JP2002517381A5 - - Google Patents
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- Publication number
- JP2002517381A5 JP2002517381A5 JP2000548298A JP2000548298A JP2002517381A5 JP 2002517381 A5 JP2002517381 A5 JP 2002517381A5 JP 2000548298 A JP2000548298 A JP 2000548298A JP 2000548298 A JP2000548298 A JP 2000548298A JP 2002517381 A5 JP2002517381 A5 JP 2002517381A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- solvent
- triiodo
- oxopropyl
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI001005A IT1299202B1 (it) | 1998-05-08 | 1998-05-08 | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
| IT98A001005 | 1998-05-08 | ||
| PCT/EP1999/002804 WO1999058494A2 (en) | 1998-05-08 | 1999-04-26 | Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002517381A JP2002517381A (ja) | 2002-06-18 |
| JP2002517381A5 true JP2002517381A5 (https=) | 2006-06-15 |
| JP4390389B2 JP4390389B2 (ja) | 2009-12-24 |
Family
ID=11379983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000548298A Expired - Lifetime JP4390389B2 (ja) | 1998-05-08 | 1999-04-26 | Ｓ−ｎ，ｎ′−ビス〔２−ヒドロキシ−１−（ヒドロキシメチル）エチル〕−５−〔（２−ヒドロキシ−１−オキソプロピル）アミノ〕−２，４，６−トリヨード−１，３−ベンゼンジカルボキシアミドを製造する方法 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1075462B1 (https=) |
| JP (1) | JP4390389B2 (https=) |
| KR (1) | KR100612480B1 (https=) |
| CN (1) | CN100336800C (https=) |
| AT (1) | ATE243676T1 (https=) |
| AU (1) | AU749785B2 (https=) |
| CA (1) | CA2331660C (https=) |
| CZ (1) | CZ293801B6 (https=) |
| DE (1) | DE69909078T2 (https=) |
| DK (1) | DK1075462T3 (https=) |
| ES (1) | ES2201719T3 (https=) |
| IT (1) | IT1299202B1 (https=) |
| NO (1) | NO326203B1 (https=) |
| PT (1) | PT1075462E (https=) |
| WO (1) | WO1999058494A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101098553B1 (ko) * | 2008-04-30 | 2011-12-26 | 주식회사 엘지생명과학 | 이오프로마이드의 신규한 제조방법 |
| EP2365963B1 (en) * | 2008-11-18 | 2017-06-28 | Bracco Imaging S.p.A | Process for the preparation of iodinated contrast agent |
| EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
| HUE040143T2 (hu) | 2012-12-11 | 2019-02-28 | Bracco Imaging Spa | Folyamatos eljárás (S)-2-acetiloxipropionsav elõállítására |
| PT3369724T (pt) | 2013-11-05 | 2021-02-10 | Bracco Imaging Spa | Processo para a preparação de iopamidol |
| EP3154928B1 (en) | 2014-06-10 | 2020-03-04 | Bracco Imaging S.p.A | Method for the preparation of (s)-2-acetyloxypropionic acid and derivatives thereof |
| CN105272899B (zh) * | 2015-11-17 | 2017-09-22 | 浙江海洲制药有限公司 | 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法 |
| WO2018104228A1 (en) | 2016-12-05 | 2018-06-14 | Bracco Imaging Spa | Mechanochemical synthesis of radiographic agents intermediates |
| CN110687226B (zh) * | 2019-10-18 | 2022-10-25 | 上海明捷医药科技有限公司 | 一种测定碘帕醇中2-氯丙酸含量的方法 |
| EP4452931A1 (en) * | 2021-12-20 | 2024-10-30 | Bracco Imaging SPA | Process for the preparation of 2,4,6-triiodoisophthalic bisamides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (https=) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| DE2628517C2 (de) * | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
| DE2928417A1 (de) * | 1979-07-12 | 1981-01-29 | Schering Ag | Trijodierte basen |
| IT1256163B (it) * | 1992-10-27 | 1995-11-29 | Zambon Spa | Processo per la preparazione di un intermedio della sintesi organica |
| IT1283319B1 (it) * | 1996-03-29 | 1998-04-16 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
| IT1288114B1 (it) * | 1996-06-13 | 1998-09-10 | Fructamine Spa | Processo per la purificazione di un intermedio |
-
1998
- 1998-05-08 IT IT98MI001005A patent/IT1299202B1/it active IP Right Grant
-
1999
- 1999-04-26 EP EP19990924824 patent/EP1075462B1/en not_active Expired - Lifetime
- 1999-04-26 DK DK99924824T patent/DK1075462T3/da active
- 1999-04-26 JP JP2000548298A patent/JP4390389B2/ja not_active Expired - Lifetime
- 1999-04-26 PT PT99924824T patent/PT1075462E/pt unknown
- 1999-04-26 AU AU41356/99A patent/AU749785B2/en not_active Expired
- 1999-04-26 CZ CZ20004124A patent/CZ293801B6/cs not_active IP Right Cessation
- 1999-04-26 WO PCT/EP1999/002804 patent/WO1999058494A2/en not_active Ceased
- 1999-04-26 CN CNB998059226A patent/CN100336800C/zh not_active Expired - Lifetime
- 1999-04-26 ES ES99924824T patent/ES2201719T3/es not_active Expired - Lifetime
- 1999-04-26 AT AT99924824T patent/ATE243676T1/de active
- 1999-04-26 DE DE69909078T patent/DE69909078T2/de not_active Expired - Lifetime
- 1999-04-26 KR KR1020007012448A patent/KR100612480B1/ko not_active Expired - Lifetime
- 1999-04-26 CA CA002331660A patent/CA2331660C/en not_active Expired - Lifetime
-
2000
- 2000-11-07 NO NO20005616A patent/NO326203B1/no not_active IP Right Cessation
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