JP2006528700A5 - - Google Patents
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- JP2006528700A5 JP2006528700A5 JP2006533314A JP2006533314A JP2006528700A5 JP 2006528700 A5 JP2006528700 A5 JP 2006528700A5 JP 2006533314 A JP2006533314 A JP 2006533314A JP 2006533314 A JP2006533314 A JP 2006533314A JP 2006528700 A5 JP2006528700 A5 JP 2006528700A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- independently
- medicinal composition
- formulated
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- HCZKYJDFEPMADG-UHFFFAOYSA-N nordihydroguaiaretic acid Chemical compound C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims 46
- 239000003937 drug carrier Substances 0.000 claims 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 229920002988 biodegradable polymer Polymers 0.000 claims 1
- 239000004621 biodegradable polymer Substances 0.000 claims 1
- 239000001273 butane Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- ORQFDHFZSMXRLM-UHFFFAOYSA-N 4-[4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene Chemical compound C1=C(OC)C(OC)=CC=C1CC(C)C(C)CC1=CC=C(OC)C(OC)=C1 ORQFDHFZSMXRLM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47229903P | 2003-05-20 | 2003-05-20 | |
| US47228203P | 2003-05-20 | 2003-05-20 | |
| US47214403P | 2003-05-20 | 2003-05-20 | |
| US47218803P | 2003-05-20 | 2003-05-20 | |
| US47200803P | 2003-05-20 | 2003-05-20 | |
| PCT/US2004/016114 WO2004112695A2 (en) | 2003-05-20 | 2004-05-20 | Methods and compositions for delivery of catecholic butanes for treatment of obesity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528700A JP2006528700A (ja) | 2006-12-21 |
| JP2006528700A5 true JP2006528700A5 (https=) | 2007-07-12 |
Family
ID=33545640
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533316A Pending JP2006528701A (ja) | 2003-05-20 | 2004-05-20 | 疾患の治療のためのカテコールブタンの投与のための方法と組成物 |
| JP2006533343A Pending JP2007500229A (ja) | 2003-05-20 | 2004-05-20 | 腫瘍の治療のためのカテコールブタンの投与のための方法と組成物 |
| JP2006533314A Pending JP2006528700A (ja) | 2003-05-20 | 2004-05-20 | 肥満の治療のためのカテコールブタンの投与のための方法と組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533316A Pending JP2006528701A (ja) | 2003-05-20 | 2004-05-20 | 疾患の治療のためのカテコールブタンの投与のための方法と組成物 |
| JP2006533343A Pending JP2007500229A (ja) | 2003-05-20 | 2004-05-20 | 腫瘍の治療のためのカテコールブタンの投与のための方法と組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060141047A1 (https=) |
| EP (3) | EP1631271A4 (https=) |
| JP (3) | JP2006528701A (https=) |
| CN (1) | CN103585136A (https=) |
| AU (3) | AU2004249123A1 (https=) |
| WO (3) | WO2004112695A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10214983A1 (de) | 2002-04-04 | 2004-04-08 | TransMIT Gesellschaft für Technologietransfer mbH | Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen |
| US20060017597A1 (en) * | 2002-09-09 | 2006-01-26 | Koninklijke Philips Electronics N.V. | Method of signal reconstruction, imaging device and computer program product |
| JP2008528510A (ja) * | 2005-01-20 | 2008-07-31 | サートリス ファーマシューティカルズ， インコーポレイテッド | 紅潮および／または薬物誘発性体重増加を処置するためのサーチュイン活性化化合物の使用 |
| AU2006208108A1 (en) * | 2005-01-27 | 2006-08-03 | Erimos Pharmaceuticals Llc | Oral formulations for delivery of catecholic butanes including NDGA compounds |
| WO2007043057A2 (en) * | 2005-10-11 | 2007-04-19 | Yissum, Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| US20070128289A1 (en) * | 2005-12-07 | 2007-06-07 | Zhao Jonathon Z | Nano-and/or micro-particulate formulations for local injection-based treatment of vascular diseases |
| FR2896694A1 (fr) * | 2006-01-30 | 2007-08-03 | Genfit S A | Utilisation d'inhibiteurs de 15-lipoxygenases dans le traitement du syndrome metabolique |
| US7863157B2 (en) * | 2006-03-17 | 2011-01-04 | Silicon Genesis Corporation | Method and structure for fabricating solar cells using a layer transfer process |
| DE102006013531A1 (de) * | 2006-03-24 | 2007-09-27 | Lts Lohmann Therapie-Systeme Ag | Polylactid-Nanopartikel |
| GB2441499B (en) * | 2006-09-08 | 2011-09-14 | Jasin El Sammadoni | Slimming Spray |
| CN101547689B (zh) | 2006-10-02 | 2014-02-26 | 埃里莫斯医药品有限公司 | 通过醚键和氨基甲酸酯键四取代的ndga衍生物、它们的合成方法和药学用途 |
| US9067875B2 (en) | 2006-10-02 | 2015-06-30 | Erimos Pharmaceuticals Llc | Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use |
| EP1970051A1 (en) * | 2007-03-14 | 2008-09-17 | Merz Pharma GmbH & Co.KGaA | Use of an aqueous micro-emulsion for the preparation of a formulation for the treatment of adipose diseases |
| EP2039352A1 (en) * | 2007-09-18 | 2009-03-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules |
| US9145453B2 (en) * | 2007-09-28 | 2015-09-29 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
| US8846053B2 (en) * | 2008-09-26 | 2014-09-30 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
| US20100080773A1 (en) | 2008-09-26 | 2010-04-01 | Sdg, Inc. | Orally Bioavailable Lipid-Based Constructs |
| US8962015B2 (en) | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
| US9161943B2 (en) | 2007-12-31 | 2015-10-20 | Industrial Technology Research Institute | Sustained release composition and manufacturing method thereof |
| US20100093872A1 (en) * | 2008-10-15 | 2010-04-15 | Erimos Pharmaceuticals Llc | Stable aqueous formulations of water insoluble or poorly soluble drugs |
| US8685458B2 (en) | 2009-03-05 | 2014-04-01 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
| EP2411137B1 (en) | 2009-03-27 | 2016-09-07 | Bend Research, Inc. | Spray-drying process |
| DE102009031274A1 (de) * | 2009-06-30 | 2011-01-13 | Justus-Liebig-Universität Giessen | Liposomen zur pulmonalen Applikation |
| WO2011106702A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| WO2012031133A2 (en) | 2010-09-03 | 2012-03-08 | Bench Research, Inc. | Spray-drying apparatus and methods of using the same |
| US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
| EP2611529B1 (en) | 2010-09-03 | 2019-01-23 | Bend Research, Inc. | Spray-drying method |
| JP5222917B2 (ja) * | 2010-09-21 | 2013-06-26 | 財團法人工業技術研究院 | 徐放性組成物およびその製造方法 |
| WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| WO2012109363A2 (en) | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
| US9060938B2 (en) | 2011-05-10 | 2015-06-23 | Bend Research, Inc. | Pharmaceutical compositions of active agents and cationic dextran polymer derivatives |
| BR112014014262A2 (pt) * | 2011-12-14 | 2017-06-13 | Univ Johns Hopkins | nanopartículas; composição farmacêutica; método de administrar um ou mais agentes terapêuticos, profiláticos, e/ou diagnósticos a um paciente em necessidade dos mesmos e método de preparação das partículas. |
| US9834575B2 (en) * | 2013-02-26 | 2017-12-05 | Triact Therapeutics, Inc. | Cancer therapy |
| US10335500B2 (en) | 2014-05-12 | 2019-07-02 | The Johns Hopkins University | Highly stable biodegradable gene vector platforms for overcoming biological barriers |
| AU2017210319A1 (en) * | 2016-01-20 | 2018-08-23 | Flurry Powders, Llc | Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation |
| US11077173B2 (en) | 2017-03-13 | 2021-08-03 | Sdg, Inc. | Lipid-based nanoparticles and methods using same |
| JP7306718B2 (ja) | 2017-03-13 | 2023-07-11 | エスディージー インコーポレイテッド | 向上した安定性を有する脂質ベースのナノ粒子 |
| US12496279B2 (en) | 2019-04-11 | 2025-12-16 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| CN114831938B (zh) * | 2022-05-24 | 2023-04-18 | 郑州大学第一附属医院 | 一种包载阿托伐他汀钙的聚合物胶束、制剂及制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3934034A (en) * | 1972-08-21 | 1976-01-20 | Sandoz, Inc. | Hydroxy substituted diphenylalkyls for treatment of lipidemia |
| US4098908A (en) * | 1975-10-20 | 1978-07-04 | Sandoz, Inc. | Phenoxyphenyl pyridyl ketones and derivatives and their use as hypolepidemic agents |
| US5008294A (en) * | 1985-02-11 | 1991-04-16 | Chemex Pharmaceuticals, Inc. | Methods of treating tumors with compositions of catecholic butanes |
| US4774229A (en) * | 1982-04-05 | 1988-09-27 | Chemex Pharmaceuticals, Inc. | Modification of plant extracts from zygophyllaceae and pharmaceutical use therefor |
| US4708964A (en) * | 1984-02-09 | 1987-11-24 | Chemex Pharmaceuticals | Lipoxygenase inhibitors |
| GB8416234D0 (en) * | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
| US4880637A (en) * | 1985-02-11 | 1989-11-14 | Chemex Pharmaceuticals, Inc. | Compositions of catecholic butanes with zinc |
| KR890700023A (ko) * | 1986-11-19 | 1989-03-02 | 케맥스 파마슈우티칼스 인코포레이티드 | 리폭시게나제 저해제 |
| AU7629694A (en) * | 1993-08-17 | 1995-03-14 | Schering-Plough Healthcare Products, Inc. | Compositions for treating corns, calluses and warts |
| US6365787B1 (en) * | 1994-09-30 | 2002-04-02 | The Johns Hopkins University | Compounds for the suppression of HIV TAT transactivation |
| WO1996040090A1 (en) * | 1995-06-07 | 1996-12-19 | University Of Southern California | Method for reducing or preventing post-surgical adhesion formation using 5-lipoxygenase inhibitors |
| US5837252A (en) * | 1996-07-01 | 1998-11-17 | Larreacorp, Ltd. | Nontoxic extract of Larrea tridentata and method of making same |
| US5827898A (en) * | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
| WO1999017761A1 (en) * | 1997-10-06 | 1999-04-15 | Shaman Pharmaceuticals, Inc. | Use of nordihydroguaiaretic acid to lower serum triglycerides, blood pressure and to treat syndrome x |
| EP1027045A4 (en) * | 1997-10-31 | 2004-12-08 | Arch Dev Corp | METHODS AND COMPILATIONS FOR REGULATING S-ALPHA REDUCTASE ACTIVITY |
| US6214874B1 (en) * | 1999-10-15 | 2001-04-10 | John Hopkins University | Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N |
| US6608108B2 (en) * | 1999-10-15 | 2003-08-19 | Johns Hopkins University | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
| US6545019B2 (en) * | 2000-07-13 | 2003-04-08 | Bristol-Myers Squibb Company | Method of modulating microglial activation for the treatment of acute and chronic neurodegenerative disorders |
| US7365099B2 (en) * | 2001-05-31 | 2008-04-29 | Wisconsin Alumni Research Foundation | Animal body fat control |
| KR100575944B1 (ko) * | 2001-06-28 | 2006-05-02 | 화이자 프로덕츠 인코포레이티드 | 미소체 트리글리세라이드 전달 단백질(ｍｔｐ) 및/또는아포지방단백질 ｂ(ａｐｏ ｂ)분비의 억제제로서의트리아미드-치환된 인돌, 벤조푸란 및 벤조티오펜 |
| JP2005533042A (ja) * | 2002-06-10 | 2005-11-04 | オクラホマ メディカル リサーチ ファウンデーション | 中枢神経系の炎症状態の治療において連結ビス（ポリヒドロキシフェニル）およびそのｏ−アルキル誘導体を使用するための方法 |
-
2004
- 2004-05-20 WO PCT/US2004/016114 patent/WO2004112695A2/en not_active Ceased
- 2004-05-20 CN CN201310488557.XA patent/CN103585136A/zh active Pending
- 2004-05-20 EP EP04776086A patent/EP1631271A4/en not_active Ceased
- 2004-05-20 JP JP2006533316A patent/JP2006528701A/ja active Pending
- 2004-05-20 EP EP04753013A patent/EP1631269A4/en not_active Withdrawn
- 2004-05-20 EP EP04753016A patent/EP1631270A4/en not_active Ceased
- 2004-05-20 JP JP2006533343A patent/JP2007500229A/ja active Pending
- 2004-05-20 JP JP2006533314A patent/JP2006528700A/ja active Pending
- 2004-05-20 WO PCT/US2004/016235 patent/WO2005007080A2/en not_active Ceased
- 2004-05-20 AU AU2004249123A patent/AU2004249123A1/en not_active Abandoned
- 2004-05-20 WO PCT/US2004/016117 patent/WO2004112696A2/en not_active Ceased
- 2004-05-20 AU AU2004249124A patent/AU2004249124A1/en not_active Abandoned
- 2004-05-20 AU AU2004257575A patent/AU2004257575A1/en not_active Abandoned
-
2005
- 2005-11-21 US US11/284,280 patent/US20060141047A1/en not_active Abandoned
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