JP2002527389A5 - - Google Patents
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- Publication number
- JP2002527389A5 JP2002527389A5 JP2000575502A JP2000575502A JP2002527389A5 JP 2002527389 A5 JP2002527389 A5 JP 2002527389A5 JP 2000575502 A JP2000575502 A JP 2000575502A JP 2000575502 A JP2000575502 A JP 2000575502A JP 2002527389 A5 JP2002527389 A5 JP 2002527389A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- alkanoyl
- vitis
- composition
- carnitine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 11
- 125000001589 carboacyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 241000219095 Vitis Species 0.000 claims 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims 3
- -1 alkanoyl L-carnitine Chemical compound 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- PDHAOJSHSJQANO-OWOJBTEDSA-N Oxyresveratrol Chemical compound OC1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 PDHAOJSHSJQANO-OWOJBTEDSA-N 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- 235000009392 Vitis Nutrition 0.000 claims 2
- 244000068697 Vitis rotundifolia Species 0.000 claims 2
- 235000004305 Vitis rotundifolia Nutrition 0.000 claims 2
- 240000006365 Vitis vinifera Species 0.000 claims 2
- 230000004075 alteration Effects 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 235000002532 grape seed extract Nutrition 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- LXOPCHVYWBGPND-VOTSOKGWSA-N 4-[(e)-2-phenylethenyl]benzene-1,2,3-triol Chemical group OC1=C(O)C(O)=CC=C1\C=C\C1=CC=CC=C1 LXOPCHVYWBGPND-VOTSOKGWSA-N 0.000 claims 1
- SIMYWHHAEQQGEH-UHFFFAOYSA-N 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol Chemical compound C1=CC(O)=CC=C1C=CC1=CC(O)=CC(O)=C1.C1=CC(O)=CC=C1C=CC1=CC(O)=CC(O)=C1 SIMYWHHAEQQGEH-UHFFFAOYSA-N 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 241001289529 Fallopia multiflora Species 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 241000205407 Polygonum Species 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 229930014626 natural product Natural products 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000002581 neurotoxin Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98A000636 | 1998-10-09 | ||
| IT1998RM000636A IT1302365B1 (it) | 1998-10-09 | 1998-10-09 | Uso di carnitine e resveratrolo per produrre una composizione per laprevenzione o il trattamento terapeutico di alterazioni cerebrali |
| PCT/IT1999/000311 WO2000021526A1 (en) | 1998-10-09 | 1999-10-06 | Combination of carnitines and resveratrol for prevention or treatment of cerebral and ageing disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002527389A JP2002527389A (ja) | 2002-08-27 |
| JP2002527389A5 true JP2002527389A5 (enExample) | 2005-06-30 |
| JP4166951B2 JP4166951B2 (ja) | 2008-10-15 |
Family
ID=11406160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000575502A Expired - Fee Related JP4166951B2 (ja) | 1998-10-09 | 1999-10-06 | 脳性および加齢性疾患の予防または治療のためのカルニチンおよびレスベラトロールの組み合わせ |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6515020B1 (enExample) |
| EP (1) | EP1117394B1 (enExample) |
| JP (1) | JP4166951B2 (enExample) |
| KR (1) | KR20010079981A (enExample) |
| CN (1) | CN1323205A (enExample) |
| AR (1) | AR020762A1 (enExample) |
| AT (1) | ATE249823T1 (enExample) |
| AU (1) | AU767492B2 (enExample) |
| BR (1) | BR9915918A (enExample) |
| CA (1) | CA2344893C (enExample) |
| CZ (1) | CZ2001920A3 (enExample) |
| DE (1) | DE69911441T2 (enExample) |
| DK (1) | DK1117394T3 (enExample) |
| EE (1) | EE200100205A (enExample) |
| ES (1) | ES2207287T3 (enExample) |
| HK (1) | HK1040935A1 (enExample) |
| HU (1) | HU229364B1 (enExample) |
| IL (1) | IL142046A0 (enExample) |
| IS (1) | IS5896A (enExample) |
| IT (1) | IT1302365B1 (enExample) |
| NO (1) | NO20011693L (enExample) |
| PL (1) | PL197342B1 (enExample) |
| PT (1) | PT1117394E (enExample) |
| SK (1) | SK3782001A3 (enExample) |
| TN (1) | TNSN99186A1 (enExample) |
| TR (1) | TR200100947T2 (enExample) |
| WO (1) | WO2000021526A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002047193A (ja) * | 2000-07-31 | 2002-02-12 | Sunstar Inc | アレルギー性皮膚炎予防または治療用組成物 |
| WO2002038141A2 (en) * | 2000-11-08 | 2002-05-16 | Massachusetts Institute Of Technology | Compositions and methods for treatment of mild cognitive impairment |
| BRPI0106382B1 (pt) * | 2001-03-13 | 2017-07-11 | Universidade Do Estado Do Rio De Janeiro - Uerj | Process for obtaining decocts from vitis labrusca and vitis vinifera casts, process for obtaining the hydro-alcoholic extract, process for obtaining the hydro-alcoholic extract-ethyl acetate and pharmaceutical compositions |
| DE50111204D1 (de) * | 2001-08-18 | 2006-11-23 | Cognis Ip Man Gmbh | Wirkstoffmischungen |
| US20070218152A1 (en) * | 2002-03-12 | 2007-09-20 | Roberto Moura | Process for obtention of decoctions of Vitis labrusca and Vitis vinifera skins |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| KR100574392B1 (ko) * | 2003-02-07 | 2006-05-02 | 재단법인서울대학교산학협력재단 | 신경보호활성을 갖는 신규 페닐환 유도체 및 이를함유하는 약학 조성물 |
| US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| EP2236131A3 (en) * | 2003-07-01 | 2011-03-02 | President and Fellows of Harvard College | Sirt1 modulators for manipulating cell/organism lifespan/stress response |
| KR100543056B1 (ko) * | 2003-11-07 | 2006-01-20 | (주)네추럴에프앤피 | 신경세포 보호 활성이 있는 포도씨 추출물을 포함하는뇌질환 예방 및 치료용 조성물 |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US20050171027A1 (en) | 2003-12-29 | 2005-08-04 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| ES2245609B1 (es) * | 2004-06-18 | 2007-08-16 | Universidad De Barcelona | Nuevo agente terapeutico para el tratamiento de la infertilidad y/o subfertilidad masculina en mamiferos. |
| US20060014705A1 (en) * | 2004-06-30 | 2006-01-19 | Howitz Konrad T | Compositions and methods for selectively activating human sirtuins |
| US20060121137A1 (en) * | 2004-12-07 | 2006-06-08 | Hartle Diane K | Muscadine grape pomace in the treatment of intestinal inflammation |
| CA2595159A1 (en) * | 2005-01-13 | 2006-07-20 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| WO2006138418A2 (en) * | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| EP1993522A2 (en) | 2005-10-26 | 2008-11-26 | Kao Corporation | Resveratrol and/or grape leaf extract as i.a. endurance improver, anti-aging agent, muscle strength improver |
| FR2898493B1 (fr) * | 2006-03-16 | 2008-08-08 | Af Consulting | Compositions cosmetiques, pharmaceutiques, alimentaires et veterinaires dont l'action d'activation de genes de type sirtuin permet de retarder le vieillissement des mammiferes et ses effets nefastes |
| US20120016037A1 (en) * | 2006-07-24 | 2012-01-19 | Frank Toppo | Method for prevention and treatment of Alzheimers |
| EP2124985A4 (en) * | 2007-01-26 | 2011-06-08 | Univ Washington | METHOD AND COMPOSITIONS FOR TREATING NERVOUS ELEMENTS |
| AT506014A1 (de) * | 2007-10-24 | 2009-05-15 | Karl Mag Dr Zehethofer | Functional drink |
| MX2012014127A (es) * | 2010-06-16 | 2013-06-28 | Sigma Tau Ind Farmaceuti | Acetil-carnitina para uso en un metodo para incrementar neurogenesis en tejido nervioso. |
| KR101327936B1 (ko) * | 2011-07-06 | 2013-11-13 | 한국식품연구원 | 옥시레스베라트롤 이민 유도체를 유효성분으로 함유하는 뇌신경보호 효과를 가지는 조성물 |
| CN102919943A (zh) * | 2012-10-26 | 2013-02-13 | 郑全辉 | 保健饮品-葡藤素 |
| CN103877170B (zh) * | 2012-12-19 | 2015-11-04 | 中国医学科学院药用植物研究所 | 一种虎杖的乙酸乙酯提取物及其制备方法和应用 |
| CN119424497B (zh) * | 2025-01-08 | 2025-06-24 | 万邦德制药集团有限公司 | 一种用于防治阿尔茨海默病、皮肤光老化的组合物、制剂及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
| IT1283967B1 (it) * | 1996-03-29 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Uso di l-carnitina o derivati della l-carnitina ed antiossidanti nella prevenzione e trattamento di patologie derivanti da danni ossidativi |
| CA2280093A1 (en) | 1997-02-04 | 1998-08-06 | John V. Kosbab | Compositions and methods for prevention and treatment of vascular degenerative diseases |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| CH692837A5 (it) * | 1997-07-02 | 2002-11-29 | Lisapharma Spa | Composizione farmaceutica per uso alimentare, dietetico o medicinale adatta a migliorare l'assorbimento orale dei polifenoli e particolarmente del resveratrolo presenti nell'uva e nei suoi p |
| US5904924A (en) * | 1997-11-04 | 1999-05-18 | Oncologics, Inc. | Green nutritional powder composition |
| AU4084599A (en) | 1998-05-18 | 1999-12-06 | Oklahoma Medical Research Foundation | Resveratrol inhibition of myeloperoxidase |
-
1998
- 1998-10-09 IT IT1998RM000636A patent/IT1302365B1/it active IP Right Grant
-
1999
- 1999-10-05 TN TNTNSN99186A patent/TNSN99186A1/fr unknown
- 1999-10-06 AU AU61213/99A patent/AU767492B2/en not_active Ceased
- 1999-10-06 HU HU0104021A patent/HU229364B1/hu unknown
- 1999-10-06 EE EEP200100205A patent/EE200100205A/xx unknown
- 1999-10-06 CN CN99811952A patent/CN1323205A/zh active Pending
- 1999-10-06 SK SK378-2001A patent/SK3782001A3/sk unknown
- 1999-10-06 PL PL347209A patent/PL197342B1/pl not_active IP Right Cessation
- 1999-10-06 ES ES99947853T patent/ES2207287T3/es not_active Expired - Lifetime
- 1999-10-06 CA CA002344893A patent/CA2344893C/en not_active Expired - Fee Related
- 1999-10-06 HK HK02102885.2A patent/HK1040935A1/zh unknown
- 1999-10-06 IL IL14204699A patent/IL142046A0/xx unknown
- 1999-10-06 CZ CZ2001920A patent/CZ2001920A3/cs unknown
- 1999-10-06 DE DE69911441T patent/DE69911441T2/de not_active Expired - Lifetime
- 1999-10-06 KR KR1020017004267A patent/KR20010079981A/ko not_active Withdrawn
- 1999-10-06 TR TR2001/00947T patent/TR200100947T2/xx unknown
- 1999-10-06 JP JP2000575502A patent/JP4166951B2/ja not_active Expired - Fee Related
- 1999-10-06 US US09/806,454 patent/US6515020B1/en not_active Expired - Fee Related
- 1999-10-06 DK DK99947853T patent/DK1117394T3/da active
- 1999-10-06 AT AT99947853T patent/ATE249823T1/de active
- 1999-10-06 EP EP99947853A patent/EP1117394B1/en not_active Expired - Lifetime
- 1999-10-06 WO PCT/IT1999/000311 patent/WO2000021526A1/en not_active Ceased
- 1999-10-06 BR BR9915918-0A patent/BR9915918A/pt not_active Application Discontinuation
- 1999-10-06 PT PT99947853T patent/PT1117394E/pt unknown
- 1999-10-08 AR ARP990105115A patent/AR020762A1/es unknown
-
2001
- 2001-03-16 IS IS5896A patent/IS5896A/is unknown
- 2001-04-04 NO NO20011693A patent/NO20011693L/no not_active Application Discontinuation
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