JP2004517045A5 - - Google Patents
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- Publication number
- JP2004517045A5 JP2004517045A5 JP2002521491A JP2002521491A JP2004517045A5 JP 2004517045 A5 JP2004517045 A5 JP 2004517045A5 JP 2002521491 A JP2002521491 A JP 2002521491A JP 2002521491 A JP2002521491 A JP 2002521491A JP 2004517045 A5 JP2004517045 A5 JP 2004517045A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- betulinic acid
- cancer
- hydrogen
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C)([C@@](CC1)[C@](C)(CC2)[C@@](CC3)[C@]1(C)[C@@]1(C)[C@]3[C@@]([C@@](CC3)C(CO)=C)[C@@]3(*)CC1)[C@]2O Chemical compound CC(C)([C@@](CC1)[C@](C)(CC2)[C@@](CC3)[C@]1(C)[C@@]1(C)[C@]3[C@@]([C@@](CC3)C(CO)=C)[C@@]3(*)CC1)[C@]2O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22653600P | 2000-08-18 | 2000-08-18 | |
| PCT/US2001/025581 WO2002016395A1 (en) | 2000-08-18 | 2001-08-15 | Prodrugs of betulinic acid derivatives for the treatment of cancer and hiv |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004517045A JP2004517045A (ja) | 2004-06-10 |
| JP2004517045A5 true JP2004517045A5 (https=) | 2008-10-02 |
Family
ID=22849310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002521491A Pending JP2004517045A (ja) | 2000-08-18 | 2001-08-15 | 癌およびｈｉｖの治療用ベツリン酸誘導体のプロドラッグ |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6569842B2 (https=) |
| EP (1) | EP1309605A1 (https=) |
| JP (1) | JP2004517045A (https=) |
| AU (2) | AU8494601A (https=) |
| CA (1) | CA2418479C (https=) |
| NO (1) | NO20030748L (https=) |
| NZ (1) | NZ524087A (https=) |
| WO (1) | WO2002016395A1 (https=) |
| ZA (1) | ZA200301269B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6943260B2 (en) * | 2002-02-02 | 2005-09-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for obtaining betulinic acid |
| EP2186811A1 (en) * | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| CN100432094C (zh) * | 2003-02-11 | 2008-11-12 | 诺瓦利克斯制药公司 | 抑制肿瘤生长的药物 |
| PL378577A1 (pl) | 2003-03-24 | 2006-05-02 | Sterix Limited | Pochodne estrogenu jako inhibitory sulfatazy steroidowej |
| AU2004289174B2 (en) * | 2003-07-29 | 2011-05-19 | Signature R&D Holdings, Lcc | Amino acid prodrugs |
| WO2005112929A2 (en) * | 2004-05-20 | 2005-12-01 | Cornell Research Foundation, Inc. | Anti-hiv-1 activity of betulinol derivatives |
| ES2319996T3 (es) * | 2004-08-02 | 2009-05-18 | Ambrilia Biopharma Inc. | Compuestos basados en lisina. |
| WO2006031756A2 (en) * | 2004-09-10 | 2006-03-23 | Cornell Research Foundation, Inc | Betulinol derivatives as anti-cancer agents |
| AR051475A1 (es) * | 2004-11-05 | 2007-01-17 | Merck & Co Inc | Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico |
| JP4810642B2 (ja) * | 2004-11-30 | 2011-11-09 | 秋田県 | 癌転移抑制用トリテルペン誘導体及び該トリテルペン誘導体を用いた癌転移抑制用組成物 |
| EP1869063A2 (en) * | 2005-03-29 | 2007-12-26 | Regents Of The University Of Minnesota | Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid |
| US20070111936A1 (en) | 2005-11-15 | 2007-05-17 | Vladimir Pak | Complex of alpha-fetoprotein and inducers of apoptosis for the treatment of cancer |
| CN101374527A (zh) * | 2005-12-16 | 2009-02-25 | 帕纳克斯医药公司 | 3-o-(3’,3’-二甲基琥珀酰基)桦木酸的药物盐的制备方法 |
| GB0604535D0 (en) | 2006-03-07 | 2006-04-12 | Sndv Sprl | Betulonic acid derivatives |
| US20110152229A1 (en) * | 2006-11-22 | 2011-06-23 | Duke University | Betulinic acid derivatives as anti-hiv agents |
| WO2009020732A1 (en) * | 2007-08-03 | 2009-02-12 | Advanced Life Sciences, Inc. | Lupane-type triterpenoids modified at 30-position and analogues thereof |
| EP2371368A3 (en) * | 2008-05-30 | 2012-08-22 | Novelix Pharmaceuticals, Inc. | Compositions and methods for treatment of inflammation and hyperkeratotic lesions |
| US8372808B2 (en) * | 2008-10-31 | 2013-02-12 | Wisconsin Alumni Research Foundation | Suppression of glial fibrillary acidic protein |
| WO2010068668A1 (en) * | 2008-12-10 | 2010-06-17 | Advanced Life Sciences, Inc. | 23-substituted derivatives of lupane-type pentacyclic triterpenoids |
| RU2551647C2 (ru) * | 2012-11-12 | 2015-05-27 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Трифенилфосфониевые соли лупановых тритерпеноидов, способ получения и применение в качестве противоопухолевых веществ |
| KR101531821B1 (ko) * | 2013-11-27 | 2015-06-24 | 주식회사 휴메딕스 | 페길레이션된 베튤린 유도체를 포함하는 경구 투여용 항암제 조성물 |
| CN107011406A (zh) * | 2016-01-28 | 2017-08-04 | 思路迪（北京）医药科技有限公司 | 一种具有抗肿瘤作用的化合物及其制备方法和应用 |
| CA3075729A1 (en) | 2017-09-14 | 2019-03-21 | Phoenix Biotechnology, Inc. | Use of oleandrin to treatn viral infection |
| MX2020002884A (es) | 2017-09-14 | 2020-10-05 | Phoenix Biotechnology Inc | Método y composición neuroprotectora mejorada para tratar afecciones neurológicas. |
| AU2019292599B2 (en) | 2018-06-29 | 2022-03-03 | Dfh Therapeutics | Triterpene amine derivatives |
| WO2020124043A1 (en) * | 2018-12-13 | 2020-06-18 | Gordon Erlinda M | Methods of exploiting oncogenic drivers along the human cyclin g1 pathway for cancer gene therapy |
| KR20220151038A (ko) | 2020-03-31 | 2022-11-11 | 피닉스 바이오테크놀러지 인코포레이티드. | 코로나바이러스 감염 예방를 위한 조성물 |
| EP4295854A3 (en) | 2020-03-31 | 2024-04-03 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2683531B1 (fr) * | 1991-11-13 | 1993-12-31 | Rhone Poulenc Rorer Sa | Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2705097B1 (fr) * | 1993-05-11 | 1995-08-04 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du lupane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5658947A (en) | 1995-03-21 | 1997-08-19 | Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma using betalinic acid |
| US5869535A (en) * | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
| US5962527A (en) | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
| JPH0987156A (ja) * | 1995-09-19 | 1997-03-31 | Pola Chem Ind Inc | 光老化防止剤及び皮膚化粧料 |
| US5804575A (en) | 1997-03-27 | 1998-09-08 | The Board Of Trustees Of The University Of Illinois | Methods of manufacturing betulinic acid |
| US6670345B1 (en) * | 1997-09-30 | 2003-12-30 | Dabur Research Foundation | Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid |
| US6048847A (en) * | 1997-09-30 | 2000-04-11 | Dabur Research Foundation | Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this |
| EP0943620B1 (en) | 1998-03-18 | 2005-11-16 | Dabur Pharma Ltd. | Betulinic acid derivatives for inhibiting cancer growth |
| WO2000046235A1 (en) | 1998-11-18 | 2000-08-10 | Dabur Research Foundation | Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors |
| EP1189607A2 (en) * | 1999-04-07 | 2002-03-27 | Washington State University Research Foundation | Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives |
| CA2418117A1 (en) | 2000-07-31 | 2003-01-30 | The Nisshin Oillio, Ltd. | Antitumor agent |
-
2001
- 2001-08-15 AU AU8494601A patent/AU8494601A/xx active Pending
- 2001-08-15 NZ NZ524087A patent/NZ524087A/en unknown
- 2001-08-15 EP EP01964047A patent/EP1309605A1/en not_active Ceased
- 2001-08-15 WO PCT/US2001/025581 patent/WO2002016395A1/en not_active Ceased
- 2001-08-15 US US09/930,656 patent/US6569842B2/en not_active Expired - Fee Related
- 2001-08-15 JP JP2002521491A patent/JP2004517045A/ja active Pending
- 2001-08-15 CA CA002418479A patent/CA2418479C/en not_active Expired - Fee Related
- 2001-08-15 AU AU2001284946A patent/AU2001284946B2/en not_active Ceased
-
2003
- 2003-01-13 US US10/340,934 patent/US7091195B2/en not_active Expired - Fee Related
- 2003-02-17 ZA ZA200301269A patent/ZA200301269B/xx unknown
- 2003-02-17 NO NO20030748A patent/NO20030748L/no not_active Application Discontinuation
-
2006
- 2006-06-28 US US11/477,177 patent/US20070072835A1/en not_active Abandoned
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