JP2002536013A5 - - Google Patents
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- JP2002536013A5 JP2002536013A5 JP2000598619A JP2000598619A JP2002536013A5 JP 2002536013 A5 JP2002536013 A5 JP 2002536013A5 JP 2000598619 A JP2000598619 A JP 2000598619A JP 2000598619 A JP2000598619 A JP 2000598619A JP 2002536013 A5 JP2002536013 A5 JP 2002536013A5
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- Prior art keywords
- dendritic cells
- imidazoquinoline
- disease
- treating
- stimulating
- Prior art date
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- 210000004443 dendritic cell Anatomy 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 230000028993 immune response Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
Description
【特許請求の範囲】
【請求項1】 イミダゾキノリン型免疫応答改良化合物で未成熟な樹状細胞を刺激するステップを含む、前記未成熟な樹状細胞をインビトロにおいて成熟化する方法。
【請求項2】 イミダゾキノリン型免疫応答改良化合物で樹状細胞を刺激するステップを含む、樹状細胞の抗原提示能力を増強する方法。
【請求項3】 疾患を治療するための細胞アジュバントを作製する方法であって、
(a)イミダゾキノリン型免疫応答改良化合物で樹状細胞を処理することによってインビトロにおいて樹状細胞を成熟化するステップと、
(b)前記疾患に関連する抗原に前記成熟した樹状細胞を暴露するステップとを含む方法。
【請求項4】 イミダゾキノリン型IRMで刺激することによって成熟化した治療的に有効量の樹状細胞をそのような治療を必要としている哺乳類に投与するステップを含む、疾患を治療する方法。
【請求項1】 イミダゾキノリン型免疫応答改良化合物で未成熟な樹状細胞を刺激するステップを含む、前記未成熟な樹状細胞をインビトロにおいて成熟化する方法。
【請求項2】 イミダゾキノリン型免疫応答改良化合物で樹状細胞を刺激するステップを含む、樹状細胞の抗原提示能力を増強する方法。
【請求項3】 疾患を治療するための細胞アジュバントを作製する方法であって、
(a)イミダゾキノリン型免疫応答改良化合物で樹状細胞を処理することによってインビトロにおいて樹状細胞を成熟化するステップと、
(b)前記疾患に関連する抗原に前記成熟した樹状細胞を暴露するステップとを含む方法。
【請求項4】 イミダゾキノリン型IRMで刺激することによって成熟化した治療的に有効量の樹状細胞をそのような治療を必要としている哺乳類に投与するステップを含む、疾患を治療する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/248,439 US6558951B1 (en) | 1999-02-11 | 1999-02-11 | Maturation of dendritic cells with immune response modifying compounds |
US09/248,439 | 1999-02-11 | ||
PCT/US2000/000757 WO2000047719A2 (en) | 1999-02-11 | 2000-01-12 | Maturation of dendritic cells with immune response modifying compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002536013A JP2002536013A (ja) | 2002-10-29 |
JP2002536013A5 true JP2002536013A5 (ja) | 2007-02-15 |
Family
ID=22939138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000598619A Withdrawn JP2002536013A (ja) | 1999-02-11 | 2000-01-12 | 免疫応答改良化合物による樹状細胞の成熟化 |
Country Status (10)
Country | Link |
---|---|
US (2) | US6558951B1 (ja) |
EP (1) | EP1153122B1 (ja) |
JP (1) | JP2002536013A (ja) |
AT (1) | ATE366800T1 (ja) |
AU (1) | AU2504300A (ja) |
CA (1) | CA2362377A1 (ja) |
DE (1) | DE60035487T2 (ja) |
ES (1) | ES2286996T3 (ja) |
NO (1) | NO20013875L (ja) |
WO (1) | WO2000047719A2 (ja) |
Families Citing this family (178)
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