DE60017152D1 - Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung - Google Patents
Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendungInfo
- Publication number
- DE60017152D1 DE60017152D1 DE60017152T DE60017152T DE60017152D1 DE 60017152 D1 DE60017152 D1 DE 60017152D1 DE 60017152 T DE60017152 T DE 60017152T DE 60017152 T DE60017152 T DE 60017152T DE 60017152 D1 DE60017152 D1 DE 60017152D1
- Authority
- DE
- Germany
- Prior art keywords
- spray drying
- porous particles
- large porous
- particles available
- pulmonary application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 title abstract 3
- 230000002685 pulmonary effect Effects 0.000 title abstract 2
- 238000001694 spray drying Methods 0.000 title abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000008105 phosphatidylcholines Chemical class 0.000 abstract 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1
- 229940067605 phosphatidylethanolamines Drugs 0.000 abstract 1
- 229940067626 phosphatidylinositols Drugs 0.000 abstract 1
- 150000003905 phosphatidylinositols Chemical class 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15066299P | 1999-08-25 | 1999-08-25 | |
| PCT/US2000/023118 WO2001013892A2 (en) | 1999-08-25 | 2000-08-23 | Large porous particles by spray-drying |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60017152D1 true DE60017152D1 (de) | 2005-02-03 |
Family
ID=22535487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60017152T Expired - Lifetime DE60017152D1 (de) | 1999-08-25 | 2000-08-23 | Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1210069B1 (https=) |
| JP (1) | JP2003507411A (https=) |
| AT (1) | ATE285755T1 (https=) |
| AU (1) | AU768299B2 (https=) |
| CA (1) | CA2383491A1 (https=) |
| DE (1) | DE60017152D1 (https=) |
| WO (1) | WO2001013892A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| PT1280520E (pt) * | 2000-05-10 | 2014-12-16 | Novartis Ag | Pós à base de fosfolípidos para administração de fármacos |
| US7871598B1 (en) * | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US6848197B2 (en) | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| EP1390012A4 (en) * | 2001-04-26 | 2009-10-28 | Novartis Ag | NEW METHODS AND COMPOSITIONS FOR RELEASING MACROMOLECULES TO OR BY THE AIRWAY |
| GB0120123D0 (en) * | 2001-08-17 | 2001-10-10 | Upperton Ltd | Preparation of microparticles |
| JP2005511629A (ja) * | 2001-11-20 | 2005-04-28 | アドバンスト インハレーション リサーチ，インコーポレイテッド | 持続作用生成物送達用組成物 |
| PT1458360E (pt) | 2001-12-19 | 2011-07-13 | Novartis Ag | Derivados de indole como agonistas do recetor s1p1 |
| EP1569626A1 (en) | 2002-12-13 | 2005-09-07 | Adagit | Pharmaceutical porous particles |
| US20120058198A1 (en) * | 2009-03-26 | 2012-03-08 | Pulmatrix, Inc. | Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis |
| ES2625260T5 (es) | 2009-03-26 | 2020-07-29 | Pulmatrix Operating Co Inc | Formulaciones de polvo seco y métodos para el tratamiento de enfermedades pulmonares |
| CN103200938B (zh) * | 2010-08-30 | 2018-07-31 | 普马特里克斯营业公司 | 干燥粉末配方及用于治疗肺部疾病的方法 |
| WO2012030645A1 (en) | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
| PT3470057T (pt) * | 2010-09-29 | 2021-12-03 | Pulmatrix Operating Co Inc | Pós secos catiónicos compreendendo sais de magnésio |
| BR112013007304B1 (pt) * | 2010-09-29 | 2021-12-14 | Pulmatrix, Inc. | Pós secos de cátion de metal monovalente para inalação |
| CN107596518B (zh) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | 可吸入干粉剂 |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| PL3104853T3 (pl) | 2014-02-10 | 2020-05-18 | Respivant Sciences Gmbh | Leczenie stabilizatorami komórek tucznych zaburzeń ogólnoustrojowych |
| ES2792682T3 (es) | 2014-02-10 | 2020-11-11 | Respivant Sciences Gmbh | Métodos para el tratamiento de enfermedades pulmonares con estabilizadores de mastocitos |
| MX392636B (es) | 2014-10-31 | 2025-03-24 | Glaxosmithkline Ip Dev Ltd | Formulacion en polvo. |
| WO2017027402A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| WO2018044942A1 (en) | 2016-08-31 | 2018-03-08 | Patara Pharma, LLC | Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis |
| EP3522983A4 (en) | 2016-10-07 | 2020-06-03 | Respivant Sciences GmbH | CROMOLYN COMPOSITION FOR TREATING LUNG FIBROSIS |
| CA3133804A1 (en) * | 2019-03-22 | 2020-10-01 | Mannkind Corporation | Inhalable dry powders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| PT877602E (pt) * | 1996-01-24 | 2002-07-31 | Byk Gulden Lomberg Chem Fab | Processo para o fabrico de composicoes de surfactantes pulmonares em po |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| CA2277801C (en) * | 1997-01-16 | 2002-10-15 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
-
2000
- 2000-08-23 DE DE60017152T patent/DE60017152D1/de not_active Expired - Lifetime
- 2000-08-23 JP JP2001518030A patent/JP2003507411A/ja not_active Withdrawn
- 2000-08-23 WO PCT/US2000/023118 patent/WO2001013892A2/en not_active Ceased
- 2000-08-23 CA CA002383491A patent/CA2383491A1/en not_active Abandoned
- 2000-08-23 AT AT00959327T patent/ATE285755T1/de not_active IP Right Cessation
- 2000-08-23 EP EP00959327A patent/EP1210069B1/en not_active Expired - Lifetime
- 2000-08-23 AU AU70666/00A patent/AU768299B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001013892A3 (en) | 2001-06-21 |
| JP2003507411A (ja) | 2003-02-25 |
| WO2001013892A2 (en) | 2001-03-01 |
| CA2383491A1 (en) | 2001-03-01 |
| AU7066600A (en) | 2001-03-19 |
| EP1210069B1 (en) | 2004-12-29 |
| ATE285755T1 (de) | 2005-01-15 |
| EP1210069A2 (en) | 2002-06-05 |
| AU768299B2 (en) | 2003-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |