JP2003511205A5 - - Google Patents

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JP2003511205A5
JP2003511205A5 JP2001531071A JP2001531071A JP2003511205A5 JP 2003511205 A5 JP2003511205 A5 JP 2003511205A5 JP 2001531071 A JP2001531071 A JP 2001531071A JP 2001531071 A JP2001531071 A JP 2001531071A JP 2003511205 A5 JP2003511205 A5 JP 2003511205A5
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JP
Japan
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JP2001531071A
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JP2003511205A (ja
JP4685311B2 (ja
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Priority claimed from US09/664,790 external-priority patent/US6416777B1/en
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Publication of JP4685311B2 publication Critical patent/JP4685311B2/ja
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JP2001531071A 1999-10-21 2000-10-12 眼薬送出装置 Expired - Fee Related JP4685311B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16067399P 1999-10-21 1999-10-21
US60/160,673 1999-10-21
US09/664,790 US6416777B1 (en) 1999-10-21 2000-09-19 Ophthalmic drug delivery device
US09/664,790 2000-09-19
PCT/US2000/028187 WO2001028474A1 (en) 1999-10-21 2000-10-12 Ophthalmic drug delivery device

Publications (3)

Publication Number Publication Date
JP2003511205A JP2003511205A (ja) 2003-03-25
JP2003511205A5 true JP2003511205A5 (ja) 2007-11-29
JP4685311B2 JP4685311B2 (ja) 2011-05-18

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JP2001531071A Expired - Fee Related JP4685311B2 (ja) 1999-10-21 2000-10-12 眼薬送出装置

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US (4) US6416777B1 (ja)
EP (1) EP1221919B1 (ja)
JP (1) JP4685311B2 (ja)
KR (1) KR100752821B1 (ja)
CN (1) CN100341470C (ja)
AR (2) AR026183A1 (ja)
AT (1) ATE289500T1 (ja)
AU (2) AU764226B2 (ja)
BR (1) BR0014928B1 (ja)
CA (1) CA2384255C (ja)
DE (1) DE60018298T2 (ja)
DK (1) DK1221919T3 (ja)
ES (1) ES2237463T3 (ja)
HK (1) HK1048428B (ja)
PL (1) PL196539B1 (ja)
PT (1) PT1221919E (ja)
TR (1) TR200201046T2 (ja)
TW (1) TW539560B (ja)
WO (1) WO2001028474A1 (ja)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1040837A3 (en) * 1999-02-26 2002-01-02 Erasmus Universiteit Rotterdam Medicaments for the treatment of a choroidal neovascularization (CNV) related disorder
DE60037406T2 (de) 1999-04-26 2008-05-21 GMP Vision Solutions, Inc., Ft. Lauderdale Aufblasbare vorrichtung zur behandlung von glaukoma
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US7943162B2 (en) * 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
AR030346A1 (es) 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
WO2002078681A2 (en) * 2001-04-02 2002-10-10 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7488303B1 (en) * 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
CA2683224C (en) 2001-04-07 2014-12-02 Glaukos Corporation System and methods thereof for treatment of ocular disorders
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
JP4677538B2 (ja) 2001-06-12 2011-04-27 ジョンズ ホプキンズ ユニヴァーシティ スクール オヴ メディシン 眼内薬物送達のためのリザーバデバイス
CA2446741C (en) * 2001-07-23 2009-09-29 Alcon, Inc. Ophthalmic drug delivery device
CA2447802C (en) 2001-07-23 2009-09-29 Alcon, Inc. Ophthalmic drug delivery device
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
ES2393101T3 (es) * 2001-08-29 2012-12-18 Ricardo A. P. De Carvalho Sistema implantable y sellable para la administración unidireccional de agentes terapéuticos a tejidos diana
US7749528B2 (en) * 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
AU2003218127B2 (en) * 2002-03-11 2007-07-12 Alcon, Inc. Implantable drug delivery system
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
PL373787A1 (en) * 2002-05-03 2005-09-19 Alcon Inc. Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac
AU2003281817A1 (en) * 2002-08-05 2004-02-23 Alcon, Inc. Use of anecortave acetate for the protection of visual acuity in patients with age related macular degeneration
DE10238310A1 (de) * 2002-08-21 2004-03-04 Erich Jaeger Gmbh Elektrodenanordnung
CA2498489C (en) * 2002-09-29 2010-02-23 Surmodics, Inc. Method for subretinal administration of therapeutics including steroids;method for localizing pharmacodynamic action at the choroid and the retina; and related methods for treatment and/or prevention of retinal diseases
US20030187072A1 (en) * 2003-02-14 2003-10-02 Kapin Michael A. Method of treating angiogenesis-related disorders
PL378209A1 (pl) * 2003-02-20 2006-03-20 Alcon, Inc. Formulacje glikokortykoidów do leczenia patologicznej angiogenezy w gałce ocznej
US20060154910A1 (en) * 2003-02-20 2006-07-13 Bingaman David P Use of steroids to treat ocular disorders
US20040236343A1 (en) * 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
KR20060019579A (ko) * 2003-06-13 2006-03-03 알콘, 인코퍼레이티드 병적 눈 혈관형성을 치료하기 위한 비-스테로이드성항-염증제 제제
WO2004112796A1 (en) * 2003-06-20 2004-12-29 Alcon, Inc. Treatment of amd with combination of ingredients
ZA200508654B (en) * 2003-07-10 2007-01-31 Alcon Inc Ophthalmic drug delivery device
US20050009910A1 (en) * 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
US8167855B2 (en) * 2003-08-26 2012-05-01 Vista Scientific Llc Ocular drug delivery device
KR20060085246A (ko) 2003-09-18 2006-07-26 마커사이트, 인코포레이티드 경공막 전달
US20050158365A1 (en) * 2003-12-22 2005-07-21 David Watson Drug delivery device with mechanical locking mechanism
US7276050B2 (en) * 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US9549895B2 (en) * 2004-04-23 2017-01-24 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US7722669B2 (en) * 2004-08-13 2010-05-25 Richard Foulkes Method and insert for modifying eye color
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
CN100428958C (zh) * 2004-09-06 2008-10-29 段亚东 一种治疗眼病的植入剂
AU2006213588B2 (en) * 2005-02-09 2011-11-17 Santen Pharmaceutical Co., Ltd. Liquid formulations for treatment of diseases or conditions
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
BRPI0609432A2 (pt) * 2005-03-21 2010-04-06 Macusight Inc sistemas de distribuição de fármacos para tratamento de doenças ou condições
WO2006110487A1 (en) 2005-04-08 2006-10-19 Surmodics, Inc. Sustained release implants for subretinal delivery
US20060258994A1 (en) * 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
JP2009502954A (ja) 2005-07-27 2009-01-29 ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド タンパク質のミスフォールディングを修正する小分子及びその使用
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
US20070134244A1 (en) * 2005-10-14 2007-06-14 Alcon, Inc. Combination treatment for pathologic ocular angiogenesis
WO2007064752A2 (en) 2005-11-29 2007-06-07 Smithkline Beecham Corporation Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema
US8492400B2 (en) * 2006-02-09 2013-07-23 Santen Pharmaceutical Co., Ltd. Stable formulations, and methods of their preparation and use
US7887508B2 (en) * 2006-03-14 2011-02-15 The University Of Southern California MEMS device and method for delivery of therapeutic agents
CN103127100A (zh) 2006-03-23 2013-06-05 参天制药株式会社 用于与血管通透性有关的疾病或病症的制剂和方法
US20070293807A1 (en) * 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
CN101484088A (zh) * 2006-05-04 2009-07-15 赫伯特·考夫曼 眼治疗剂的给药方法、装置和系统
WO2008061043A2 (en) 2006-11-10 2008-05-22 Glaukos Corporation Uveoscleral shunt and methods for implanting same
WO2008063639A2 (en) * 2006-11-21 2008-05-29 Massachusetts Eye And Ear Infirmary Compositions and methods for preserving cells of the eye
WO2008076544A2 (en) * 2006-12-18 2008-06-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
DE102007024642A1 (de) 2007-05-24 2008-11-27 Eyesense Ag Hydrogel-Implantat für Sensorik von Metaboliten am Auge
MX2010006840A (es) 2007-12-20 2010-08-12 Univ Southern California Aparato y métodos para suministrar agentes terapeuticos.
EP2240220B1 (en) * 2008-01-03 2016-04-13 University Of Southern California Implantable drug-delivery devices, and apparatus for refilling the devices
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
CN103349803B (zh) * 2008-05-08 2016-12-28 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
US8231608B2 (en) * 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
MX2010012213A (es) * 2008-05-08 2011-05-03 Minipumps Llc Bombas implantables y cánulas para las mismas.
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
EP2276439A4 (en) 2008-05-12 2013-11-27 Univ Utah Res Found INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS
WO2010056677A1 (en) 2008-11-12 2010-05-20 Duke University Methods of inhibiting cancer cell growth with hdac inhibitors and methods of screening for hdac10 inhibitors
AU2010208046B2 (en) 2009-01-29 2014-10-02 Forsight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8372036B2 (en) 2009-05-06 2013-02-12 Alcon Research, Ltd. Multi-layer heat assembly for a drug delivery device
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
IN2012DN00352A (ja) 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
AU2010284216B2 (en) 2009-08-18 2015-10-15 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
WO2011039648A1 (en) 2009-09-30 2011-04-07 Glaxo Wellcome Manufacturing Pte Ltd. Methods of administration and treatment
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US20130137642A1 (en) 2010-04-23 2013-05-30 Demetrios Vavvas Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells
EP2571526B1 (en) 2010-05-17 2019-03-13 Novaer Holdings, Inc. Drug delivery devices for delivery of ocular therapeutic agents
CN103153316B (zh) 2010-08-05 2015-08-19 弗赛特影像4股份有限公司 组合药物递送方法和设备
EP2600812B1 (en) 2010-08-05 2021-09-22 ForSight Vision4, Inc. Apparatus to treat an eye
PT2600930T (pt) 2010-08-05 2021-03-22 Forsight Vision4 Inc Aparelho injetor e método para distribuição de fármacos
US8689439B2 (en) 2010-08-06 2014-04-08 Abbott Laboratories Method for forming a tube for use with a pump delivery system
US8377000B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Enteral feeding apparatus having a feeding set
US8377001B2 (en) 2010-10-01 2013-02-19 Abbott Laboratories Feeding set for a peristaltic pump system
US20120109054A1 (en) * 2010-10-29 2012-05-03 Vista Scientific Llc Devices with an erodible surface for delivering at least one active agent to tissue over a prolonged period of time
US20140024598A1 (en) 2010-11-01 2014-01-23 Demetrios Vavvas Methods and compositions for preserving retinal ganglion cells
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP2720539B1 (en) 2011-06-14 2018-10-24 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
WO2013003467A2 (en) 2011-06-27 2013-01-03 Massachusetts Eye And Ear Infirmary Methods for treating ocular inflammatory disorders
EP2726016B1 (en) 2011-06-28 2023-07-19 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
WO2013025840A1 (en) 2011-08-15 2013-02-21 Massachusetts Eye And Ear Infirmary Methods for preserving photoreceptor cell viability following retinal detachment
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
US11363951B2 (en) 2011-09-13 2022-06-21 Glaukos Corporation Intraocular physiological sensor
KR102192603B1 (ko) 2011-09-14 2020-12-17 포사이트 비젼5, 인크. 안내 삽입물 장치 및 방법
LT2755600T (lt) 2011-09-16 2021-04-26 Forsight Vision4, Inc. Skysčio pakeitimo aparatas
WO2013058809A1 (en) 2011-10-19 2013-04-25 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
JP6254090B2 (ja) 2011-10-21 2017-12-27 マサチューセッツ・アイ・アンド・イア・インファーマリー 軸索再生および神経機能を促進するための方法および組成物
US9353063B2 (en) 2011-11-30 2016-05-31 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
CA2862746A1 (en) 2011-12-01 2013-06-06 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
ES2752028T3 (es) 2012-10-26 2020-04-02 Forsight Vision5 Inc Sistema oftálmico para la liberación sostenida del fármaco en el ojo
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
WO2014152959A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
EP2991621B1 (en) * 2013-05-02 2020-12-09 Retina Foundation of the Southwest Two-layer ocular implant
CN106459995B (zh) 2013-11-07 2020-02-21 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
EP3089748A4 (en) 2014-01-02 2017-09-27 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
US11028388B2 (en) 2014-03-05 2021-06-08 Editas Medicine, Inc. CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
US11339437B2 (en) 2014-03-10 2022-05-24 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
DK3116997T3 (da) 2014-03-10 2019-08-19 Editas Medicine Inc Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10)
US11141493B2 (en) 2014-03-10 2021-10-12 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP3679908A1 (en) 2014-07-15 2020-07-15 ForSight Vision4, Inc. Ocular implant delivery device
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
BR112017009660A2 (pt) 2014-11-10 2017-12-19 Forsight Vision4 Inc dispositivos de administração de fármacos expansíveis e métodos de utilização
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
US10010502B2 (en) 2015-05-19 2018-07-03 Amorphex Therapeutics Llc Device that delivers a sustained low-dose of a myopia-suppressing drug, while preserving pupillary function and accommodation
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017075475A1 (en) 2015-10-30 2017-05-04 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus
EP3377009B1 (en) 2015-11-20 2020-10-28 ForSight Vision4, Inc. Porous structures for extended release drug delivery devices
CN105997338B (zh) * 2016-03-09 2019-04-26 泰山医学院 经玻璃体纳米材料给药系统
JP7009384B2 (ja) 2016-04-05 2022-01-25 フォーサイト・ビジョン フォー・インコーポレーテッド 移植可能な眼薬送達デバイス
CN109937025B (zh) 2016-04-20 2022-07-29 多斯医学公司 生物可吸收眼部药物的递送装置
CA3032822A1 (en) 2016-08-02 2018-02-08 Editas Medicine, Inc. Compositions and methods for treating cep290 associated disease
AU2017312499B2 (en) 2016-08-19 2023-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration
WO2018081504A1 (en) 2016-10-28 2018-05-03 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus
CN110582286B (zh) 2017-05-05 2024-01-30 联邦高等教育系统匹兹堡大学 基质结合囊泡(mbv)的眼部应用
PE20200743A1 (es) 2017-06-30 2020-07-24 Univ California Composiciones y metodos para modular el crecimiento del cabello
JP7314155B2 (ja) 2017-11-21 2023-07-25 フォーサイト・ビジョン4・インコーポレーテッド 膨張可能ポート送達システムのための流体交換装置及びその使用方法
EP3758736B1 (en) 2018-03-02 2024-05-01 The United States of America, as represented by The Secretary, Department of Health and Human Services Il-34 for use in a method of treating retinal inflammation and neurodegeneration
DE112019001996T5 (de) * 2018-04-18 2020-12-31 Nikon Corporation Bildverarbeitungsverfahren, Programm und Bildverarbeitungsvorrichtung
US20220079899A1 (en) * 2019-01-14 2022-03-17 The Regents Of The University Of California Compositions and methods for treating ocular conditions
AU2020227740A1 (en) 2019-02-25 2021-10-07 Editas Medicine, Inc. CRISPR/RNA-guided nuclease-related methods and compositions for treating RHO-associated autosomal-dominant retinitis pigmentosa (adRP)
JP2023510186A (ja) 2020-01-17 2023-03-13 ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ Crx常染色体優性網膜症の処置のための遺伝子治療
JP2023532134A (ja) 2020-07-02 2023-07-26 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 網膜変性の処置において使用するための環式化合物
WO2022221741A1 (en) 2021-04-16 2022-10-20 Editas Medicine, Inc. Crispr/rna-guided nuclease-related methods and compositions for treating rho-associated autosomal-dominant retinitis pigmentosa (adrp)

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3756478A (en) * 1971-02-03 1973-09-04 D Podell Eye drop dispenser with liquid metering device
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
DE3905050A1 (de) 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (ii)
US4946450A (en) 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
EP0486589B1 (en) * 1989-08-14 1998-03-04 PHOTOGENESIS Incorporated Surgical instrument and cell isolation
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
DE4022553A1 (de) 1990-07-16 1992-01-23 Hund Helmut Gmbh Vorrichtung zur hochreproduzierbaren applikation definierter volumina von loesungen und suspensionen diagnostisch oder therapeutisch wirksamer substanzen auf der cornea-oberflaeche
US5290892A (en) 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5679666A (en) * 1991-11-22 1997-10-21 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids
US5770592A (en) 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
WO1993020785A1 (en) * 1992-04-20 1993-10-28 Basilice Vincent P Improvements in dispensing eye drops
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
FR2690846B1 (fr) 1992-05-05 1995-07-07 Aiache Jean Marc Forme galenique pour administration oculaire et procede de preparation.
US5387202A (en) * 1992-07-20 1995-02-07 Aaron Medical Industries Eye drop dispensing device
AU5092493A (en) 1992-09-08 1994-03-29 Allergan, Inc. Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle
US5707643A (en) * 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
JPH09501065A (ja) * 1993-03-16 1997-02-04 フォトジェネシス インコーポレイテッド 渦巻き状移植片の調製および移植法並びにそのための外科用機器
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
EP0754046A1 (en) 1994-04-04 1997-01-22 FREEMAN, William R. Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5710165A (en) * 1994-07-06 1998-01-20 Synthelabo Use of polyamine antagonists for the treatment of glaucoma
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
PT788351E (pt) 1994-11-10 2003-06-30 Univ Kentucky Res Foundation T Dispositivo implantavel recarregavel de libertacaocontrolada para administrar medicamentos direc tamente numa porcao interna do corpo
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
EP0957949B1 (en) 1995-05-14 2004-08-04 Optonol Ltd. Intraocular implant, delivery device, and method of implantation
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
AUPN605795A0 (en) 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
US5824073A (en) 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
US5743274A (en) * 1996-03-18 1998-04-28 Peyman; Gholam A. Macular bandage for use in the treatment of subretinal neovascular members
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
JP3309175B2 (ja) 1996-03-25 2002-07-29 参天製薬株式会社 タンパク性薬物含有強膜プラグ
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6120460A (en) * 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US5941250A (en) * 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
NZ500018A (en) 1997-03-31 2001-07-27 Alza Corp Diffusional implantable delivery system with capillary tube of cross-sectional area and length to deliver beneficial agent
JPH1170138A (ja) * 1997-07-02 1999-03-16 Santen Pharmaceut Co Ltd ポリ乳酸強膜プラグ
EP1003569B1 (en) 1997-08-11 2004-10-20 Allergan, Inc. Sterile bioerodible implant device containing retinoid with improved biocompatability and method of manufacture
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
AU756515B2 (en) 1998-03-13 2003-01-16 Johns Hopkins University School Of Medicine, The The use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy or ocular inflammation
US6146366A (en) 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
US6399655B1 (en) 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6416777B1 (en) * 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
BR0014929B1 (pt) * 1999-10-21 2009-01-13 dispositivo para distribuiÇço de medicamento oftÁlmico.
RU2149615C1 (ru) 1999-11-10 2000-05-27 Нестеров Аркадий Павлович Способ введения лекарственных препаратов при заболеваниях заднего отрезка глаза
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
JP4471568B2 (ja) * 2000-08-30 2010-06-02 ジョンズ・ホプキンス・ユニバーシティ 眼内薬剤送達装置

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