JP2004514663A5 - - Google Patents
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- Publication number
- JP2004514663A5 JP2004514663A5 JP2002544387A JP2002544387A JP2004514663A5 JP 2004514663 A5 JP2004514663 A5 JP 2004514663A5 JP 2002544387 A JP2002544387 A JP 2002544387A JP 2002544387 A JP2002544387 A JP 2002544387A JP 2004514663 A5 JP2004514663 A5 JP 2004514663A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- formula
- alkyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 239000012458 free base Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000000491 Tendinopathy Diseases 0.000 claims 2
- 206010043255 Tendonitis Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012907 medicinal substance Substances 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000004415 tendinitis Diseases 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- GJFNRSDCSTVPCJ-UHFFFAOYSA-N 1,8-bis(dimethylamino)naphthalene Chemical compound C1=CC(N(C)C)=C2C(N(C)C)=CC=CC2=C1 GJFNRSDCSTVPCJ-UHFFFAOYSA-N 0.000 claims 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- -1 methoxy-1-naphthyl Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0028702.9A GB0028702D0 (en) | 2000-11-24 | 2000-11-24 | Organic compounds |
| GB0028702.9 | 2000-11-24 | ||
| PCT/EP2001/013605 WO2002042248A2 (en) | 2000-11-24 | 2001-11-22 | Naphthalene derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007236718A Division JP2008050361A (ja) | 2000-11-24 | 2007-09-12 | ナフタレン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004514663A JP2004514663A (ja) | 2004-05-20 |
| JP2004514663A5 true JP2004514663A5 (https=) | 2005-04-07 |
| JP4836396B2 JP4836396B2 (ja) | 2011-12-14 |
Family
ID=9903825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002544387A Expired - Fee Related JP4836396B2 (ja) | 2000-11-24 | 2001-11-22 | ナフタレン誘導体 |
| JP2007236718A Pending JP2008050361A (ja) | 2000-11-24 | 2007-09-12 | ナフタレン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007236718A Pending JP2008050361A (ja) | 2000-11-24 | 2007-09-12 | ナフタレン誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7045533B2 (https=) |
| EP (2) | EP1339663B1 (https=) |
| JP (2) | JP4836396B2 (https=) |
| KR (1) | KR100810948B1 (https=) |
| CN (1) | CN1224598C (https=) |
| AR (1) | AR035505A1 (https=) |
| AT (1) | ATE540013T1 (https=) |
| AU (1) | AU2002226350A1 (https=) |
| BR (1) | BR0115605A (https=) |
| CA (1) | CA2427844C (https=) |
| CZ (1) | CZ20031424A3 (https=) |
| EC (1) | ECSP034574A (https=) |
| ES (1) | ES2378881T3 (https=) |
| GB (1) | GB0028702D0 (https=) |
| HU (1) | HUP0302125A3 (https=) |
| IL (1) | IL155235A0 (https=) |
| MX (1) | MXPA03004593A (https=) |
| MY (1) | MY129613A (https=) |
| NO (1) | NO330005B1 (https=) |
| NZ (1) | NZ548553A (https=) |
| PE (1) | PE20020532A1 (https=) |
| PT (1) | PT1339663E (https=) |
| RU (1) | RU2354646C2 (https=) |
| SK (1) | SK6222003A3 (https=) |
| TW (1) | TWI314140B (https=) |
| WO (1) | WO2002042248A2 (https=) |
| ZA (1) | ZA200302916B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0028702D0 (en) * | 2000-11-24 | 2001-01-10 | Novartis Ag | Organic compounds |
| US7067539B2 (en) | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| ATE447971T1 (de) | 2002-02-19 | 2009-11-15 | Shionogi & Co | Antipruriginosa |
| WO2003075917A1 (en) | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| JP4202319B2 (ja) * | 2002-07-29 | 2008-12-24 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ベンゾジオキソール |
| WO2004037168A2 (en) * | 2002-10-18 | 2004-05-06 | Amylin Pharmaceuticals, Inc. | Treatment of pancreatitis with amylin |
| DK1569896T3 (da) * | 2002-12-06 | 2007-12-10 | Xention Ltd | Tetrahydronaphthalenderivater |
| AU2003288200A1 (en) * | 2002-12-09 | 2004-06-30 | Bayer Healthcare Ag | Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists |
| TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
| JP2006528241A (ja) | 2003-03-28 | 2006-12-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ベンゾ［１，２，５］チアジアゾール化合物 |
| WO2005023761A2 (en) | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
| SE0303490D0 (sv) * | 2003-12-19 | 2003-12-19 | Astrazeneca Ab | New use V |
| GB0504950D0 (en) * | 2005-03-10 | 2005-04-20 | Novartis Ag | Organic compositions |
| EA200801120A1 (ru) * | 2005-10-18 | 2008-08-29 | Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. | Нафтильные производные в качестве ингибиторов агрегирования бета-амилоида |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| IE20070928A1 (en) * | 2007-12-21 | 2009-09-30 | Giuliani Int Ltd | Multi target ligands |
| WO2009106574A2 (en) * | 2008-02-28 | 2009-09-03 | Novartis Ag | Combinations for treating hiv-associated pain |
| CA2736117C (en) * | 2008-09-04 | 2013-11-19 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| JP5164755B2 (ja) * | 2008-09-09 | 2013-03-21 | キヤノン株式会社 | ビス−アセチルアミノフェニル化合物の結晶の製造方法 |
| BRPI0921038A2 (pt) * | 2008-11-17 | 2019-09-24 | Hoffmann La Roche | ácido naftilacéticos |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| BR112012016111B1 (pt) * | 2010-01-04 | 2017-06-13 | Nippon Soda Co | composto heterocíclico contendo nitrogênio, e, fungicida agrícola |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
| WO2012090177A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Cannabinoid receptor modulators |
| WO2012090179A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Isoquinoline derivatives as cannabinoid receptor modulators |
| AR086411A1 (es) | 2011-05-20 | 2013-12-11 | Nippon Soda Co | Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| WO2013005168A2 (en) | 2011-07-05 | 2013-01-10 | Lupin Limited | Cannabinoid receptor modulators |
| CA2867043A1 (en) | 2012-05-03 | 2013-11-07 | Novartis Ag | L-malate salt of 2,7-diaza-spiro[4.5]dec-7-yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
| GB2532990A (en) | 2014-12-05 | 2016-06-08 | Schlumberger Holdings | Corrosion inhibition |
| GB2543498A (en) | 2015-10-19 | 2017-04-26 | Schlumberger Holdings | Corrosion inhibition |
| AU2016371466B2 (en) | 2015-12-17 | 2020-04-09 | Alonbio Ltd | Small Molecules for Inhibiting Chemokine Activity and/or Cancer Cells Growth |
| EP3390378B1 (en) | 2015-12-17 | 2022-03-30 | AlonBio Ltd. | Small molecules against cancer |
| CN109316479B (zh) * | 2018-10-22 | 2023-09-05 | 河南省锐达医药科技有限公司 | 一种萘酚类化合物的制备及其在癌症治疗方面的应用 |
| RU2684117C1 (ru) * | 2018-10-29 | 2019-04-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Способ получения N-(нафталин-2-ил)бензамидина |
| RU2694263C1 (ru) * | 2019-02-14 | 2019-07-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Анальгезирующее и противовоспалительное средство с противомикробной активностью |
| ES3014809T3 (en) | 2019-05-15 | 2025-04-25 | Alonbio Ltd | Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1874581A (en) * | 1930-01-15 | 1932-08-30 | Gen Aniline Works Inc | Aromatic monoaroyl diamines |
| FR1110460A (fr) * | 1954-09-03 | 1956-02-13 | Cfmc | Nouveaux colorants azoïques, complexes métallifères en dérivant et produits intermédiaires utilisables pour leur préparation |
| DE1016717B (de) * | 1956-04-30 | 1957-10-03 | Kalle & Co Ag | Verfahren zur Herstellung aromatischer Amine mit sekundaerer Aminogruppe |
| CH505152A (de) * | 1968-11-21 | 1971-03-31 | Shell Int Research | Verfahren zur Herstellung von Phosphonsäureestern, Phosphinsäureestern bzw. Phosphinoxiden |
| US3932381A (en) * | 1973-02-12 | 1976-01-13 | Eastman Kodak Company | Magenta image-providing phenylazo-naphthyl dyes |
| US4067903A (en) * | 1975-10-04 | 1978-01-10 | Basf Aktiengesellschaft | Manufacture of arylamines |
| EP0264883A3 (en) * | 1986-10-21 | 1990-04-04 | Banyu Pharmaceutical Co., Ltd. | Substituted pyridine derivatives |
| US5013837A (en) * | 1990-03-08 | 1991-05-07 | Sterling Drug Inc. | 3-Arylcarbonyl-1H-indole-containing compounds |
| RU2051146C1 (ru) * | 1991-06-28 | 1995-12-27 | Институт молекулярной генетики РАН | 5-замещенные нафталин-1-сульфониламиды и способ их получения |
| AU4385293A (en) | 1992-05-21 | 1993-12-13 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| US5430062A (en) | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| US5679866A (en) | 1995-01-20 | 1997-10-21 | American Cyanamid Company | Fungicidal methods, compounds and compositions containing benzophenones |
| US5773663A (en) | 1996-05-01 | 1998-06-30 | American Cyanamid Company | Fungicidal methods, compounds and compositions containing benzophenones |
| CZ294096B6 (cs) | 1995-01-20 | 2004-10-13 | Americanácyanamidácompany | Benzofenonové sloučeninyŹ způsob jejich výrobyŹ fungicidní prostředky s jejich obsahem a způsob ochrany rostlin |
| US6090850A (en) * | 1996-02-05 | 2000-07-18 | Eli Lilly And Company | Naphthyl glyoxamides as SPLA2 inhibitors |
| NZ334148A (en) * | 1996-08-12 | 2001-12-21 | Celgene Corp | 3-Substituted phenyl-ethyl or ethenyl derivatives terminated with a nitrile, alkane, carboxyl or carbamoyl group useful to reduce cytokine levels |
| PA8444901A1 (es) * | 1997-01-28 | 2000-05-24 | Hoffmann La Roche | Derivados de 5-aroilnaftaleno como agentes anti-inflamatorios |
| AU735137B2 (en) | 1997-02-21 | 2001-07-05 | Bayer Intellectual Property Gmbh | Arylsulphonamides and analogues and their use for the treatment and neurovegetative disorders |
| FR2760744B1 (fr) * | 1997-03-12 | 1999-04-23 | Rhodia Chimie Sa | Procede d'acylation d'un compose aromatique |
| US5945567A (en) * | 1997-08-20 | 1999-08-31 | American Cyanamid Company | Fungicidal 2-methoxybenzophenones |
| US5939429A (en) * | 1997-09-30 | 1999-08-17 | Virginia Commonwealth University | Cardiovascular uses of cannabinoid compounds |
| US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| GB0028702D0 (en) * | 2000-11-24 | 2001-01-10 | Novartis Ag | Organic compounds |
-
2000
- 2000-11-24 GB GBGB0028702.9A patent/GB0028702D0/en not_active Ceased
-
2001
- 2001-11-20 TW TW090128718A patent/TWI314140B/zh active
- 2001-11-21 MY MYPI20015337A patent/MY129613A/en unknown
- 2001-11-22 PT PT01995657T patent/PT1339663E/pt unknown
- 2001-11-22 AU AU2002226350A patent/AU2002226350A1/en not_active Abandoned
- 2001-11-22 NZ NZ548553A patent/NZ548553A/en unknown
- 2001-11-22 KR KR1020037005038A patent/KR100810948B1/ko not_active Expired - Fee Related
- 2001-11-22 HU HU0302125A patent/HUP0302125A3/hu unknown
- 2001-11-22 AR ARP010105448A patent/AR035505A1/es not_active Application Discontinuation
- 2001-11-22 IL IL15523501A patent/IL155235A0/xx not_active IP Right Cessation
- 2001-11-22 BR BR0115605-5A patent/BR0115605A/pt active Search and Examination
- 2001-11-22 WO PCT/EP2001/013605 patent/WO2002042248A2/en not_active Ceased
- 2001-11-22 SK SK622-2003A patent/SK6222003A3/sk not_active Application Discontinuation
- 2001-11-22 CA CA2427844A patent/CA2427844C/en not_active Expired - Fee Related
- 2001-11-22 JP JP2002544387A patent/JP4836396B2/ja not_active Expired - Fee Related
- 2001-11-22 CZ CZ20031424A patent/CZ20031424A3/cs unknown
- 2001-11-22 CN CNB018194389A patent/CN1224598C/zh not_active Expired - Fee Related
- 2001-11-22 ES ES01995657T patent/ES2378881T3/es not_active Expired - Lifetime
- 2001-11-22 US US10/432,120 patent/US7045533B2/en not_active Expired - Fee Related
- 2001-11-22 EP EP01995657A patent/EP1339663B1/en not_active Expired - Lifetime
- 2001-11-22 MX MXPA03004593A patent/MXPA03004593A/es active IP Right Grant
- 2001-11-22 AT AT01995657T patent/ATE540013T1/de active
- 2001-11-22 RU RU2003117459/04A patent/RU2354646C2/ru not_active IP Right Cessation
- 2001-11-22 PE PE2001001166A patent/PE20020532A1/es not_active Application Discontinuation
- 2001-11-22 EP EP10175729.2A patent/EP2338886A3/en not_active Withdrawn
-
2003
- 2003-04-11 ZA ZA200302916A patent/ZA200302916B/en unknown
- 2003-04-29 EC EC2003004574A patent/ECSP034574A/es unknown
- 2003-05-22 NO NO20032327A patent/NO330005B1/no not_active IP Right Cessation
-
2007
- 2007-09-12 JP JP2007236718A patent/JP2008050361A/ja active Pending
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