JP2007525527A5 - - Google Patents

Info

Publication number

JP2007525527A5

JP2007525527A5 JP2007501073A JP2007501073A JP2007525527A5 JP 2007525527 A5 JP2007525527 A5 JP 2007525527A5 JP 2007501073 A JP2007501073 A JP 2007501073A JP 2007501073 A JP2007501073 A JP 2007501073A JP 2007525527 A5 JP2007525527 A5 JP 2007525527A5

Authority

JP

Japan

Prior art keywords

group

carbon atoms

compound according

formula

pyridyl

Prior art date

2004-08-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims 76
• 125000004432 carbon atom Chemical group C* 0.000 claims 64
• 125000000217 alkyl group Chemical group 0.000 claims 36
• -1 tetrahydro-3-furanyloxy group Chemical group 0.000 claims 32
• 125000000753 cycloalkyl group Chemical group 0.000 claims 20
• 150000003839 salts Chemical class 0.000 claims 17
• GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 8
• 101150065749 Churc1 gene Proteins 0.000 claims 8
• 102100038239 Protein Churchill Human genes 0.000 claims 8
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 7
• 125000001624 naphthyl group Chemical group 0.000 claims 7
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 5
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
• 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 4
• 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims 4
• 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 4
• 241000790917 Dioxys <bee> Species 0.000 claims 4
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• 125000005530 alkylenedioxy group Chemical group 0.000 claims 4
• 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 4
• 125000004076 pyridyl group Chemical group 0.000 claims 4
• 208000031886 HIV Infections Diseases 0.000 claims 2
• 208000037357 HIV infectious disease Diseases 0.000 claims 2
• 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 2
• 229910052783 alkali metal Inorganic materials 0.000 claims 2
• 150000001340 alkali metals Chemical class 0.000 claims 2
• 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
• 150000001342 alkaline earth metals Chemical class 0.000 claims 2
• 229920001577 copolymer Chemical group 0.000 claims 2
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
• 125000003386 piperidinyl group Chemical group 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
• RSJAAVKNQYKXBN-QCDSWUKFSA-N CC(C)CN([C@@H](CCCCNC(=O)[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC(=O)O)COP(=O)(O)O)S(=O)(=O)C3=CC(=C(C=C3)N)F Chemical compound CC(C)CN([C@@H](CCCCNC(=O)[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC(=O)O)COP(=O)(O)O)S(=O)(=O)C3=CC(=C(C=C3)N)F RSJAAVKNQYKXBN-QCDSWUKFSA-N 0.000 claims 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000004702 methyl esters Chemical class 0.000 claims 1
• KHASNRBNVBIREH-IZEXYCQBSA-N methyl n-[(2s)-1-[[(5s)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-phosphonooxyhexyl]amino]-1-oxo-3,3-diphenylpropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C([C@H](NC(=O)OC)C(=O)NCCCC[C@@H](COP(O)(O)=O)N(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)C1=CC=CC=C1 KHASNRBNVBIREH-IZEXYCQBSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 159000000000 sodium salts Chemical class 0.000 claims 1
• 0 C*N(C(*)**NC(C(*)N*)=O)S(C1=CC=CCC1)(=O)=O Chemical compound C*N(C(*)**NC(C(*)N*)=O)S(C1=CC=CCC1)(=O)=O 0.000 description 2
• BSZXAFXFTLXUFV-UHFFFAOYSA-N CC(c1ccccc1)c1ccccc1 Chemical compound CC(c1ccccc1)c1ccccc1 BSZXAFXFTLXUFV-UHFFFAOYSA-N 0.000 description 1