JP2002539152A5 - - Google Patents
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- Publication number
- JP2002539152A5 JP2002539152A5 JP2000604832A JP2000604832A JP2002539152A5 JP 2002539152 A5 JP2002539152 A5 JP 2002539152A5 JP 2000604832 A JP2000604832 A JP 2000604832A JP 2000604832 A JP2000604832 A JP 2000604832A JP 2002539152 A5 JP2002539152 A5 JP 2002539152A5
- Authority
- JP
- Japan
- Prior art keywords
- fifteen
- scn
- nitrate
- optionally
- ssr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 64
- 229910052717 sulfur Inorganic materials 0.000 description 62
- 229910052760 oxygen Inorganic materials 0.000 description 58
- 229910002651 NO3 Inorganic materials 0.000 description 51
- 125000001931 aliphatic group Chemical group 0.000 description 46
- 125000004432 carbon atom Chemical group C* 0.000 description 39
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 38
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 37
- 125000000217 alkyl group Chemical group 0.000 description 34
- 125000003118 aryl group Chemical group 0.000 description 33
- 125000000623 heterocyclic group Chemical group 0.000 description 33
- 125000004122 cyclic group Chemical group 0.000 description 30
- 229910052799 carbon Inorganic materials 0.000 description 28
- 229910052739 hydrogen Inorganic materials 0.000 description 26
- 229910052757 nitrogen Inorganic materials 0.000 description 20
- 238000000034 method Methods 0.000 description 17
- 125000002252 acyl group Chemical group 0.000 description 16
- 239000001257 hydrogen Substances 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 11
- 150000002431 hydrogen Chemical class 0.000 description 10
- 230000001225 therapeutic effect Effects 0.000 description 8
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical group O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 7
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 125000003282 alkyl amino group Chemical group 0.000 description 7
- 125000004947 alkyl aryl amino group Chemical group 0.000 description 7
- 125000001769 aryl amino group Chemical group 0.000 description 7
- 125000004104 aryloxy group Chemical group 0.000 description 7
- 125000004663 dialkyl amino group Chemical group 0.000 description 7
- 125000004986 diarylamino group Chemical group 0.000 description 7
- 150000002823 nitrates Chemical class 0.000 description 6
- 229910052698 phosphorus Inorganic materials 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 5
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 125000000625 hexosyl group Chemical group 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 125000001805 pentosyl group Chemical group 0.000 description 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 125000004437 phosphorous atom Chemical group 0.000 description 4
- 239000011593 sulfur Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- -1 nitrate ester Chemical class 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 208000029028 brain injury Diseases 0.000 description 2
- 229930195712 glutamate Natural products 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000002265 sensory receptor cell Anatomy 0.000 description 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 1
- 0 CN(OC)O** Chemical compound CN(OC)O** 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 108010078321 Guanylate Cyclase Proteins 0.000 description 1
- 102000014469 Guanylate cyclase Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000006931 brain damage Effects 0.000 description 1
- 231100000874 brain damage Toxicity 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000037410 cognitive enhancement Effects 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- ZWWCURLKEXEFQT-UHFFFAOYSA-N dinitrogen pentaoxide Chemical compound [O-][N+](=O)O[N+]([O-])=O ZWWCURLKEXEFQT-UHFFFAOYSA-N 0.000 description 1
- 125000002228 disulfide group Chemical group 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 150000003944 halohydrins Chemical class 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- JCZMXVGQBBATMY-UHFFFAOYSA-N nitro acetate Chemical compound CC(=O)O[N+]([O-])=O JCZMXVGQBBATMY-UHFFFAOYSA-N 0.000 description 1
- FYWSTUCDSVYLPV-UHFFFAOYSA-N nitrooxythallium Chemical compound [Tl+].[O-][N+]([O-])=O FYWSTUCDSVYLPV-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/267,379 US6310052B1 (en) | 1996-06-04 | 1999-03-15 | Nitrate esters and their use for neurological conditions |
| US09/267,379 | 1999-03-15 | ||
| PCT/CA2000/000280 WO2000054756A2 (en) | 1999-03-15 | 2000-03-15 | Nitrate esters and their use for introducing neuroprotection and cognition enhancement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002539152A JP2002539152A (ja) | 2002-11-19 |
| JP2002539152A5 true JP2002539152A5 (enExample) | 2007-05-10 |
Family
ID=23018534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604832A Pending JP2002539152A (ja) | 1999-03-15 | 2000-03-15 | 神経学的状態のための硝酸エステルおよびそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6310052B1 (enExample) |
| EP (1) | EP1163029B1 (enExample) |
| JP (1) | JP2002539152A (enExample) |
| AT (1) | ATE546195T1 (enExample) |
| AU (1) | AU783036B2 (enExample) |
| CA (1) | CA2364493C (enExample) |
| IL (1) | IL145367A0 (enExample) |
| MX (1) | MXPA01009246A (enExample) |
| WO (1) | WO2000054756A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6310052B1 (en) * | 1996-06-04 | 2001-10-30 | Queen's University At Kingston | Nitrate esters and their use for neurological conditions |
| US20050137191A1 (en) * | 1996-06-04 | 2005-06-23 | Thatcher Gregory R. | Nitrate esters and their use for mitigating cellular damage |
| US7115661B1 (en) * | 1999-12-29 | 2006-10-03 | Queen's University At Kingston | Methods and compositions for mitigating pain |
| US6491039B1 (en) | 1998-01-23 | 2002-12-10 | Innercool Therapies, Inc. | Medical procedure |
| US7371254B2 (en) | 1998-01-23 | 2008-05-13 | Innercool Therapies, Inc. | Medical procedure |
| US7202279B1 (en) | 1998-02-11 | 2007-04-10 | Georgetown University | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders |
| EP1406608B1 (en) | 2001-05-02 | 2009-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| DE10224462A1 (de) * | 2002-06-03 | 2003-12-11 | Bayer Ag | Verwendung von cGMP stimulierenden Verbindungen |
| EP1539729A4 (en) * | 2002-07-03 | 2008-02-20 | Nitromed Inc | NITROSED NON-TESTED OXIDE COMPOUNDS, COMPOSITIONS, AND APPLICATION METHODS |
| US8134010B2 (en) * | 2004-05-05 | 2012-03-13 | Renopharm Ltd. | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof |
| US7968575B2 (en) * | 2004-05-05 | 2011-06-28 | Renopharm Ltd. | Nitric oxide donors and uses thereof |
| US7498445B2 (en) * | 2004-05-05 | 2009-03-03 | Renopharm Ltd. | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof |
| WO2005105765A1 (en) * | 2004-05-05 | 2005-11-10 | Renopharm Ltd. | Nitric oxide donors and uses thereof |
| WO2006027711A2 (en) | 2004-08-26 | 2006-03-16 | Nicholas Piramal India Limited | Prodrugs and codrugs containing bio- cleavable disulfide linkers |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| CA2580627A1 (en) * | 2004-09-17 | 2006-03-23 | Queen's University At Kingston | Nitrate esters and their use for mitigating cellular damage |
| US20060293384A1 (en) * | 2004-10-16 | 2006-12-28 | Whewell Christopher J | Isethionyl nitrates and compounds thereof |
| WO2007016677A2 (en) | 2005-08-02 | 2007-02-08 | Nitromed, Inc. | Nitric oxide enhancing antimicrobial compounds, compositions and methods of use |
| WO2007126609A1 (en) | 2006-03-29 | 2007-11-08 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
| CA2649740A1 (en) * | 2008-01-14 | 2009-07-14 | Queen's University At Kingston | Therapies for cognition and learning enhancement |
| US7807716B2 (en) * | 2008-09-24 | 2010-10-05 | Oral Delivery Technology Ltd. | Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use |
| KR102210133B1 (ko) | 2009-06-09 | 2021-02-01 | 프로롱 파마슈티컬스, 엘엘씨 | 헤모글로빈 조성물 |
| US9023890B2 (en) * | 2009-12-02 | 2015-05-05 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
| CA2798272C (en) * | 2010-05-05 | 2019-03-26 | The Board Of Trustees Of The University Of Illinois | Compounds and methods of treating brain disorders |
| WO2012027471A1 (en) | 2010-08-24 | 2012-03-01 | Sgc Pharma, Inc. | Salt compound |
| US9452117B2 (en) | 2011-06-01 | 2016-09-27 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
| WO2014013338A2 (en) * | 2012-07-16 | 2014-01-23 | Sgc Pharma, Inc. | Compounds for the treatment of alzheimer's disease |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| CN108239040B (zh) * | 2016-12-26 | 2021-12-07 | 中国医学科学院药物研究所 | 硝酸2-（4-甲基噻唑-5-基）乙酯盐酸盐的制备方法 |
| CN108721239B (zh) * | 2017-04-24 | 2021-01-12 | 中国医学科学院药物研究所 | 一种治疗阿尔茨海默病的缓释制剂及其制备方法 |
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| CA792246A (en) | 1968-08-13 | Muhlbauer Ernst | Process for the preparation of substituted 1,3-oxathiol-2-ones | |
| CA764461A (en) | 1967-08-01 | Fink Walter | Metallorganic halonitrates | |
| US3962226A (en) | 1972-06-30 | 1976-06-08 | Eli Lilly And Company | 3-nitrooxycepham compounds and process for preparing desacetoxycephalosporins therefrom |
| JPS51125750A (en) | 1974-09-17 | 1976-11-02 | Rikagaku Kenkyusho | Agermicide for agricuture and gardening |
| JPS56113748A (en) | 1980-02-13 | 1981-09-07 | Kowa Co | Aminoethanol derivative and its preparation |
| US5087618A (en) | 1982-05-18 | 1992-02-11 | University Of Florida | Redox carriers for brain-specific drug delivery |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
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| JPS59171956A (ja) | 1983-03-18 | 1984-09-28 | Fuji Photo Film Co Ltd | カラ−画像形成方法 |
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| DE3512627A1 (de) | 1985-04-06 | 1986-10-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel |
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| US6140309A (en) | 1996-03-12 | 2000-10-31 | University Of South Florida | Vasoactive effects and free radical generation by β-amyloid peptides |
| US6310052B1 (en) * | 1996-06-04 | 2001-10-30 | Queen's University At Kingston | Nitrate esters and their use for neurological conditions |
| US5807847A (en) | 1996-06-04 | 1998-09-15 | Queen's University At Kingston | Nitrate esters |
| JPH1036337A (ja) | 1996-07-19 | 1998-02-10 | Sumitomo Chem Co Ltd | アリールビニルスルホンの製造方法およびその中間体 |
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| US6436996B1 (en) | 1997-09-30 | 2002-08-20 | Duke University | Modulation of nitric oxide production |
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| JPH11217330A (ja) | 1998-01-30 | 1999-08-10 | Sumitomo Pharmaceut Co Ltd | 神経栄養因子分泌促進剤 |
| WO2000001688A1 (en) | 1998-07-02 | 2000-01-13 | Sankyo Company, Limited | Five-membered heteroaryl compounds |
| AU775388B2 (en) | 1998-11-25 | 2004-07-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Scavenger compounds |
| WO2000054773A1 (en) | 1999-03-12 | 2000-09-21 | Nitromed, Inc. | Dopamine agonists in combination with nitric oxide donors, compositions and methods of use |
| CN1370044A (zh) | 1999-06-14 | 2002-09-18 | 亨利福特保健系统公司 | 用于诱导神经发生的氧化氮供体 |
-
1999
- 1999-03-15 US US09/267,379 patent/US6310052B1/en not_active Expired - Lifetime
-
2000
- 2000-03-15 AU AU32673/00A patent/AU783036B2/en not_active Ceased
- 2000-03-15 IL IL14536700A patent/IL145367A0/xx unknown
- 2000-03-15 MX MXPA01009246A patent/MXPA01009246A/es not_active Application Discontinuation
- 2000-03-15 JP JP2000604832A patent/JP2002539152A/ja active Pending
- 2000-03-15 CA CA2364493A patent/CA2364493C/en not_active Expired - Lifetime
- 2000-03-15 WO PCT/CA2000/000280 patent/WO2000054756A2/en not_active Ceased
- 2000-03-15 AT AT00910456T patent/ATE546195T1/de active
- 2000-03-15 EP EP00910456A patent/EP1163029B1/en not_active Expired - Lifetime
-
2001
- 2001-05-10 US US09/851,591 patent/US6365579B2/en not_active Expired - Lifetime
-
2002
- 2002-03-29 US US10/108,513 patent/US6677374B2/en not_active Expired - Lifetime
- 2002-05-20 US US10/147,808 patent/US6916835B2/en not_active Expired - Lifetime
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