JP2003507411A5 - - Google Patents
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- Publication number
- JP2003507411A5 JP2003507411A5 JP2001518030A JP2001518030A JP2003507411A5 JP 2003507411 A5 JP2003507411 A5 JP 2003507411A5 JP 2001518030 A JP2001518030 A JP 2001518030A JP 2001518030 A JP2001518030 A JP 2001518030A JP 2003507411 A5 JP2003507411 A5 JP 2003507411A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- particles
- phospholipid
- particle
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002245 particle Substances 0.000 description 32
- 150000003839 salts Chemical class 0.000 description 26
- 238000000034 method Methods 0.000 description 20
- 150000003904 phospholipids Chemical class 0.000 description 16
- 239000002253 acid Substances 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 8
- 229940039227 diagnostic agent Drugs 0.000 description 7
- 239000000032 diagnostic agent Substances 0.000 description 7
- 230000000069 prophylactic effect Effects 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- -1 phosphatidyl glycerols Chemical class 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 150000001805 chlorine compounds Chemical group 0.000 description 3
- 150000008105 phosphatidylcholines Chemical class 0.000 description 3
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 3
- 229940067605 phosphatidylethanolamines Drugs 0.000 description 3
- 229940067626 phosphatidylinositols Drugs 0.000 description 3
- 150000003905 phosphatidylinositols Chemical class 0.000 description 3
- 150000008106 phosphatidylserines Chemical class 0.000 description 3
- 229960002052 salbutamol Drugs 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15066299P | 1999-08-25 | 1999-08-25 | |
| US60/150,662 | 1999-08-25 | ||
| PCT/US2000/023118 WO2001013892A2 (en) | 1999-08-25 | 2000-08-23 | Large porous particles by spray-drying |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507411A JP2003507411A (ja) | 2003-02-25 |
| JP2003507411A5 true JP2003507411A5 (https=) | 2007-06-21 |
Family
ID=22535487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518030A Withdrawn JP2003507411A (ja) | 1999-08-25 | 2000-08-23 | 噴霧乾燥大多孔性粒子製剤 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1210069B1 (https=) |
| JP (1) | JP2003507411A (https=) |
| AT (1) | ATE285755T1 (https=) |
| AU (1) | AU768299B2 (https=) |
| CA (1) | CA2383491A1 (https=) |
| DE (1) | DE60017152D1 (https=) |
| WO (1) | WO2001013892A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US7871598B1 (en) * | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| ES2525087T5 (es) | 2000-05-10 | 2018-06-28 | Novartis Ag | Polvos basados en fosfolípidos para administración de fármacos |
| US6848197B2 (en) * | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| EP1390012A4 (en) * | 2001-04-26 | 2009-10-28 | Novartis Ag | NEW METHODS AND COMPOSITIONS FOR RELEASING MACROMOLECULES TO OR BY THE AIRWAY |
| GB0120123D0 (en) * | 2001-08-17 | 2001-10-10 | Upperton Ltd | Preparation of microparticles |
| EP1458361A4 (en) * | 2001-11-20 | 2007-04-25 | Advanced Inhalation Res Inc | COMPOSITIONS FOR DISTRIBUTING PRODUCTS WITH LASTING EFFECT |
| JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
| AU2003287132B2 (en) * | 2002-12-13 | 2009-03-12 | Adagit | Pharmaceutical porous particles |
| CA2754691C (en) * | 2009-03-26 | 2019-07-30 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US20120058198A1 (en) * | 2009-03-26 | 2012-03-08 | Pulmatrix, Inc. | Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis |
| AU2011296343B2 (en) * | 2010-08-30 | 2015-12-10 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| EP2464346A1 (en) | 2010-08-30 | 2012-06-20 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| EP3470057B1 (en) | 2010-09-29 | 2021-11-03 | Pulmatrix Operating Company, Inc. | Cationic dry powders comprising magnesium salt |
| RU2017144619A (ru) | 2010-09-29 | 2019-02-20 | Пулмэтрикс, Инк. | Катионы одновалентных металлов сухих порошков для ингаляций |
| CN107596518B (zh) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | 可吸入干粉剂 |
| JP6473738B2 (ja) | 2013-04-01 | 2019-02-20 | パルマトリックス，インコーポレイテッド | チオトロピウム乾燥粉末 |
| WO2015120389A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
| PL3104854T3 (pl) | 2014-02-10 | 2020-11-30 | Respivant Sciences Gmbh | Stabilizatory komórek tucznych do leczenia choroby płuc |
| WO2016067252A1 (en) | 2014-10-31 | 2016-05-06 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
| US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| WO2017027387A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| EP3506893A4 (en) | 2016-08-31 | 2020-01-22 | Respivant Sciences GmbH | CROMOLYN COMPOSITIONS FOR THE TREATMENT OF CHRONIC COUGH DUE TO IDIOPATHIC PULMONAL FIBROSIS |
| JP2019531308A (ja) | 2016-10-07 | 2019-10-31 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングＲｅｓｐｉｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | 肺線維症の治療のためのクロモリン組成物 |
| CA3133804A1 (en) * | 2019-03-22 | 2020-10-01 | Mannkind Corporation | Inhalable dry powders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| UA59358C2 (uk) * | 1996-01-24 | 2003-09-15 | Бик Гулден Ломберг Хеміше Фабрік Гмбх | Спосіб приготування порошкоподібного пульмонологічного порошкоподібного препарату та препарат, одержаний в такий спосіб |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| DE69732306T2 (de) * | 1997-01-16 | 2006-01-12 | Massachusetts Institute Of Technology, Cambridge | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
-
2000
- 2000-08-23 AU AU70666/00A patent/AU768299B2/en not_active Ceased
- 2000-08-23 JP JP2001518030A patent/JP2003507411A/ja not_active Withdrawn
- 2000-08-23 CA CA002383491A patent/CA2383491A1/en not_active Abandoned
- 2000-08-23 AT AT00959327T patent/ATE285755T1/de not_active IP Right Cessation
- 2000-08-23 EP EP00959327A patent/EP1210069B1/en not_active Expired - Lifetime
- 2000-08-23 WO PCT/US2000/023118 patent/WO2001013892A2/en not_active Ceased
- 2000-08-23 DE DE60017152T patent/DE60017152D1/de not_active Expired - Lifetime
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