BR112013003031A2 - método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs - Google Patents

método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs

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Publication number
BR112013003031A2
BR112013003031A2 BR112013003031A BR112013003031A BR112013003031A2 BR 112013003031 A2 BR112013003031 A2 BR 112013003031A2 BR 112013003031 A BR112013003031 A BR 112013003031A BR 112013003031 A BR112013003031 A BR 112013003031A BR 112013003031 A2 BR112013003031 A2 BR 112013003031A2
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Prior art keywords
stem cells
neural stem
chn
therapeutic composition
nscs
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BR112013003031A
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English (en)
Inventor
Klaus Christensen
Martin Graf
Ravi Jagasia
Roberto Iacone
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Hoffmann La Roche
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Publication date
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Publication of BR112013003031A2 publication Critical patent/BR112013003031A2/pt

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Abstract

método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nsns. o presente pedido refere-se a um método de conversão de células somáticas em células hastes neurais (nscs). além disso, o presente pedido refere-se a um método de conversão de fibroblastas humanos, queratinócitos ou adipócitos em células hastes neurais com base em etapas ligadas de transdução genética e indução de meio quimicamente definido.
BR112013003031A 2010-08-19 2011-08-16 método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs BR112013003031A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10173455 2010-08-19
PCT/EP2011/064051 WO2012022725A2 (en) 2010-08-19 2011-08-16 Conversion of somatic cells to induced reprogrammed neural stem cells (irnscs)

Publications (1)

Publication Number Publication Date
BR112013003031A2 true BR112013003031A2 (pt) 2016-06-14

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BR112013003031A BR112013003031A2 (pt) 2010-08-19 2011-08-16 método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs

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US (2) US9297025B2 (pt)
EP (1) EP2606126B1 (pt)
JP (1) JP5905006B2 (pt)
KR (2) KR101788903B1 (pt)
CN (1) CN103068974B (pt)
BR (1) BR112013003031A2 (pt)
CA (1) CA2807226A1 (pt)
ES (1) ES2580837T3 (pt)
HK (1) HK1184492A1 (pt)
MX (1) MX348419B (pt)
RU (1) RU2562111C2 (pt)
WO (1) WO2012022725A2 (pt)

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WO2012022725A2 (en) 2010-08-19 2012-02-23 F. Hoffmann-La Roche Ag Conversion of somatic cells to induced reprogrammed neural stem cells (irnscs)
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PL223189B1 (pl) * 2012-11-15 2016-10-31 Celther Polska Spółka Z Ograniczoną Odpowiedzialnością Komórka iNS oraz sposób reprogramowania komórek somatycznych za pomocą czynnika Sox2 oraz Sox2 i c-Myc do komórki iNS
CA2892045C (en) * 2012-11-21 2022-05-31 Ptc Therapeutics, Inc. Substituted reverse pyrimidine bmi-1 inhibitors
KR20140121317A (ko) * 2013-04-06 2014-10-15 서울대학교산학협력단 비신경 세포로부터 유도 신경 줄기 세포의 생산 방법 및 이에 의하여 생산되는 유도 신경 줄기 세포
MX2016000557A (es) * 2013-07-23 2016-04-20 Hoffmann La Roche Conversion basada en moleculas pequeñas de celulas somaticas en celulas de cresta neural.
CN104342401B (zh) * 2013-07-25 2017-04-05 中国科学院广州生物医药与健康研究院 利用确定的细胞因子组合促进成纤维细胞转分化为脂肪细胞
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AU2016226203A1 (en) * 2015-03-04 2017-10-05 The University Of North Carolina At Chapel Hill Methods for making neural stem cells and uses thereof
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JP6691756B2 (ja) 2015-09-29 2020-05-13 東亞合成株式会社 合成ペプチドを用いた神経幹細胞の生産方法
CN116064540A (zh) * 2015-11-12 2023-05-05 豪夫迈·罗氏有限公司 用于诱导父本ube3a表达的寡核苷酸
CN108884444A (zh) * 2016-03-31 2018-11-23 味之素株式会社 使神经分化能力增强的神经干细胞用培养基
KR102311121B1 (ko) 2016-04-20 2021-10-13 교토후고리츠다이가쿠호진 배양 상피 시트의 제조 방법
EP3807402A4 (en) * 2018-06-14 2022-04-27 Academia Sinica METHOD FOR GENERATE INDUCED OLIGODENDROCYTE LINEAGE CELLS AND TREATMENT USING SUCH CELLS
WO2020038851A1 (en) 2018-08-21 2020-02-27 F. Hoffmann-La Roche Ag Methods for assessing transendothelial barrier integrity
US20230340405A1 (en) * 2020-06-09 2023-10-26 Unist (Ulsan National Institute Of Science And Technology) Composition for Inducing Direct Cross Differentiation of Somatic Cell into Motor Neuron, and Method for Using Same
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RU2013110127A (ru) 2014-09-27
HK1184492A1 (zh) 2014-01-24
MX2013001587A (es) 2013-03-21
WO2012022725A2 (en) 2012-02-23
EP2606126B1 (en) 2016-05-18
WO2012022725A3 (en) 2012-04-12
US9297025B2 (en) 2016-03-29
JP2013535973A (ja) 2013-09-19
RU2562111C2 (ru) 2015-09-10
ES2580837T3 (es) 2016-08-29
CN103068974B (zh) 2016-05-11
KR101788903B1 (ko) 2017-10-23
MX348419B (es) 2017-06-12
JP5905006B2 (ja) 2016-04-20
US20160369234A1 (en) 2016-12-22
CN103068974A (zh) 2013-04-24
EP2606126A2 (en) 2013-06-26
KR20160033798A (ko) 2016-03-28
KR20130030303A (ko) 2013-03-26
CA2807226A1 (en) 2012-02-23
US20140051171A1 (en) 2014-02-20

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