JP2002527389A5 - - Google Patents
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- Publication number
- JP2002527389A5 JP2002527389A5 JP2000575502A JP2000575502A JP2002527389A5 JP 2002527389 A5 JP2002527389 A5 JP 2002527389A5 JP 2000575502 A JP2000575502 A JP 2000575502A JP 2000575502 A JP2000575502 A JP 2000575502A JP 2002527389 A5 JP2002527389 A5 JP 2002527389A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- alkanoyl
- vitis
- composition
- carnitine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 11
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Resveratrol Natural products C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 4
- 125000001589 carboacyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 241000219095 Vitis Species 0.000 claims 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims 3
- -1 alkanoyl L-carnitine Chemical compound 0.000 claims 3
- 125000004432 carbon atoms Chemical group C* 0.000 claims 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 2
- HNYOPLTXPVRDBG-UHFFFAOYSA-N Barbituric acid Chemical group O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 claims 2
- 210000004556 Brain Anatomy 0.000 claims 2
- PDHAOJSHSJQANO-OWOJBTEDSA-N Oxyresveratrol Chemical compound OC1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 PDHAOJSHSJQANO-OWOJBTEDSA-N 0.000 claims 2
- 235000009392 Vitis Nutrition 0.000 claims 2
- 240000000274 Vitis rotundifolia Species 0.000 claims 2
- 235000004305 Vitis rotundifolia Nutrition 0.000 claims 2
- 240000006365 Vitis vinifera Species 0.000 claims 2
- 230000004075 alteration Effects 0.000 claims 2
- 235000002532 grape seed extract Nutrition 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- SIMYWHHAEQQGEH-UHFFFAOYSA-N 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol Chemical compound C1=CC(O)=CC=C1C=CC1=CC(O)=CC(O)=C1.C1=CC(O)=CC=C1C=CC1=CC(O)=CC(O)=C1 SIMYWHHAEQQGEH-UHFFFAOYSA-N 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 241001289529 Fallopia multiflora Species 0.000 claims 1
- 241000205407 Polygonum Species 0.000 claims 1
- 208000008042 Presenile And Senile Dementia Diseases 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 235000009754 grape Nutrition 0.000 claims 1
- 235000012333 grape Nutrition 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000005445 natural product Substances 0.000 claims 1
- 229930014626 natural products Natural products 0.000 claims 1
- 210000003867 nerve cell Anatomy 0.000 claims 1
- 210000002569 neurons Anatomy 0.000 claims 1
- 239000002581 neurotoxin Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Claims (11)
- (Ａ)Ｌ-カルニチンまたは、アルカノイルが２-８の炭素原子を含む直鎖または分枝鎖の基であるアルカノイルＬ-カルニチンまたは薬理学上許容されるその塩;および、(Ｂ)トリヒドロキシまたはテトラヒドロキシスチルベンを含有する、神経細胞または脳の変質による病態の予防および治療のための栄養補助食品または医薬組成物。
- アルカノイルが２-６の炭素原子を含む請求項１記載の組成物。
- アルカノイルが、アセチル、プロピオニル、ブチリル、バレリルおよびイソバレリルから成る群から選択される請求項２記載の組成物。
- 成分(Ｂ)が、３,４',５-トリヒドロキシスチルベン(レスベラトロール)または３,４',５-トリヒドロキシスチルベン-３-β-モノ-Ｄ-グルコシドまたは薬理学上許容されるその塩またはそのエステルである請求項１-３いずれかに記載の組成物。
- レスベラトロールが、ビティス・ビニフェラ、ビティス・ロタンジフォリア、またはビティス・ラブラスカから抽出されるレスベラトロールである請求項４記載の組成物。
- 成分(Ｂ)が、ビティス・ビニフェラ、ビティス・ロタンジフォリアまたはビティス・ラブラスカのブドウの皮またはブドウの茎の、および、ポリゴナム・カスピダーツムまたはポリゴナム・マルチフローラムの根の抽出物または天然生成物の粉末から成る請求項１-５いずれかに記載の組成物。
- 重量比(Ｂ):(Ａ)が１:１〜１:１,０００である請求項１-６いずれかに記載の組成物。
- 重量比(Ｂ):(Ａ)が１:１〜１:５００である請求項７記載の組成物。
- 加齢および、神経毒性薬の組成物による脳の変質の予防または治療のための請求項１-８いずれかに記載の組成物。
- 脳卒中、記憶喪失および初老性および老年性痴呆およびアルツハイマー病の予防および治療のための請求項９記載の組成物。
- (Ａ)Ｌ-カルニチンまたは、アルカノイルが２-８の炭素原子を含む直鎖または分枝鎖の基であるアルカノイルＬ-カルニチンまたは薬理学上許容されるその塩および、
(Ｂ)トリヒドロキシまたはテトラヒドロキシスチルベンを、
(Ａ)および(Ｂ)が混合された状態で、または（Ａ）および（Ｂ）が別個に保持されている、請求項１〜１０いずれかに記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998RM000636A IT1302365B1 (it) | 1998-10-09 | 1998-10-09 | Uso di carnitine e resveratrolo per produrre una composizione per laprevenzione o il trattamento terapeutico di alterazioni cerebrali |
| IT98A000636 | 1998-10-09 | ||
| PCT/IT1999/000311 WO2000021526A1 (en) | 1998-10-09 | 1999-10-06 | Combination of carnitines and resveratrol for prevention or treatment of cerebral and ageing disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002527389A JP2002527389A (ja) | 2002-08-27 |
| JP2002527389A5 true JP2002527389A5 (ja) | 2005-06-30 |
| JP4166951B2 JP4166951B2 (ja) | 2008-10-15 |
Family
ID=11406160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000575502A Expired - Fee Related JP4166951B2 (ja) | 1998-10-09 | 1999-10-06 | 脳性および加齢性疾患の予防または治療のためのカルニチンおよびレスベラトロールの組み合わせ |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6515020B1 (ja) |
| EP (1) | EP1117394B1 (ja) |
| JP (1) | JP4166951B2 (ja) |
| KR (1) | KR20010079981A (ja) |
| CN (1) | CN1323205A (ja) |
| AR (1) | AR020762A1 (ja) |
| AT (1) | ATE249823T1 (ja) |
| AU (1) | AU767492B2 (ja) |
| BR (1) | BR9915918A (ja) |
| CA (1) | CA2344893C (ja) |
| CZ (1) | CZ2001920A3 (ja) |
| DE (1) | DE69911441T2 (ja) |
| DK (1) | DK1117394T3 (ja) |
| EE (1) | EE200100205A (ja) |
| ES (1) | ES2207287T3 (ja) |
| HK (1) | HK1040935A1 (ja) |
| HU (1) | HU229364B1 (ja) |
| IL (1) | IL142046A0 (ja) |
| IS (1) | IS5896A (ja) |
| IT (1) | IT1302365B1 (ja) |
| NO (1) | NO20011693D0 (ja) |
| PL (1) | PL197342B1 (ja) |
| PT (1) | PT1117394E (ja) |
| SK (1) | SK3782001A3 (ja) |
| TN (1) | TNSN99186A1 (ja) |
| TR (1) | TR200100947T2 (ja) |
| WO (1) | WO2000021526A1 (ja) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002047193A (ja) * | 2000-07-31 | 2002-02-12 | Sunstar Inc | アレルギー性皮膚炎予防または治療用組成物 |
| AU2002230423A1 (en) * | 2000-11-08 | 2002-05-21 | Massachusetts Institute Of Technology | Serotonergic compositions and methods for treatment of mild cognitive impairment |
| BRPI0106382B1 (pt) * | 2001-03-13 | 2017-07-11 | Universidade Do Estado Do Rio De Janeiro - Uerj | Process for obtaining decocts from vitis labrusca and vitis vinifera casts, process for obtaining the hydro-alcoholic extract, process for obtaining the hydro-alcoholic extract-ethyl acetate and pharmaceutical compositions |
| DE50111204D1 (de) * | 2001-08-18 | 2006-11-23 | Cognis Ip Man Gmbh | Wirkstoffmischungen |
| US20070218151A1 (en) * | 2002-03-12 | 2007-09-20 | Universidade Do Estado Do Rio De Janeiro | Process for obtention of decoctions of Vitis labrusca and Vitis vinifera skins |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| KR100574392B1 (ko) * | 2003-02-07 | 2006-05-02 | 재단법인서울대학교산학협력재단 | 신경보호활성을 갖는 신규 페닐환 유도체 및 이를함유하는 약학 조성물 |
| US20050096256A1 (en) * | 2003-07-01 | 2005-05-05 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| KR100543056B1 (ko) * | 2003-11-07 | 2006-01-20 | (주)네추럴에프앤피 | 신경세포 보호 활성이 있는 포도씨 추출물을 포함하는뇌질환 예방 및 치료용 조성물 |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| CA2548671C (en) | 2003-12-29 | 2015-02-24 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| ES2245609B1 (es) * | 2004-06-18 | 2007-08-16 | Universidad De Barcelona | Nuevo agente terapeutico para el tratamiento de la infertilidad y/o subfertilidad masculina en mamiferos. |
| US20060014705A1 (en) * | 2004-06-30 | 2006-01-19 | Howitz Konrad T | Compositions and methods for selectively activating human sirtuins |
| US20060121137A1 (en) * | 2004-12-07 | 2006-06-08 | Hartle Diane K | Muscadine grape pomace in the treatment of intestinal inflammation |
| US20060276393A1 (en) * | 2005-01-13 | 2006-12-07 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| WO2006138418A2 (en) * | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| EP2322158B1 (en) * | 2005-10-26 | 2020-06-10 | Kao Corporation | Resveratrol and/or grape leaf extract for energy metabolism activation |
| FR2898493B1 (fr) * | 2006-03-16 | 2008-08-08 | Af Consulting | Compositions cosmetiques, pharmaceutiques, alimentaires et veterinaires dont l'action d'activation de genes de type sirtuin permet de retarder le vieillissement des mammiferes et ses effets nefastes |
| US20120016037A1 (en) * | 2006-07-24 | 2012-01-19 | Frank Toppo | Method for prevention and treatment of Alzheimers |
| MX2009008022A (es) * | 2007-01-26 | 2009-12-11 | Univ Washington | Metodos y composiciones para tratar neuropatias. |
| AT506014A1 (de) * | 2007-10-24 | 2009-05-15 | Karl Mag Dr Zehethofer | Functional drink |
| SG10201503032UA (en) * | 2010-06-16 | 2015-06-29 | Sigma Tau Ind Farmaceuti | Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue |
| KR101327936B1 (ko) * | 2011-07-06 | 2013-11-13 | 한국식품연구원 | 옥시레스베라트롤 이민 유도체를 유효성분으로 함유하는 뇌신경보호 효과를 가지는 조성물 |
| CN102919943A (zh) * | 2012-10-26 | 2013-02-13 | 郑全辉 | 保健饮品-葡藤素 |
| CN103877170B (zh) * | 2012-12-19 | 2015-11-04 | 中国医学科学院药用植物研究所 | 一种虎杖的乙酸乙酯提取物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
| IT1276225B1 (it) | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
| IT1283967B1 (it) * | 1996-03-29 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Uso di l-carnitina o derivati della l-carnitina ed antiossidanti nella prevenzione e trattamento di patologie derivanti da danni ossidativi |
| EP1021177A4 (en) * | 1997-02-04 | 2002-05-15 | John V Kosbab | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF VASCULAR DEGENERATIVE DISEASES |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| CH692837A5 (it) * | 1997-07-02 | 2002-11-29 | Lisapharma Spa | Composizione farmaceutica per uso alimentare, dietetico o medicinale adatta a migliorare l'assorbimento orale dei polifenoli e particolarmente del resveratrolo presenti nell'uva e nei suoi p |
| US5904924A (en) * | 1997-11-04 | 1999-05-18 | Oncologics, Inc. | Green nutritional powder composition |
| WO1999059561A2 (en) * | 1998-05-18 | 1999-11-25 | Hensley, Kenneth, L. | Resveratrol inhibition of myeloperoxidase |
-
1998
- 1998-10-09 IT IT1998RM000636A patent/IT1302365B1/it active IP Right Grant
-
1999
- 1999-10-05 TN TNTNSN99186A patent/TNSN99186A1/fr unknown
- 1999-10-06 TR TR2001/00947T patent/TR200100947T2/xx unknown
- 1999-10-06 HU HU0104021A patent/HU229364B1/hu unknown
- 1999-10-06 EE EEP200100205A patent/EE200100205A/xx unknown
- 1999-10-06 DK DK99947853T patent/DK1117394T3/da active
- 1999-10-06 SK SK378-2001A patent/SK3782001A3/sk unknown
- 1999-10-06 AT AT99947853T patent/ATE249823T1/de active
- 1999-10-06 AU AU61213/99A patent/AU767492B2/en not_active Ceased
- 1999-10-06 CZ CZ2001920A patent/CZ2001920A3/cs unknown
- 1999-10-06 DE DE69911441T patent/DE69911441T2/de not_active Expired - Lifetime
- 1999-10-06 ES ES99947853T patent/ES2207287T3/es not_active Expired - Lifetime
- 1999-10-06 KR KR1020017004267A patent/KR20010079981A/ko not_active Application Discontinuation
- 1999-10-06 IL IL14204699A patent/IL142046A0/xx unknown
- 1999-10-06 CN CN99811952A patent/CN1323205A/zh active Pending
- 1999-10-06 JP JP2000575502A patent/JP4166951B2/ja not_active Expired - Fee Related
- 1999-10-06 EP EP99947853A patent/EP1117394B1/en not_active Expired - Lifetime
- 1999-10-06 US US09/806,454 patent/US6515020B1/en not_active Expired - Fee Related
- 1999-10-06 PL PL347209A patent/PL197342B1/pl not_active IP Right Cessation
- 1999-10-06 WO PCT/IT1999/000311 patent/WO2000021526A1/en not_active Application Discontinuation
- 1999-10-06 BR BR9915918-0A patent/BR9915918A/pt not_active Application Discontinuation
- 1999-10-06 PT PT99947853T patent/PT1117394E/pt unknown
- 1999-10-06 CA CA002344893A patent/CA2344893C/en not_active Expired - Fee Related
- 1999-10-08 AR ARP990105115A patent/AR020762A1/es unknown
-
2001
- 2001-03-16 IS IS5896A patent/IS5896A/is unknown
- 2001-04-04 NO NO20011693A patent/NO20011693D0/no not_active Application Discontinuation
-
2002
- 2002-04-17 HK HK02102885.2A patent/HK1040935A1/zh unknown
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