JP2002522399A5 - - Google Patents

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Publication number
JP2002522399A5
JP2002522399A5 JP2000563311A JP2000563311A JP2002522399A5 JP 2002522399 A5 JP2002522399 A5 JP 2002522399A5 JP 2000563311 A JP2000563311 A JP 2000563311A JP 2000563311 A JP2000563311 A JP 2000563311A JP 2002522399 A5 JP2002522399 A5 JP 2002522399A5
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JP
Japan
Prior art keywords
uricase
conjugate
peg
kda
liver
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JP2000563311A
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English (en)
Japanese (ja)
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JP2002522399A (ja
JP5183836B2 (ja
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Priority claimed from PCT/US1999/017514 external-priority patent/WO2000007629A2/en
Publication of JP2002522399A publication Critical patent/JP2002522399A/ja
Publication of JP2002522399A5 publication Critical patent/JP2002522399A5/ja
Application granted granted Critical
Publication of JP5183836B2 publication Critical patent/JP5183836B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2000563311A 1998-08-06 1999-08-02 Ｐｅｇ−尿酸酸化酵素結合体およびその使用 Expired - Fee Related JP5183836B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13039298A 1998-08-06 1998-08-06
US09/130,392 1998-08-06
PCT/US1999/017514 WO2000007629A2 (en) 1998-08-06 1999-08-02 Peg-urate oxidase conjugates and use thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009173148A Division JP5290901B2 (ja) 1998-08-06 2009-07-24 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2012248770A Division JP5291235B2 (ja) 1998-08-06 2012-11-12 Ｐｅｇ−尿酸酸化酵素結合体およびその使用

Publications (3)

Publication Number Publication Date
JP2002522399A JP2002522399A (ja) 2002-07-23
JP2002522399A5 true JP2002522399A5 (enExample) 2008-05-08
JP5183836B2 JP5183836B2 (ja) 2013-04-17

Family

ID=22444494

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000563311A Expired - Fee Related JP5183836B2 (ja) 1998-08-06 1999-08-02 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2009173148A Expired - Fee Related JP5290901B2 (ja) 1998-08-06 2009-07-24 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2012248770A Expired - Fee Related JP5291235B2 (ja) 1998-08-06 2012-11-12 Ｐｅｇ−尿酸酸化酵素結合体およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009173148A Expired - Fee Related JP5290901B2 (ja) 1998-08-06 2009-07-24 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2012248770A Expired - Fee Related JP5291235B2 (ja) 1998-08-06 2012-11-12 Ｐｅｇ−尿酸酸化酵素結合体およびその使用

Country Status (13)

Country Link
EP (1) EP1100542B1 (enExample)
JP (3) JP5183836B2 (enExample)
KR (2) KR100488848B1 (enExample)
AU (1) AU770014B2 (enExample)
BR (2) BRPI9917760B8 (enExample)
CZ (1) CZ303751B6 (enExample)
HU (2) HU226294B1 (enExample)
IL (3) IL141220A0 (enExample)
NZ (1) NZ509595A (enExample)
PL (2) PL220873B1 (enExample)
RU (3) RU2278680C2 (enExample)
TW (1) TW570981B (enExample)
WO (1) WO2000007629A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007629A2 (en) * 1998-08-06 2000-02-17 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
CN1896231B (zh) 1998-08-06 2012-09-05 山景药品公司 分离四聚体尿酸氧化酶的方法
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
JP2002524053A (ja) 1998-08-06 2002-08-06 デューク・ユニバーシティー 尿酸オキシダーゼ
AU2006203252B8 (en) * 2000-02-10 2009-06-18 Duke University Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
WO2001074400A1 (en) 2000-04-03 2001-10-11 Santen Pharmaceutical Co., Ltd. Transporters and drug delivery system by using the same
DE60137635D1 (de) 2000-06-28 2009-03-26 Merck & Co Inc Verwendung von allopurinol zur behandlung von bluthochdruck
EP1421175B1 (en) 2001-06-28 2008-11-19 Mountain View Pharmaceuticals, Inc. Polymer stabilized proteinases
US6913915B2 (en) * 2001-08-02 2005-07-05 Phoenix Pharmacologics, Inc. PEG-modified uricase
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
HRP20120989T1 (hr) 2003-05-12 2013-01-31 Affymax, Inc. Peptidi koji se vežu za receptor eritropoetina
AU2004238364A1 (en) 2003-05-12 2004-11-25 Affymax, Inc. Spacer moiety for poly(ethylene glycol) -modified peptides
KR101100059B1 (ko) * 2004-06-30 2011-12-29 넥타르 테라퓨틱스 중합체­인자 ｉｘ 부분의 접합체
DK3321359T3 (da) 2005-04-11 2021-03-08 Horizon Pharma Rheumatology Llc Variante former af uratoxidase og anvendelse deraf
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
BRPI0612942A2 (pt) 2005-04-11 2012-10-09 Savient Pharmaceuticals Inc forma variante de oxidase de urato e uso do mesmo
WO2006121995A2 (en) 2005-05-09 2006-11-16 Tap Pharmaceutical Products, Inc. Methods for treating nephrolithiasis
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
CN101622270B (zh) 2006-04-12 2014-01-01 萨文特医药公司 用阳离子表面活性剂纯化蛋白质的方法
JP4890132B2 (ja) * 2006-07-20 2012-03-07 東洋紡績株式会社 ウリカーゼの比活性を向上させる方法、および比活性の向上した改変型ウリカーゼ
RU2382048C1 (ru) * 2008-12-25 2010-02-20 Общество С Ограниченной Ответственностью "Фармапарк" Лекарственное средство на основе модифицированного интерферона альфа с пролонгированным терапевтическим действием
BRPI1010069A2 (pt) 2009-06-25 2016-03-15 Savient Pharmaceuticals Inc "método para prevenir reações à infusão durante terapia por uricase peguilada em pacientes; e método para diagnosticar se um paciente tratado com uricase peguilada desenvolverá reações à infusão ou desenvolverá liberação de uricase peguilada mediada por anticorpo sem a medição de títulos de anticorpos anti-peg e anti-uricase peguilada"
KR101797936B1 (ko) 2010-09-10 2017-11-15 다케다 파마슈티칼스 유에스에이, 인코포레이티드 테오필린과 페북소스타트의 병용 치료 방법
CN102634492B (zh) 2011-02-14 2015-06-10 重庆富进生物医药有限公司 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用
US9744175B2 (en) 2012-04-06 2017-08-29 Indus Pharmaceuticals, Inc. Compositions of combinations of non-covalent DNA binding agents and anti-cancer and/or anti-inflammatory agents and their use in disease treatment
KR20240119160A (ko) 2013-05-03 2024-08-06 셀렉타 바이오사이언시즈, 인크. 바람직하지 않은 체액성 면역 반응을 감소시키기 위한 투약 조합물
JP2018515101A (ja) * 2015-05-15 2018-06-14 メディミューン，エルエルシー 改善されたウリカーゼ配列および処置の方法
CN105412942B (zh) * 2015-12-23 2019-02-26 沈阳三生制药有限责任公司 聚乙二醇化的重组产朊假丝酵母尿酸氧化酶冻干注射剂
CN116637177A (zh) 2016-11-11 2023-08-25 好利恩治疗美国公司 泼尼松和尿酸酶分子的组合疗法及其用途
KR102753928B1 (ko) 2017-03-11 2025-01-14 셀렉타 바이오사이언시즈, 인크. 항염증제, 및 면역억제제를 포함하는 합성 나노담체를 사용한 조합 치료와 관련된 방법 및 조성물
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
CN112980808B (zh) * 2019-12-12 2024-10-29 深圳迈瑞生物医疗电子股份有限公司 尿酸酶、及其制备方法和用途
WO2022097141A1 (en) 2020-11-03 2022-05-12 Protalix Ltd. Modified uricase and uses thereof
CN114438048B (zh) * 2020-11-05 2024-10-22 重庆派金生物科技有限公司 尿酸氧化酶制剂及其应用
CN114438047B (zh) * 2020-11-05 2024-11-22 重庆派金生物科技有限公司 制备聚乙二醇修饰的尿酸氧化酶的方法
CA3211023A1 (en) 2021-02-10 2022-08-18 Oriental Yeast Co., Ltd. Uricase activator and uric acid measurement reagent
CN114181917B (zh) * 2022-02-14 2022-06-03 潍坊华卓生物科技有限公司 一种改造尿酸酶、基因序列、制备方法及应用
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
FR1529675A (fr) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et Urate oxydase à haute activité et sa préparation
US3616231A (en) * 1968-11-14 1971-10-26 Boehringer Mannheim Gmbh Process for the production of uricase
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6031472B2 (ja) * 1978-12-14 1985-07-22 協和醗酵工業株式会社 酸性ウリカ−ゼ
JPS55135590A (en) * 1979-04-05 1980-10-22 Mihama Hisaharu Modified asparaginase and uricase and their preparation
JPS57192435A (en) * 1981-05-20 1982-11-26 Toyobo Co Ltd Modified polypeptide
JPS6255079A (ja) * 1986-04-23 1987-03-10 Mihama Hisaharu 修飾ウリカ−ゼ
NZ234453A (en) * 1989-07-13 1993-01-27 Sanofi Sa Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
JP2002524053A (ja) * 1998-08-06 2002-08-06 デューク・ユニバーシティー 尿酸オキシダーゼ
WO2000007629A2 (en) * 1998-08-06 2000-02-17 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof

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