DE60120962D1 - Substituierte chalkone als arzneimitteln - Google Patents
Substituierte chalkone als arzneimittelnInfo
- Publication number
- DE60120962D1 DE60120962D1 DE60120962T DE60120962T DE60120962D1 DE 60120962 D1 DE60120962 D1 DE 60120962D1 DE 60120962 T DE60120962 T DE 60120962T DE 60120962 T DE60120962 T DE 60120962T DE 60120962 D1 DE60120962 D1 DE 60120962D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- substituted
- 4alkyl
- compounds
- chalkones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- WUXJXFIZNJPAMA-UHFFFAOYSA-N 1-(3,5-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one Chemical class C1=CC(OC)=CC=C1C=CC(=O)C1=CC(OC)=CC(OC)=C1 WUXJXFIZNJPAMA-UHFFFAOYSA-N 0.000 abstract 1
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001789 chalcones Chemical class 0.000 abstract 1
- 235000005513 chalcones Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
- C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90209—Oxidoreductases (1.) acting on NADH or NADPH (1.6), e.g. those with a heme protein as acceptor (1.6.2) (general), Cytochrome-b5 reductase (1.6.2.2) or NADPH-cytochrome P450 reductase (1.6.2.4)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0007401.3A GB0007401D0 (en) | 2000-03-27 | 2000-03-27 | Substituted chalcones as therapeeutic compounds |
GB0007401 | 2000-03-27 | ||
PCT/GB2001/001341 WO2001072680A1 (en) | 2000-03-27 | 2001-03-26 | Substituted chalcones as therapeutic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60120962D1 true DE60120962D1 (de) | 2006-08-03 |
DE60120962T2 DE60120962T2 (de) | 2007-02-08 |
Family
ID=9888505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60120962T Expired - Lifetime DE60120962T2 (de) | 2000-03-27 | 2001-03-26 | Substituierte chalkone als arzneimittel |
Country Status (14)
Country | Link |
---|---|
US (1) | US6787672B2 (de) |
EP (1) | EP1284952B1 (de) |
JP (1) | JP5235257B2 (de) |
AT (1) | ATE330928T1 (de) |
AU (1) | AU784609B2 (de) |
CA (1) | CA2403900C (de) |
CY (1) | CY1107519T1 (de) |
DE (1) | DE60120962T2 (de) |
DK (1) | DK1284952T3 (de) |
ES (1) | ES2269360T3 (de) |
GB (1) | GB0007401D0 (de) |
NZ (1) | NZ521595A (de) |
PT (1) | PT1284952E (de) |
WO (1) | WO2001072680A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0123777D0 (en) * | 2001-10-03 | 2001-11-21 | Cancer Res Ventures Ltd | Substituted chalcones as therapeutic agents |
GB0123780D0 (en) | 2001-10-03 | 2001-11-21 | Cancer Res Ventures Ltd | Substituted chalcones as therapeutic agents |
IL162533A0 (en) * | 2001-12-19 | 2005-11-20 | Atherogenics Inc | Chalcone derivatives and their use to treat diseases |
CN103356636A (zh) * | 2004-05-23 | 2013-10-23 | 杰勒德·M·豪斯 | Theramutein调节剂 |
KR100597871B1 (ko) * | 2004-06-08 | 2006-07-06 | 학교법인 영남학원 | 방향환을 함유하는 신규 프로페논 유도체 및 이를 함유하는 항염증제 |
DE102006018988B3 (de) * | 2006-04-25 | 2007-08-09 | Nateco2 Gmbh & Co. Kg | Verfahren zur Herstellung eines Xanthohumol-haltigen Pulvers hoher Reinheit und dessen Verwendung |
US7714025B2 (en) * | 2006-05-10 | 2010-05-11 | Arizona Biomedical Research Commission | Modified chalcone compounds as antimitotic agents |
JP5302328B2 (ja) | 2007-11-21 | 2013-10-02 | オキシジーン, インコーポレイテッド | 造血性新生物を治療するための方法 |
GB0907551D0 (en) | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
WO2011009826A2 (en) | 2009-07-21 | 2011-01-27 | ADAMED Sp.z o.o. | Novel chalcone derivatives with cytotoxic activity |
CN102397269B (zh) * | 2011-09-20 | 2015-01-07 | 温州医学院 | 查尔酮类化合物在制备抗炎药物中的应用 |
KR101333735B1 (ko) * | 2011-11-01 | 2013-11-27 | 건국대학교 산학협력단 | 디페닐프로페논 화합물를 유효성분으로 포함하는 신경계 염증질환 예방 및 치료용 약학조성물 |
CN103102283B (zh) * | 2011-11-09 | 2014-05-28 | 南京大学 | 一种查耳酮肟类化合物作为新型免疫抑制剂的制备方法与用途 |
CN103664689A (zh) * | 2013-11-04 | 2014-03-26 | 南京大学 | 对癌细胞微管蛋白聚合有抑制作用的一类查尔酮肟衍生物及其制备方法 |
KR101558500B1 (ko) * | 2014-02-26 | 2015-10-12 | 건국대학교 산학협력단 | 신규한 메톡시칼콘 유도체 및 그 항암제로의 용도 |
EP3337495A4 (de) | 2015-08-18 | 2019-04-10 | Mateon Therapeutics, Inc. | Verwendung von vdas zur verbesserung von immunmodulierenden therapien gegen tumoren |
BR112020015745A2 (pt) | 2018-02-02 | 2020-12-08 | Maverix Oncology, Inc. | Conjugados de fármacos de moléculas pequenas de monofosfato de gemcitabina |
CN115850048B (zh) * | 2022-12-01 | 2024-05-10 | 东南大学 | 一种合成2芳基丁烯酮类化合物的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4279930A (en) * | 1978-10-10 | 1981-07-21 | The Upjohn Company | Process for treating inflammation |
JPS60237039A (ja) * | 1984-05-08 | 1985-11-25 | Nippon Oil & Fats Co Ltd | ベンザルアセトフエノン及びその誘導体の製造方法 |
JPS6176433A (ja) | 1984-09-21 | 1986-04-18 | Toyobo Co Ltd | 新規なカルコン誘導体 |
LU86715A1 (fr) | 1986-12-16 | 1988-07-14 | Oreal | Composition cosmetique contenant des derives hydroxyles de chalcone et son utilisation pour la protection de la peau et des cheveux contre les radiations lumineuses,nouveaux derives hydroxyles de chalcone utilises et leur procede de preparation |
JPH02142717A (ja) | 1988-11-22 | 1990-05-31 | Kanebo Ltd | 養毛化粧料 |
JPH05246932A (ja) | 1992-03-04 | 1993-09-24 | Nippon High Potsukusu:Kk | 3,4−ジヒドロキシカルコン誘導体 |
US5430062A (en) | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
AU693110B2 (en) | 1993-08-19 | 1998-06-25 | Warner-Lambert Company | Substituted 2(5H)furanone, 2(5H)thiophenone and 2(5H)pyrrolone derivatives, their preparation and their use as endothelin antagonists |
JPH08188546A (ja) | 1995-01-04 | 1996-07-23 | Kyowa Hakko Kogyo Co Ltd | カルコン誘導体 |
GB9519490D0 (en) | 1995-09-25 | 1995-11-29 | Melvin William T | Use of a cytochrome P450 enzyme in tumour cells as a marker and target |
EP0996432A2 (de) | 1997-06-26 | 2000-05-03 | Statens Seruminstitut | Biologisch-wirksame 1,3-bis-aromatische-prop-2-en-1-on, 1,3-bis-aromatische-propan-1-on, and 1,3-bis-aromatische-prop-2-yn-1-on |
GB9802522D0 (en) | 1998-02-06 | 1998-04-01 | Montford University De | Hydroxylation activated prodrugs |
JP4642226B2 (ja) | 1998-02-06 | 2011-03-02 | デ モントフォート ユニヴァーシティ | ヒドロキシル化により活性化されたプロドラッグ |
CA2395191A1 (en) | 1999-12-23 | 2001-06-28 | Tedman Ehlers | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
-
2000
- 2000-03-27 GB GBGB0007401.3A patent/GB0007401D0/en not_active Ceased
-
2001
- 2001-03-26 CA CA2403900A patent/CA2403900C/en not_active Expired - Fee Related
- 2001-03-26 US US10/239,757 patent/US6787672B2/en not_active Expired - Fee Related
- 2001-03-26 AT AT01914064T patent/ATE330928T1/de active
- 2001-03-26 WO PCT/GB2001/001341 patent/WO2001072680A1/en active IP Right Grant
- 2001-03-26 AU AU39450/01A patent/AU784609B2/en not_active Ceased
- 2001-03-26 JP JP2001570595A patent/JP5235257B2/ja not_active Expired - Fee Related
- 2001-03-26 ES ES01914064T patent/ES2269360T3/es not_active Expired - Lifetime
- 2001-03-26 PT PT01914064T patent/PT1284952E/pt unknown
- 2001-03-26 DK DK01914064T patent/DK1284952T3/da active
- 2001-03-26 DE DE60120962T patent/DE60120962T2/de not_active Expired - Lifetime
- 2001-03-26 EP EP01914064A patent/EP1284952B1/de not_active Expired - Lifetime
- 2001-03-26 NZ NZ521595A patent/NZ521595A/en not_active IP Right Cessation
-
2006
- 2006-09-20 CY CY20061101338T patent/CY1107519T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1284952B1 (de) | 2006-06-21 |
US6787672B2 (en) | 2004-09-07 |
DK1284952T3 (da) | 2006-10-30 |
ATE330928T1 (de) | 2006-07-15 |
CA2403900C (en) | 2011-02-08 |
AU784609B2 (en) | 2006-05-11 |
EP1284952A1 (de) | 2003-02-26 |
JP5235257B2 (ja) | 2013-07-10 |
GB0007401D0 (en) | 2000-05-17 |
AU3945001A (en) | 2001-10-08 |
US20030100538A1 (en) | 2003-05-29 |
CA2403900A1 (en) | 2001-10-04 |
PT1284952E (pt) | 2006-11-30 |
CY1107519T1 (el) | 2013-03-13 |
WO2001072680A1 (en) | 2001-10-04 |
NZ521595A (en) | 2005-04-29 |
ES2269360T3 (es) | 2007-04-01 |
DE60120962T2 (de) | 2007-02-08 |
JP2003528842A (ja) | 2003-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SPEAR THERAPEUTICS LTD., LEICESTER, LEICESTERS, GB |