HUP9803034A2 - Eljárás 1-(aminometil)-ciklohexán ecetsav előállítására és új köztitermékek - Google Patents
Eljárás 1-(aminometil)-ciklohexán ecetsav előállítására és új köztitermékekInfo
- Publication number
- HUP9803034A2 HUP9803034A2 HU9803034A HUP9803034A HUP9803034A2 HU P9803034 A2 HUP9803034 A2 HU P9803034A2 HU 9803034 A HU9803034 A HU 9803034A HU P9803034 A HUP9803034 A HU P9803034A HU P9803034 A2 HUP9803034 A2 HU P9803034A2
- Authority
- HU
- Hungary
- Prior art keywords
- amino
- acetic
- metyl
- cyclohexene
- acid
- Prior art date
Links
- BJOKVBITSGPVGY-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohex-2-en-1-yl]acetic acid Chemical compound OC(=O)CC1(CN)CCCC=C1 BJOKVBITSGPVGY-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 abstract 2
- KTVHUWOVEOQHPU-UHFFFAOYSA-N 2-[1-(nitromethyl)cyclohexyl]acetic acid Chemical class OC(=O)CC1(C[N+]([O-])=O)CCCCC1 KTVHUWOVEOQHPU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány tárgya új eljárás az (I) képletű 1-(amino-metil)-ciklohexil-ecetsav előállítására új (II) általános képletű 1-(nitro-metil)-ciklohexil-ecetsav-származék köztitermékeken keresztül, ahol Rjelentése hidrogénatom, benzilcsoport, difenil-metil-csoport vagy ezekaromás gyűrűn 1-4 szénatomos alkil- vagy alkoxicsoporttalszubsztituált származékai. Ó
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9803034A HU225502B1 (en) | 1998-12-29 | 1998-12-29 | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
JP2000590987A JP2002533431A (ja) | 1998-12-29 | 1999-12-23 | 1−(アミノメチル)シクロヘキシル酢酸の合成方法 |
UA2001075268A UA73108C2 (en) | 1998-12-29 | 1999-12-23 | Method of synthesis of 1-(aminomethyl)cyclohexyl-acetic acid and intermedier compounds |
PL348461A PL196854B1 (pl) | 1998-12-29 | 1999-12-23 | Sposób syntezy kwasu 1-(aminometylo)cykloheksylooctowego |
CZ20012070A CZ301922B6 (cs) | 1998-12-29 | 1999-12-23 | Zpusob prípravy kyseliny 1-(aminomethyl)cyklohexyloctové a meziprodukt pri její príprave |
DE69911646T DE69911646T2 (de) | 1998-12-29 | 1999-12-23 | Verfahren zur herstellung von 1-aminomethylcyclohexanessigsäure |
CA002349826A CA2349826C (en) | 1998-12-29 | 1999-12-23 | Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid |
EEP200100295A EE04587B1 (et) | 1998-12-29 | 1999-12-23 | 1-(aminometüül)tsükloheksüüläädikhappe sünteesi protsess |
CNB998129593A CN1221525C (zh) | 1998-12-29 | 1999-12-23 | 1-(氨甲基)环己基乙酸的合成方法 |
AT99963652T ATE250569T1 (de) | 1998-12-29 | 1999-12-23 | Verfahren zur herstellung von 1- aminomethylcyclohexanessigsäure |
DK99963652T DK1140793T3 (da) | 1998-12-29 | 1999-12-23 | Fremgangsmåde til syntese af 1-(aminomethyl)cyclohexyl-eddikesyre |
ES99963652T ES2207979T3 (es) | 1998-12-29 | 1999-12-23 | Proceso para la sintesis de acido 1-(amino-metil)-ciclohexil-acetico. |
AU19963/00A AU1996300A (en) | 1998-12-29 | 1999-12-23 | Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid |
EA200100723A EA003555B1 (ru) | 1998-12-29 | 1999-12-23 | Способ получения 1-(аминометил)циклогексилуксусной кислоты |
SK937-2001A SK287019B6 (sk) | 1998-12-29 | 1999-12-23 | Spôsob prípravy kyseliny 1-(aminometyl)cyklohexyloctovej a medziprodukt pri jej príprave |
US09/856,517 US6765114B1 (en) | 1998-12-29 | 1999-12-23 | Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid |
PCT/HU1999/000102 WO2000039074A1 (en) | 1998-12-29 | 1999-12-23 | Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid |
BG105491A BG65056B1 (bg) | 1998-12-29 | 2001-05-07 | Метод за синтез на 1-(аминометил)циклохексилоцетна киселина |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9803034A HU225502B1 (en) | 1998-12-29 | 1998-12-29 | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9803034D0 HU9803034D0 (en) | 1999-02-01 |
HUP9803034A2 true HUP9803034A2 (hu) | 2001-02-28 |
HU225502B1 HU225502B1 (en) | 2007-01-29 |
Family
ID=89997614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9803034A HU225502B1 (en) | 1998-12-29 | 1998-12-29 | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
Country Status (18)
Country | Link |
---|---|
US (1) | US6765114B1 (hu) |
JP (1) | JP2002533431A (hu) |
CN (1) | CN1221525C (hu) |
AT (1) | ATE250569T1 (hu) |
AU (1) | AU1996300A (hu) |
BG (1) | BG65056B1 (hu) |
CA (1) | CA2349826C (hu) |
CZ (1) | CZ301922B6 (hu) |
DE (1) | DE69911646T2 (hu) |
DK (1) | DK1140793T3 (hu) |
EA (1) | EA003555B1 (hu) |
EE (1) | EE04587B1 (hu) |
ES (1) | ES2207979T3 (hu) |
HU (1) | HU225502B1 (hu) |
PL (1) | PL196854B1 (hu) |
SK (1) | SK287019B6 (hu) |
UA (1) | UA73108C2 (hu) |
WO (1) | WO2000039074A1 (hu) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL153441A0 (en) * | 2000-06-16 | 2003-07-06 | Teva Pharma | Stable gabapentin having ph within a controlled range |
CA2660769C (en) * | 2006-06-30 | 2013-12-03 | Zach System S.P.A. | Process for preparing gabapentin |
US20110190393A1 (en) * | 2008-06-03 | 2011-08-04 | Generics (Uk) Limited | Novel and efficient method for the synthesis of an amino acid |
CN104974037B (zh) * | 2014-04-13 | 2019-04-30 | 江苏康缘药业股份有限公司 | 一种含羧基多羰基姜黄素衍生物及其制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3253039A (en) * | 1962-02-05 | 1966-05-24 | Engelhard Ind Inc | Catalytic hydrogenation of organic nitrocompounds |
US3594419A (en) * | 1968-04-15 | 1971-07-20 | Gulf Research Development Co | Process for converting nitroparaffins to amines |
US3766271A (en) * | 1971-03-04 | 1973-10-16 | Texaco Inc | Homogeneous catalysts useful in the reduction of nitroparaffins to amines |
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
DE3928183A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
DE3928182A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
FI905584A (fi) | 1989-11-16 | 1991-05-17 | Lonza Ag | Foerfarande foer framstaellning av 1-(aminometyl)cyklohexanaettikssyra. |
CA2303244C (en) * | 1997-10-27 | 2005-12-06 | Warner-Lambert Company | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents |
-
1998
- 1998-12-29 HU HU9803034A patent/HU225502B1/hu not_active IP Right Cessation
-
1999
- 1999-12-23 EE EEP200100295A patent/EE04587B1/xx not_active IP Right Cessation
- 1999-12-23 JP JP2000590987A patent/JP2002533431A/ja active Pending
- 1999-12-23 AT AT99963652T patent/ATE250569T1/de not_active IP Right Cessation
- 1999-12-23 DE DE69911646T patent/DE69911646T2/de not_active Expired - Lifetime
- 1999-12-23 WO PCT/HU1999/000102 patent/WO2000039074A1/en active IP Right Grant
- 1999-12-23 CA CA002349826A patent/CA2349826C/en not_active Expired - Fee Related
- 1999-12-23 SK SK937-2001A patent/SK287019B6/sk not_active IP Right Cessation
- 1999-12-23 EA EA200100723A patent/EA003555B1/ru not_active IP Right Cessation
- 1999-12-23 ES ES99963652T patent/ES2207979T3/es not_active Expired - Lifetime
- 1999-12-23 UA UA2001075268A patent/UA73108C2/uk unknown
- 1999-12-23 PL PL348461A patent/PL196854B1/pl not_active IP Right Cessation
- 1999-12-23 AU AU19963/00A patent/AU1996300A/en not_active Abandoned
- 1999-12-23 US US09/856,517 patent/US6765114B1/en not_active Expired - Fee Related
- 1999-12-23 DK DK99963652T patent/DK1140793T3/da active
- 1999-12-23 CZ CZ20012070A patent/CZ301922B6/cs not_active IP Right Cessation
- 1999-12-23 CN CNB998129593A patent/CN1221525C/zh not_active Expired - Fee Related
-
2001
- 2001-05-07 BG BG105491A patent/BG65056B1/bg unknown
Also Published As
Publication number | Publication date |
---|---|
PL196854B1 (pl) | 2008-02-29 |
EA003555B1 (ru) | 2003-06-26 |
CN1221525C (zh) | 2005-10-05 |
CZ20012070A3 (cs) | 2001-09-12 |
DE69911646D1 (de) | 2003-10-30 |
BG105491A (en) | 2001-12-29 |
WO2000039074A1 (en) | 2000-07-06 |
BG65056B1 (bg) | 2007-01-31 |
CA2349826C (en) | 2009-05-12 |
US6765114B1 (en) | 2004-07-20 |
JP2002533431A (ja) | 2002-10-08 |
CN1325378A (zh) | 2001-12-05 |
CZ301922B6 (cs) | 2010-07-28 |
UA73108C2 (en) | 2005-06-15 |
AU1996300A (en) | 2000-07-31 |
HU9803034D0 (en) | 1999-02-01 |
DE69911646T2 (de) | 2004-07-08 |
ATE250569T1 (de) | 2003-10-15 |
SK9372001A3 (en) | 2002-01-07 |
DK1140793T3 (da) | 2004-02-02 |
PL348461A1 (en) | 2002-05-20 |
EE04587B1 (et) | 2006-02-15 |
CA2349826A1 (en) | 2000-07-06 |
SK287019B6 (sk) | 2009-09-07 |
ES2207979T3 (es) | 2004-06-01 |
HU225502B1 (en) | 2007-01-29 |
EA200100723A1 (ru) | 2001-12-24 |
EE200100295A (et) | 2002-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: RICHTER GEDEON NYRT., HU Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU |
|
MM4A | Lapse of definitive patent protection due to non-payment of fees |