DE69232008D1 - Verwendung von insulinähnlichen Wachstumsfaktoren und Analogen zur BEHANDLUNG VON ERKRANKUNGEN DER SEHNERVEN - Google Patents
Verwendung von insulinähnlichen Wachstumsfaktoren und Analogen zur BEHANDLUNG VON ERKRANKUNGEN DER SEHNERVENInfo
- Publication number
- DE69232008D1 DE69232008D1 DE69232008T DE69232008T DE69232008D1 DE 69232008 D1 DE69232008 D1 DE 69232008D1 DE 69232008 T DE69232008 T DE 69232008T DE 69232008 T DE69232008 T DE 69232008T DE 69232008 D1 DE69232008 D1 DE 69232008D1
- Authority
- DE
- Germany
- Prior art keywords
- insulin
- analogs
- growth factors
- optic nerve
- nerve disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 3
- 102000013275 Somatomedins Human genes 0.000 title 1
- 208000020911 optic nerve disease Diseases 0.000 title 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 2
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 abstract 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000006576 neuronal survival Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000002207 retinal effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
- A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3813—N-Phosphonomethylglycine; Salts or complexes thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79069091A | 1991-11-08 | 1991-11-08 | |
US07/963,329 US6310040B1 (en) | 1991-11-08 | 1992-10-15 | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
PCT/US1992/009443 WO1993008826A1 (en) | 1991-11-08 | 1992-11-03 | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232008D1 true DE69232008D1 (de) | 2001-09-20 |
DE69232008T2 DE69232008T2 (de) | 2001-11-29 |
Family
ID=27121062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232008T Expired - Lifetime DE69232008T2 (de) | 1991-11-08 | 1992-11-03 | Verwendung von insulinähnlichen Wachstumsfaktoren und Analogen zur BEHANDLUNG VON ERKRANKUNGEN DER SEHNERVEN |
Country Status (9)
Country | Link |
---|---|
US (1) | US6310040B1 (de) |
EP (1) | EP0670729B1 (de) |
JP (1) | JP3445269B2 (de) |
AT (1) | ATE204176T1 (de) |
CA (1) | CA2122340C (de) |
DE (1) | DE69232008T2 (de) |
DK (1) | DK0670729T3 (de) |
ES (1) | ES2160581T3 (de) |
WO (1) | WO1993008826A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
JPH09509140A (ja) * | 1993-11-15 | 1997-09-16 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 神経学的障害の治療方法 |
US5712249A (en) * | 1994-09-08 | 1998-01-27 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
AU3545795A (en) * | 1994-09-08 | 1996-03-27 | Chiron Corporation | A method of improved production of insulin-like growth factor |
JP3191038B2 (ja) * | 1996-06-26 | 2001-07-23 | 輝夫 西田 | 眼科用医薬組成物 |
WO2000053760A2 (en) * | 1999-03-12 | 2000-09-14 | Genentech, Inc. | Method of preventing the death of retinal neurons and treating ocular diseases |
US6514937B1 (en) | 1997-02-25 | 2003-02-04 | Celtrix Pharmaceuticals, Inc. | Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3 |
US6015786A (en) * | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
US6025368A (en) * | 1997-02-25 | 2000-02-15 | Celtrix Pharmaceuticals, Inc. | Method for treating the symptoms of chronic stress-related disorders using IGF |
EP1005869A4 (de) * | 1997-03-24 | 2004-06-23 | Fujisawa Pharmaceutical Co | Gallensekretion fördernde verbindungen |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6331523B1 (en) | 1998-03-12 | 2001-12-18 | Genentech, Inc. | Method of enhancing the survival of retinal neurons and treating ocular diseases using FGF-5 |
US6875741B2 (en) | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
US7173005B2 (en) | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
PT1141014E (pt) | 1999-01-06 | 2005-04-29 | Genentech Inc | Variante mutante do factor de crescimento semelhante a insulina (igf-i) |
AU6391000A (en) * | 1999-07-28 | 2001-02-19 | Genentech Inc. | Method of preventing the injury or death of retinal cells and treating ocular diseases |
GB9928323D0 (en) * | 1999-11-30 | 2000-01-26 | Cyclacel Ltd | Peptides |
US20050245451A1 (en) * | 2000-04-05 | 2005-11-03 | Pincus Matthew R | Peptides selectively lethal to malignant and transformed mammalian cells |
EP1282437B1 (de) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Behandlung von knorpelerkrankungen |
US7427598B2 (en) * | 2000-05-31 | 2008-09-23 | The United States Of Americas As Represented By The Secretary Of The Department Of Health And Human Services | Post-natal administration of activity-dependent neurotrophic factor-derived polypeptides for enhancing learning and memory |
ATE439378T1 (de) | 2001-02-09 | 2009-08-15 | Genentech Inc | Verfahren zur identifizierung von indirekten igf- 1-agonisten |
US7714020B2 (en) | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
EP1401808B1 (de) | 2001-05-24 | 2009-07-08 | Neuren Pharmaceuticals Limited | Gpe-analoga und peptidomimetika |
US7605177B2 (en) | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
TWI305778B (en) * | 2001-12-03 | 2009-02-01 | Nishida Teruo | Peptides of an expressing unit for igf-i minimal activity and their pharmaceutical use |
JP4253743B2 (ja) * | 2001-12-03 | 2009-04-15 | 輝夫 西田 | 新規ペプチドおよびその医薬用途 |
US20080103457A1 (en) * | 2005-01-11 | 2008-05-01 | Heart Failure Technologies, Inc. University Enterprise Laboratories (Uel) | Method and System for Treating Heart Failure |
WO2006112737A1 (en) * | 2005-04-20 | 2006-10-26 | Protemix Discovery Limited | Vesiculins |
US8309057B2 (en) * | 2005-06-10 | 2012-11-13 | The Invention Science Fund I, Llc | Methods for elevating neurotrophic agents |
CN101395179B (zh) * | 2006-03-06 | 2013-01-02 | 凯尔杰有限公司 | 具有胰岛素样生长因子-i活性的肽及其用途 |
US9539327B2 (en) * | 2007-11-26 | 2017-01-10 | The Research Foundation For The State University Of New York | Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells |
ES2830350T3 (es) | 2008-05-07 | 2021-06-03 | Biomarin Pharm Inc | Péptidos de dirección lisosómica y usos de los mismos |
CN102471769A (zh) | 2009-07-17 | 2012-05-23 | 亚伦·T.·塔波尔 | 用于具有美容功能的细胞的遗传修饰以提高美容外观的方法和组合物 |
WO2011011073A1 (en) * | 2009-07-22 | 2011-01-27 | Ipsen Pharma S.A.S. | Site-specific pegylated or site-specific lipidated igf-1 and analogues of igf-1 |
UA103104C2 (ru) | 2009-07-22 | 2013-09-10 | Ипсен Фарма С.А.С. | Аналоги инсулиноподобного фактора роста-1 (igf-1), содержащие аминокислотную замену в положении 59 |
TWI490371B (zh) | 2009-07-28 | 2015-07-01 | Industrie De Nora Spa | 電解應用上的電極及其製法以及在電極表面上陽極釋氧之電解法和電冶法 |
WO2011071995A2 (en) | 2009-12-08 | 2011-06-16 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
KR101669140B1 (ko) * | 2015-04-28 | 2016-10-26 | (주)케어젠 | 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도 |
CN111763680A (zh) * | 2019-05-22 | 2020-10-13 | 杭州杰迪生物科技有限公司 | 一种人胰岛素样生长因子-i或其类似物的制备方法、编码基因、表达载体及宿主细胞 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0720993B2 (ja) * | 1985-08-22 | 1995-03-08 | グロペップ プロプライエタリー リミテッド | 生長因子 |
US4783524A (en) | 1985-09-17 | 1988-11-08 | Monsanto Company | Growth factors |
SE8505920D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | New protein and its use |
ES2063033T3 (es) | 1987-04-28 | 1995-01-01 | Boehringer Mannheim Gmbh | Empleo de igf-ii en el tratamiento de la enfermedades de los huesos. |
SE8703625D0 (sv) | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | New medical use |
DE3852636T2 (de) | 1987-12-24 | 1995-05-04 | Gropep Pty Ltd | Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2). |
US5652214A (en) * | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
DE69218948T2 (de) * | 1991-08-01 | 1997-07-31 | Auckland Uniservices Ltd | IGF-I zur Verbesserung der neuronale Lage |
US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
-
1992
- 1992-10-15 US US07/963,329 patent/US6310040B1/en not_active Expired - Lifetime
- 1992-11-03 ES ES92924246T patent/ES2160581T3/es not_active Expired - Lifetime
- 1992-11-03 WO PCT/US1992/009443 patent/WO1993008826A1/en active IP Right Grant
- 1992-11-03 DK DK92924246T patent/DK0670729T3/da active
- 1992-11-03 JP JP50868193A patent/JP3445269B2/ja not_active Expired - Lifetime
- 1992-11-03 DE DE69232008T patent/DE69232008T2/de not_active Expired - Lifetime
- 1992-11-03 CA CA002122340A patent/CA2122340C/en not_active Expired - Lifetime
- 1992-11-03 AT AT92924246T patent/ATE204176T1/de active
- 1992-11-03 EP EP92924246A patent/EP0670729B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1993008826A1 (en) | 1993-05-13 |
EP0670729A1 (de) | 1995-09-13 |
EP0670729B1 (de) | 2001-08-16 |
JP3445269B2 (ja) | 2003-09-08 |
CA2122340C (en) | 2007-06-12 |
DE69232008T2 (de) | 2001-11-29 |
DK0670729T3 (da) | 2001-12-10 |
JPH07500839A (ja) | 1995-01-26 |
ES2160581T3 (es) | 2001-11-16 |
CA2122340A1 (en) | 1993-05-13 |
US6310040B1 (en) | 2001-10-30 |
ATE204176T1 (de) | 2001-09-15 |
EP0670729A4 (de) | 1995-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R071 | Expiry of right |
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