JP2002518990A5 - - Google Patents

Download PDF

Info

Publication number
JP2002518990A5
JP2002518990A5 JP2000508770A JP2000508770A JP2002518990A5 JP 2002518990 A5 JP2002518990 A5 JP 2002518990A5 JP 2000508770 A JP2000508770 A JP 2000508770A JP 2000508770 A JP2000508770 A JP 2000508770A JP 2002518990 A5 JP2002518990 A5 JP 2002518990A5
Authority
JP
Japan
Prior art keywords
medium
cells
cell culture
culture
neurons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000508770A
Other languages
English (en)
Japanese (ja)
Other versions
JP4848538B2 (ja
JP2002518990A (ja
Filing date
Publication date
Priority claimed from US08/926,313 external-priority patent/US5968829A/en
Application filed filed Critical
Publication of JP2002518990A publication Critical patent/JP2002518990A/ja
Publication of JP2002518990A5 publication Critical patent/JP2002518990A5/ja
Application granted granted Critical
Publication of JP4848538B2 publication Critical patent/JP4848538B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2000508770A 1997-09-05 1998-09-04 ヒトcns神経幹細胞の培養 Expired - Fee Related JP4848538B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/926,313 1997-09-05
US08/926,313 US5968829A (en) 1997-09-05 1997-09-05 Human CNS neural stem cells
PCT/US1998/018597 WO1999011758A2 (en) 1997-09-05 1998-09-04 Cultures of human cns neural stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008331441A Division JP2009106301A (ja) 1997-09-05 2008-12-25 ヒトcns神経幹細胞の培養

Publications (3)

Publication Number Publication Date
JP2002518990A JP2002518990A (ja) 2002-07-02
JP2002518990A5 true JP2002518990A5 (https=) 2006-01-05
JP4848538B2 JP4848538B2 (ja) 2011-12-28

Family

ID=25453045

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000508770A Expired - Fee Related JP4848538B2 (ja) 1997-09-05 1998-09-04 ヒトcns神経幹細胞の培養
JP2008331441A Pending JP2009106301A (ja) 1997-09-05 2008-12-25 ヒトcns神経幹細胞の培養

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008331441A Pending JP2009106301A (ja) 1997-09-05 2008-12-25 ヒトcns神経幹細胞の培養

Country Status (6)

Country Link
US (6) US5968829A (https=)
EP (1) EP1007636B1 (https=)
JP (2) JP4848538B2 (https=)
AU (1) AU758270B2 (https=)
CA (1) CA2302484C (https=)
WO (1) WO1999011758A2 (https=)

Families Citing this family (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6093531A (en) * 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
US5958767A (en) * 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US20020168766A1 (en) * 2000-01-11 2002-11-14 Gold Joseph D. Genetically altered human pluripotent stem cells
US7410798B2 (en) * 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6488930B1 (en) * 1999-01-15 2002-12-03 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
AU780256B2 (en) * 1999-02-12 2005-03-10 Boco Silicon Valley, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7105150B2 (en) * 1999-02-12 2006-09-12 Stemcells California, Inc. In vivo screening methods using enriched neural stem cells
US6468794B1 (en) 1999-02-12 2002-10-22 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7217565B2 (en) * 1999-02-12 2007-05-15 Stemcells California, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7037719B1 (en) 1999-02-12 2006-05-02 Stemcells California, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
JP2002538820A (ja) * 1999-03-17 2002-11-19 ザ・ユニバーシティ・オブ・テネシー・リサーチ・コーポレイション ミクロクローンのクローニングされていないcDNAライブラリーの作製および使用
EP1161523A4 (en) * 1999-03-18 2003-04-02 Wellstat Biologics Corp CELLS, CELL POPULATIONS, AND METHOD FOR THE PRODUCTION AND USE THEREOF
EP1176970B1 (en) * 1999-04-30 2010-05-19 NeurotrophinCell Pty Ltd Xenotransplant for cns therapy
US20090047325A1 (en) * 1999-04-30 2009-02-19 Neurotrophincell Pty. Limited Xenotransplant for cns therapy
US20050265977A1 (en) * 1999-04-30 2005-12-01 Elliott Robert B Xenotransplant for CNS therapy
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
EP2348104A1 (en) * 1999-08-05 2011-07-27 Mcl Llc Multipotent adult stem cells and methods for isolation
US8609412B2 (en) 1999-08-05 2013-12-17 Regents Of The University Of Minnesota Mapc generation of lung tissue
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US7838289B2 (en) 2001-02-14 2010-11-23 Abt Holding Company Assay utilizing multipotent adult stem cells
US6749850B1 (en) 1999-08-18 2004-06-15 The General Hospital Corporation Methods, compositions and kits for promoting recovery from damage to the central nervous system
AU2118501A (en) * 1999-10-20 2001-04-30 Stemcells, Inc. Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain
US6878543B1 (en) 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
AU779273B2 (en) * 1999-12-07 2005-01-13 Monash University Long-term cell culture compositions and genetically modified animals derived therefrom
WO2001042421A2 (en) * 1999-12-07 2001-06-14 Monash University Long-term cell culture compositions and genetically modified animals derived therefrom
EP1107003A1 (en) * 1999-12-09 2001-06-13 Trophos Methods for screening compounds active on neurons
AU2913801A (en) * 1999-12-23 2001-07-03 Cornell Research Foundation Inc. A method for isolating and purifying multipotential neural progenitor cells and multipotential neural progenitor cells
US20050042749A1 (en) * 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
US7455983B2 (en) * 2000-01-11 2008-11-25 Geron Corporation Medium for growing human embryonic stem cells
ES2272482T3 (es) * 2000-01-20 2007-05-01 Diabcell Pty Limited Preparacion y xenotransplante de islotes porcinos.
AU3499801A (en) * 2000-02-11 2001-08-20 Schepens Eye Res Inst Isolation and transplantation of retinal stem cells
WO2001064239A1 (en) * 2000-03-03 2001-09-07 The Walter And Eliza Hall Institute Of Medical Research A method of treatment
US7011828B2 (en) * 2000-03-14 2006-03-14 Es Cell International Pte. Ltd. Implanting neural progenitor cells derived for human embryonic stem cells
CA2403000C (en) 2000-03-14 2015-06-23 Es Cell International Pte Ltd Embryonic stem cells and neural progenitor cells derived therefrom
AU2001253425A1 (en) 2000-04-13 2001-10-30 Board Of Regents, The University Of Texas System Treatment of disorders by implanting stem cells and/or progeny thereof into gastrointestinal organs
US7037493B2 (en) 2000-05-01 2006-05-02 Cornell Research Foundation, Inc. Method of inducing neuronal production in the brain and spinal cord
US6828145B2 (en) 2000-05-10 2004-12-07 Cedars-Sinai Medical Center Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker
US7250294B2 (en) * 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
JP5943533B2 (ja) * 2000-05-17 2016-07-06 アステリアス バイオセラピューティクス インコーポレイテッド 神経前駆細胞の集団
US6897061B1 (en) * 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
US6602680B2 (en) 2000-07-14 2003-08-05 The Regents Of The University Of California Production of gabaergic cells
US20040014212A1 (en) * 2000-10-17 2004-01-22 Elliott Robert Bartlett Preparation and xenotransplantation or porcine islets
US20020086005A1 (en) * 2000-11-22 2002-07-04 Choy-Pik Chiu Tolerizing allografts of pluripotent stem cells
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US6921665B2 (en) * 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2305795B1 (en) 2000-12-06 2019-07-03 Celularity, Inc. Method of collecting placental stem cells
EP2316918B1 (en) 2001-02-14 2015-07-01 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
WO2002069976A2 (en) * 2001-03-02 2002-09-12 Stem Cell Therapeutics Inc. Use of ovarian hormone for increasing neural stem cell number
WO2002076206A2 (en) * 2001-03-23 2002-10-03 University Of Ottawa Methods and compositions for cryopreservation of dissociated primary animal cells
JP3763749B2 (ja) * 2001-03-28 2006-04-05 独立行政法人科学技術振興機構 脊髄におけるシナプス形成ニューロンを誘導する中枢神経系前駆細胞
US7838292B1 (en) 2001-03-29 2010-11-23 University Of Louisville Research Foundation, Inc. Methods for obtaining adult human olfactory progenitor cells
US20020169102A1 (en) * 2001-04-03 2002-11-14 Frey William H. Intranasal delivery of agents for regulating development of implanted cells in the CNS
EP1385938A1 (en) * 2001-04-23 2004-02-04 Nsgene A/S Method and culture medium for producing neural cells expressing tyrosine hydroxylase
US7943376B2 (en) 2001-04-27 2011-05-17 Stem Cell Therapuetics Inc. Platelet derived growth factor (PDGF)-derived neurospheres define a novel class of progenitor cells
AU2002315337A1 (en) * 2001-06-18 2003-01-02 Psychiatric Genomics, Inc. Method for neural stem cell differentiation using valproate
US7132287B2 (en) * 2001-06-18 2006-11-07 Psychiatric Genomics, Inc. Method for neural stem cell differentiation using 5HT-1A agonists
WO2003000852A2 (en) * 2001-06-22 2003-01-03 The University Of Texas System Method of producing region-specific neurons from human neuronal stem cells
DE60222427T2 (de) * 2001-07-16 2008-06-12 Protein Forest, Inc., Waltham Puffer-arrays zum nachweis von biomolekülen anhand ihres isoelektrischen punktes
AU2002324645C1 (en) * 2001-08-08 2008-11-06 Levesque Biosciences, Inc. Compositions and methods for isolation, propagation, and differentiation of human stem cells and uses thereof
AU2002327433A1 (en) * 2001-08-10 2003-02-24 Cornell Research Foundation, Inc. Telomerase immortalized human neutral stem cells and phenotypically-restricted progenitor cells
WO2003027270A1 (en) * 2001-09-28 2003-04-03 Diabcell Pty Limited Growing xenotransplant material in culture
EP1448053A4 (en) * 2001-10-02 2005-03-09 Becton Dickinson Co PROLIFERATION AND DIFFERENTIATION OF STEM CELLS BY EXTRACELLULAR MATRIX AND OTHER MOLECULES
US8153424B2 (en) * 2001-10-03 2012-04-10 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US7588937B2 (en) 2001-10-03 2009-09-15 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US7129034B2 (en) * 2001-10-25 2006-10-31 Cedars-Sinai Medical Center Differentiation of whole bone marrow
NZ515310A (en) * 2001-11-07 2004-08-27 Diabcell Pty Ltd Methods of treatment and delivery modes
WO2003044158A1 (en) * 2001-11-15 2003-05-30 Becton, Dickinson And Company Methods and devices for the integrated discovery of cell culture environments
EP1471970A4 (en) * 2002-01-14 2006-08-02 Univ Illinois NOVEL MULTIPOTENT STEM CELLS OF MAMMALIAN ORIGIN, METHODS OF PREPARATION AND METHODS OF ADMINISTRATION OF SAID CELLS
WO2003070189A2 (en) * 2002-02-15 2003-08-28 Cornell Research Foundation, Inc. Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein
US20040029269A1 (en) * 2002-05-07 2004-02-12 Goldman Steven A Promoter-based isolation, purification, expansion, and transplantation of neuronal progenitor cells, oligodendrocyte progenitor cells, or neural stem cells from a population of embryonic stem cells
US20050101014A1 (en) * 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US7285415B2 (en) * 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
JP2006506970A (ja) * 2002-07-12 2006-03-02 ユニバーシティ オブ ワシントン 神経細胞の延長されたインビトロ培養のための方法および系
EP1546346A4 (en) * 2002-07-23 2006-02-08 Nanodiagnostics Inc MARKERS OF EMBRYONIC STEM CELLS, AND USE THEREOF
WO2007116408A2 (en) * 2006-04-11 2007-10-18 Nanodiagnostics Israel Ltd. Pluripotent stem cells characterized by expression of germline specific genes
AU2003276924A1 (en) * 2002-09-25 2004-04-19 Bresagen, Inc. Compositions and methods for enrichment of neural stem cells using ceramide analogs
AU2003273332A1 (en) * 2002-09-26 2004-04-19 Children's Medical Center Corporation Method of enhancing proliferation and/or hematopoietic differentiation of stem cells
US20040147020A1 (en) * 2002-11-01 2004-07-29 The Regents Of The University Of Colorado, A Body Corporate Dopamine neurons from human embryonic stem cells
US20050265983A1 (en) * 2002-11-17 2005-12-01 Eldad Melamed Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
DE60335743D1 (de) * 2002-11-20 2011-02-24 Neuronova Ab Verbindungen und verfahren zur erhöhung der neurogenese
AU2003298775B2 (en) 2002-11-26 2008-07-17 Anthrogenesis Corporation Cytotherapeutics, cytotherapeutic units and methods for treatments using them
DE60326003D1 (de) * 2002-12-02 2009-03-12 Anges Mg Inc Ter verwendung des hepatozytenwachstumsfaktors
AU2003293409A1 (en) 2002-12-09 2004-06-30 Karl K. Johe Method for discovering neurogenic agents
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
US20060211111A1 (en) * 2002-12-18 2006-09-21 Maisam Mitalipova Compositions and methods for neural cell production and stabilization
EP1624936B1 (en) 2003-05-16 2009-10-28 Universite Laval Cns chloride modulation and uses thereof
WO2006040615A2 (en) * 2003-06-11 2006-04-20 Jan Remmereit Differenciation of stem cells for therapeutic use
US9321997B2 (en) 2003-06-20 2016-04-26 Axiogenesis Ag Tissue modeling in embryonic stem (ES) cell system
CN1791670A (zh) * 2003-06-24 2006-06-21 戴伯塞尔有限公司 用于异种移植的用猪支持细胞培养的猪胰岛
US8426200B2 (en) 2003-07-02 2013-04-23 Regents Of The University Of Minnesota Neuronal differentiation of stem cells
EP1644485B9 (en) 2003-07-08 2012-01-04 Axiogenesis Ag Secreted proteins as markers for cell differentiation
EP1674566B1 (en) * 2003-09-09 2011-04-13 Keio University Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening
CN1867678B (zh) * 2003-09-12 2012-10-03 干细胞技术公司 神经集落形成分析
WO2005033297A1 (en) * 2003-09-19 2005-04-14 The Rockefeller University Compositions, methods and kits relating to reprogramming adult differentiated cells and production of embryonic stem cell-like cells
WO2005030932A2 (en) * 2003-09-24 2005-04-07 The Board Of Trustees Of The Leland Stanford Junior University Igf-1 instructs multipotent adult cns neural stem cells to an oligodendroglial lineage
JP2005139164A (ja) * 2003-11-10 2005-06-02 Toudai Tlo Ltd 神経障害及び神経変性疾患を治療するための薬学的組成物
US20070269412A1 (en) * 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
WO2005056755A2 (en) * 2003-12-02 2005-06-23 Catholic Healthcare West Compositions and methods for propagation of neural progenitor cells
US20050196864A1 (en) * 2004-02-10 2005-09-08 Goldman Steven A. Induction and high-yield preparative purification of mesencephalic dopaminergic neuronal progenitor cells and dopaminergic neurons from human embryonic stem cells
WO2005079250A2 (en) * 2004-02-13 2005-09-01 Cornell Research Foundation, Inc. Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom
US7622108B2 (en) 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
WO2005108559A2 (en) 2004-04-23 2005-11-17 Bioe, Inc. Multi-lineage progenitor cells
CA2569978C (en) * 2004-06-09 2017-06-06 The University Court Of The University Of Edinburgh Neural stem cells
DE602005002430T2 (de) 2004-09-30 2008-06-19 Reneuron Ltd., Guildford Zelllinie
CN101084303A (zh) * 2004-11-17 2007-12-05 神经干公司 用于治疗神经变性症状的人类神经细胞的移植
US20090010873A1 (en) * 2004-11-29 2009-01-08 Yeda Research And Development Co. Ltd. Methods of Cell Therapy, Neurogenesis and Oligodendrogenesis
EP1831354A4 (en) 2004-12-01 2008-01-23 Stem Cell Therapeutics Corp NEURAL PRECURSOR CELLS SENSITIVE TO PLATELET GROWTH FACTOR AND PROHIBITION OF SAID CELLS
US20060121443A1 (en) * 2004-12-03 2006-06-08 Orion Biosolutions, Inc. Determination of cell viability
US7018804B1 (en) 2004-12-03 2006-03-28 Orion Biosolutions, Inc. Determination of cell viability and phenotype
SG158851A1 (en) * 2005-01-04 2010-02-26 Stemcells California Inc Methods for the treatment of lysosomal storage disorders
BRPI0607045A2 (pt) * 2005-01-31 2009-08-04 Cognate Therapeutics Inc células estromais adultas derivadas de adiposas exibindo caracterìsticas de células endoteliais
NZ540597A (en) * 2005-06-08 2007-02-23 Neurotrophincell Pty Ltd A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells
EP1893747B1 (en) 2005-06-16 2014-09-03 Ramot at Tel Aviv University Ltd. Isolated cells and populations comprising same for the treatment of cns diseases
KR20160116024A (ko) * 2005-06-22 2016-10-06 아스테리아스 바이오세라퓨틱스, 인크. 인간 배아 줄기 세포의 현탁 배양
AU2006269231A1 (en) * 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
KR20080036590A (ko) * 2005-07-28 2008-04-28 주식회사 브레인가드 줄기세포 구조 지지체로서의 탄소나노튜브
US9095573B2 (en) * 2005-08-01 2015-08-04 University Of Central Florida Research Foundation, Inc. Method of biasing implanted human neural stem cells away from differentiation into glial cells by (+)phenserine to modulate the concentration of soluble βAPP in tissue or CSF
US8357666B2 (en) * 2005-08-01 2013-01-22 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through RNA interference
NZ597304A (en) 2005-10-13 2013-06-28 Anthrogenesis Corp Immunomodulation using placental stem cells
EP1969119B1 (en) * 2005-11-17 2011-07-20 The Cleveland Clinic Foundation Multipotent neural stem cells
US7803364B2 (en) 2005-11-17 2010-09-28 The Cleveland Clinic Foundation Multipotent neural stem cells
EP1976978A2 (en) 2005-12-29 2008-10-08 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
PL2471907T3 (pl) 2005-12-29 2019-07-31 Celularity, Inc. Populacje komórek macierzystych łożyska
EP2422802A3 (en) 2006-03-07 2013-03-06 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
WO2007117440A2 (en) * 2006-03-30 2007-10-18 Research Foundation Of City University Of New York Stimulation of neuron regeneration by secretory leukocyte protease inhibitor
CA2646491A1 (en) 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
AU2007285483B2 (en) 2006-05-11 2011-12-22 Regenics As Administration of cells and cellular extracts for rejuvenation
US20080003676A1 (en) * 2006-06-26 2008-01-03 Millipore Corporation Growth of embryonic stem cells
US20080124276A1 (en) 2006-07-24 2008-05-29 Lifeline Cell Technology Synthetic cornea from retinal stem cells
EP2617428A1 (en) 2006-08-15 2013-07-24 Agency for Science, Technology and Research Mesenchymal stem cell conditioned medium
WO2008027848A2 (en) * 2006-08-31 2008-03-06 The University Of Louisville Research Foundation, Inc. Transcription factors for differentiation of adult human olfactory progenitor cells
ES2882360T3 (es) 2006-11-03 2021-12-01 Univ Leland Stanford Junior Inmunoempobrecimiento selectivo de un nicho de células madre endógenas para injerto
US8685720B2 (en) 2006-11-03 2014-04-01 The Trustees Of Princeton University Engineered cellular pathways for programmed autoregulation of differentiation
WO2008063675A2 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
US20090136456A1 (en) * 2006-12-22 2009-05-28 Yadong Huang Methods of treating neurodegenerative disorders
NZ612888A (en) 2007-02-12 2015-02-27 Anthrogenesis Corp Treatment of inflammatory diseases using placental stem cells
US20080213892A1 (en) * 2007-03-02 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Self-renewal of neural stem cells is promoted by wnt proteins
WO2008109119A2 (en) * 2007-03-05 2008-09-12 The Board Of Trustees Of The Leland Stanford Junior University Wnt compositions and methods of use thereof
WO2008109320A1 (en) * 2007-03-08 2008-09-12 Sekula Raymond F Jr A method of producing purified neural stem cells and related methods of treating a patient
US20100196328A1 (en) * 2007-04-25 2010-08-05 Tonya Bliss ISCHEMIA-INDUCED NEOVASCULARIZATION IS ENHANCED BY hCNS-SC TRANSPLANTATION
EP2137300B1 (en) * 2007-04-26 2011-10-26 Ramot at Tel-Aviv University Ltd. Pluripotent autologous stem cells from oral or gastrointestinal mucosa
EP2192908A4 (en) * 2007-07-25 2010-09-01 Bioe Inc DIFFERENTIATION OF PRECURSOR CELLS OF MULTIPLE ABSTRACTS AGAINST CHONDROCYTES
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
EP2028268A1 (en) 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
EP2192916A4 (en) * 2007-08-23 2012-04-04 Univ Leland Stanford Junior MODULATION OF SYNAPTOGENESIS
CN101802174B (zh) 2007-09-11 2013-06-05 北海道公立大学法人札幌医科大学 细胞增殖方法以及用于组织修复及再生的药物
RU2536242C2 (ru) 2007-09-28 2014-12-20 Антродженезис Корпорейшн Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров
US20090090214A1 (en) * 2007-10-04 2009-04-09 Chung Yuan Christian University Method for forming nano-scale metal particles
CA2714010C (en) 2008-01-30 2020-06-16 Corning Incorporated Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
SG188918A1 (https=) 2008-03-17 2013-04-30 Agency Science Tech & Res
AU2009234424A1 (en) 2008-04-07 2009-10-15 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through use of an HDAC modulator
CA2723848C (en) 2008-05-09 2013-01-08 Regenics As Method of making salmon egg cytoplasmic extracts and use for increasing collagen production in skin
CA2724839A1 (en) * 2008-05-21 2009-11-26 Bioe Llc Differentiation of multi-lineage progenitor cells to pancreatic cells
EP2620493B1 (en) 2008-05-28 2019-03-27 Ramot at Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
US8669048B2 (en) * 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof
KR20200011604A (ko) 2008-08-20 2020-02-03 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
CA2734237C (en) 2008-08-20 2019-07-02 Anthrogenesis Corporation Treatment of stroke using isolated placental cells
CA2734446C (en) 2008-08-22 2017-06-20 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
RU2015130665A (ru) 2008-11-19 2018-12-24 Антродженезис Корпорейшн Амниотические адгезивные клетки
GB0822246D0 (en) * 2008-12-05 2009-01-14 Reneuron Ltd Composition
US20100158878A1 (en) 2008-12-23 2010-06-24 Alexandra Capela Target populations of oligodendrocyte precursor cells and methods of making and using same
WO2010090007A1 (en) * 2009-02-03 2010-08-12 Keio University Culture method of embryoid bodies and/or neural stem cells derived from human differentiated cell-derived pluripotent stem cells
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
US20100209399A1 (en) * 2009-02-13 2010-08-19 Celavie Biosciences, Llc Brain-derived stem cells for repair of musculoskeletal system in vertebrate subjects
US9101570B1 (en) 2009-02-13 2015-08-11 Endocellutions, Inc. Adult and neonatal stem cell therapy to treat diabetes through the repair of the gastrointestinal tract
WO2010111278A1 (en) 2009-03-23 2010-09-30 The Texas A&M University System Compositions of mesenchymal stem cells to regenerate bone
JP5783504B2 (ja) * 2009-03-30 2015-09-24 国立研究開発法人国立環境研究所 胎生プログラミングに対する影響を評価するための方法
ES2647823T3 (es) 2009-05-08 2017-12-26 Vaccinex, Inc. Anticuerpos anti-CD100 y métodos de uso de los mismos
MX353489B (es) 2009-07-02 2018-01-16 Anthrogenesis Corp Metodo para producir eritrocitos sin celulas alimentadoras.
EP2456860B1 (en) 2009-07-21 2018-09-05 ABT Holding Company Use of stem cells to reduce leukocyte extravasation
SG178064A1 (en) 2009-07-21 2012-03-29 Abt Holding Co Use of stem cells to reduce leukocyte extravasation
CN104293646A (zh) 2009-08-22 2015-01-21 里兰斯坦福初级大学理事会 成像并评估胚胎、卵母细胞和干细胞
CN102725399B (zh) 2009-12-18 2015-03-11 上海赛傲生物技术有限公司 制备多能干细胞的材料和方法
DK3284818T3 (da) 2010-01-26 2022-06-20 Celularity Inc Behandling af knoglerelateret kræft ved hjælp af placenta stamceller
US8927276B2 (en) * 2010-02-17 2015-01-06 Cellin Technologies Oue Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous system
WO2011106521A1 (en) 2010-02-25 2011-09-01 Abt Holding Company Modulation of macrophage activation
DK2556145T3 (en) 2010-04-07 2016-11-07 Anthrogenesis Corp Angiogenesis using placental stem cells
EP2555783A1 (en) 2010-04-08 2013-02-13 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
HRP20182039T1 (hr) 2010-04-23 2019-02-08 Cold Spring Harbor Laboratory NOVE STRUKTURNO DIZAJNIRANE MOLEKULE shRNA
AU2011249478B2 (en) 2010-05-06 2014-12-04 Regenics As Use of cellular extracts for skin rejuvenation
MX342995B (es) 2010-07-13 2016-10-21 Anthrogenesis Corp Métodos de generar células asesinas naturales.
CN103237553A (zh) 2010-07-28 2013-08-07 神经干细胞公司 治疗和/或逆转神经退行性疾病和/或病症的方法
BR112013003031A2 (pt) 2010-08-19 2016-06-14 Hoffmann La Roche método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs
WO2012034070A1 (en) 2010-09-09 2012-03-15 The Board Of Trustees Of The Leland Stanford Junior University Use of liposomal wnt compositions to enhance osseointegration
EP2625264B1 (en) 2010-10-08 2022-12-07 Terumo BCT, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
WO2012092485A1 (en) 2010-12-31 2012-07-05 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory rna molecules
EP2670426B1 (en) 2011-01-31 2017-05-10 The General Hospital Corporation Multimodal trail molecules and uses in cellular therapies
EP2678675B1 (en) 2011-02-23 2017-10-11 The Board of Trustees of the Leland Stanford Junior University Methods of detecting aneuploidy in human embryos
WO2012164137A1 (es) 2011-05-30 2012-12-06 Fundación Investigación En Regeneración Del Sistema Nervioso Células madre y células de la estirpe neural derivadas de la glía envolvente olfatoria, y sus aplicaciones
ES2707579T3 (es) 2011-06-01 2019-04-04 Celularity Inc Tratamiento del dolor usando citoblastos placentarios
EP2718416B1 (en) 2011-06-06 2019-11-13 Regenesys bvba Expansion of stem cells in hollow fiber bioreactors
US20130046093A1 (en) * 2011-08-18 2013-02-21 Korea Institute Of Science And Technology Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
BR112014008885B1 (pt) 2011-10-11 2021-02-17 Vaccinex, Inc uso de um anticorpo isolado ou fragmento de ligação ao antígeno do mesmo que se liga especificamente à semaforina-4d para diminuir permeabilidade da barreira hematoencefálica (bbb) em um indivíduo com permeabilidade da bbb aumentada e um transtorno neuroinflamatório
WO2013076726A1 (en) 2011-11-21 2013-05-30 Ramot At Tel-Aviv University Ltd. Stem cell-derived neural cells for cell therapy in neurological disorders
CN108588025A (zh) 2012-02-17 2018-09-28 斯格本斯眼科研究所 人视网膜祖细胞的表型谱
CN102604894B (zh) 2012-02-29 2014-07-30 中国科学院广州生物医药与健康研究院 用于制备神经干细胞的培养基及其用途
GB201302468D0 (en) 2013-02-12 2013-03-27 Reneuron Ltd Stem cell product
SG11201406336YA (en) 2012-04-03 2014-11-27 Reneuron Ltd Stem cell microparticles
AU2013250089B2 (en) * 2012-04-18 2016-08-18 R Bio Co., Ltd. Method for manufacturing stem cell having appropriate size for intravascular administration
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
WO2013181549A2 (en) 2012-05-31 2013-12-05 Auxogyn, Inc. In vitro embryo blastocyst prediction methods
KR101523040B1 (ko) * 2012-06-26 2015-05-26 라정찬 고농도의 줄기세포 제조방법
CA2879322A1 (en) 2012-07-19 2014-01-23 Reneuron Limited Stem cell microparticles
WO2014035474A1 (en) 2012-08-30 2014-03-06 The General Hospital Corporation Compositions and methods for treating cancer
US10357517B1 (en) 2012-10-01 2019-07-23 University Of South Florida Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592
EP3459522B1 (en) 2012-12-10 2021-02-17 Regenics AS Use of egg cellular extracts for wound treatment
US10241108B2 (en) 2013-02-01 2019-03-26 Ares Trading S.A. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower development potential
AU2014215458A1 (en) 2013-02-05 2015-08-13 Anthrogenesis Corporation Natural killer cells from placenta
ES2927175T3 (es) 2013-02-12 2022-11-03 Reneuron Ltd Método de producción de micropartículas
JP6666240B2 (ja) 2013-04-12 2020-03-13 フランチェスカ, サベリオ ラ 移植のための臓器の改良
DK2992088T3 (da) 2013-04-30 2019-11-11 Univ Leuven Kath Celleterapi for myelodysplastiske syndromer
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
GB201317889D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product and use
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
WO2015140005A1 (en) 2014-03-19 2015-09-24 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Method of generation of pluripotent cells
US10942170B2 (en) 2014-03-20 2021-03-09 Ares Trading S.A. Quantitative measurement of human blastocyst and morula morphology developmental kinetics
FI3656869T4 (fi) 2014-08-26 2025-06-04 Univ Leland Stanford Junior Kantasolujen siirrostaminen kantasoluihin kohdentuvan aineen ja immunoregulatorista signaalia moduloivan aineen yhdistelmän kanssa
MX382488B (es) 2014-10-20 2025-03-13 Neuralstem Inc Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.
CN107567494A (zh) 2015-03-04 2018-01-09 迈索布拉斯特国际有限公司 间充质干细胞的细胞培养方法
EP3288570A4 (en) 2015-04-29 2018-11-21 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
CN105420105B (zh) * 2015-12-25 2017-11-17 北京工业大学 生物芯片及其制造方法
US20190216891A1 (en) 2016-03-06 2019-07-18 Yeda Research And Development Co., Ltd. Method for modulating myelination
US10513689B2 (en) 2016-04-29 2019-12-24 Hope Biosciences, Llc Culture media for multipotent stem cells
JP7321934B2 (ja) 2017-01-30 2023-08-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 幹細胞移植のための非遺伝毒性移植前処置レジメン
JP7695192B2 (ja) 2018-10-08 2025-06-18 アレン インスティテュート 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物
GB201919021D0 (en) 2019-12-20 2020-02-05 Reneuron Ltd Nucleic acid constructs for delivering polynucleotides into exosomes
EP4127138A1 (en) 2020-03-30 2023-02-08 King Abdullah University Of Science And Technology Compositions and methods for controlling cellular identity
CN112080470B (zh) * 2020-09-14 2022-07-12 中国科学院遗传与发育生物学研究所 一种神经干细胞向神经元分化的体外培养方法
WO2022087260A1 (en) 2020-10-22 2022-04-28 The Regents Of The University Of California Devices and methods for evaluating the viability of embryos
GB202114441D0 (en) 2021-10-08 2021-11-24 Reneuron Ltd Proteins and extracellular vesicles

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753635A (en) * 1986-05-23 1988-06-28 Jacqueline Sagen Inducing analgesia by implantation of cells releasing neuroactive substances
NZ226750A (en) * 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
US5082670A (en) * 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US4980174A (en) * 1988-12-23 1990-12-25 Jacqueline Sagen Method for alleviating depression
WO1991002003A1 (en) * 1989-08-04 1991-02-21 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
US5411883A (en) * 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
WO1991009936A1 (en) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Proliferated neuron progenitor cell product and process
GB9003791D0 (en) * 1990-02-20 1990-04-18 Ludwig Inst Cancer Res Transgenic animals,cell lines therefrom,and their use
JPH05507909A (ja) * 1990-04-26 1993-11-11 シェリング・コーポレーション N―置換アミノ酸および誘導体のジアステレオ選択的製造法
US5612211A (en) * 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
ES2198404T5 (es) * 1991-07-08 2008-05-01 Neurospheres Holdings Ltd. Celulas progenitoras neurales que responden a factor de crecimiento y que se pueden hacer proliferar in vitro.
US5980885A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. Growth factor-induced proliferation of neural precursor cells in vivo
US5175103A (en) * 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons
DE69228949T2 (de) * 1991-11-22 1999-09-16 Auckland Uniservices Ltd., Auckland Tgf-beta zur verbesserung der regeneration von neuronalem gewebe
US5928947A (en) * 1992-07-27 1999-07-27 California Institute Of Technology Mammalian multipotent neural stem cells
AU683023B2 (en) * 1992-10-16 1997-10-30 Neurospheres Holdings Ltd Remyelination using neural stem cells
EP0669973B9 (en) * 1992-10-28 2007-10-10 NeuroSpheres Holdings Ltd. Biological factors and neural stem cells
US5766948A (en) 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
ATE262912T1 (de) * 1993-01-29 2004-04-15 Neurospheres Holdings Ltd Genetische modifikation von neuralen stammzellen
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US5639618A (en) 1994-05-13 1997-06-17 Plurion, Inc. Method of isolating a lineage specific stem cell in vitro
DE69523771T2 (de) * 1994-09-23 2002-08-01 Neurospheres Holding Ltd., Calgary In vitro-modelle für cns-funktion und-dysfunktion
FI971956L (fi) * 1994-11-14 1997-07-04 Neurospheres Holdings Ltd Hermosolujen lisääntymisen säännöstely
JP2997995B2 (ja) 1995-09-13 2000-01-11 日本コーンスターチ株式会社 生分解性樹脂組成物の水系分散液
CA2234230A1 (en) * 1995-11-01 1997-05-09 Genentech, Inc. Normal neural epithelial precursor cells
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells

Similar Documents

Publication Publication Date Title
JP2002518990A5 (https=)
CA2307017C (en) Erythropoietin-mediated neurogenesis
JP4023822B2 (ja) ドーパミン作動性細胞のインビトロ誘導
US9387226B2 (en) Neural cell proliferation induced through the culture of neural cells with umbilical cord blood-derived mesenchymal stem cells
CA2006015A1 (en) Method of modifying cellular differentiation and function and compositions therefor
Globus Neurotrophic contribution to a proposed tripartite control of the mitotic cycle in the regeneration blastema of the newt, Notophthalmus (Triturus) viridescens
JP2023060125A (ja) 表皮水疱症の治療剤
CN101735976B (zh) 一种用于表皮黑素细胞体外培养的培养基
Stein et al. Temporal factors influence recovery of function after embryonic brain tissue transplants in adult rats with frontal cortex lesions.
Kalderon Role of the plasmin‐generating system in the developing nervous tissue: I. Proteolysis as a mitogenic signal for the glial cells
Frodl et al. Effects of hibernation or cryopreservation on the survival and integration of striatal grafts placed in the ibotenate-lesioned rat caudate-putamen
CN113194968B (zh) 包含克隆干细胞的用于治疗移植物抗宿主疾病的药学组合物
JP7313133B2 (ja) 脳卒中のための神経幹細胞治療
Westergaard et al. Characterization of microcarrier cultures of neurons and astrocytes from cerebral cortex and cerebellum
JP5584875B2 (ja) 成体膵由来膵幹細胞の製造方法
Fazzini Transplantation in the treatment of paralysis agitans (Parkinson's disease)
Ronnett Development of human neuronal cell lines
MXPA97003493A (en) In vitro induction of dopaminergi cells
WO2001090315A2 (en) Production of neurons from stem cells