JP2003231634A5 - - Google Patents
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- Publication number
- JP2003231634A5 JP2003231634A5 JP2003014987A JP2003014987A JP2003231634A5 JP 2003231634 A5 JP2003231634 A5 JP 2003231634A5 JP 2003014987 A JP2003014987 A JP 2003014987A JP 2003014987 A JP2003014987 A JP 2003014987A JP 2003231634 A5 JP2003231634 A5 JP 2003231634A5
- Authority
- JP
- Japan
- Prior art keywords
- solid oral
- compressed solid
- oral preparation
- present
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007787 solid Substances 0.000 claims 37
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 7
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims 7
- 239000011230 binding agent Substances 0.000 claims 7
- 229960002003 hydrochlorothiazide Drugs 0.000 claims 7
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 7
- 229960004699 valsartan Drugs 0.000 claims 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 239000006186 oral dosage form Substances 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 5
- 239000000654 additive Substances 0.000 claims 5
- 230000000996 additive effect Effects 0.000 claims 5
- 239000007884 disintegrant Substances 0.000 claims 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000000945 filler Substances 0.000 claims 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 4
- 229920002472 Starch Polymers 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 239000012748 slip agent Substances 0.000 claims 3
- 239000000454 talc Substances 0.000 claims 3
- 229910052623 talc Inorganic materials 0.000 claims 3
- 235000012222 talc Nutrition 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000008119 colloidal silica Substances 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 208000021908 Myocardial disease Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims 1
- 229940063655 aluminum stearate Drugs 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000391 magnesium silicate Substances 0.000 claims 1
- 229940099273 magnesium trisilicate Drugs 0.000 claims 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 claims 1
- 235000019793 magnesium trisilicate Nutrition 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 229920001592 potato starch Polymers 0.000 claims 1
- 230000008085 renal dysfunction Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 1
- 229940100445 wheat starch Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9613470.5 | 1996-06-27 | ||
| GBGB9613470.5A GB9613470D0 (en) | 1996-06-27 | 1996-06-27 | Small solid oral dosage form |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10502269A Division JP2000506540A (ja) | 1996-06-27 | 1997-06-18 | バルサルタンの固体経口剤形 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007170267A Division JP4969338B2 (ja) | 1996-06-27 | 2007-06-28 | バルサルタンの固体経口剤形 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003231634A JP2003231634A (ja) | 2003-08-19 |
| JP2003231634A5 true JP2003231634A5 (OSRAM) | 2005-03-17 |
Family
ID=10795969
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10502269A Pending JP2000506540A (ja) | 1996-06-27 | 1997-06-18 | バルサルタンの固体経口剤形 |
| JP2003014987A Withdrawn JP2003231634A (ja) | 1996-06-27 | 2003-01-23 | バルサルタンの固体経口剤形 |
| JP2007170267A Expired - Lifetime JP4969338B2 (ja) | 1996-06-27 | 2007-06-28 | バルサルタンの固体経口剤形 |
| JP2011270429A Withdrawn JP2012051948A (ja) | 1996-06-27 | 2011-12-09 | バルサルタンの固体経口剤形 |
| JP2013221985A Pending JP2014012747A (ja) | 1996-06-27 | 2013-10-25 | バルサルタンの固体経口剤形 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10502269A Pending JP2000506540A (ja) | 1996-06-27 | 1997-06-18 | バルサルタンの固体経口剤形 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007170267A Expired - Lifetime JP4969338B2 (ja) | 1996-06-27 | 2007-06-28 | バルサルタンの固体経口剤形 |
| JP2011270429A Withdrawn JP2012051948A (ja) | 1996-06-27 | 2011-12-09 | バルサルタンの固体経口剤形 |
| JP2013221985A Pending JP2014012747A (ja) | 1996-06-27 | 2013-10-25 | バルサルタンの固体経口剤形 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US6294197B1 (OSRAM) |
| EP (7) | EP1767206B1 (OSRAM) |
| JP (5) | JP2000506540A (OSRAM) |
| KR (6) | KR20060079260A (OSRAM) |
| CN (3) | CN1475207B (OSRAM) |
| AR (2) | AR008618A1 (OSRAM) |
| AT (3) | ATE446749T1 (OSRAM) |
| BR (1) | BR9709956A (OSRAM) |
| CA (2) | CA2259148C (OSRAM) |
| CO (1) | CO4870755A1 (OSRAM) |
| CY (1) | CY2553B1 (OSRAM) |
| CZ (1) | CZ296850B6 (OSRAM) |
| DE (3) | DE69739642D1 (OSRAM) |
| DK (3) | DK0914119T3 (OSRAM) |
| ES (3) | ES2290400T3 (OSRAM) |
| GB (1) | GB9613470D0 (OSRAM) |
| HU (1) | HU229134B1 (OSRAM) |
| ID (1) | ID17553A (OSRAM) |
| IL (2) | IL127564A0 (OSRAM) |
| MY (3) | MY123149A (OSRAM) |
| NO (2) | NO317181B1 (OSRAM) |
| NZ (2) | NZ333385A (OSRAM) |
| PE (1) | PE87498A1 (OSRAM) |
| PL (2) | PL188271B1 (OSRAM) |
| PT (3) | PT914119E (OSRAM) |
| RU (5) | RU2294743C2 (OSRAM) |
| SI (2) | SI1410797T1 (OSRAM) |
| SK (1) | SK285902B6 (OSRAM) |
| TR (1) | TR199802698T2 (OSRAM) |
| TW (1) | TW473394B (OSRAM) |
| WO (1) | WO1997049394A2 (OSRAM) |
| ZA (1) | ZA975673B (OSRAM) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| US20030045561A1 (en) * | 2001-02-06 | 2003-03-06 | Smithkline Beecham Corporation | Method of treating isolated systolic hypertension |
| WO1999044590A1 (en) * | 1998-03-04 | 1999-09-10 | Takeda Chemical Industries, Ltd. | Sustained-release preparation for aii antagonist, production and use thereof |
| CN1195500C (zh) | 1998-05-18 | 2005-04-06 | 武田药品工业株式会社 | 可口腔崩解的片剂 |
| SI1096932T1 (sl) * | 1998-07-10 | 2008-04-30 | Novartis Pharma Ag | Antihipertenzivna kombinacija valsartana in zaviralca kalcijevih kanalov |
| ES2281978T3 (es) | 1998-12-23 | 2007-10-01 | Novartis Ag | Uso de un antagonista del receptor at-1 o de un modulador del receptor at-2 para tratar enfermedades asociadas con un incremento de los receptores at-1 o at-2. |
| KR100674053B1 (ko) * | 1999-01-26 | 2007-01-25 | 노파르티스 아게 | 급성 심근경색의 치료를 위한 안지오텐신 ⅱ 수용체길항물질의 용도 |
| CN101011390A (zh) | 1999-01-26 | 2007-08-08 | 诺瓦提斯公司 | 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用 |
| CA2383252A1 (en) * | 1999-08-24 | 2001-03-01 | Medicure International Inc. | Treatment of cardiovascular related pathologies |
| DE10014416B4 (de) * | 2000-03-24 | 2009-02-19 | 3M Espe Ag | Verwendung feinkörniger Pulver bzw. Pulvergemische zur Herstellung eines Mittels für supragingivales Pulverstrahlen |
| CA2311734C (en) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
| US20020132839A1 (en) * | 2000-06-22 | 2002-09-19 | Ganter Sabina Maria | Tablet formulations comprising valsartan |
| KR100659644B1 (ko) * | 2000-06-22 | 2006-12-21 | 노파르티스 아게 | 고형 발사르탄 약제학적 조성물 |
| AU2005200815B2 (en) * | 2000-06-22 | 2008-01-17 | Novartis Ag | Solid valsartan pharmaceutical compositions |
| AU8967201A (en) | 2000-07-19 | 2002-01-30 | Novartis Ag | Valsartan salts |
| US20060089389A1 (en) | 2000-08-22 | 2006-04-27 | Malcolm Allison | Combination |
| PE20020617A1 (es) * | 2000-08-22 | 2002-08-05 | Novartis Ag | Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina |
| US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| CA2456034A1 (en) * | 2001-08-03 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Sustained-release medicines |
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| EG24716A (en) * | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| DE10230272A1 (de) * | 2002-07-05 | 2004-01-22 | Solvay Pharmaceuticals Gmbh | AT1-Rezeptorantagonisten zur Prävention von Folgeschlaganfällen |
| EP1382334A1 (en) * | 2002-07-11 | 2004-01-21 | Université de Picardie Jules Verne | Use of angiotensin II AT1-receptor blockers (ARB), alone or combined with thiazide or angiotensin II for the treatment of stroke |
| CA2519490A1 (en) * | 2003-03-17 | 2004-09-30 | Teva Pharmaceutical Industries Ltd | Polymorphis of valsartan |
| EP1950204A1 (en) | 2003-03-17 | 2008-07-30 | Teva Pharmaceutical Industries Ltd. | Amorphous form of valsartan |
| US7199144B2 (en) * | 2003-04-21 | 2007-04-03 | Teva Pharmaceuticals Industries, Ltd. | Process for the preparation of valsartan and intermediates thereof |
| WO2004094391A2 (en) * | 2003-04-21 | 2004-11-04 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of valsartan and intermediates thereof |
| EP1618097A1 (en) * | 2003-04-21 | 2006-01-25 | Teva Pharmaceutical Industries Ltd | Process for the preparation of valsartan |
| KR20080083071A (ko) * | 2003-08-08 | 2008-09-12 | 아지노모토 가부시키가이샤 | 나테글리니드 함유 제제 |
| SK50472005A3 (sk) * | 2003-11-03 | 2005-09-08 | Zentiva, A. S. | Tableta s obsahom valsartanu vyrobená priamym tabletovaním |
| GB0325605D0 (en) * | 2003-11-03 | 2003-12-10 | Novartis Ag | Combination of organic compounds |
| JP2005187793A (ja) * | 2003-12-24 | 2005-07-14 | Rohm & Haas Electronic Materials Llc | 改良された接着剤 |
| WO2005082329A2 (en) * | 2004-02-19 | 2005-09-09 | Ranbaxy Laboratories Limited | Process for the preparation of solid dosage forms of valsartan and hydrochlorthiazide |
| WO2005089720A1 (en) * | 2004-03-10 | 2005-09-29 | Ranbaxy Laboratories Limited | Valsartan tablets and the process for the preparation thereof |
| CN1976926A (zh) | 2004-09-02 | 2007-06-06 | 特瓦制药工业有限公司 | 奥美沙坦酯的制备 |
| PL2316430T3 (pl) * | 2004-10-08 | 2012-11-30 | Forward Pharma As | Kompozycje farmaceutyczne o kontrolowanym uwalnianiu, zawierające ester kwasu fumarowego |
| US20080050605A1 (en) * | 2004-10-15 | 2008-02-28 | Rapp Knut M | Pan Coating Process |
| EP1674080A1 (en) * | 2004-12-24 | 2006-06-28 | KRKA, D.D., Novo Mesto | Solid pharmaceutical composition comprising valsartan |
| AU2005318365B2 (en) * | 2004-12-24 | 2011-02-03 | Krka, D.D., Novo Mesto | Solid pharmaceutical composition comprising valsartan |
| FR2882260A1 (fr) * | 2005-02-21 | 2006-08-25 | Flamel Technologies Sa | Forme pharmaceutique orale multimicroparticulaire a liberation modifiee d'antagonistes des recepteurs de l'angiotensine ii |
| AU2005332300B2 (en) * | 2005-05-31 | 2011-07-07 | Mylan Laboratories, Inc. | Compositions comprising nebivolol |
| EP1812411A2 (en) * | 2005-07-05 | 2007-08-01 | Teva Pharmaceutical Industries Ltd. | Process for preparing valsartan |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| US20080227836A1 (en) * | 2005-10-31 | 2008-09-18 | Lupin Ltd | Stable Solid Oral Dosage Forms of Valsartan |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| WO2007112288A2 (en) * | 2006-03-23 | 2007-10-04 | Mount Sinai School Of Medicine | Cardiovascular composition and use the same for the treatment of alzheimers disease |
| MX2008015621A (es) | 2006-06-06 | 2009-03-06 | Oleg Iliich Epshtein | Agente medicinal para el tratamiento de obesidad, diabetes y enfermedades relacionadas con la tolerancia deteriorada de glucosa. |
| WO2008035364A2 (en) * | 2006-06-23 | 2008-03-27 | Usv Limited | Process for the preparation of micronized valsartan |
| GB0612540D0 (en) | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
| EP1897537A1 (en) * | 2006-09-04 | 2008-03-12 | Novartis AG | Composition comprising an angiotensin II receptor antagonist |
| PE20081364A1 (es) * | 2006-09-04 | 2008-12-04 | Novartis Ag | Composicion farmaceutica que comprende valsartan |
| JP2010508266A (ja) * | 2006-10-30 | 2010-03-18 | ハナル ファーマシューティカル カンパニー リミテッド | チアジド系化合物およびアンジオテンシン−ｉｉ−受容体遮断剤を含む放出性が制御された薬学的組成物 |
| WO2008064338A2 (en) * | 2006-11-22 | 2008-05-29 | Rubicon Research Pvt. Ltd. | Valsartan formulation for pulsatile delivery |
| EP2139473A1 (en) * | 2007-03-29 | 2010-01-06 | Alembic Limited | Valsartan tablet formulations |
| TR200703568A1 (tr) | 2007-05-24 | 2008-07-21 | Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� | Valsartan formülasyonları |
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