JP2002528393A5 - - Google Patents
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- JP2002528393A5 JP2002528393A5 JP2000577627A JP2000577627A JP2002528393A5 JP 2002528393 A5 JP2002528393 A5 JP 2002528393A5 JP 2000577627 A JP2000577627 A JP 2000577627A JP 2000577627 A JP2000577627 A JP 2000577627A JP 2002528393 A5 JP2002528393 A5 JP 2002528393A5
- Authority
- JP
- Japan
- Prior art keywords
- tnf
- serum
- cells
- ccr5
- vlp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 13
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 description 13
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- 108700031455 Bovine papillomavirus L2 Proteins 0.000 description 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 1
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- 241001529936 Murinae Species 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
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- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10513298P | 1998-10-21 | 1998-10-21 | |
| US60/105,132 | 1998-10-21 | ||
| PCT/US1999/024548 WO2000023955A1 (en) | 1998-10-21 | 1999-10-20 | Virus-like particles for the induction of autoantibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002528393A JP2002528393A (ja) | 2002-09-03 |
| JP2002528393A5 true JP2002528393A5 (https=) | 2006-12-28 |
| JP4486257B2 JP4486257B2 (ja) | 2010-06-23 |
Family
ID=22304219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000577627A Expired - Lifetime JP4486257B2 (ja) | 1998-10-21 | 1999-10-20 | 自己抗体の誘導のためのウイルス様粒子 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6719978B2 (https=) |
| EP (1) | EP1123114B1 (https=) |
| JP (1) | JP4486257B2 (https=) |
| AT (1) | ATE314095T1 (https=) |
| AU (1) | AU770802B2 (https=) |
| CA (1) | CA2347411C (https=) |
| DE (1) | DE69929232T2 (https=) |
| ES (1) | ES2258869T3 (https=) |
| WO (1) | WO2000023955A1 (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5437951A (en) | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
| DE69929232T2 (de) * | 1998-10-21 | 2006-08-31 | The United States Government As Represented By The Department Of Health And Human Services | Virusähnliche partikel zur induktion von autoantikörpern |
| MXPA01005389A (es) * | 1998-11-30 | 2003-03-27 | Cytos Biotechnology Ag | Presentacion molecular ordenada de antigenos, metodos de preparacion y uso. |
| WO2003031466A2 (en) * | 2001-10-05 | 2003-04-17 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| AU2007202761B2 (en) * | 2001-01-19 | 2010-01-21 | Kuros Biosciences Ag | Molecular antigen array |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| FR2828404B1 (fr) * | 2001-08-10 | 2005-07-15 | Neovacs | Superimmunogene composite a usage vaccinal bifonctionnel pour le traitement des maladies associees a un desordre tissulaire stromal |
| DE60234375D1 (de) * | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| MXPA04002644A (es) | 2001-10-05 | 2004-07-08 | Cytos Biotechnology Ag | Conjugados que portan un peptido de angiotensina y usos de los mismos. |
| RU2350622C2 (ru) * | 2001-10-05 | 2009-03-27 | Цитос Байотекнолоджи Аг | Конъюгат ангиотензиновой пептидной составляющей с носителем, композиция вакцины, способ иммунизации животного и способ лечения или профилактики физического нарушения, ассоциированного с активируемой ренином ангиотензиновой системой |
| JP4658475B2 (ja) * | 2001-11-07 | 2011-03-23 | サイトス バイオテクノロジー アーゲー | 骨疾患治療用の抗原アレイ |
| MXPA04003901A (es) * | 2001-11-07 | 2004-07-08 | Cytos Biotechnology Ag | Disposiciones de antigenos para el tratamiento de enfermedades eosinofilicas alergicas. |
| ES2316628T3 (es) * | 2001-11-07 | 2009-04-16 | Cytos Biotechnology Ag | Disposicion ordenada de antigenos que comprende rankl para el tratamiento de enfermedades oseas. |
| AU2002363382B2 (en) * | 2001-11-07 | 2007-07-19 | Cytos Biotechnology Ag | Antigen arrays presenting IL-5, IL-3 or eotaxin for treatment of allergic eosinophilic diseases |
| US20030219459A1 (en) * | 2002-01-18 | 2003-11-27 | Cytos Biotechnology Ag | Prion protein carrier-conjugates |
| US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| WO2004042001A2 (en) * | 2002-05-17 | 2004-05-21 | Emory University | Virus-like particles, methods of preparation, and immonogenic compositions |
| US9045727B2 (en) * | 2002-05-17 | 2015-06-02 | Emory University | Virus-like particles, methods of preparation, and immunogenic compositions |
| JP2006507800A (ja) | 2002-06-07 | 2006-03-09 | ラージ・スケール・バイオロジー・コーポレイション | 可撓性ワクチンアセンブリおよびワクチン送達プラットフォーム |
| US7138252B2 (en) | 2002-07-17 | 2006-11-21 | Cytos Biotechnology Ag | Molecular antigen arrays |
| CA2487849A1 (en) | 2002-07-18 | 2004-01-29 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| EP2338510A1 (en) * | 2002-07-19 | 2011-06-29 | Novartis Pharma AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| CA2497798A1 (en) * | 2002-09-03 | 2004-04-22 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
| AU2004224761A1 (en) | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
| US20060210588A1 (en) * | 2003-03-26 | 2006-09-21 | Cytos Biotechnology Ag | Hiv-peptide-carrier-conjugates |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| WO2005005614A2 (en) * | 2003-07-03 | 2005-01-20 | Pecos Labs, Inc. | Combined b-cell and t-cell epitopes on vlp for improved vaccines |
| CA2553594A1 (en) * | 2004-01-20 | 2005-07-28 | Cytos Biotechnology Ag | Particle-induced ghrelin immune response |
| WO2005091753A2 (en) * | 2004-03-25 | 2005-10-06 | Large Scale Biology Corporation | Flexible vaccine assembly and vaccine delivery platform |
| US20090053261A1 (en) * | 2005-09-08 | 2009-02-26 | Lindbo John A | Modified tobacco mosaic virus particles as scaffolds for display of protein antigens for vaccine applications |
| EP1751186A2 (en) * | 2004-06-02 | 2007-02-14 | Cytos Biotechnology AG | Carrier conjugates of tnf-peptides |
| KR20070058426A (ko) * | 2004-06-02 | 2007-06-08 | 사이토스 바이오테크놀로지 아게 | 비-인간 ｔｎｆ-펩티드의 담체 콘쥬게이트의 의학적 용도 |
| DE102004036913A1 (de) * | 2004-07-16 | 2006-02-09 | Responsif Gmbh | Verwendung von Pentameren zur Herstellung eines Medikaments |
| US7959928B2 (en) | 2004-10-05 | 2011-06-14 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
| AU2005298689A1 (en) | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| ZA200707413B (en) * | 2005-03-18 | 2009-01-28 | Cytos Biotechnology Ag | Cat allergen fusion proteins and uses thereof |
| LT5414B (lt) | 2005-04-13 | 2007-04-25 | Biotechnologijos Institutas | Monokloninių antikūnų gavimo būdas, hibridomos, gautos šiuo būdu ir rekombinantinės chimerinės į virusus panašios dalelės su įterptais kitų baltymų fragmentais kaip imunogenai hibridomų gavimui šiuo būdu |
| CN101193654A (zh) * | 2005-06-14 | 2008-06-04 | 赛托斯生物技术公司 | 抗原偶联物及其用途 |
| ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| NZ566971A (en) * | 2005-09-28 | 2011-06-30 | Cytos Biotechnology Ag | Vaccine containing a virus like particle linked with an interleukin-1 molecule |
| CA2636139A1 (en) | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| US8541559B2 (en) | 2006-06-12 | 2013-09-24 | Cytos Biotechnology Ag | Process for producing aggregated oligonucleotides |
| US8586728B2 (en) | 2006-12-12 | 2013-11-19 | Cytos Biotechnology Ag | Oligonucleotides containing high concentrations of guanine monomers |
| EP2012122A1 (en) * | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| ES2602610T3 (es) * | 2007-05-31 | 2017-02-21 | Medigene Ag | Proteína estructural mutada de un parvovirus |
| WO2009009430A1 (en) * | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Diagnosing and protecting horses against papillomavirus |
| EP2062592A1 (en) | 2007-11-20 | 2009-05-27 | BUNDESREPUBLIK DEUTSCHLAND letztvertreten durch das Robert Koch-Institut vertreten durch seinen Präsidenten | System for delivery into a XCR1 positive cell and uses thereof |
| BRPI0922561A2 (pt) | 2008-12-09 | 2020-08-11 | Pfizer Vaccines Llc | vacina de peptídeo de ch3 da ige. |
| JP2013500326A (ja) | 2009-07-30 | 2013-01-07 | ファイザー バクシーンズ エルエルシー | 抗原性タウペプチドおよびその使用 |
| WO2011027257A2 (en) | 2009-09-03 | 2011-03-10 | Pfizer Vaccines Llc | Pcsk9 vaccine |
| EP2480251B1 (en) | 2009-09-21 | 2025-12-03 | Peptinov | Carrier conjugates of il-23-peptides and their induced antibodies |
| EP2575868A1 (en) | 2010-06-07 | 2013-04-10 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
| WO2013037961A1 (en) * | 2011-09-15 | 2013-03-21 | Medigene Ag | Anti-her2 vaccine based upon aav derived multimeric structures |
| CA2936092A1 (en) | 2013-01-23 | 2014-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Stabilized hepatitis b core polypeptide |
| US10195257B2 (en) | 2013-07-28 | 2019-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response |
| WO2015123291A1 (en) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Pcsk9 vaccine and methods of using the same |
| EP3368068B1 (en) | 2015-10-30 | 2020-11-18 | University of Copenhagen | Virus like particle with efficient epitope display |
| JP7366057B2 (ja) | 2018-04-19 | 2023-10-20 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
| JP7707161B2 (ja) | 2019-10-23 | 2025-07-14 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
| WO2022140655A1 (en) * | 2020-12-23 | 2022-06-30 | The Trustees Of Columbia University In The City Of New York | Single-molecule electronic multiplex nanopore immunoassays for biomarker detection |
| US20250332278A1 (en) * | 2022-06-01 | 2025-10-30 | The Regents Of The University Of California | Multivalent display of apoai peptide on nanoparticles against atherosclerosis |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143726A (en) | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| GB8903313D0 (en) | 1989-02-14 | 1989-04-05 | Wellcome Found | Conjugates |
| US5714374A (en) | 1990-09-12 | 1998-02-03 | Rutgers University | Chimeric rhinoviruses |
| GB9114003D0 (en) | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| JPH0519914A (ja) * | 1991-07-17 | 1993-01-29 | Sharp Corp | 半導体装置の内部降圧回路 |
| KR940008286B1 (ko) * | 1991-08-19 | 1994-09-09 | 삼성전자 주식회사 | 내부전원발생회로 |
| CH684782A5 (de) | 1992-01-27 | 1994-12-30 | Rolf M Zinkernagel C O Inst Fu | Antigen zur Auslösung von CD8+ Zellimmunantworten. |
| KR950008453B1 (ko) * | 1992-03-31 | 1995-07-31 | 삼성전자주식회사 | 내부전원전압 발생회로 |
| US5618536A (en) | 1992-09-03 | 1997-04-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric papillomavirus-like particles |
| US5437951A (en) | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
| DE69333115D1 (de) | 1992-09-22 | 2003-08-28 | Biofocus Discovery Ltd | Rekombinante viren, die an ihrer äusseren oberfläche ein nichtvirales polypeptid präsentieren |
| DK96493D0 (da) | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
| US5721485A (en) * | 1996-01-04 | 1998-02-24 | Ibm Corporation | High performance on-chip voltage regulator designs |
| EP0927044A4 (en) | 1996-04-16 | 1999-09-08 | Immusol Inc | DEFINED TARGET VIRAL VECTORS |
| KR100224669B1 (ko) * | 1996-12-10 | 1999-10-15 | 윤종용 | 내부 전원 전압 발생기 회로 |
| US6171591B1 (en) * | 1997-12-08 | 2001-01-09 | Pentamer Pharmaceuticals, Inc. | Recombinant nodavirus compositions and methods |
| JPH11231954A (ja) * | 1998-02-16 | 1999-08-27 | Mitsubishi Electric Corp | 内部電源電圧発生回路 |
| DE19827457C1 (de) | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| EP0994403B1 (en) * | 1998-10-15 | 2003-05-21 | Lucent Technologies Inc. | Current mirror |
| DE69929232T2 (de) | 1998-10-21 | 2006-08-31 | The United States Government As Represented By The Department Of Health And Human Services | Virusähnliche partikel zur induktion von autoantikörpern |
| MXPA01005389A (es) | 1998-11-30 | 2003-03-27 | Cytos Biotechnology Ag | Presentacion molecular ordenada de antigenos, metodos de preparacion y uso. |
| US6373754B1 (en) * | 2000-07-17 | 2002-04-16 | Samsung Electronics Co., Ltd. | Semiconductor memory device having stable internal supply voltage driver |
| US20060210687A1 (en) * | 2002-11-06 | 2006-09-21 | Fiberstar, Inc. | Enhanced crackers, chips, wafers and unleavened using highly refined cellulose fiber ingredients |
-
1999
- 1999-10-20 DE DE69929232T patent/DE69929232T2/de not_active Expired - Lifetime
- 1999-10-20 WO PCT/US1999/024548 patent/WO2000023955A1/en not_active Ceased
- 1999-10-20 CA CA2347411A patent/CA2347411C/en not_active Expired - Lifetime
- 1999-10-20 AU AU12143/00A patent/AU770802B2/en not_active Expired
- 1999-10-20 JP JP2000577627A patent/JP4486257B2/ja not_active Expired - Lifetime
- 1999-10-20 EP EP99970772A patent/EP1123114B1/en not_active Revoked
- 1999-10-20 AT AT99970772T patent/ATE314095T1/de not_active IP Right Cessation
- 1999-10-20 ES ES99970772T patent/ES2258869T3/es not_active Expired - Lifetime
-
2001
- 2001-04-13 US US09/835,124 patent/US6719978B2/en not_active Expired - Lifetime
-
2002
- 2002-09-24 US US10/253,443 patent/US20030072753A1/en not_active Abandoned
-
2004
- 2004-06-14 US US10/867,119 patent/US7371572B2/en not_active Expired - Lifetime
-
2006
- 2006-05-01 US US11/415,611 patent/US7479280B2/en not_active Expired - Fee Related
-
2008
- 2008-03-18 US US12/050,892 patent/US7875450B2/en not_active Expired - Fee Related
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