AU783036B2 - Nitrate esters and their use for neurological conditions - Google Patents

Nitrate esters and their use for neurological conditions Download PDF

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Publication number
AU783036B2
AU783036B2 AU32673/00A AU3267300A AU783036B2 AU 783036 B2 AU783036 B2 AU 783036B2 AU 32673/00 A AU32673/00 A AU 32673/00A AU 3267300 A AU3267300 A AU 3267300A AU 783036 B2 AU783036 B2 AU 783036B2
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nitrate
scn
substituted
amino
chain
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AU3267300A (en
Inventor
Brian M. Bennett
Roland J. Boegman
Khem Jhamandas
James N. Reynolds
Gregory R.J. Thatcher
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Queens University at Kingston
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Queens University at Kingston
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/275—Nitriles; Isonitriles
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/14—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and esterified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
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    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU32673/00A 1999-03-15 2000-03-15 Nitrate esters and their use for neurological conditions Ceased AU783036B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/267379 1999-03-15
US09/267,379 US6310052B1 (en) 1996-06-04 1999-03-15 Nitrate esters and their use for neurological conditions
PCT/CA2000/000280 WO2000054756A2 (en) 1999-03-15 2000-03-15 Nitrate esters and their use for introducing neuroprotection and cognition enhancement

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AU3267300A AU3267300A (en) 2000-10-04
AU783036B2 true AU783036B2 (en) 2005-09-15

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AU32673/00A Ceased AU783036B2 (en) 1999-03-15 2000-03-15 Nitrate esters and their use for neurological conditions

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US (4) US6310052B1 (enExample)
EP (1) EP1163029B1 (enExample)
JP (1) JP2002539152A (enExample)
AT (1) ATE546195T1 (enExample)
AU (1) AU783036B2 (enExample)
CA (1) CA2364493C (enExample)
IL (1) IL145367A0 (enExample)
MX (1) MXPA01009246A (enExample)
WO (1) WO2000054756A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310052B1 (en) * 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
US7115661B1 (en) * 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US6491039B1 (en) 1998-01-23 2002-12-10 Innercool Therapies, Inc. Medical procedure
US7371254B2 (en) 1998-01-23 2008-05-13 Innercool Therapies, Inc. Medical procedure
US7202279B1 (en) 1998-02-11 2007-04-10 Georgetown University Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
EP1406608B1 (en) 2001-05-02 2009-07-29 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
DE10224462A1 (de) * 2002-06-03 2003-12-11 Bayer Ag Verwendung von cGMP stimulierenden Verbindungen
EP1539729A4 (en) * 2002-07-03 2008-02-20 Nitromed Inc NITROSED NON-TESTED OXIDE COMPOUNDS, COMPOSITIONS, AND APPLICATION METHODS
US8134010B2 (en) * 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
US7968575B2 (en) * 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
US7498445B2 (en) * 2004-05-05 2009-03-03 Renopharm Ltd. Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
WO2005105765A1 (en) * 2004-05-05 2005-11-10 Renopharm Ltd. Nitric oxide donors and uses thereof
WO2006027711A2 (en) 2004-08-26 2006-03-16 Nicholas Piramal India Limited Prodrugs and codrugs containing bio- cleavable disulfide linkers
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
CA2580627A1 (en) * 2004-09-17 2006-03-23 Queen's University At Kingston Nitrate esters and their use for mitigating cellular damage
US20060293384A1 (en) * 2004-10-16 2006-12-28 Whewell Christopher J Isethionyl nitrates and compounds thereof
WO2007016677A2 (en) 2005-08-02 2007-02-08 Nitromed, Inc. Nitric oxide enhancing antimicrobial compounds, compositions and methods of use
WO2007126609A1 (en) 2006-03-29 2007-11-08 Nitromed, Inc. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
CA2649740A1 (en) * 2008-01-14 2009-07-14 Queen's University At Kingston Therapies for cognition and learning enhancement
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
KR102210133B1 (ko) 2009-06-09 2021-02-01 프로롱 파마슈티컬스, 엘엘씨 헤모글로빈 조성물
US9023890B2 (en) * 2009-12-02 2015-05-05 The Charlotte-Mecklenburg Hospital Authority Nitrate esters and their use for the treatment of muscle and muscle related diseases
CA2798272C (en) * 2010-05-05 2019-03-26 The Board Of Trustees Of The University Of Illinois Compounds and methods of treating brain disorders
WO2012027471A1 (en) 2010-08-24 2012-03-01 Sgc Pharma, Inc. Salt compound
US9452117B2 (en) 2011-06-01 2016-09-27 The Charlotte-Mecklenburg Hospital Authority Nitrate esters and their use for the treatment of muscle and muscle related diseases
WO2014013338A2 (en) * 2012-07-16 2014-01-23 Sgc Pharma, Inc. Compounds for the treatment of alzheimer's disease
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
CN108239040B (zh) * 2016-12-26 2021-12-07 中国医学科学院药物研究所 硝酸2-（4-甲基噻唑-5-基）乙酯盐酸盐的制备方法
CN108721239B (zh) * 2017-04-24 2021-01-12 中国医学科学院药物研究所 一种治疗阿尔茨海默病的缓释制剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455279A (en) * 1991-04-19 1995-10-03 The Children's Medical Center Corporation Regimen method of mediating neuronal damage using nitroglycerine
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
WO1998043621A1 (en) * 1997-03-31 1998-10-08 The Children's Medical Center Corporation Nitrosylation to inactivate apoptotic enzymes

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA792246A (en) 1968-08-13 Muhlbauer Ernst Process for the preparation of substituted 1,3-oxathiol-2-ones
CA764461A (en) 1967-08-01 Fink Walter Metallorganic halonitrates
US3962226A (en) 1972-06-30 1976-06-08 Eli Lilly And Company 3-nitrooxycepham compounds and process for preparing desacetoxycephalosporins therefrom
JPS51125750A (en) 1974-09-17 1976-11-02 Rikagaku Kenkyusho Agermicide for agricuture and gardening
JPS56113748A (en) 1980-02-13 1981-09-07 Kowa Co Aminoethanol derivative and its preparation
US5087618A (en) 1982-05-18 1992-02-11 University Of Florida Redox carriers for brain-specific drug delivery
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS5942390A (ja) 1982-09-02 1984-03-08 Otsuka Chem Co Ltd セフアロスポリン化合物の製造法
JPS5946292A (ja) 1982-09-09 1984-03-15 Otsuka Chem Co Ltd ２−置換セフエム誘導体の製造法
JPS59171956A (ja) 1983-03-18 1984-09-28 Fuji Photo Film Co Ltd カラ−画像形成方法
DE3443998A1 (de) 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
JPS62205052A (ja) 1986-03-05 1987-09-09 Terumo Corp 硝酸エステル誘導体およびこれを含有する血管拡張剤
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
JPH0726949B2 (ja) 1988-06-01 1995-03-29 住友化学工業株式会社 抽出溶媒の劣化度測定方法
US5428061A (en) 1988-09-15 1995-06-27 Schwarz Pharma Ag Organic nitrates and method for their preparation
NL8802276A (nl) 1988-09-15 1990-04-02 Cedona Pharm Bv Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat.
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5284872A (en) 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
DE4004841A1 (de) 1990-02-16 1991-08-22 Boehringer Mannheim Gmbh Salpetersaeureester von cyclohexanol-derivaten
EP0581856B1 (en) 1991-04-19 1999-07-14 The Children's Medical Center Corporation Method of preventing nmda receptor complex-mediated neuronal damage
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
HUT72416A (en) 1993-03-15 1996-04-29 Byk Nederland Bv Substituted alkyl-nitrates and their use to prepare pharmaceuticals for the treatment of pathologically increased intraocular pressure
DE4321306A1 (de) 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
JPH0726949A (ja) 1993-07-07 1995-01-27 Nissan Motor Co Ltd 内燃機関の排気２次空気導入装置
US5700947A (en) 1993-10-06 1997-12-23 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1995030641A1 (en) 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
JPH09202764A (ja) 1996-01-24 1997-08-05 Chugai Pharmaceut Co Ltd ニトロ化合物
US6140309A (en) 1996-03-12 2000-10-31 University Of South Florida Vasoactive effects and free radical generation by β-amyloid peptides
US6310052B1 (en) * 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
JPH1036337A (ja) 1996-07-19 1998-02-10 Sumitomo Chem Co Ltd アリールビニルスルホンの製造方法およびその中間体
US6008221A (en) 1996-11-06 1999-12-28 Bristol-Myers Squibb Company Method for treating Alzheimer's disease with folic acid
US5972943A (en) 1996-11-19 1999-10-26 Nisshin Flour Milling Co., Ltd. Pyridinecarboxamide derivatives
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US6436996B1 (en) 1997-09-30 2002-08-20 Duke University Modulation of nitric oxide production
GB9726989D0 (en) 1997-12-22 1998-02-18 Ciba Geigy Ag Organic compounds
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
JPH11217330A (ja) 1998-01-30 1999-08-10 Sumitomo Pharmaceut Co Ltd 神経栄養因子分泌促進剤
WO2000001688A1 (en) 1998-07-02 2000-01-13 Sankyo Company, Limited Five-membered heteroaryl compounds
AU775388B2 (en) 1998-11-25 2004-07-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Scavenger compounds
WO2000054773A1 (en) 1999-03-12 2000-09-21 Nitromed, Inc. Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
CN1370044A (zh) 1999-06-14 2002-09-18 亨利福特保健系统公司 用于诱导神经发生的氧化氮供体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455279A (en) * 1991-04-19 1995-10-03 The Children's Medical Center Corporation Regimen method of mediating neuronal damage using nitroglycerine
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
WO1998043621A1 (en) * 1997-03-31 1998-10-08 The Children's Medical Center Corporation Nitrosylation to inactivate apoptotic enzymes

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