JP2003507412A - 多孔性粒子を形成するための単純アミノ酸の使用 - Google Patents
多孔性粒子を形成するための単純アミノ酸の使用Info
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- JP2003507412A JP2003507412A JP2001518031A JP2001518031A JP2003507412A JP 2003507412 A JP2003507412 A JP 2003507412A JP 2001518031 A JP2001518031 A JP 2001518031A JP 2001518031 A JP2001518031 A JP 2001518031A JP 2003507412 A JP2003507412 A JP 2003507412A
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- NJGWOFRZMQRKHT-WGVNQGGSSA-N surfactin C Chemical compound CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-WGVNQGGSSA-N 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008791 toxic response Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940072690 valium Drugs 0.000 description 1
- 239000002550 vasoactive agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/382,959 US6586008B1 (en) | 1999-08-25 | 1999-08-25 | Use of simple amino acids to form porous particles during spray drying |
| US09/382,959 | 1999-08-25 | ||
| PCT/US2000/023149 WO2001013893A2 (en) | 1999-08-25 | 2000-08-23 | Use of simple amino acids to form porous particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507412A true JP2003507412A (ja) | 2003-02-25 |
| JP2003507412A5 JP2003507412A5 (https=) | 2007-06-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518031A Pending JP2003507412A (ja) | 1999-08-25 | 2000-08-23 | 多孔性粒子を形成するための単純アミノ酸の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US6586008B1 (https=) |
| EP (2) | EP1637128A3 (https=) |
| JP (1) | JP2003507412A (https=) |
| AT (1) | ATE319429T1 (https=) |
| AU (1) | AU764738B2 (https=) |
| CA (1) | CA2382651C (https=) |
| DE (1) | DE60026544T2 (https=) |
| DK (1) | DK1210068T3 (https=) |
| ES (1) | ES2258981T3 (https=) |
| PT (1) | PT1210068E (https=) |
| WO (1) | WO2001013893A2 (https=) |
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| JP2006522634A (ja) * | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| JP2007500234A (ja) * | 2003-05-28 | 2007-01-11 | ネクター セラピューティクス | 水に不溶な活性剤を含む医薬的成形 |
| JP2013231079A (ja) * | 2005-11-28 | 2013-11-14 | Verrow Pharmaceuticals Inc | 腎毒性の低減に有用な組成物及びその使用方法 |
| KR20170044670A (ko) * | 2014-08-29 | 2017-04-25 | 알지파마 에이에스 | 알기네이트 올리고머의 흡입성 분말 제형 |
| JP2018528966A (ja) * | 2015-09-16 | 2018-10-04 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2019507125A (ja) * | 2016-01-20 | 2019-03-14 | フラリー パウダーズ エルエルシーＦｌｕｒｒｙ Ｐｏｗｄｅｒｓ，Ｌｌｃ | 吸入に好適な分散性の噴霧乾燥粉末中の親油性成分の封入 |
| JP2019518782A (ja) * | 2016-06-24 | 2019-07-04 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
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| JP2021508734A (ja) * | 2017-12-21 | 2021-03-11 | キウィタス セラピューティクス，インコーポレイテッド | 吸入のための界面活性剤製剤 |
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Cited By (24)
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| JP2004523536A (ja) * | 2001-02-06 | 2004-08-05 | イノバータ・バイオミッド・リミテッド | 薬剤 |
| JP2006514679A (ja) * | 2003-03-19 | 2006-05-11 | アドバンスト インハレーション リサーチ，インコーポレイテッド | トロスピウム含有組成物 |
| JP2006522634A (ja) * | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| JP2007500234A (ja) * | 2003-05-28 | 2007-01-11 | ネクター セラピューティクス | 水に不溶な活性剤を含む医薬的成形 |
| JP2013231079A (ja) * | 2005-11-28 | 2013-11-14 | Verrow Pharmaceuticals Inc | 腎毒性の低減に有用な組成物及びその使用方法 |
| KR20170044670A (ko) * | 2014-08-29 | 2017-04-25 | 알지파마 에이에스 | 알기네이트 올리고머의 흡입성 분말 제형 |
| JP2017530952A (ja) * | 2014-08-29 | 2017-10-19 | アルギファルマ エーエス | アルギネートオリゴマーの吸入可能粉末製剤 |
| KR102582982B1 (ko) * | 2014-08-29 | 2023-09-25 | 알지파마 에이에스 | 알기네이트 올리고머의 흡입성 분말 제형 |
| US11992553B2 (en) | 2014-08-29 | 2024-05-28 | Algipharma As | Inhalable powder formulations of alginate oligomers |
| JP2018528966A (ja) * | 2015-09-16 | 2018-10-04 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2019507125A (ja) * | 2016-01-20 | 2019-03-14 | フラリー パウダーズ エルエルシーＦｌｕｒｒｙ Ｐｏｗｄｅｒｓ，Ｌｌｃ | 吸入に好適な分散性の噴霧乾燥粉末中の親油性成分の封入 |
| US11833118B2 (en) | 2016-01-20 | 2023-12-05 | Flurry Powders, Llc | Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation |
| JP2023071886A (ja) * | 2016-06-24 | 2023-05-23 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
| JP7240178B2 (ja) | 2016-06-24 | 2023-03-15 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
| JP7629159B2 (ja) | 2016-06-24 | 2025-02-13 | メルツ ファーマスーティカルズ， エルエルシー | 吸入用サーファクタント製剤 |
| JP2019518782A (ja) * | 2016-06-24 | 2019-07-04 | シヴィタス セラピューティクス、インコーポレイテッド | 吸入用サーファクタント製剤 |
| JP2022116082A (ja) * | 2016-06-30 | 2022-08-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン粒子 |
| JP2019519542A (ja) * | 2016-06-30 | 2019-07-11 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン粒子 |
| JP7583764B2 (ja) | 2016-06-30 | 2024-11-14 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン粒子 |
| JP7471774B2 (ja) | 2016-06-30 | 2024-04-22 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン粒子 |
| JP2020510002A (ja) * | 2017-03-07 | 2020-04-02 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸入可能なニコチン製剤、およびその作製および使用方法 |
| JP2021508734A (ja) * | 2017-12-21 | 2021-03-11 | キウィタス セラピューティクス，インコーポレイテッド | 吸入のための界面活性剤製剤 |
| JP2023144081A (ja) * | 2017-12-21 | 2023-10-06 | キウィタス セラピューティクス，インコーポレイテッド | 吸入のための界面活性剤製剤 |
| JP7335263B2 (ja) | 2017-12-21 | 2023-08-29 | キウィタス セラピューティクス，インコーポレイテッド | 吸入のための界面活性剤製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1210068A2 (en) | 2002-06-05 |
| US9333174B2 (en) | 2016-05-10 |
| DE60026544D1 (de) | 2006-05-04 |
| EP1210068B1 (en) | 2006-03-08 |
| US20070104658A1 (en) | 2007-05-10 |
| US20080160092A1 (en) | 2008-07-03 |
| WO2001013893A2 (en) | 2001-03-01 |
| US20130071440A1 (en) | 2013-03-21 |
| US8268358B2 (en) | 2012-09-18 |
| PT1210068E (pt) | 2006-07-31 |
| WO2001013893A3 (en) | 2001-05-03 |
| US20120020887A1 (en) | 2012-01-26 |
| US20170354602A1 (en) | 2017-12-14 |
| US6586008B1 (en) | 2003-07-01 |
| DE60026544T2 (de) | 2007-01-11 |
| AU6929600A (en) | 2001-03-19 |
| CA2382651C (en) | 2009-11-24 |
| US20160287517A1 (en) | 2016-10-06 |
| EP1637128A3 (en) | 2008-03-05 |
| EP1637128A2 (en) | 2006-03-22 |
| ATE319429T1 (de) | 2006-03-15 |
| DK1210068T3 (da) | 2006-07-17 |
| AU764738B2 (en) | 2003-08-28 |
| CA2382651A1 (en) | 2001-03-01 |
| US20080160098A1 (en) | 2008-07-03 |
| ES2258981T3 (es) | 2006-09-16 |
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