBWBMED-UHFFFAOYSA-N 4-nitrooxybutanoic acid Chemical compound OC(=O)CCCO[N+]([O-])=O ZETOHPSSBWBMED-UHFFFAOYSA-N 0.000 description 1
- IWHLYPDWHHPVAA-UHFFFAOYSA-N 6-hydroxyhexanoic acid Chemical compound OCCCCCC(O)=O IWHLYPDWHHPVAA-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 description 1
- 0 C**N(C=NC12)C1=CC(*=C)NC2=O Chemical compound C**N(C=NC12)C1=CC(*=C)NC2=O 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 229960004343 alendronic acid Drugs 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 description 1
- 229960005174 ambroxol Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 1
- 229960001685 tacrine Drugs 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT99A001817 | 1999-08-12 | ||
| IT1999MI001817A IT1314184B1 (it) | 1999-08-12 | 1999-08-12 | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| PCT/EP2000/007225 WO2001012584A2 (en) | 1999-08-12 | 2000-07-27 | Pharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003515526A JP2003515526A (ja) | 2003-05-07 |
| JP2003515526A5 true JP2003515526A5 (https=) | 2009-11-19 |
Family
ID=11383554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001516885A Ceased JP2003515526A (ja) | 1999-08-12 | 2000-07-27 | 医薬化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US7186753B1 (https=) |
| EP (2) | EP1252133B1 (https=) |
| JP (1) | JP2003515526A (https=) |
| KR (2) | KR100687809B1 (https=) |
| CN (2) | CN1289466C (https=) |
| AT (1) | ATE297375T1 (https=) |
| AU (1) | AU781643B2 (https=) |
| BR (1) | BR0013264A (https=) |
| CA (2) | CA2698353A1 (https=) |
| DE (1) | DE60020741T2 (https=) |
| DK (1) | DK1252133T3 (https=) |
| ES (1) | ES2243292T3 (https=) |
| HU (1) | HUP0203939A3 (https=) |
| IL (1) | IL147801A0 (https=) |
| IT (1) | IT1314184B1 (https=) |
| MX (1) | MXPA02001519A (https=) |
| NO (2) | NO328498B1 (https=) |
| NZ (2) | NZ535559A (https=) |
| PL (1) | PL203200B1 (https=) |
| PT (1) | PT1252133E (https=) |
| RU (1) | RU2264383C2 (https=) |
| WO (1) | WO2001012584A2 (https=) |
| ZA (1) | ZA200200628B (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US20050137191A1 (en) * | 1996-06-04 | 2005-06-23 | Thatcher Gregory R. | Nitrate esters and their use for mitigating cellular damage |
| IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| AP2002002582A0 (en) | 1999-12-23 | 2002-09-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| IT1317735B1 (it) * | 2000-01-26 | 2003-07-15 | Nicox Sa | Sali di agenti antimicrobici. |
| CA2410632A1 (en) | 2000-06-22 | 2001-12-27 | David S. Garvey | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| IT1319202B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
| DE60122939T2 (de) | 2000-12-21 | 2007-01-11 | Nitromed, Inc., Bedford | Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren |
| AU2008201838B2 (en) * | 2001-05-02 | 2010-07-29 | Nicox S.A. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| WO2002087508A2 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| SE0101702D0 (sv) | 2001-05-15 | 2001-05-15 | Ardenia Investments Ltd | Novel potentiating compounds |
| ITMI20011308A1 (it) | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
| NZ534912A (en) | 2002-02-04 | 2007-08-31 | Alfama Investigacao E Desenvol | supramolecule aggregate comprising CO containing organometallic or transition metal complex and anti-inflammatory agent or biphosphonate phosphonate derivative |
| AU2003223491A1 (en) * | 2002-04-05 | 2003-10-27 | Nitromed, Inc. | Nitric oxide donors, compositions and methods of use |
| AU2003231255A1 (en) * | 2002-05-02 | 2003-12-31 | Osteoscreen, Inc. | Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates (no-bisphosphonate) |
| CA2487414A1 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| JP2005535642A (ja) | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法 |
| AU2003247792B2 (en) | 2002-07-03 | 2009-09-24 | Nicox S.A. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| US7244753B2 (en) | 2002-07-29 | 2007-07-17 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| EP1534278A4 (en) | 2002-08-01 | 2006-09-06 | Nitromed Inc | NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD |
| ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| ITMI20022658A1 (it) | 2002-12-17 | 2004-06-18 | Nicox Sa | Farmaci per il dolore cronico. |
| US7166638B2 (en) | 2003-05-27 | 2007-01-23 | Nicox S.A. | Statin derivatives |
| US7169805B2 (en) | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
| AU2004246821A1 (en) | 2003-06-19 | 2004-12-23 | Nicox S.A. | Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases |
| JP2007502831A (ja) * | 2003-08-20 | 2007-02-15 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法 |
| DE602004014822D1 (de) * | 2003-11-20 | 2008-08-14 | Nicox Sa | Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol |
| HRP20070283T3 (en) * | 2003-12-02 | 2007-11-30 | Nicox S.A. | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs |
| AR047264A1 (es) * | 2003-12-02 | 2006-01-11 | Nicox Sa | Nitrooxiderivados de drogas antihipertensivas |
| US20090131342A1 (en) * | 2004-01-22 | 2009-05-21 | Nitromed, Inc. | Nitrosated and/or nitrosylated compounds, compositions and methods of use |
| KR100503443B1 (ko) * | 2004-02-02 | 2005-07-22 | 한림제약(주) | 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 |
| US7723529B2 (en) * | 2004-07-20 | 2010-05-25 | Nicox S.A. | Process for preparing nitrooxy esters, nitrooxy thioesters nitrooxy carbonates and nitrooxy thiocarbinates, intermediates useful in said process and preparation thereof |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| KR20070053214A (ko) | 2004-08-26 | 2007-05-23 | 니콜라스 피라말 인디아 리미티드 | 신규 생분해성 링커를 함유하는 프로드럭 |
| PT2057139E (pt) * | 2006-07-18 | 2013-12-05 | Antibe Holdings Inc | Derivados de sulfureto de hidrogénio de fármacos antiinflamatórios não esteroidais |
| TW200831079A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
| RU2340597C1 (ru) * | 2007-03-21 | 2008-12-10 | Институт физиологически активных веществ Российской Академии наук | Нитроксиалкиламинокислоты |
| US20080317673A1 (en) | 2007-06-20 | 2008-12-25 | Fatema Salem Al-Thallab | Method for diagnosing and treating bronchial asthma |
| US20080319221A1 (en) * | 2007-06-22 | 2008-12-25 | Bernd Junker | Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids |
| EP2167070A1 (en) | 2007-07-09 | 2010-03-31 | Nicox S.A. | Use of nitric oxide releasing compounds in the treatment of chronic pain |
| WO2009024998A1 (en) | 2007-08-17 | 2009-02-26 | Council Of Scientific & Industrial Research | Nitric oxide releasing derivatives of paracetamol |
| US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| ES2590604T3 (es) * | 2008-01-04 | 2016-11-22 | Schabar Research Associates Llc | Composición que comprende un analgésico y un antihistamínico |
| RU2364394C1 (ru) * | 2008-03-19 | 2009-08-20 | Михаил Владимирович Покровский | Способ коррекции эндотелиальной дисфункции клопидогрелем при l-name индуцированном дефиците оксида азота |
| US8207208B2 (en) * | 2008-05-15 | 2012-06-26 | Merck Sharp & Dohme Corp. | Angiotensin II receptor antagonists |
| CA2728301A1 (en) | 2008-07-03 | 2010-01-07 | Osteogenex Inc. | Vinpocetine and eburnamonine derivatives for promoting bone growth |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
| HRP20140929T1 (hr) | 2008-08-01 | 2014-12-05 | Onconox Aps | Antitumorska svojstva no-modificiranih inhibitora proteaze |
| WO2010108843A1 (en) | 2009-03-27 | 2010-09-30 | Nicox S.A. | Use of nitrooxyderivative of paracetamol for the treatment of muscular dystrophies |
| FR2953145B1 (fr) * | 2009-11-30 | 2013-07-19 | Inst Francais Du Petrole | Solution absorbante contenant un inhibiteur de degradation derive de la pyrimidine ou de la triazine et procede d'absorption de composes acides contenus dans un effluent gazeux |
| CN101863900B (zh) * | 2010-06-29 | 2012-07-25 | 天津药物研究院 | 一氧化氮供体型噻吩并吡啶衍生物、其制备方法和用途 |
| CN102442908A (zh) * | 2010-10-14 | 2012-05-09 | 天津药物研究院 | 制备萘普西诺的中间体及方法 |
| RU2584163C2 (ru) * | 2010-11-02 | 2016-05-20 | Нагоя Индастриал Сайенс Рисерч Инститьют | Производное транс-2-деценовой кислоты и содержащее его фармацевтическое средство |
| JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
| EP2699242B1 (en) | 2011-04-19 | 2017-11-01 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
| JP6134710B2 (ja) | 2011-07-21 | 2017-05-24 | アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． | 一酸化ルテニウム放出分子およびその使用 |
| CN102557967A (zh) * | 2011-12-28 | 2012-07-11 | 合肥科尚医药科技有限公司 | 一种盐酸氨溴索的制备方法 |
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| US10881654B2 (en) | 2015-04-24 | 2021-01-05 | University Of Louisville Research Foundation, Inc. | Selective PFKFB4 inhibitors for the treatment of cancer |
| WO2018161039A1 (en) * | 2017-03-03 | 2018-09-07 | Synovo Gmbh | Novel anti-infective and anti-inflammatory compounds |
| CA3073952A1 (en) | 2017-08-31 | 2019-03-07 | University Of Louisville Research Foundation, Inc. | Quinoline derivative, compositions comprising this compound and uses thereof in the treatment of cancer |
| US10774046B2 (en) | 2017-10-26 | 2020-09-15 | University Of Louisville Research Foundation, Inc. | Inhibitors for the treatment of cancer and related methods |
| RU2709067C1 (ru) * | 2018-07-23 | 2019-12-13 | федеральное государственное бюджетное образовательное учреждение высшего образования "Тольяттинский государственный университет" | Способ термосиловой обработки длинномерных осесимметричных деталей и устройство для его осуществления |
| US11324727B2 (en) | 2020-07-15 | 2022-05-10 | Schabar Research Associates, Llc | Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn |
| US12514846B2 (en) | 2020-07-15 | 2026-01-06 | Schabar Research Associates Llc | Unit oral dose compositions composed of ibuprofen or a pharmaceutically acceptable salt thereof and famotidine or a pharmaceutically acceptable salt thereof for the treatment of acute pain and the reduction of the severity and/or risk of heartburn and/or upset stomach |
| KR20230051164A (ko) | 2020-07-15 | 2023-04-17 | 샤바르 리서치 어소시에이츠 엘엘씨 | 급성 통증의 치료 및 속쓰림의 중증도 및/또는 위험의 감소를 위한 이부프로펜 및 파모티딘으로 구성된 단위 경구 투여 조성물 |
| CN112316158B (zh) * | 2020-11-19 | 2021-09-21 | 四川大学 | 一种利用超分子包合剂关闭胶原溶液中抗菌剂活性的方法 |
| CN116270562B (zh) * | 2022-03-18 | 2025-07-01 | 北京诺和德美医药科技有限公司 | 一种制备稳定的吸入用2-氨基-3,5-二溴苯甲胺衍生物溶液的方法 |
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| IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| IT1311923B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
-
1999
- 1999-08-12 IT IT1999MI001817A patent/IT1314184B1/it active
-
2000
- 2000-07-27 HU HU0203939A patent/HUP0203939A3/hu unknown
- 2000-07-27 NZ NZ535559A patent/NZ535559A/en not_active IP Right Cessation
- 2000-07-27 WO PCT/EP2000/007225 patent/WO2001012584A2/en not_active Ceased
- 2000-07-27 BR BR0013264-0A patent/BR0013264A/pt active Search and Examination
- 2000-07-27 CN CNB008140499A patent/CN1289466C/zh not_active Expired - Fee Related
- 2000-07-27 US US10/048,469 patent/US7186753B1/en not_active Expired - Fee Related
- 2000-07-27 PL PL353451A patent/PL203200B1/pl not_active IP Right Cessation
- 2000-07-27 NZ NZ516889A patent/NZ516889A/en not_active IP Right Cessation
- 2000-07-27 RU RU2002103509/04A patent/RU2264383C2/ru not_active IP Right Cessation
- 2000-07-27 EP EP00953102A patent/EP1252133B1/en not_active Expired - Lifetime
- 2000-07-27 CN CNB2006101362310A patent/CN100528834C/zh not_active Expired - Fee Related
- 2000-07-27 KR KR1020027001883A patent/KR100687809B1/ko not_active Expired - Fee Related
- 2000-07-27 MX MXPA02001519A patent/MXPA02001519A/es active IP Right Grant
- 2000-07-27 ES ES00953102T patent/ES2243292T3/es not_active Expired - Lifetime
- 2000-07-27 AU AU65670/00A patent/AU781643B2/en not_active Ceased
- 2000-07-27 CA CA2698353A patent/CA2698353A1/en not_active Abandoned
- 2000-07-27 KR KR1020067024051A patent/KR100760394B1/ko not_active Expired - Fee Related
- 2000-07-27 DE DE60020741T patent/DE60020741T2/de not_active Expired - Lifetime
- 2000-07-27 IL IL14780100A patent/IL147801A0/xx not_active IP Right Cessation
- 2000-07-27 DK DK00953102T patent/DK1252133T3/da active
- 2000-07-27 PT PT00953102T patent/PT1252133E/pt unknown
- 2000-07-27 EP EP05104064A patent/EP1593664A1/en not_active Withdrawn
- 2000-07-27 AT AT00953102T patent/ATE297375T1/de not_active IP Right Cessation
- 2000-07-27 CA CA002381409A patent/CA2381409A1/en not_active Abandoned
- 2000-07-27 JP JP2001516885A patent/JP2003515526A/ja not_active Ceased
-
2002
- 2002-01-23 ZA ZA200200628A patent/ZA200200628B/xx unknown
- 2002-02-08 NO NO20020623A patent/NO328498B1/no not_active IP Right Cessation
-
2006
- 2006-12-21 US US11/642,783 patent/US7399878B2/en not_active Expired - Fee Related
-
2008
- 2008-06-03 US US12/132,245 patent/US7759392B2/en not_active Expired - Fee Related
-
2009
- 2009-10-29 NO NO20093253A patent/NO20093253L/no unknown
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