DE69909078T2 - Verfahren zur herstellung von s-n,n'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamid - Google Patents

Verfahren zur herstellung von s-n,n'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamid

Info

Publication number
DE69909078T2
DE69909078T2 DE69909078T DE69909078T DE69909078T2 DE 69909078 T2 DE69909078 T2 DE 69909078T2 DE 69909078 T DE69909078 T DE 69909078T DE 69909078 T DE69909078 T DE 69909078T DE 69909078 T2 DE69909078 T2 DE 69909078T2
Authority
DE
Germany
Prior art keywords
hydroxy
triiodo
oxopropyl
amino
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69909078T
Other languages
English (en)
Other versions
DE69909078D1 (de
Inventor
Nicola Desantis
Salvatore Incandela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Publication of DE69909078D1 publication Critical patent/DE69909078D1/de
Application granted granted Critical
Publication of DE69909078T2 publication Critical patent/DE69909078T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
DE69909078T 1998-05-08 1999-04-26 Verfahren zur herstellung von s-n,n'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamid Expired - Lifetime DE69909078T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI001005A IT1299202B1 (it) 1998-05-08 1998-05-08 Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
PCT/EP1999/002804 WO1999058494A2 (en) 1998-05-08 1999-04-26 Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide

Publications (2)

Publication Number Publication Date
DE69909078D1 DE69909078D1 (de) 2003-07-31
DE69909078T2 true DE69909078T2 (de) 2003-12-18

Family

ID=11379983

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909078T Expired - Lifetime DE69909078T2 (de) 1998-05-08 1999-04-26 Verfahren zur herstellung von s-n,n'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamid

Country Status (15)

Country Link
EP (1) EP1075462B1 (de)
JP (1) JP4390389B2 (de)
KR (1) KR100612480B1 (de)
CN (1) CN100336800C (de)
AT (1) ATE243676T1 (de)
AU (1) AU749785B2 (de)
CA (1) CA2331660C (de)
CZ (1) CZ293801B6 (de)
DE (1) DE69909078T2 (de)
DK (1) DK1075462T3 (de)
ES (1) ES2201719T3 (de)
IT (1) IT1299202B1 (de)
NO (1) NO326203B1 (de)
PT (1) PT1075462E (de)
WO (1) WO1999058494A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009317450B2 (en) 2008-11-18 2015-05-07 Bracco Imaging Spa Process for the preparation of iodinated contrast agent
EP2230227A1 (de) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Verfahren zur Herstellung von aromatischen Trijodid-Carboxyl- Derivaten
DK2931696T3 (en) 2012-12-11 2018-12-17 Bracco Imaging Spa CONTINUOUS PROCEDURE FOR THE PREPARATION OF (S) -2-ACETYLOXYPROPIONIC ACID
RU2657238C2 (ru) 2013-11-05 2018-06-09 Бракко Имэджинг Спа Способ получения йопамидола
KR102358241B1 (ko) 2014-06-10 2022-02-04 브라코 이미징 에스.피.에이. (s)-2-아세틸옥시프로피온산 및 그것의 유도체의 제조 방법
CN105272899B (zh) * 2015-11-17 2017-09-22 浙江海洲制药有限公司 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
EP3548461B1 (de) 2016-12-05 2021-02-03 Bracco Imaging SpA Mechanochemische synthese von radiographischen mittelzwischenprodukten
CN110687226B (zh) * 2019-10-18 2022-10-25 上海明捷医药科技有限公司 一种测定碘帕醇中2-氯丙酸含量的方法
WO2023117667A1 (en) 2021-12-20 2023-06-29 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodoisophthalic bisamides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio

Also Published As

Publication number Publication date
ES2201719T3 (es) 2004-03-16
WO1999058494A3 (en) 2000-01-20
CZ293801B6 (cs) 2004-08-18
EP1075462B1 (de) 2003-06-25
PT1075462E (pt) 2003-10-31
NO20005616L (no) 2000-11-07
NO326203B1 (no) 2008-10-20
ITMI981005A1 (it) 1999-11-08
DK1075462T3 (da) 2003-10-13
AU749785B2 (en) 2002-07-04
AU4135699A (en) 1999-11-29
JP2002517381A (ja) 2002-06-18
CN100336800C (zh) 2007-09-12
EP1075462A2 (de) 2001-02-14
KR100612480B1 (ko) 2006-08-16
CZ20004124A3 (cs) 2002-03-13
KR20010071221A (ko) 2001-07-28
IT1299202B1 (it) 2000-02-29
WO1999058494A2 (en) 1999-11-18
JP4390389B2 (ja) 2009-12-24
CN1302288A (zh) 2001-07-04
CA2331660A1 (en) 1999-11-18
ATE243676T1 (de) 2003-07-15
NO20005616D0 (no) 2000-11-07
CA2331660C (en) 2008-07-08
DE69909078D1 (de) 2003-07-31

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