DE69228949T2 - Tgf-beta zur verbesserung der regeneration von neuronalem gewebe - Google Patents
Tgf-beta zur verbesserung der regeneration von neuronalem gewebeInfo
- Publication number
- DE69228949T2 DE69228949T2 DE69228949T DE69228949T DE69228949T2 DE 69228949 T2 DE69228949 T2 DE 69228949T2 DE 69228949 T DE69228949 T DE 69228949T DE 69228949 T DE69228949 T DE 69228949T DE 69228949 T2 DE69228949 T2 DE 69228949T2
- Authority
- DE
- Germany
- Prior art keywords
- tgf
- regeneration
- beta
- improving
- neuronal tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ24069691 | 1991-11-22 | ||
PCT/US1992/009974 WO1993009802A2 (en) | 1991-11-22 | 1992-11-20 | Tgf-beta to improve neural outcome |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69228949D1 DE69228949D1 (de) | 1999-05-20 |
DE69228949T2 true DE69228949T2 (de) | 1999-09-16 |
Family
ID=19923808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69228949T Expired - Lifetime DE69228949T2 (de) | 1991-11-22 | 1992-11-20 | Tgf-beta zur verbesserung der regeneration von neuronalem gewebe |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0625050B1 (de) |
JP (2) | JP4101284B2 (de) |
AT (1) | ATE178801T1 (de) |
CA (1) | CA2122058C (de) |
DE (1) | DE69228949T2 (de) |
DK (1) | DK0625050T3 (de) |
ES (1) | ES2133333T3 (de) |
GR (1) | GR3030651T3 (de) |
WO (1) | WO1993009802A2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6497872B1 (en) | 1991-07-08 | 2002-12-24 | Neurospheres Holdings Ltd. | Neural transplantation using proliferated multipotent neural stem cells and their progeny |
US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US7166277B1 (en) | 1991-07-08 | 2007-01-23 | Neurospheres Holdings Ltd. | Remyelination of neurons using multipotent neural stem cell progeny |
US6294346B1 (en) | 1991-07-08 | 2001-09-25 | Neurospheres Holdings, Ltd. | Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents |
US7361505B1 (en) | 1991-07-08 | 2008-04-22 | Neurospheres Holdings Ltd. | Multipotent neural stem cell compositions |
US6071889A (en) * | 1991-07-08 | 2000-06-06 | Neurospheres Holdings Ltd. | In vivo genetic modification of growth factor-responsive neural precursor cells |
US5980885A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | Growth factor-induced proliferation of neural precursor cells in vivo |
US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
US6399369B1 (en) | 1991-07-08 | 2002-06-04 | Neurospheres Holdings Ltd. | Multipotent neural stem cell cDNA libraries |
US5650396A (en) * | 1994-03-15 | 1997-07-22 | Celtrix Pharmaceuticals, Inc. | Methods of modulating inflammatory cytokines in the CNS using TGF-β |
WO1997034618A1 (en) * | 1996-03-22 | 1997-09-25 | The General Hospital Corporation | Administration of polypeptide growth factors following central nervous system ischemia or trauma |
US7544511B2 (en) | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
CA2296056A1 (en) * | 1997-07-10 | 1999-01-21 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
EP1576134B1 (de) | 2002-12-09 | 2013-03-06 | Judith Kelleher-Andersson | Verfahren zur entdeckung neurogener wirkstoffe |
AU2005252434B2 (en) | 2004-06-09 | 2011-11-24 | The University Court Of The University Of Edinburgh | Neural stem cells |
EP1814979B1 (de) | 2004-11-17 | 2015-04-08 | Neuralstem, Inc. | Transplantation menschlicher nervenzellen zur behandlung neurodegenerativer erkrankungen |
EP3187581A1 (de) | 2008-12-23 | 2017-07-05 | BOCO Silicon Valley, Inc. | Zielpopulationen von oligodendrozyten-vorläuferzellen und verfahren zur herstellung und verwendung davon |
WO2012016049A1 (en) | 2010-07-28 | 2012-02-02 | Neuralstem, Inc. | Methods for treating and/or reversing neurodegenerative diseases and/or disorders |
EP3209306B1 (de) | 2014-10-20 | 2024-04-24 | Neuralstem, Inc. | Stabile neurale stammzellen mit einem exogenen polynukleotid zur codierung eines wachstumsfaktors und verfahren zur verwendung davon |
-
1992
- 1992-11-20 WO PCT/US1992/009974 patent/WO1993009802A2/en active IP Right Grant
- 1992-11-20 EP EP92925330A patent/EP0625050B1/de not_active Expired - Lifetime
- 1992-11-20 DK DK92925330T patent/DK0625050T3/da active
- 1992-11-20 ES ES92925330T patent/ES2133333T3/es not_active Expired - Lifetime
- 1992-11-20 AT AT92925330T patent/ATE178801T1/de active
- 1992-11-20 CA CA002122058A patent/CA2122058C/en not_active Expired - Lifetime
- 1992-11-20 JP JP50951593A patent/JP4101284B2/ja not_active Expired - Lifetime
- 1992-11-20 DE DE69228949T patent/DE69228949T2/de not_active Expired - Lifetime
-
1999
- 1999-06-30 GR GR990401737T patent/GR3030651T3/el unknown
-
2003
- 2003-11-13 JP JP2003384121A patent/JP2004115532A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
GR3030651T3 (en) | 1999-10-29 |
CA2122058A1 (en) | 1993-05-27 |
DK0625050T3 (da) | 1999-10-25 |
EP0625050A1 (de) | 1994-11-23 |
JP2004115532A (ja) | 2004-04-15 |
JP4101284B2 (ja) | 2008-06-18 |
ATE178801T1 (de) | 1999-04-15 |
CA2122058C (en) | 2001-07-31 |
ES2133333T3 (es) | 1999-09-16 |
JPH07501080A (ja) | 1995-02-02 |
EP0625050B1 (de) | 1999-04-14 |
WO1993009802A2 (en) | 1993-05-27 |
DE69228949D1 (de) | 1999-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |