WO1999047101A3 - Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof - Google Patents

Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof Download PDF

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Publication number
WO1999047101A3
WO1999047101A3 PCT/US1999/005943 US9905943W WO9947101A3 WO 1999047101 A3 WO1999047101 A3 WO 1999047101A3 US 9905943 W US9905943 W US 9905943W WO 9947101 A3 WO9947101 A3 WO 9947101A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
compositions containing
lysophosphatidic acids
inhibit apoptosis
agents
Prior art date
Application number
PCT/US1999/005943
Other languages
French (fr)
Other versions
WO1999047101A2 (en
Inventor
John G Goddard
Donald H Picker
Samuil R Umansky
Steven Price
Jacobus C H M Wijkmans
Edward Andrew Boyd
Anthony David Baxter
Original Assignee
Lxr Biotechnology Inc
Oxford Asymmetry Ltd
John G Goddard
Donald H Picker
Samuil R Umansky
Steven Price
Jacobus C H M Wijkmans
Edward Andrew Boyd
Anthony David Baxter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lxr Biotechnology Inc, Oxford Asymmetry Ltd, John G Goddard, Donald H Picker, Samuil R Umansky, Steven Price, Jacobus C H M Wijkmans, Edward Andrew Boyd, Anthony David Baxter filed Critical Lxr Biotechnology Inc
Priority to AU31915/99A priority Critical patent/AU3191599A/en
Priority to EP99913956A priority patent/EP1069895A4/en
Priority to US09/646,599 priority patent/US6949528B1/en
Publication of WO1999047101A2 publication Critical patent/WO1999047101A2/en
Publication of WO1999047101A3 publication Critical patent/WO1999047101A3/en
Priority to US11/236,429 priority patent/US7259273B1/en
Priority to US11/834,505 priority patent/US20080076736A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.
PCT/US1999/005943 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof WO1999047101A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU31915/99A AU3191599A (en) 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
EP99913956A EP1069895A4 (en) 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
US09/646,599 US6949528B1 (en) 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
US11/236,429 US7259273B1 (en) 1998-03-18 2005-09-26 Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof
US11/834,505 US20080076736A1 (en) 1998-03-18 2007-08-06 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7837598P 1998-03-18 1998-03-18
US60/078,375 1998-03-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09646599 A-371-Of-International 1999-03-17
US11/236,429 Division US7259273B1 (en) 1998-03-18 2005-09-26 Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof

Publications (2)

Publication Number Publication Date
WO1999047101A2 WO1999047101A2 (en) 1999-09-23
WO1999047101A3 true WO1999047101A3 (en) 1999-11-25

Family

ID=22143648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005943 WO1999047101A2 (en) 1998-03-18 1999-03-17 Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof

Country Status (3)

Country Link
EP (1) EP1069895A4 (en)
AU (1) AU3191599A (en)
WO (1) WO1999047101A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495532B1 (en) 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US6380177B1 (en) 1999-06-25 2002-04-30 Atairgin Technologies, Inc. LPA analogs as agonists of the Edg2 LPA receptor
WO2001012838A2 (en) * 1999-08-18 2001-02-22 Atairgin Technologies, Inc. Compounds which modulate the activity of an lpa receptor
CA2380640A1 (en) 1999-08-18 2001-02-22 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
US6500810B2 (en) * 1999-12-14 2002-12-31 Sky High, Llc Method of regulating expression of adhesion molecules on circulating leukocytes
US6492334B1 (en) 1999-12-30 2002-12-10 Robert James Generale Tri-compound analgesic for treating inflammation and pain
ATE380187T1 (en) * 2000-03-17 2007-12-15 Univ Tennessee Res Corp AGONISTS AND ANTAGONISTS FOR THE LPA RECEPTOR AND METHODS OF APPLICATION
US20030130237A1 (en) * 2000-03-17 2003-07-10 Miller Duane D. LPA receptor agonists and antagonists and methods of use
CA2371398A1 (en) * 2001-02-16 2002-08-16 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
JP4836345B2 (en) * 2001-04-13 2011-12-14 きみ子 室伏 Neuronal survival promoter containing cyclic phosphatidic acid derivative
JP4815063B2 (en) * 2001-04-13 2011-11-16 きみ子 室伏 Drugs for promoting the proliferation, differentiation and / or survival of glial cells containing cyclic phosphatidic acid
JP4162927B2 (en) 2002-06-11 2008-10-08 きみ子 室伏 Carbacyclic phosphatidic acid derivatives
JP5048333B2 (en) * 2003-10-09 2012-10-17 ユニバーシティ オブ テネシー リサーチ ファウンデーション LPA receptor agonists and antagonists and methods of use
WO2005115150A2 (en) * 2004-05-06 2005-12-08 University Of Virginia Patent Foundation Novel lysophosphatidic acid receptor selective antagonists
WO2007011905A2 (en) * 2005-07-19 2007-01-25 The University Of Tennessee Research Foundation Lpa2 receptor agonist inhibitors of cftr
JP2010535193A (en) * 2007-08-01 2010-11-18 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク セエンエールエス Thiophosphine (thiophosphonic) acid derivatives and their therapeutic applications

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS492266B1 (en) * 1970-06-06 1974-01-19
JPS57167364A (en) * 1981-04-07 1982-10-15 Sankin Kogyo Kk Adhesive for hard tissue of human body
JPS5810559A (en) * 1981-07-10 1983-01-21 Ajinomoto Co Inc Preparation of alpha-chloro-beta-thiosulfo-propionic acid ester salt
US4504409A (en) * 1981-12-16 1985-03-12 Kao Corporation Emulsifying composition
JPS63265972A (en) * 1987-04-24 1988-11-02 Denki Kagaku Kogyo Kk Modified vinyl chloride resin solution
JPH05311200A (en) * 1992-05-13 1993-11-22 Sanyo Chem Ind Ltd Alkaline detergent
WO1998036639A1 (en) * 1997-02-19 1998-08-27 Ultradent Products, Inc. Adhesive, antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938961A (en) 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
US5759548A (en) 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
AU1743495A (en) * 1994-02-04 1995-08-21 Cell Therapeutics, Inc. Composition for wound healing, neuron growth and vascularization
WO1998041213A1 (en) * 1997-03-19 1998-09-24 Lxr Biotechnology Inc. Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
WO1999008514A1 (en) * 1997-08-20 1999-02-25 Lxr Biotechnology, Inc. Compositions containing polyethylene glycol and uses thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS492266B1 (en) * 1970-06-06 1974-01-19
JPS57167364A (en) * 1981-04-07 1982-10-15 Sankin Kogyo Kk Adhesive for hard tissue of human body
JPS5810559A (en) * 1981-07-10 1983-01-21 Ajinomoto Co Inc Preparation of alpha-chloro-beta-thiosulfo-propionic acid ester salt
US4504409A (en) * 1981-12-16 1985-03-12 Kao Corporation Emulsifying composition
JPS63265972A (en) * 1987-04-24 1988-11-02 Denki Kagaku Kogyo Kk Modified vinyl chloride resin solution
JPH05311200A (en) * 1992-05-13 1993-11-22 Sanyo Chem Ind Ltd Alkaline detergent
WO1998036639A1 (en) * 1997-02-19 1998-08-27 Ultradent Products, Inc. Adhesive, antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1069895A4 *

Also Published As

Publication number Publication date
EP1069895A4 (en) 2002-07-31
AU3191599A (en) 1999-10-11
WO1999047101A2 (en) 1999-09-23
EP1069895A2 (en) 2001-01-24

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