ATE250569T1 - Verfahren zur herstellung von 1- aminomethylcyclohexanessigsäure - Google Patents
Verfahren zur herstellung von 1- aminomethylcyclohexanessigsäureInfo
- Publication number
- ATE250569T1 ATE250569T1 AT99963652T AT99963652T ATE250569T1 AT E250569 T1 ATE250569 T1 AT E250569T1 AT 99963652 T AT99963652 T AT 99963652T AT 99963652 T AT99963652 T AT 99963652T AT E250569 T1 ATE250569 T1 AT E250569T1
- Authority
- AT
- Austria
- Prior art keywords
- aminomethylcyclohexanetic
- producing
- acid
- cyclohexyl
- formula
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- KTVHUWOVEOQHPU-UHFFFAOYSA-N 2-[1-(nitromethyl)cyclohexyl]acetic acid Chemical class OC(=O)CC1(C[N+]([O-])=O)CCCCC1 KTVHUWOVEOQHPU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9803034A HU225502B1 (en) | 1998-12-29 | 1998-12-29 | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
| PCT/HU1999/000102 WO2000039074A1 (en) | 1998-12-29 | 1999-12-23 | Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250569T1 true ATE250569T1 (de) | 2003-10-15 |
Family
ID=89997614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99963652T ATE250569T1 (de) | 1998-12-29 | 1999-12-23 | Verfahren zur herstellung von 1- aminomethylcyclohexanessigsäure |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6765114B1 (enExample) |
| JP (1) | JP2002533431A (enExample) |
| CN (1) | CN1221525C (enExample) |
| AT (1) | ATE250569T1 (enExample) |
| AU (1) | AU1996300A (enExample) |
| BG (1) | BG65056B1 (enExample) |
| CA (1) | CA2349826C (enExample) |
| CZ (1) | CZ301922B6 (enExample) |
| DE (1) | DE69911646T2 (enExample) |
| DK (1) | DK1140793T3 (enExample) |
| EA (1) | EA003555B1 (enExample) |
| EE (1) | EE04587B1 (enExample) |
| ES (1) | ES2207979T3 (enExample) |
| HU (1) | HU225502B1 (enExample) |
| PL (1) | PL196854B1 (enExample) |
| SK (1) | SK287019B6 (enExample) |
| UA (1) | UA73108C2 (enExample) |
| WO (1) | WO2000039074A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL363155A1 (en) * | 2000-06-16 | 2004-11-15 | Teva Pharmaceutical Industries, Ltd. | Stable gabapentin having ph within a controlled range |
| CA2660769C (en) * | 2006-06-30 | 2013-12-03 | Zach System S.P.A. | Process for preparing gabapentin |
| WO2009147434A1 (en) * | 2008-06-03 | 2009-12-10 | Generics [Uk] Limited | A novel and efficient method for the synthesis of an amino acid |
| CN104974037B (zh) * | 2014-04-13 | 2019-04-30 | 江苏康缘药业股份有限公司 | 一种含羧基多羰基姜黄素衍生物及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3253039A (en) * | 1962-02-05 | 1966-05-24 | Engelhard Ind Inc | Catalytic hydrogenation of organic nitrocompounds |
| US3594419A (en) * | 1968-04-15 | 1971-07-20 | Gulf Research Development Co | Process for converting nitroparaffins to amines |
| US3766271A (en) * | 1971-03-04 | 1973-10-16 | Texaco Inc | Homogeneous catalysts useful in the reduction of nitroparaffins to amines |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
| DE3928182A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
| DE3928183A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
| FI905584A7 (fi) * | 1989-11-16 | 1991-05-17 | Lonza Ag | Menetelmä 1-(aminometyyli)sykloheksaanietikkahapon valmistamiseksi |
| CN1303059C (zh) | 1997-10-27 | 2007-03-07 | 沃尼尔·朗伯公司 | 作为药物的环状氨基酸及其衍生物 |
-
1998
- 1998-12-29 HU HU9803034A patent/HU225502B1/hu not_active IP Right Cessation
-
1999
- 1999-12-23 CZ CZ20012070A patent/CZ301922B6/cs not_active IP Right Cessation
- 1999-12-23 EE EEP200100295A patent/EE04587B1/xx not_active IP Right Cessation
- 1999-12-23 US US09/856,517 patent/US6765114B1/en not_active Expired - Fee Related
- 1999-12-23 ES ES99963652T patent/ES2207979T3/es not_active Expired - Lifetime
- 1999-12-23 EA EA200100723A patent/EA003555B1/ru not_active IP Right Cessation
- 1999-12-23 JP JP2000590987A patent/JP2002533431A/ja active Pending
- 1999-12-23 AU AU19963/00A patent/AU1996300A/en not_active Abandoned
- 1999-12-23 DK DK99963652T patent/DK1140793T3/da active
- 1999-12-23 UA UA2001075268A patent/UA73108C2/uk unknown
- 1999-12-23 PL PL348461A patent/PL196854B1/pl not_active IP Right Cessation
- 1999-12-23 CN CNB998129593A patent/CN1221525C/zh not_active Expired - Fee Related
- 1999-12-23 DE DE69911646T patent/DE69911646T2/de not_active Expired - Lifetime
- 1999-12-23 SK SK937-2001A patent/SK287019B6/sk not_active IP Right Cessation
- 1999-12-23 WO PCT/HU1999/000102 patent/WO2000039074A1/en not_active Ceased
- 1999-12-23 CA CA002349826A patent/CA2349826C/en not_active Expired - Fee Related
- 1999-12-23 AT AT99963652T patent/ATE250569T1/de not_active IP Right Cessation
-
2001
- 2001-05-07 BG BG105491A patent/BG65056B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000039074A1 (en) | 2000-07-06 |
| PL348461A1 (en) | 2002-05-20 |
| JP2002533431A (ja) | 2002-10-08 |
| DK1140793T3 (da) | 2004-02-02 |
| CA2349826A1 (en) | 2000-07-06 |
| SK9372001A3 (en) | 2002-01-07 |
| BG65056B1 (bg) | 2007-01-31 |
| HU225502B1 (en) | 2007-01-29 |
| CN1325378A (zh) | 2001-12-05 |
| PL196854B1 (pl) | 2008-02-29 |
| EA200100723A1 (ru) | 2001-12-24 |
| US6765114B1 (en) | 2004-07-20 |
| BG105491A (en) | 2001-12-29 |
| SK287019B6 (sk) | 2009-09-07 |
| EE04587B1 (et) | 2006-02-15 |
| AU1996300A (en) | 2000-07-31 |
| DE69911646T2 (de) | 2004-07-08 |
| CA2349826C (en) | 2009-05-12 |
| EE200100295A (et) | 2002-12-16 |
| CN1221525C (zh) | 2005-10-05 |
| HUP9803034A2 (hu) | 2001-02-28 |
| DE69911646D1 (de) | 2003-10-30 |
| HU9803034D0 (en) | 1999-02-01 |
| ES2207979T3 (es) | 2004-06-01 |
| UA73108C2 (en) | 2005-06-15 |
| EA003555B1 (ru) | 2003-06-26 |
| CZ301922B6 (cs) | 2010-07-28 |
| CZ20012070A3 (cs) | 2001-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1140793 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |