JP2002533431A5 - - Google Patents
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- Publication number
- JP2002533431A5 JP2002533431A5 JP2000590987A JP2000590987A JP2002533431A5 JP 2002533431 A5 JP2002533431 A5 JP 2002533431A5 JP 2000590987 A JP2000590987 A JP 2000590987A JP 2000590987 A JP2000590987 A JP 2000590987A JP 2002533431 A5 JP2002533431 A5 JP 2002533431A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- nitromethyl
- acid
- group
- diphenylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- KTVHUWOVEOQHPU-UHFFFAOYSA-N 2-[1-(nitromethyl)cyclohexyl]acetic acid Chemical compound OC(=O)CC1(C[N+]([O-])=O)CCCCC1 KTVHUWOVEOQHPU-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- UKYISVNNIPKTNG-UHFFFAOYSA-N 2-cyclohexylideneacetic acid Chemical compound OC(=O)C=C1CCCCC1 UKYISVNNIPKTNG-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 125000005907 alkyl ester group Chemical group 0.000 description 3
- -1 benzyl halide Chemical class 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- JCCOEMBKLSKROY-UHFFFAOYSA-N benzyl 2-[1-(nitromethyl)cyclohexyl]acetate Chemical compound C=1C=CC=CC=1COC(=O)CC1(C[N+](=O)[O-])CCCCC1 JCCOEMBKLSKROY-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9803034A HU225502B1 (en) | 1998-12-29 | 1998-12-29 | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
| HU9803034 | 1998-12-29 | ||
| PCT/HU1999/000102 WO2000039074A1 (en) | 1998-12-29 | 1999-12-23 | Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002533431A JP2002533431A (ja) | 2002-10-08 |
| JP2002533431A5 true JP2002533431A5 (enExample) | 2007-03-01 |
Family
ID=89997614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000590987A Pending JP2002533431A (ja) | 1998-12-29 | 1999-12-23 | １−（アミノメチル）シクロヘキシル酢酸の合成方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6765114B1 (enExample) |
| JP (1) | JP2002533431A (enExample) |
| CN (1) | CN1221525C (enExample) |
| AT (1) | ATE250569T1 (enExample) |
| AU (1) | AU1996300A (enExample) |
| BG (1) | BG65056B1 (enExample) |
| CA (1) | CA2349826C (enExample) |
| CZ (1) | CZ301922B6 (enExample) |
| DE (1) | DE69911646T2 (enExample) |
| DK (1) | DK1140793T3 (enExample) |
| EA (1) | EA003555B1 (enExample) |
| EE (1) | EE04587B1 (enExample) |
| ES (1) | ES2207979T3 (enExample) |
| HU (1) | HU225502B1 (enExample) |
| PL (1) | PL196854B1 (enExample) |
| SK (1) | SK287019B6 (enExample) |
| UA (1) | UA73108C2 (enExample) |
| WO (1) | WO2000039074A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001097782A1 (en) * | 2000-06-16 | 2001-12-27 | Teva Pharmaceutical Industries, Ltd. | Stable gabapentin having ph within a controlled range |
| JP5144656B2 (ja) * | 2006-06-30 | 2013-02-13 | ザック システム エス．ピー．エー． | ガバペンチンの調製プロセス |
| CN102112436A (zh) * | 2008-06-03 | 2011-06-29 | 基因里克斯(英国)有限公司 | 用于合成氨基酸的新的和有效方法 |
| CN104974037B (zh) * | 2014-04-13 | 2019-04-30 | 江苏康缘药业股份有限公司 | 一种含羧基多羰基姜黄素衍生物及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3253039A (en) * | 1962-02-05 | 1966-05-24 | Engelhard Ind Inc | Catalytic hydrogenation of organic nitrocompounds |
| US3594419A (en) * | 1968-04-15 | 1971-07-20 | Gulf Research Development Co | Process for converting nitroparaffins to amines |
| US3766271A (en) * | 1971-03-04 | 1973-10-16 | Texaco Inc | Homogeneous catalysts useful in the reduction of nitroparaffins to amines |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
| DE3928182A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
| DE3928183A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
| FI905584A7 (fi) * | 1989-11-16 | 1991-05-17 | Lonza Ag | Menetelmä 1-(aminometyyli)sykloheksaanietikkahapon valmistamiseksi |
| BR9813284B1 (pt) * | 1997-10-27 | 2012-08-21 | aminoácidos cìclicos e derivados dos mesmos úteis como agentes farmacêuticos e composição farmacêutica. |
-
1998
- 1998-12-29 HU HU9803034A patent/HU225502B1/hu not_active IP Right Cessation
-
1999
- 1999-12-23 EA EA200100723A patent/EA003555B1/ru not_active IP Right Cessation
- 1999-12-23 DK DK99963652T patent/DK1140793T3/da active
- 1999-12-23 ES ES99963652T patent/ES2207979T3/es not_active Expired - Lifetime
- 1999-12-23 CN CNB998129593A patent/CN1221525C/zh not_active Expired - Fee Related
- 1999-12-23 EE EEP200100295A patent/EE04587B1/xx not_active IP Right Cessation
- 1999-12-23 SK SK937-2001A patent/SK287019B6/sk not_active IP Right Cessation
- 1999-12-23 PL PL348461A patent/PL196854B1/pl not_active IP Right Cessation
- 1999-12-23 CZ CZ20012070A patent/CZ301922B6/cs not_active IP Right Cessation
- 1999-12-23 AT AT99963652T patent/ATE250569T1/de not_active IP Right Cessation
- 1999-12-23 CA CA002349826A patent/CA2349826C/en not_active Expired - Fee Related
- 1999-12-23 WO PCT/HU1999/000102 patent/WO2000039074A1/en not_active Ceased
- 1999-12-23 US US09/856,517 patent/US6765114B1/en not_active Expired - Fee Related
- 1999-12-23 AU AU19963/00A patent/AU1996300A/en not_active Abandoned
- 1999-12-23 UA UA2001075268A patent/UA73108C2/uk unknown
- 1999-12-23 JP JP2000590987A patent/JP2002533431A/ja active Pending
- 1999-12-23 DE DE69911646T patent/DE69911646T2/de not_active Expired - Lifetime
-
2001
- 2001-05-07 BG BG105491A patent/BG65056B1/bg unknown
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