JP2002512983A5 - - Google Patents
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- Publication number
- JP2002512983A5 JP2002512983A5 JP2000545574A JP2000545574A JP2002512983A5 JP 2002512983 A5 JP2002512983 A5 JP 2002512983A5 JP 2000545574 A JP2000545574 A JP 2000545574A JP 2000545574 A JP2000545574 A JP 2000545574A JP 2002512983 A5 JP2002512983 A5 JP 2002512983A5
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- polyol
- peg
- complex
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002202 Polyethylene glycol Substances 0.000 description 22
- 229920001223 polyethylene glycol Polymers 0.000 description 22
- 238000000034 method Methods 0.000 description 20
- 229960001388 interferon-beta Drugs 0.000 description 16
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 229920005862 polyol Polymers 0.000 description 5
- 150000003077 polyols Chemical class 0.000 description 5
- 230000001588 bifunctional effect Effects 0.000 description 4
- 101001054334 Homo sapiens Interferon beta Proteins 0.000 description 3
- 102000003996 Interferon-beta Human genes 0.000 description 3
- 108090000467 Interferon-beta Proteins 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010040070 Septic Shock Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 2
- 230000001363 autoimmune Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 206010025135 lupus erythematosus Diseases 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000012070 reactive reagent Substances 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 230000036303 septic shock Effects 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 101100379079 Emericella variicolor andA gene Proteins 0.000 description 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 229920001427 mPEG Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8333998P | 1998-04-28 | 1998-04-28 | |
| US60/083,339 | 1998-04-28 | ||
| PCT/US1999/009161 WO1999055377A2 (en) | 1998-04-28 | 1999-04-28 | Polyol-ifn-beta conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010100840A Division JP2010184929A (ja) | 1998-04-28 | 2010-04-26 | ポリオール−ｉｆｎ−ベータ複体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512983A JP2002512983A (ja) | 2002-05-08 |
| JP2002512983A5 true JP2002512983A5 (enExample) | 2010-01-14 |
| JP4574007B2 JP4574007B2 (ja) | 2010-11-04 |
Family
ID=22177687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000545574A Expired - Lifetime JP4574007B2 (ja) | 1998-04-28 | 1999-04-28 | ポリオール−ｉｆｎ−ベータ複体 |
| JP2010100840A Pending JP2010184929A (ja) | 1998-04-28 | 2010-04-26 | ポリオール−ｉｆｎ−ベータ複体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010100840A Pending JP2010184929A (ja) | 1998-04-28 | 2010-04-26 | ポリオール−ｉｆｎ−ベータ複体 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6638500B1 (enExample) |
| EP (2) | EP1421956B1 (enExample) |
| JP (2) | JP4574007B2 (enExample) |
| KR (1) | KR100622796B1 (enExample) |
| CN (2) | CN1187094C (enExample) |
| AR (1) | AR020070A1 (enExample) |
| AT (2) | ATE365563T1 (enExample) |
| AU (1) | AU762621B2 (enExample) |
| BG (2) | BG64694B1 (enExample) |
| BR (1) | BR9910023A (enExample) |
| CA (2) | CA2330451A1 (enExample) |
| CY (1) | CY1108022T1 (enExample) |
| CZ (2) | CZ298579B6 (enExample) |
| DE (2) | DE69936409T2 (enExample) |
| DK (2) | DK1075281T3 (enExample) |
| EA (2) | EA003789B1 (enExample) |
| EE (1) | EE05214B1 (enExample) |
| ES (2) | ES2285286T3 (enExample) |
| HU (1) | HUP0300548A3 (enExample) |
| IL (1) | IL139286A (enExample) |
| NO (2) | NO329749B1 (enExample) |
| NZ (1) | NZ507456A (enExample) |
| PL (2) | PL193352B1 (enExample) |
| PT (2) | PT1421956E (enExample) |
| SI (2) | SI1075281T1 (enExample) |
| SK (2) | SK286654B6 (enExample) |
| TR (2) | TR200101751T2 (enExample) |
| TW (2) | TWI266800B (enExample) |
| UA (2) | UA66857C2 (enExample) |
| WO (1) | WO1999055377A2 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US7220717B2 (en) | 1997-08-14 | 2007-05-22 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use |
| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| US7704944B2 (en) | 1997-08-14 | 2010-04-27 | Yeda Research And Development Company Ltd. | Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis |
| DK1656952T3 (da) | 1998-10-16 | 2014-01-20 | Biogen Idec Inc | Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf |
| AU766190B2 (en) | 1998-10-16 | 2003-10-09 | Biogen Idec Ma Inc. | Interferon-beta fusion proteins and uses |
| US7238368B2 (en) * | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
| US7303760B2 (en) * | 1999-04-23 | 2007-12-04 | Alza Corporation | Method for treating multi-drug resistant tumors |
| HUP0201425A3 (en) * | 1999-04-23 | 2006-07-28 | Hadasit Med Res Service | Conjugate having a cleavable linkage for use in a liposome |
| US7431921B2 (en) | 1999-08-27 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
| US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
| US7144574B2 (en) | 1999-08-27 | 2006-12-05 | Maxygen Aps | Interferon β variants and conjugates |
| TR200101086A3 (enExample) * | 1999-10-15 | 2001-08-21 | ||
| US7691367B2 (en) | 1999-12-24 | 2010-04-06 | Kyowa Hakko Kirin Co., Ltd. | Branched polyalkylene glycols |
| HUP0203751A3 (en) | 2000-01-10 | 2005-01-28 | Maxygen Holdings Ltd Redwood C | G-csf conjugates |
| WO2001058935A2 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| CA2436623C (en) * | 2001-01-30 | 2011-08-02 | Kyowa Hakko Kogyo Co., Ltd. | Branched polyalkylene glycols |
| EP1234583A1 (en) | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
| EP1366075B1 (en) | 2001-02-27 | 2009-05-27 | Maxygen Aps | New interferon beta-like molecules |
| KR100961859B1 (ko) | 2001-07-11 | 2010-06-09 | 맥시겐 홀딩스 엘티디 | 지-씨에스에프 접합체 |
| PT3025726T (pt) | 2002-01-18 | 2020-01-09 | Biogen Ma Inc | Compostos do polímero polialquileno e utilizações dos mesmos |
| TWI334785B (en) | 2002-06-03 | 2010-12-21 | Serono Lab | Use of recombinant ifn-β1a and pharmaceutical composition comprising recombinant ifn-β1a for the treatment of hcv infection in patients of asian race |
| WO2004020468A2 (en) * | 2002-08-28 | 2004-03-11 | Maxygen Aps | Interferon beta-like molecules for treatment of cancer |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| RS20050501A (sr) | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polimerni konjugati citokina,hemokina,faktora rasta, polipeptidnih hormona i njihovih antagonista sa očuvanom aktivnošću vezivanja receptora |
| GEP20084486B (en) | 2002-12-26 | 2008-09-25 | Mountain View Pharmaceuticals | Polymer conjugates of interferon-beta with enhanced biological potency |
| EP2085470B1 (en) | 2003-03-20 | 2012-05-16 | Bayer HealthCare LLC | FVII or FVIIa variants |
| TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| ES2428358T3 (es) | 2003-10-17 | 2013-11-07 | Novo Nordisk A/S | Terapia de combinación |
| AU2008201682B2 (en) * | 2004-02-02 | 2011-02-24 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
| BRPI0507169A (pt) * | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| EP1586334A1 (en) * | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF conjugates with peg |
| US7879320B2 (en) | 2004-05-17 | 2011-02-01 | Ares Trading S.A. | Hydrogel interferon formulations |
| US7731948B2 (en) | 2004-06-01 | 2010-06-08 | Ares Trading S.A. | Stabilized interferon liquid formulations |
| EA012281B1 (ru) | 2004-06-01 | 2009-08-28 | Арес Трейдинг С.А. | Способ стабилизации белков |
| TW200633718A (en) * | 2004-12-16 | 2006-10-01 | Applied Research Systems | Treatment of hepatitis c in the asian population |
| JP5243041B2 (ja) * | 2004-12-21 | 2013-07-24 | ネクター セラピューティックス | 安定化ポリマーチオール試薬 |
| CA2594557C (en) | 2004-12-22 | 2016-04-26 | Ambrx, Inc. | Modified human growth hormone |
| BRPI0519170A8 (pt) | 2004-12-22 | 2018-05-08 | Ambrx Inc | formulações de hormônio de crescimento humano que compreendem um aminoácido não naturalmente codificado |
| JP2008525032A (ja) | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 組換えヒト成長ホルモンを発現及び精製するための方法 |
| US8633300B2 (en) | 2005-06-17 | 2014-01-21 | Novo Nordisk Healthcare Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
| BRPI0614257A2 (pt) * | 2005-08-04 | 2011-03-15 | Nektar Therapeutics Al Corp | conjugados de uma porção de g-csf e um polìmero |
| US20080219952A1 (en) | 2005-08-26 | 2008-09-11 | Ares Trading S.A. | Process For the Preparation of Glycosylated Interferon Beta |
| EP1933860A2 (en) | 2005-09-01 | 2008-06-25 | Ares Trading S.A. | Treatment of optic neuritis |
| US20070238656A1 (en) * | 2006-04-10 | 2007-10-11 | Eastman Kodak Company | Functionalized poly(ethylene glycol) |
| CA2653748A1 (en) * | 2006-05-02 | 2007-11-15 | Allozyne, Inc. | Non-natural amino acid substituted polypeptides |
| US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| AU2007253264A1 (en) | 2006-05-24 | 2007-11-29 | Novo Nordisk Health Care Ag | Factor IX analogues having prolonged in vivo half life |
| MX2008014971A (es) | 2006-05-24 | 2008-12-05 | Serono Lab | Regimen de cladribine para tratar esclerosis multiple. |
| CN101675071B (zh) | 2007-05-02 | 2014-06-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
| CA2707840A1 (en) * | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| RS52417B (sr) | 2007-12-20 | 2013-02-28 | Merck Serono S.A. | Formulacije peg-interferona-beta |
| SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| CN101525381B (zh) * | 2008-03-04 | 2012-04-18 | 北京百川飞虹生物科技有限公司 | 一种重组复合干扰素及其表达载体的构建和表达 |
| US20100112660A1 (en) * | 2008-05-30 | 2010-05-06 | Barofold, Inc. | Method for Derivatization of Proteins Using Hydrostatic Pressure |
| US20110124614A1 (en) * | 2008-10-25 | 2011-05-26 | Halina Offner | Methods And Compositions For The Treatment of Autoimmune Disorders |
| DE102009032179A1 (de) * | 2009-07-07 | 2011-01-13 | Biogenerix Ag | Verfahren zur Reinigung von Interferon beta |
| ES2365343B1 (es) | 2009-11-19 | 2012-07-10 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de cd98 como marcador de receptividad endometrial. |
| EP2536753B1 (en) | 2010-02-16 | 2017-12-20 | Novo Nordisk A/S | Factor viii molecules with reduced vwf binding |
| EP4450523A3 (en) | 2010-04-02 | 2025-03-12 | Amunix Pharmaceuticals, Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| AR080993A1 (es) | 2010-04-02 | 2012-05-30 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina |
| EP2569331A1 (en) | 2010-05-10 | 2013-03-20 | Perseid Therapeutics LLC | Polypeptide inhibitors of vla4 |
| JP2013532176A (ja) | 2010-07-15 | 2013-08-15 | ノヴォ ノルディスク アー／エス | 安定化させた第ｖｉｉｉ因子バリアント |
| CN104788557A (zh) | 2010-09-15 | 2015-07-22 | 诺沃—诺迪斯克有限公司 | 具有减少的细胞摄取的因子viii变体 |
| JP2014506889A (ja) * | 2011-02-18 | 2014-03-20 | ステムディーアール インク． | Ｓｉｒｔ１発現誘導物質を含む敗血症または敗血症性ショックの予防または治療用組成物 |
| AU2012280474A1 (en) | 2011-07-01 | 2014-01-16 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| IN2014CN02982A (enExample) * | 2011-10-01 | 2015-07-03 | Glytech Inc | |
| CN104302408B (zh) | 2012-02-27 | 2016-12-14 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| US20150030564A1 (en) | 2012-02-29 | 2015-01-29 | Toray Industries, Inc. | Inhibitory agent for body cavity fluid accumulation |
| US9675678B2 (en) | 2013-01-29 | 2017-06-13 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for treatment of homocystinuria |
| AU2014245917B2 (en) | 2013-03-29 | 2017-09-28 | Glytech, Inc. | Polypeptide having sialylated sugar chains attached thereto |
| US11759500B2 (en) | 2014-07-24 | 2023-09-19 | Abion Inc. | PEGylated interferon-beta variant |
| WO2016013697A1 (ko) * | 2014-07-24 | 2016-01-28 | 에이비온 주식회사 | 인터페론-베타 변이체의 폴리에틸렌글리콜 배합체 |
| SI3183264T1 (sl) | 2014-08-19 | 2021-03-31 | Biogen Ma Inc. | Metoda pegilacije |
| ES2903448T3 (es) | 2015-05-01 | 2022-04-01 | Allysta Pharmaceuticals Inc | Peptidomiméticos de adiponectina para el tratamiento de trastornos oculares |
| EP3795591B1 (en) * | 2015-06-19 | 2023-09-27 | Eisai R&D Management Co., Ltd. | Cys80 conjugated immunoglobulins |
| DK3998067T3 (da) | 2015-11-09 | 2024-10-28 | Univ Colorado Regents | Sammensætninger og fremgangsmåder til behandling af homocystinuri |
| CA3059592A1 (en) * | 2017-04-17 | 2018-10-25 | The Regents Of The University Of Colorado, A Body Corporate | Optimization of enzyme replacement therapy for treatment of homocystinuria |
| AR113906A1 (es) | 2017-11-24 | 2020-06-24 | Merck Patent Ges Mit Beschraenkter Haftung | Régimen con cladribina para tratar formas progresivas de la esclerosis múltiple |
| CN113382775A (zh) | 2019-01-28 | 2021-09-10 | 东丽株式会社 | 肝细胞生长因子或其活性片段的聚乙二醇修饰物 |
| EP3919128A4 (en) | 2019-01-28 | 2023-01-11 | Toray Industries, Inc. | POLYETHYLENE GLYCOL MODIFIED BODY FOR HEPATORYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOF |
| IL301246A (en) | 2020-09-10 | 2023-05-01 | Merck Patent Gmbh | Treatment regimen with cladribine |
Family Cites Families (21)
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| EP0229108B1 (en) * | 1985-06-26 | 1990-12-27 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US5208344A (en) * | 1987-07-31 | 1993-05-04 | American Home Products Corporation | Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| HUT75533A (en) | 1993-11-10 | 1997-05-28 | Schering Corp | Improved interferon polymer conjugates |
| EE9600121A (et) | 1994-03-31 | 1997-04-15 | Amgen Inc. | Megakarüotsüütide kasvu ja diferentseerumist stimuleerivad kompositsioonid ja meetodid |
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| US5851984A (en) * | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| KR0176625B1 (ko) | 1996-11-05 | 1999-04-01 | 삼성전자주식회사 | 적외선 물체검출장치 |
| AU5773798A (en) * | 1997-01-29 | 1998-08-18 | Polymasc Pharmaceuticals Plc | Pegylation process |
| ATE375363T1 (de) * | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| US6531122B1 (en) * | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
-
1999
- 1999-04-28 DE DE69936409T patent/DE69936409T2/de not_active Expired - Lifetime
- 1999-04-28 EP EP04003053A patent/EP1421956B1/en not_active Expired - Lifetime
- 1999-04-28 TR TR2001/01751T patent/TR200101751T2/xx unknown
- 1999-04-28 CN CNB998054968A patent/CN1187094C/zh not_active Expired - Fee Related
- 1999-04-28 CA CA002330451A patent/CA2330451A1/en not_active Abandoned
- 1999-04-28 NZ NZ507456A patent/NZ507456A/en not_active IP Right Cessation
- 1999-04-28 JP JP2000545574A patent/JP4574007B2/ja not_active Expired - Lifetime
- 1999-04-28 EE EEP200000614A patent/EE05214B1/xx not_active IP Right Cessation
- 1999-04-28 EP EP99920094A patent/EP1075281B1/en not_active Expired - Lifetime
- 1999-04-28 ES ES04003053T patent/ES2285286T3/es not_active Expired - Lifetime
- 1999-04-28 ES ES99920094T patent/ES2224649T3/es not_active Expired - Lifetime
- 1999-04-28 UA UA2000116719A patent/UA66857C2/uk unknown
- 1999-04-28 SI SI9930662T patent/SI1075281T1/xx unknown
- 1999-04-28 PL PL344490A patent/PL193352B1/pl not_active IP Right Cessation
- 1999-04-28 AT AT04003053T patent/ATE365563T1/de active
- 1999-04-28 BR BR9910023-1A patent/BR9910023A/pt active Search and Examination
- 1999-04-28 PT PT04003053T patent/PT1421956E/pt unknown
- 1999-04-28 WO PCT/US1999/009161 patent/WO1999055377A2/en not_active Ceased
- 1999-04-28 KR KR1020007011587A patent/KR100622796B1/ko not_active Expired - Fee Related
- 1999-04-28 CA CA002565375A patent/CA2565375A1/en not_active Abandoned
- 1999-04-28 EA EA200001111A patent/EA003789B1/ru not_active IP Right Cessation
- 1999-04-28 DK DK99920094T patent/DK1075281T3/da active
- 1999-04-28 SI SI9930974T patent/SI1421956T1/sl unknown
- 1999-04-28 CZ CZ20003995A patent/CZ298579B6/cs not_active IP Right Cessation
- 1999-04-28 AT AT99920094T patent/ATE275422T1/de active
- 1999-04-28 UA UA20031212655A patent/UA79430C2/uk unknown
- 1999-04-28 SK SK66-2007A patent/SK286654B6/sk not_active IP Right Cessation
- 1999-04-28 CN CNB2004100898478A patent/CN100335503C/zh not_active Expired - Fee Related
- 1999-04-28 PL PL378728A patent/PL196533B1/pl not_active IP Right Cessation
- 1999-04-28 TR TR2000/03161T patent/TR200003161T2/xx unknown
- 1999-04-28 DK DK04003053T patent/DK1421956T3/da active
- 1999-04-28 IL IL13928699A patent/IL139286A/xx not_active IP Right Cessation
- 1999-04-28 AU AU37674/99A patent/AU762621B2/en not_active Ceased
- 1999-04-28 SK SK1622-2000A patent/SK286217B6/sk not_active IP Right Cessation
- 1999-04-28 HU HU0300548A patent/HUP0300548A3/hu unknown
- 1999-04-28 PT PT99920094T patent/PT1075281E/pt unknown
- 1999-04-28 EA EA200300382A patent/EA200300382A1/ru not_active IP Right Cessation
- 1999-04-28 CZ CZ20050048A patent/CZ298597B6/cs not_active IP Right Cessation
- 1999-04-28 DE DE69920002T patent/DE69920002T2/de not_active Expired - Lifetime
- 1999-04-29 AR ARP990101987A patent/AR020070A1/es active IP Right Grant
- 1999-07-26 TW TW093123043A patent/TWI266800B/zh active
- 1999-07-26 TW TW088112596A patent/TWI232882B/zh active
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2000
- 2000-10-17 BG BG104871A patent/BG64694B1/bg unknown
- 2000-10-17 BG BG109291A patent/BG65046B1/bg unknown
- 2000-10-23 NO NO20005337A patent/NO329749B1/no not_active IP Right Cessation
- 2000-10-30 US US09/698,133 patent/US6638500B1/en not_active Expired - Lifetime
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2003
- 2003-08-28 US US10/649,609 patent/US7357925B2/en not_active Expired - Fee Related
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2007
- 2007-02-13 US US11/674,476 patent/US7700314B2/en not_active Expired - Fee Related
- 2007-07-19 CY CY20071100966T patent/CY1108022T1/el unknown
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2010
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- 2010-04-26 JP JP2010100840A patent/JP2010184929A/ja active Pending
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