JP2003507412A5 - - Google Patents
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- Publication number
- JP2003507412A5 JP2003507412A5 JP2001518031A JP2001518031A JP2003507412A5 JP 2003507412 A5 JP2003507412 A5 JP 2003507412A5 JP 2001518031 A JP2001518031 A JP 2001518031A JP 2001518031 A JP2001518031 A JP 2001518031A JP 2003507412 A5 JP2003507412 A5 JP 2003507412A5
- Authority
- JP
- Japan
- Prior art keywords
- particle
- microns
- particles
- amino acid
- phospholipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 description 37
- 229940024606 amino acid Drugs 0.000 description 17
- 235000001014 amino acid Nutrition 0.000 description 17
- 150000001413 amino acids Chemical class 0.000 description 17
- 150000003904 phospholipids Chemical class 0.000 description 13
- 238000000034 method Methods 0.000 description 12
- 230000002209 hydrophobic effect Effects 0.000 description 10
- 229940039227 diagnostic agent Drugs 0.000 description 8
- 239000000032 diagnostic agent Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 230000000069 prophylactic effect Effects 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 4
- 235000004279 alanine Nutrition 0.000 description 4
- 229960000310 isoleucine Drugs 0.000 description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 4
- 150000008105 phosphatidylcholines Chemical class 0.000 description 4
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 4
- 229940067605 phosphatidylethanolamines Drugs 0.000 description 4
- 229940067626 phosphatidylinositols Drugs 0.000 description 4
- 150000003905 phosphatidylinositols Chemical class 0.000 description 4
- 150000008106 phosphatidylserines Chemical class 0.000 description 4
- 239000004474 valine Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- -1 phosphatidyl glycerols Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/382,959 US6586008B1 (en) | 1999-08-25 | 1999-08-25 | Use of simple amino acids to form porous particles during spray drying |
| US09/382,959 | 1999-08-25 | ||
| PCT/US2000/023149 WO2001013893A2 (en) | 1999-08-25 | 2000-08-23 | Use of simple amino acids to form porous particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507412A JP2003507412A (ja) | 2003-02-25 |
| JP2003507412A5 true JP2003507412A5 (https=) | 2007-06-28 |
Family
ID=23511119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518031A Pending JP2003507412A (ja) | 1999-08-25 | 2000-08-23 | 多孔性粒子を形成するための単純アミノ酸の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US6586008B1 (https=) |
| EP (2) | EP1637128A3 (https=) |
| JP (1) | JP2003507412A (https=) |
| AT (1) | ATE319429T1 (https=) |
| AU (1) | AU764738B2 (https=) |
| CA (1) | CA2382651C (https=) |
| DE (1) | DE60026544T2 (https=) |
| DK (1) | DK1210068T3 (https=) |
| ES (1) | ES2258981T3 (https=) |
| PT (1) | PT1210068E (https=) |
| WO (1) | WO2001013893A2 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US6458338B1 (en) * | 1998-09-22 | 2002-10-01 | Aeropharm Technology Incorporated | Amino acid stabilized medicinal aerosol formulations |
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| US6749835B1 (en) * | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| WO2002032396A2 (en) * | 2000-10-16 | 2002-04-25 | Massachusetts Institute Of Technology | Lipid-protein-sugar particles for delivery of nucleic acids |
| EP1359902B1 (en) * | 2001-02-06 | 2007-08-08 | Innovata Biomed Limited | Bimodal dry powder formulation for inhalation |
| US6848197B2 (en) * | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| AU2002335046A1 (en) * | 2001-10-19 | 2003-05-06 | Inhale Therapeutic Systems, Inc. | The use of proton sequestering agents in drug formulations |
| WO2003035028A1 (en) * | 2001-10-19 | 2003-05-01 | Nektar Therapeutics | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
| CN1607941A (zh) * | 2001-11-19 | 2005-04-20 | 贝克顿迪肯森公司 | 粒状药物组合物 |
| EP1458361A4 (en) * | 2001-11-20 | 2007-04-25 | Advanced Inhalation Res Inc | COMPOSITIONS FOR DISTRIBUTING PRODUCTS WITH LASTING EFFECT |
| JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
| CN1642533A (zh) * | 2002-03-18 | 2005-07-20 | 山之内制药株式会社 | 吸入用粉末医药组合物及其制备方法 |
| US7754242B2 (en) * | 2002-03-20 | 2010-07-13 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
| EP1487411B1 (en) * | 2002-03-20 | 2019-01-02 | Civitas Therapeutics, Inc. | Inhalable sustained therapeutic formulations |
| US20110123574A1 (en) * | 2002-03-20 | 2011-05-26 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) * | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| JP2006522634A (ja) * | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
| CA2523475C (en) * | 2003-05-28 | 2013-02-05 | Nektar Therapeutics | Pharmaceutical formulation comprising a water-insoluble active agent |
| EP1663164A2 (en) * | 2003-09-15 | 2006-06-07 | Vectura Limited | Methods for preparing pharmaceutical compositions |
| US20050191360A1 (en) * | 2004-02-10 | 2005-09-01 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| US7611709B2 (en) | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
| US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
| MXPA06014567A (es) | 2004-06-18 | 2007-07-24 | Novartis Vaccines & Diagnostic | Metodo para el tratamiento de infecciones endobronquiales. |
| MX2007000979A (es) * | 2004-07-26 | 2007-07-11 | Cotherix Inc | Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada. |
| WO2007011396A2 (en) | 2004-10-29 | 2007-01-25 | President And Fellows Of Harvard College | Particles for treatment of pulmonary infection |
| US20060105051A1 (en) * | 2004-11-18 | 2006-05-18 | Blair Jackson | Manufacture of particles for pulmonary drug delivery by carbon dioxide assisted nebulization |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| US20060134009A1 (en) * | 2004-12-16 | 2006-06-22 | Daniel Deaver | Low dose corticosteroid powders for inhalation |
| EP1901749B1 (en) | 2005-05-18 | 2016-08-03 | Raptor Pharmaceuticals Inc. | Aerosolized fluoroquinolones and uses thereof |
| US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| GB0524194D0 (en) * | 2005-11-28 | 2006-01-04 | Univ Aston | Respirable powders |
| AU2006318216C1 (en) * | 2005-11-28 | 2012-02-16 | Verrow Pharmaceuticals, Inc. | Compositions useful for reducing nephrotoxicity and methods of use thereof |
| US20070219127A1 (en) * | 2006-03-20 | 2007-09-20 | Walt John G | Cyclosporin a compositions |
| DE102006030164A1 (de) * | 2006-06-29 | 2008-01-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Pulver |
| WO2008130220A1 (en) * | 2007-04-20 | 2008-10-30 | N.V. Nutricia | Process for dispersing amino acids |
| EP2346509B1 (en) | 2008-10-07 | 2020-05-13 | Horizon Orphan LLC | Inhalation of levofloxacin for reducing lung inflammation |
| JP2012505223A (ja) | 2008-10-07 | 2012-03-01 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 薬物動態の改善のためのエアゾールフルオロキノロン配合物 |
| GB0908129D0 (en) * | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
| MX337126B (es) | 2009-05-29 | 2016-02-12 | Pearl Therapeutics Inc | Administracion respiratoria de agentes activos. |
| US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
| RU2563809C2 (ru) | 2009-09-04 | 2015-09-20 | Мпекс Фармасьютикалс, Инк. | Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза |
| JP6021117B2 (ja) | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| US9572774B2 (en) | 2011-05-19 | 2017-02-21 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
| EP2709646A4 (en) * | 2011-05-19 | 2015-05-13 | Savara Inc | DRY POWDER VANCOMYCIN COMPOSITIONS AND RELATED METHODS |
| CN102225058A (zh) * | 2011-06-22 | 2011-10-26 | 中国药科大学 | 磷酸奥司他韦吸入粉雾剂及其制备方法 |
| BR112015010601B1 (pt) | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | Composição farmacêutica e uso da composição |
| AU2014212109B2 (en) | 2013-02-01 | 2018-05-31 | Glialogix, Inc. | Compositions and methods for the treatment of neurodegenerative and other diseases |
| KR102391332B1 (ko) | 2013-03-15 | 2022-04-26 | 펄 테라퓨틱스 인코포레이티드 | 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템 |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク． | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| NZ760541A (en) | 2014-01-10 | 2022-08-26 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| PL3104854T3 (pl) | 2014-02-10 | 2020-11-30 | Respivant Sciences Gmbh | Stabilizatory komórek tucznych do leczenia choroby płuc |
| WO2015120389A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
| US10202426B2 (en) * | 2014-07-30 | 2019-02-12 | Genome Protection, Inc. | Flagellin compositions and uses |
| GB201415381D0 (en) * | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
| WO2016067252A1 (en) | 2014-10-31 | 2016-05-06 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
| MA40910A (fr) | 2014-11-07 | 2017-09-12 | Civitas Therapeutics Inc | Poudres de rapamycine pour administration pulmonaire |
| WO2017027387A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| US9585835B1 (en) * | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| JP6953414B2 (ja) * | 2016-01-20 | 2021-10-27 | フラリー パウダーズ エルエルシーＦｌｕｒｒｙ Ｐｏｗｄｅｒｓ，Ｌｌｃ | 親油性成分を含む吸入に好適な分散性の噴霧乾燥粉末を製造する方法 |
| US11833118B2 (en) | 2016-01-20 | 2023-12-05 | Flurry Powders, Llc | Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation |
| WO2017223502A1 (en) * | 2016-06-24 | 2017-12-28 | Civitas Therapeutics, Inc. | Surfactant formulations for inhalation |
| RU2741309C2 (ru) | 2016-06-30 | 2021-01-25 | Филип Моррис Продактс С.А. | Никотиносодержащие частицы |
| KR102523677B1 (ko) * | 2016-06-30 | 2023-04-20 | 필립모리스 프로덕츠 에스.에이. | 니코틴 입자 및 조성물 |
| EP3506893A4 (en) | 2016-08-31 | 2020-01-22 | Respivant Sciences GmbH | CROMOLYN COMPOSITIONS FOR THE TREATMENT OF CHRONIC COUGH DUE TO IDIOPATHIC PULMONAL FIBROSIS |
| JP2019531308A (ja) | 2016-10-07 | 2019-10-31 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングＲｅｓｐｉｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | 肺線維症の治療のためのクロモリン組成物 |
| TW201818933A (zh) | 2016-10-21 | 2018-06-01 | 美商吉利亞洛吉克斯公司 | 用於神經退化性及其他疾病的治療之組成物和方法 |
| KR20190126772A (ko) * | 2017-03-07 | 2019-11-12 | 필립모리스 프로덕츠 에스.에이. | 흡입 가능한 니코틴 제형, 및 이의 제조 및 사용 방법 |
| GB2577420B (en) | 2017-05-22 | 2022-07-06 | Insmed Inc | Glycopeptide derivative compounds and uses thereof |
| EP3727418B1 (en) * | 2017-12-21 | 2026-04-08 | Merz Pharmaceuticals, LLC | Surfactant formulations for inhalation |
| CA3085944A1 (en) * | 2017-12-21 | 2019-06-27 | Civitas Therapeutics, Inc. | Surfactant formulations for inhalation |
| JP2021531299A (ja) | 2018-07-23 | 2021-11-18 | トレビ セラピューティクス インコーポレイテッド | 慢性咳嗽、息切れ、及び呼吸困難の治療 |
| KR20220127849A (ko) | 2020-01-10 | 2022-09-20 | 트레비 테라퓨틱스, 인코포레이티드 | 날부핀의 투여 방법 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US5874063A (en) | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
| SE9302777D0 (sv) | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| ES2179831T3 (es) | 1992-09-29 | 2003-02-01 | Inhale Therapeutic Syst | Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana. |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| NZ281112A (en) | 1994-03-07 | 1998-04-27 | Inhale Therapeutic Syst | Powdered insulin delivered as an aerosol |
| ES2245780T3 (es) | 1994-05-18 | 2006-01-16 | Nektar Therapeutics | Metodos y composiciones para la formulacion de interferones como un polvo seco. |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| ES2237767T3 (es) | 1995-04-14 | 2005-08-01 | Nektar Therapeutics | Composiciones farmaceuticas en polvo que tienen una dispersabilidad mejorada. |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| WO1998016245A1 (fr) * | 1996-10-15 | 1998-04-23 | Shionogi & Co., Ltd. | Procede de determination d'un auto-anticorps |
| DE69732306T2 (de) | 1997-01-16 | 2006-01-12 | Massachusetts Institute Of Technology, Cambridge | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| CN1169520C (zh) | 1997-09-29 | 2004-10-06 | 耐科塔医药公司 | 多孔微粒及其使用方法 |
| GB9827145D0 (en) | 1998-12-09 | 1999-02-03 | Co Ordinated Drug Dev | Improvements in or relating to powders |
-
1999
- 1999-08-25 US US09/382,959 patent/US6586008B1/en not_active Expired - Lifetime
-
2000
- 2000-08-23 CA CA002382651A patent/CA2382651C/en not_active Expired - Lifetime
- 2000-08-23 AU AU69296/00A patent/AU764738B2/en not_active Ceased
- 2000-08-23 AT AT00957716T patent/ATE319429T1/de active
- 2000-08-23 JP JP2001518031A patent/JP2003507412A/ja active Pending
- 2000-08-23 PT PT00957716T patent/PT1210068E/pt unknown
- 2000-08-23 EP EP05077639A patent/EP1637128A3/en not_active Withdrawn
- 2000-08-23 EP EP00957716A patent/EP1210068B1/en not_active Expired - Lifetime
- 2000-08-23 ES ES00957716T patent/ES2258981T3/es not_active Expired - Lifetime
- 2000-08-23 DE DE60026544T patent/DE60026544T2/de not_active Expired - Lifetime
- 2000-08-23 DK DK00957716T patent/DK1210068T3/da active
- 2000-08-23 WO PCT/US2000/023149 patent/WO2001013893A2/en not_active Ceased
-
2006
- 2006-12-12 US US11/637,353 patent/US20070104658A1/en not_active Abandoned
-
2007
- 2007-10-17 US US11/873,472 patent/US20080160098A1/en not_active Abandoned
- 2007-10-17 US US11/873,467 patent/US20080160092A1/en not_active Abandoned
-
2011
- 2011-01-20 US US13/010,032 patent/US8268358B2/en not_active Expired - Fee Related
-
2012
- 2012-08-17 US US13/588,549 patent/US9333174B2/en not_active Expired - Fee Related
-
2016
- 2016-04-07 US US15/092,799 patent/US20160287517A1/en not_active Abandoned
-
2017
- 2017-01-26 US US15/416,328 patent/US20170354602A1/en not_active Abandoned
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