EP1161523A4 - Cells, cell populations, and methods of making and using same - Google Patents

Cells, cell populations, and methods of making and using same

Info

Publication number
EP1161523A4
EP1161523A4 EP00916410A EP00916410A EP1161523A4 EP 1161523 A4 EP1161523 A4 EP 1161523A4 EP 00916410 A EP00916410 A EP 00916410A EP 00916410 A EP00916410 A EP 00916410A EP 1161523 A4 EP1161523 A4 EP 1161523A4
Authority
EP
European Patent Office
Prior art keywords
cells
making
methods
same
cell populations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00916410A
Other languages
German (de)
French (fr)
Other versions
EP1161523A1 (en
Inventor
Eugene O Major
Jeffery L Barker
Dragan Maric
Harvey Rabin
Abby Sandler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government Of United States, A
Wellstat Biologics Corp
Original Assignee
US Department of Health and Human Services
Wellstat Biologics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, Wellstat Biologics Corp filed Critical US Department of Health and Human Services
Publication of EP1161523A1 publication Critical patent/EP1161523A1/en
Publication of EP1161523A4 publication Critical patent/EP1161523A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
    • C12N2710/22051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP00916410A 1999-03-18 2000-03-17 Cells, cell populations, and methods of making and using same Withdrawn EP1161523A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12488999P 1999-03-18 1999-03-18
US124889P 1999-03-18
PCT/US2000/006940 WO2000055306A1 (en) 1999-03-18 2000-03-17 Cells, cell populations, and methods of making and using same

Publications (2)

Publication Number Publication Date
EP1161523A1 EP1161523A1 (en) 2001-12-12
EP1161523A4 true EP1161523A4 (en) 2003-04-02

Family

ID=22417290

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00916410A Withdrawn EP1161523A4 (en) 1999-03-18 2000-03-17 Cells, cell populations, and methods of making and using same

Country Status (4)

Country Link
EP (1) EP1161523A4 (en)
JP (1) JP2003524396A (en)
AU (1) AU3751800A (en)
WO (1) WO2000055306A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
WO1999011758A2 (en) * 1997-09-05 1999-03-11 Cytotherapeutics, Inc. Cultures of human cns neural stem cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5753491A (en) * 1993-04-13 1998-05-19 Us Health Use of neuro-derived fetal cell lines for transplantation therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
WO1999011758A2 (en) * 1997-09-05 1999-03-11 Cytotherapeutics, Inc. Cultures of human cns neural stem cells

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
CARPENTER M K ET AL: "IN VITRO PROLIFERATION OF HUMAN NEURAL PROGENITOR CELLS THAT MAINTAIN GROWTH FACTOR REGULATION", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, vol. 24, no. 1/2, 1998, pages 815, XP001002087, ISSN: 0190-5295 *
FLAX JONATHAN D ET AL: "Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 16, no. 11, November 1998 (1998-11-01), pages 1033 - 1039, XP002197601, ISSN: 1087-0156 *
KALYANI A ET AL: "NEUROEPITHELIAL STEM CELLS FROM THE EMBRYONIC SPINAL CORD: ISOLATION, CHARACTERIZATION, AND CLONAL ANALYSIS", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 186, 1997, pages 202 - 223, XP000916226, ISSN: 0012-1606 *
MARIC D. ET AL: "Prospective cell sorting of embryonic rat neural stem cells and neuronal and glial progenitors reveals selective effects of basic fibroblast growth factor and epidermal growth factor on self-renewal and differentiation", J. NEUROSCIENCE, vol. 23, no. 1, 1 January 2003 (2003-01-01), pages 240 - 251 *
MCKAY R ET AL: "IMMORTALIZED STEM CELLS FROM THE CENTRAL NERVOUS SYSTEM", COMPTES RENDUS DES SEANCES DE L'ACADEMIE DES SCIENCES. SERIE III: SCIENCES DE LA VIE, ELSEVIER, AMSTERDAM, NL, vol. 316, 1993, pages 1452 - 1457, XP002022773, ISSN: 0764-4469 *
MCKAY R: "Stem cells in the central nervous system.", SCIENCE. UNITED STATES 4 APR 1997, vol. 276, no. 5309, 4 April 1997 (1997-04-04), pages 66 - 71, XP002229585, ISSN: 0036-8075 *
NUNES M.C. ET AL: "Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain", NATURE MEDICINE, vol. 9, no. 4, April 2003 (2003-04-01), pages 439 - 447 *
PALMER T D ET AL: "The adult rat hippocampus contains primordial neural stem cells", MOLECULAR AND CELLULAR NEUROSCIENCES, SAN DIEGO, US, vol. 8, 1997, pages 389 - 404, XP002160100, ISSN: 1044-7431 *
SCHEFFLER B. ET AL: "Phenotypic and functional characterization of adult brain neuropoiesis", PNAS, vol. 102, no. 26, June 2005 (2005-06-01), pages 9353 - 9358 *
See also references of WO0055306A1 *
SHINDLER K.S. ET AL: "Cholera toxin binds to differentiating neurons in the developing murine basal ganglia", DEVELOPMENTAL BRAIN RESEARCH, vol. 92, no. 2, 30 April 1996 (1996-04-30), NETHERLANDS, pages 199 - 210 *
ST JOHN P A ET AL: "Analysis and isolation of embryonic mammalian neurons by fluorescence-activated cell sorting.", THE JOURNAL OF NEUROSCIENCE: THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE. UNITED STATES MAY 1986, vol. 6, no. 5, May 1986 (1986-05-01), pages 1492 - 1512, XP009004683, ISSN: 0270-6474 *
TORNATORE C ET AL: "EXPRESSION OF TYROSINE HYDROXYLASE IN AN IMMORTALIZED HUMAN FETAL ASTROCYTE CELL LINE;IN VITRO CHARACTERIZATION AND ENGRAFTMENT INTOTHE RODENT STRIATUM", CELL TRANSPLANTATION, ELSEVIER SCIENCE, US, vol. 5, no. 2, 1996, pages 145 - 163, XP000974237, ISSN: 0963-6897 *
WHITTEMORE S R ET AL: "Physiological relevance and functional potential of central nervous system-derived cell lines.", MOLECULAR NEUROBIOLOGY. UNITED STATES FEB 1996, vol. 12, no. 1, February 1996 (1996-02-01), pages 13 - 38, XP009004407, ISSN: 0893-7648 *

Also Published As

Publication number Publication date
EP1161523A1 (en) 2001-12-12
JP2003524396A (en) 2003-08-19
AU3751800A (en) 2000-10-04
WO2000055306A1 (en) 2000-09-21

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