JP2003503022A5 - - Google Patents
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- Publication number
- JP2003503022A5 JP2003503022A5 JP2001505675A JP2001505675A JP2003503022A5 JP 2003503022 A5 JP2003503022 A5 JP 2003503022A5 JP 2001505675 A JP2001505675 A JP 2001505675A JP 2001505675 A JP2001505675 A JP 2001505675A JP 2003503022 A5 JP2003503022 A5 JP 2003503022A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- oxygenated fluid
- membrane
- gas permeable
- inlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000007788 liquid Substances 0.000 description 59
- 239000012530 fluid Substances 0.000 description 39
- 239000012528 membrane Substances 0.000 description 37
- 239000007789 gas Substances 0.000 description 24
- 210000004027 cells Anatomy 0.000 description 16
- 210000002381 Plasma Anatomy 0.000 description 15
- 238000004113 cell culture Methods 0.000 description 15
- 239000001301 oxygen Substances 0.000 description 11
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 210000003494 Hepatocytes Anatomy 0.000 description 6
- -1 polyethylene Polymers 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene (PE) Substances 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000010899 nucleation Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 230000003915 cell function Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- YZKZXTBSUSEYQZ-UHFFFAOYSA-N 1-[(4-ethoxy-3-methoxyphenyl)methyl]-6,7-dimethoxy-3-methylisoquinoline;phosphoric acid Chemical compound OP(O)(O)=O.C1=C(OC)C(OCC)=CC=C1CC1=NC(C)=CC2=CC(OC)=C(OC)C=C12 YZKZXTBSUSEYQZ-UHFFFAOYSA-N 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 210000000601 Blood Cells Anatomy 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 210000002744 Extracellular Matrix Anatomy 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010021113 Hypothermia Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- BFMKFCLXZSUVPI-UHFFFAOYSA-N ethyl but-3-enoate Chemical compound CCOC(=O)CC=C BFMKFCLXZSUVPI-UHFFFAOYSA-N 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 230000002631 hypothermal Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14012599P | 1999-06-21 | 1999-06-21 | |
US14023999P | 1999-06-21 | 1999-06-21 | |
US60/140,239 | 1999-06-21 | ||
US60/140,125 | 1999-06-21 | ||
US18163400P | 2000-02-10 | 2000-02-10 | |
US60/181,634 | 2000-02-10 | ||
PCT/US2000/017133 WO2000078932A1 (en) | 1999-06-21 | 2000-06-21 | Cell culture systems and methods for organ assist devices |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2003503022A JP2003503022A (ja) | 2003-01-28 |
JP2003503022A5 true JP2003503022A5 (de) | 2010-09-30 |
JP4605734B2 JP4605734B2 (ja) | 2011-01-05 |
Family
ID=27385447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001505675A Expired - Fee Related JP4605734B2 (ja) | 1999-06-21 | 2000-06-21 | 臓器補助装置のための細胞培養システム及び方法 |
Country Status (10)
Country | Link |
---|---|
US (2) | US6759245B1 (de) |
EP (1) | EP1203075B1 (de) |
JP (1) | JP4605734B2 (de) |
AT (1) | ATE373079T1 (de) |
AU (1) | AU5756700A (de) |
CA (1) | CA2375505A1 (de) |
DE (1) | DE60036385T2 (de) |
IL (1) | IL147207A0 (de) |
MX (1) | MXPA01013423A (de) |
WO (1) | WO2000078932A1 (de) |
Families Citing this family (91)
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CN108728360B (zh) * | 2018-06-09 | 2024-04-09 | 上海天引生物科技有限公司 | 一种细胞共培养的装置及其方法 |
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CN110669671B (zh) * | 2019-09-04 | 2022-10-14 | 杭州师范大学 | 一种基于中空纤维膜的细胞代谢连续监测装置与方法 |
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JPH1176400A (ja) * | 1997-09-09 | 1999-03-23 | Masahito Nagaki | 人工臓器 |
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US6394812B1 (en) * | 1999-07-22 | 2002-05-28 | Organogenesis Inc. | Vivo induction for enhanced function of isolated hepatocytes |
-
2000
- 2000-06-21 WO PCT/US2000/017133 patent/WO2000078932A1/en active IP Right Grant
- 2000-06-21 AU AU57567/00A patent/AU5756700A/en not_active Abandoned
- 2000-06-21 JP JP2001505675A patent/JP4605734B2/ja not_active Expired - Fee Related
- 2000-06-21 EP EP00943034A patent/EP1203075B1/de not_active Expired - Lifetime
- 2000-06-21 DE DE60036385T patent/DE60036385T2/de not_active Expired - Lifetime
- 2000-06-21 MX MXPA01013423A patent/MXPA01013423A/es active IP Right Grant
- 2000-06-21 IL IL14720700A patent/IL147207A0/xx unknown
- 2000-06-21 CA CA002375505A patent/CA2375505A1/en not_active Abandoned
- 2000-06-21 AT AT00943034T patent/ATE373079T1/de not_active IP Right Cessation
- 2000-06-21 US US09/599,891 patent/US6759245B1/en not_active Expired - Fee Related
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2002
- 2002-07-15 US US10/196,653 patent/US20030017142A1/en not_active Abandoned
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