|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
CN1853630A
(zh)
*
|
2001-02-21 |
2006-11-01 |
Nps制药公司 |
杂多环化合物及其在亲代谢的谷氨酸受体拮抗剂中的应用
|
|
US6916821B2
(en)
|
2001-04-02 |
2005-07-12 |
Brown University |
Methods of treating disorders with Group I mGluR antagonists
|
|
AU2002307049A1
(en)
|
2001-04-02 |
2002-10-15 |
Brown University Research Foundation |
Use of mglur5 antagonists in the manufacture of a medicament in the treatment of autism, mental retardation, schizophrenia
|
|
CA2469821C
(en)
*
|
2001-12-18 |
2009-10-20 |
Merck & Co., Inc. |
Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
|
|
WO2003051833A2
(en)
*
|
2001-12-18 |
2003-06-26 |
Merck & Co., Inc. |
Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
|
|
CA2470612A1
(en)
*
|
2001-12-19 |
2003-07-03 |
Merck & Co., Inc. |
Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
|
|
DE60334781D1
(de)
*
|
2002-03-12 |
2010-12-16 |
Merck Sharp & Dohme |
Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5
|
|
US7964609B2
(en)
|
2002-06-20 |
2011-06-21 |
Astrazeneca Ab |
Use of mGluR5 antagonists for the treatment of gerd
|
|
SE0201943D0
(sv)
*
|
2002-06-20 |
2002-06-20 |
Astrazeneca Ab |
New use
|
|
AU2003264018A1
(en)
|
2002-08-09 |
2004-02-25 |
Astrazeneca Ab |
Compounds having an activity at metabotropic glutamate receptors
|
|
IL166510A0
(en)
|
2002-08-09 |
2006-01-15 |
Nps Pharma Inc |
1,2,4"oxadiazole as modulators of metabotropic glutamate receptor-5
|
|
MXPA05001592A
(es)
*
|
2002-08-09 |
2005-05-05 |
Astrazeneca Ab |
Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico.
|
|
GB0303503D0
(en)
*
|
2003-02-14 |
2003-03-19 |
Novartis Ag |
Organic compounds
|
|
CA2521396A1
(en)
*
|
2003-04-04 |
2004-10-21 |
Merck & Co., Inc. |
Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5
|
|
US20060252741A1
(en)
*
|
2003-05-15 |
2006-11-09 |
Colandrea Vincent J |
3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
|
|
WO2005060961A2
(en)
*
|
2003-12-18 |
2005-07-07 |
Astrazeneca Ab |
Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
|
|
JP4958560B2
(ja)
*
|
2003-12-24 |
2012-06-20 |
プロシディオン・リミテッド |
Gpcr受容体作動薬としてのヘテロ環誘導体
|
|
US7585881B2
(en)
|
2004-02-18 |
2009-09-08 |
Astrazeneca Ab |
Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
RU2381226C2
(ru)
*
|
2004-02-18 |
2010-02-10 |
Астразенека Аб |
Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата
|
|
DK1716152T3
(da)
*
|
2004-02-18 |
2008-11-03 |
Astrazeneca Ab |
Kondenserade heterocykliske forbindelser og deres anvendelse som metabotrope receptorantagonister til behandling af gastrointentinde lidelser
|
|
TW200538108A
(en)
|
2004-02-19 |
2005-12-01 |
Astrazeneca Ab |
Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
US7858800B2
(en)
*
|
2004-06-30 |
2010-12-28 |
Banyu Pharmaceutical Co., Ltd. |
Biaryl derivatives
|
|
KR100621192B1
(ko)
*
|
2004-10-13 |
2006-09-19 |
한국화학연구원 |
무스카린 수용체 작용물질로서 작용하는1,2,3,4-테트라하이드로피리미디닐-1,2,4-옥사다이아졸유도체와 이의 제조방법
|
|
JP4557685B2
(ja)
|
2004-11-15 |
2010-10-06 |
独立行政法人理化学研究所 |
蛍光蛋白質
|
|
AU2006205920B2
(en)
|
2005-01-14 |
2012-11-15 |
F. Hoffmann-La Roche Ag |
Thiazole-4-carboxamide derivatives as mGluR5 antagonists
|
|
GB0510142D0
(en)
*
|
2005-05-18 |
2005-06-22 |
Addex Pharmaceuticals Sa |
Novel compounds A1
|
|
EP1896011A1
(en)
*
|
2005-06-28 |
2008-03-12 |
AstraZeneca AB |
New use
|
|
AR058439A1
(es)
|
2005-07-26 |
2008-02-06 |
Portela & Ca Sa |
Derivados de nitrocatecol como inhibidores de comt. procesos de obtencion y composiciones farmaceuticas.
|
|
AR058807A1
(es)
|
2005-09-29 |
2008-02-27 |
Astrazeneca Ab |
5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5
|
|
ATE553108T1
(de)
|
2005-11-08 |
2012-04-15 |
Hoffmann La Roche |
Thiazoloä4,5-cüpyridinderivative als antagonisten des mglu5-rezeptors
|
|
US7951824B2
(en)
|
2006-02-17 |
2011-05-31 |
Hoffman-La Roche Inc. |
4-aryl-pyridine-2-carboxyamide derivatives
|
|
MX2008012738A
(es)
*
|
2006-04-03 |
2009-02-06 |
Astellas Pharma Inc |
Heterocompuesto.
|
|
EP1845097A1
(en)
|
2006-04-10 |
2007-10-17 |
Portela & Ca., S.A. |
Oxadiazole derivatives as COMT inhibitors
|
|
US20100234349A1
(en)
*
|
2006-09-04 |
2010-09-16 |
Olsen Gunnar M |
Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
|
|
TWI392671B
(zh)
|
2006-09-07 |
2013-04-11 |
Actelion Pharmaceuticals Ltd |
吡啶-4-基衍生物
|
|
ES2400163T3
(es)
|
2006-09-08 |
2013-04-08 |
Actelion Pharmaceuticals Ltd. |
Derivados de piridil-3-ilo como agentes de inmunomodulación
|
|
MX2009002915A
(es)
|
2006-09-21 |
2009-03-31 |
Actelion Pharmaceuticals Ltd |
Derivados de fenilo y su uso como inmunomoduladores.
|
|
EP2481410B1
(en)
|
2007-01-31 |
2016-07-13 |
BIAL - Portela & Ca., S.A. |
Nitrocatechol derivates as COMT inhibitors administered with a specific dosage regime
|
|
PT2125797E
(pt)
|
2007-03-16 |
2014-03-11 |
Actelion Pharmaceuticals Ltd |
Derivados aminopiridina como agonistas do receptor s1p1/edg1
|
|
US8598208B2
(en)
|
2007-08-17 |
2013-12-03 |
Actelion Pharmaceuticals Ltd. |
Pyridine derivatives as S1P1/EDG1 receptor modulators
|
|
CA2703909A1
(en)
|
2007-10-31 |
2009-05-07 |
Merck Sharp & Dohme Corp. |
P2x3, receptor antagonists for treatment of pain
|
|
RU2010121969A
(ru)
|
2007-11-01 |
2011-12-10 |
Актелион Фармасьютиклз Лтд (Ch) |
Новые производные пиримидина
|
|
US8288402B2
(en)
*
|
2007-12-20 |
2012-10-16 |
Bayer Intellectual Property Gmbh |
4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use
|
|
EP2732819B1
(en)
|
2008-02-07 |
2019-10-16 |
Massachusetts Eye & Ear Infirmary |
Compounds that enhance Atoh-1 expression
|
|
AU2009220893A1
(en)
|
2008-03-07 |
2009-09-11 |
Actelion Pharmaceuticals Ltd |
Novel aminomethyl benzene derivatives
|
|
KR20110002462A
(ko)
|
2008-03-17 |
2011-01-07 |
바이알 - 포르텔라 앤드 씨에이 에스에이 |
5-[3-(2,5-디클로로-4,6-디메틸-1-옥시-피리딘-3-일)-[1,2,4]옥사디아졸-5-일]-3-나이트로벤젠-1,2-디올의 결정형
|
|
ES2534199T3
(es)
|
2008-10-31 |
2015-04-20 |
Merck Sharp & Dohme Corp. |
Antagonistas del receptor P2X3 para el tratamiento del dolor
|
|
DE102008057364A1
(de)
|
2008-11-14 |
2010-05-20 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte Aryl-Verbindungen und ihre Verwendung
|
|
DE102009041242A1
(de)
|
2009-09-11 |
2011-12-15 |
Bayer Schering Pharma Aktiengesellschaft |
Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung
|
|
DE102008057344A1
(de)
|
2008-11-14 |
2010-05-20 |
Bayer Schering Pharma Aktiengesellschaft |
Aminoalkyl-substituierte Aryl-Verbindungen und ihre Verwendung
|
|
DE102008057343A1
(de)
|
2008-11-14 |
2010-05-20 |
Bayer Schering Pharma Aktiengesellschaft |
Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung
|
|
DE102009041241A1
(de)
|
2009-09-11 |
2011-08-04 |
Bayer Schering Pharma Aktiengesellschaft, 13353 |
Substituierte Aryl-Verbindungen und ihre Verwendung
|
|
US8946231B2
(en)
|
2009-03-23 |
2015-02-03 |
Merck Sharp & Dohme Corp. |
P2X3, receptor antagonists for treatment of pain
|
|
WO2010111058A1
(en)
|
2009-03-23 |
2010-09-30 |
Merck Sharp & Dohme Corp. |
P2x3, receptor antagonists for treatment of pain
|
|
AU2010229144B2
(en)
|
2009-03-23 |
2012-07-12 |
Merck Sharp & Dohme Corp. |
P2X3, receptor antagonists for treatment of pain
|
|
AU2010231961B2
(en)
|
2009-04-01 |
2015-05-21 |
Bial - Portela & Ca., S.A. |
Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof
|
|
CA2758587A1
(en)
*
|
2009-04-13 |
2010-10-21 |
Irm Llc |
Compositions and methods for modulating retinol binding to retinol binding protein 4 (rbp4)
|
|
CN102471328B
(zh)
|
2009-07-16 |
2015-04-01 |
埃科特莱茵药品有限公司 |
吡啶-4-基衍生物
|
|
US20130058915A1
(en)
|
2010-03-02 |
2013-03-07 |
Children's Medica Center Corporation |
Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
|
|
HRP20150919T1
(hr)
|
2011-01-19 |
2015-09-25 |
Actelion Pharmaceuticals Ltd. |
Derivati 2-metoksi-piridin-4-ila
|
|
US20140045900A1
(en)
|
2011-02-11 |
2014-02-13 |
Bial-Portela & Ca, S.A. |
Administration regime for nitrocatechols
|
|
WO2013089573A1
(en)
|
2011-12-13 |
2013-06-20 |
BIAL - PORTELA & Cª., S.A. |
Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor
|
|
JP5946288B2
(ja)
*
|
2012-02-24 |
2016-07-06 |
公立大学法人名古屋市立大学 |
新規ヒドロキサム酸誘導体及びその用途
|
|
CA2901006A1
(en)
|
2013-02-15 |
2014-08-21 |
Monsanto Technology Llc |
3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles for controlling nematode pests
|
|
EP2853532B1
(en)
*
|
2013-09-28 |
2020-12-09 |
Instytut Farmakologii Polskiej Akademii Nauk |
1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
|
|
JP2018500300A
(ja)
|
2014-11-28 |
2018-01-11 |
ノヴィファーマ,エス.アー. |
パーキンソン病を遅延させるための医薬
|
|
BR112017024785B1
(pt)
|
2015-05-20 |
2022-05-17 |
Idorsia Pharmaceuticals Ltd |
Forma cristalina do composto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4] oxadiazol-3- il]-2-etil-6-metilfenoxi}-propano-1,2-diol, composição farmacêutica, e, uso
|
|
AU2016281346B2
(en)
|
2015-06-23 |
2020-01-02 |
Kissei Pharmaceutical Co., Ltd. |
Pyrazole derivative, or pharmaceutically acceptable salt thereof
|
|
CN108883104A
(zh)
*
|
2016-03-30 |
2018-11-23 |
森泰克希斯公司 |
用于在治疗成熟脑损伤中使用的mGluR5的负性变构调节剂
|
|
DK3904350T3
(da)
*
|
2018-04-12 |
2023-11-13 |
Bayer Ag |
N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}benzamidderivater og de tilsvarende pyridincarboxamidderivater som pesticider
|
|
KR102276327B1
(ko)
*
|
2019-06-25 |
2021-07-12 |
연세대학교 산학협력단 |
신규 옥사다이아졸 화합물 및 이를 포함하는 당뇨 예방 또는 치료용 조성물
|
|
AU2020341464A1
(en)
*
|
2019-09-05 |
2022-04-21 |
Trevena, Inc. |
Methods of treating epilepsy using the same
|