JP2002512239A5 - - Google Patents
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- Publication number
- JP2002512239A5 JP2002512239A5 JP2000544658A JP2000544658A JP2002512239A5 JP 2002512239 A5 JP2002512239 A5 JP 2002512239A5 JP 2000544658 A JP2000544658 A JP 2000544658A JP 2000544658 A JP2000544658 A JP 2000544658A JP 2002512239 A5 JP2002512239 A5 JP 2002512239A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- alkyl
- group
- ethenyl
- heptadecane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 20
- 125000000547 substituted alkyl group Chemical group 0.000 description 18
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- 125000000623 heterocyclic group Chemical group 0.000 description 12
- 229910052717 sulfur Inorganic materials 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 10
- 125000003107 substituted aryl group Chemical group 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 8
- -1 R 42 Chemical compound 0.000 description 6
- 125000000753 cycloalkyl group Chemical group 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- LZWPOLSJFGLQCE-UHFFFAOYSA-N heptadecane-5,9-dione Chemical compound CCCCCCCCC(=O)CCCC(=O)CCCC LZWPOLSJFGLQCE-UHFFFAOYSA-N 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8256498P | 1998-04-21 | 1998-04-21 | |
| US60/082,564 | 1998-04-21 | ||
| PCT/US1999/007475 WO1999054319A1 (en) | 1998-04-21 | 1999-04-05 | 12,13-modified epothilone derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512239A JP2002512239A (ja) | 2002-04-23 |
| JP2002512239A5 true JP2002512239A5 (enExample) | 2006-06-01 |
| JP4476483B2 JP4476483B2 (ja) | 2010-06-09 |
Family
ID=22171978
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000544658A Expired - Fee Related JP4476483B2 (ja) | 1998-04-21 | 1999-04-05 | １２，１３−修飾エポチロン誘導体 |
| JP2000544657A Pending JP2002512238A (ja) | 1998-04-21 | 1999-04-05 | １２，１３−シクロプロパンエポチロン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000544657A Pending JP2002512238A (ja) | 1998-04-21 | 1999-04-05 | １２，１３−シクロプロパンエポチロン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6380395B1 (enExample) |
| EP (3) | EP1073647B1 (enExample) |
| JP (2) | JP4476483B2 (enExample) |
| CN (1) | CN1142923C (enExample) |
| AR (2) | AR015007A1 (enExample) |
| AT (2) | ATE340177T1 (enExample) |
| AU (2) | AU748526B2 (enExample) |
| BR (1) | BR9909795A (enExample) |
| CA (2) | CA2329181C (enExample) |
| CY (2) | CY1105836T1 (enExample) |
| DE (2) | DE69933287T2 (enExample) |
| DK (3) | DK1073648T3 (enExample) |
| ES (3) | ES2400049T3 (enExample) |
| PE (1) | PE20000460A1 (enExample) |
| PT (3) | PT1073648E (enExample) |
| TR (1) | TR200003036T2 (enExample) |
| WO (2) | WO1999054319A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| EP0977563B1 (en) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| GB9810659D0 (en) | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| DE19826988A1 (de) * | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
| EP1135470A2 (en) | 1998-11-20 | 2001-09-26 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| EA003326B1 (ru) * | 1998-12-02 | 2003-04-24 | Пфайзер Продактс Инк. | Способ лечения рака |
| US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO2000057874A1 (en) * | 1999-03-29 | 2000-10-05 | Bristol-Myers Squibb Co. | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| CN1348370A (zh) | 1999-04-15 | 2002-05-08 | 布里斯托尔-迈尔斯斯奎布公司 | 环状蛋白酪氨酸激酶抑制剂 |
| US6593115B2 (en) * | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
| JP2005500974A (ja) | 2000-10-13 | 2005-01-13 | ザ ユニバーシテイ オブ ミシシッピー | エポシロン類及び関連類似体の合成 |
| NZ526871A (en) * | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
| IL156578A0 (en) * | 2001-01-25 | 2004-01-04 | Bristol Myers Squibb Co | A method for formulating an epothilone analog for pharmaceutical use and pharmaceutical preparations including an epothilone analog |
| EE05301B1 (et) * | 2001-01-25 | 2010-06-15 | Bristol-Myers Squibb Company | Meetod epotilooni analooge sisaldavate ravimvormide valmistamiseks ning nende kasutamine ravimi valmistamiseks |
| RU2003126171A (ru) * | 2001-01-25 | 2005-02-27 | Бристол-Маерс Сквибб Компани (Us) | Парентеральный состав, содержащий аналоги эпотилона |
| EP1368030A1 (en) | 2001-02-20 | 2003-12-10 | Bristol-Myers Squibb Company | Epothilone derivatives for the treatment of refractory tumors |
| EE200300396A (et) | 2001-02-20 | 2003-12-15 | Bristol-Myers Squibb Company | Epotilooni derivaatide kasutamine refraktaarsete kasvajate raviks |
| WO2002072085A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| EP1389209B1 (en) * | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| WO2002098868A1 (en) | 2001-06-01 | 2002-12-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| BR0212107A (pt) * | 2001-08-23 | 2004-08-24 | Novartis Ag | Análogos da ciclopropil e da ciclobutil epotilona |
| WO2003026744A1 (en) * | 2001-09-25 | 2003-04-03 | Alcon, Inc. | The use of epothilones and analogs in conjunction with ophthalmic surgery |
| TW200303202A (en) * | 2002-02-15 | 2003-09-01 | Bristol Myers Squibb Co | Method of preparation of 21-amino epothilone derivatives |
| DK1483251T3 (da) | 2002-03-12 | 2010-04-12 | Bristol Myers Squibb Co | C3-cyano-epothilon-derivater |
| US7211593B2 (en) * | 2002-03-12 | 2007-05-01 | Bristol-Myers Squibb Co. | C12-cyano epothilone derivatives |
| TW200403994A (en) | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
| TW200400191A (en) | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
| ES2324708T3 (es) * | 2002-05-15 | 2009-08-13 | Endocyte, Inc. | Conjugados de vitamina-mitomicina. |
| US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| AU2003243561A1 (en) * | 2002-06-14 | 2003-12-31 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| RU2338741C2 (ru) * | 2002-07-31 | 2008-11-20 | Мершан Корпорейшн | Новые физиологически активные вещества |
| AU2003266961A1 (en) * | 2002-08-02 | 2004-02-25 | Novartis Ag | Epothilone derivatives |
| WO2004018478A2 (en) | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| RS20050235A (sr) | 2002-09-23 | 2007-06-04 | Bristol Myers Squibb Company, | Postupci za pripremanje,izolaciju i prečišćavanje epotilona b i kristalne strukture epotilona b dobijene primenom x-zraka |
| JP2006504743A (ja) * | 2002-10-09 | 2006-02-09 | コーザン バイオサイエンシス インコーポレイテッド | 治療製剤 |
| CN100553634C (zh) * | 2002-10-11 | 2009-10-28 | 达纳-法伯癌症研究公司 | 用于治疗多发性骨髓瘤的埃坡霉素衍生物 |
| US7632858B2 (en) | 2002-11-15 | 2009-12-15 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
| EP1592457B1 (en) | 2003-01-27 | 2012-07-25 | Endocyte, Inc. | Folate-vinblastine conjugate as medicament |
| BRPI0415428A (pt) * | 2003-10-09 | 2006-12-05 | Kosan Biosciences Inc | formulações terapêuticas |
| EP1670487A4 (en) * | 2003-10-09 | 2008-05-21 | Kosan Biosciences Inc | THERAPEUTIC FORMULATIONS |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
| US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
| US8288557B2 (en) * | 2004-07-23 | 2012-10-16 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| US10675326B2 (en) | 2004-10-07 | 2020-06-09 | The Board Of Trustees Of The University Of Illinois | Compositions comprising cupredoxins for treating cancer |
| EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
| BRPI0518286A2 (pt) * | 2004-11-18 | 2008-11-11 | Bristol Myers Squibb Co | microesfera com revestimento entÉrico contendo ixabepilona e sua preparaÇço |
| EP1856255A4 (en) | 2005-02-11 | 2010-01-27 | Univ Southern California | PROCESS FOR EXPRESSING PROTEINS VIA DISULPHIDE BRIDGES |
| CN101175757B (zh) | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| US7772177B2 (en) | 2005-05-18 | 2010-08-10 | Aegera Therapeutics, Inc. | BIR domain binding compounds |
| CN103893779A (zh) * | 2005-08-19 | 2014-07-02 | 恩多塞特公司 | 多药物配体缀合物 |
| EP1948240A2 (en) * | 2005-08-19 | 2008-07-30 | Endocyte, Inc. | Ligand conjugates of vinca alkaloids, analogs and derivatives |
| EP2029156A4 (en) * | 2006-05-01 | 2010-07-21 | Univ Southern California | COMBINATION THERAPY FOR CANCER TREATMENT |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| PE20080102A1 (es) * | 2006-05-25 | 2008-02-11 | Bristol Myers Squibb Co | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| AR061181A1 (es) * | 2006-05-25 | 2008-08-13 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
| JP2010511408A (ja) | 2006-12-04 | 2010-04-15 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 癌をＣｐＧリッチＤＮＡおよびキュプレドキシンで治療するための組成物および方法 |
| WO2008098216A2 (en) | 2007-02-08 | 2008-08-14 | The Board Of Trustees Of The University Of Illinois | Compositions and methods to prevent cancer with cupredoxins |
| US20100104626A1 (en) * | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN101678124A (zh) * | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| EP2152717A1 (en) | 2007-05-25 | 2010-02-17 | Bristol-Myers Squibb Company | Processes for making epothilone compounds and analogs |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| AU2008316835B2 (en) | 2007-10-25 | 2015-07-16 | Endocyte, Inc. | Tubulysins and processes for preparing |
| WO2009146152A2 (en) * | 2008-04-04 | 2009-12-03 | Emory University | Non-myelosuppressive compounds, pharmaceutical compositions thereof, and methods of treatment |
| MX2010011209A (es) * | 2008-04-24 | 2010-11-12 | Squibb Bristol Myers Co | Uso de epotilona d en el tratamiento de enfermedades asociadas a tau incluyendo enfermedad de alzheimer. |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| NZ602368A (en) | 2010-02-12 | 2014-10-31 | Pharmascience Inc | Iap bir domain binding compounds |
| CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| CN103442737B (zh) | 2011-01-20 | 2017-03-29 | 得克萨斯系统大学董事会 | Mri标记、递送和提取系统及其制造方法和用途 |
| CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
| CN102993239A (zh) | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| US9662402B2 (en) | 2012-10-16 | 2017-05-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| WO2014075391A1 (zh) | 2012-11-17 | 2014-05-22 | 北京市丰硕维康技术开发有限责任公司 | 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物 |
| EP3371176A4 (en) * | 2015-10-16 | 2019-09-04 | William Marsh Rice University | EPOTHILON ANALOGUE, SYNTHESIS METHOD, TREATMENT METHOD AND MEDICAMENT CONJUGATE THEREFOR |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
| DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
| EP1440973A3 (de) | 1995-11-17 | 2004-10-20 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilonderivate, Herstellung und Mittel |
| DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
| DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
| WO1998008849A1 (de) | 1996-08-30 | 1998-03-05 | Novartis Aktiengesellschaft | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
| PL193229B1 (pl) | 1996-11-18 | 2007-01-31 | F Biotechnologische Forschung | Epotylon C, epotylon D, epotylon E i epotylon F, sposób biotransformacji epotylonu A, sposób biotransformacji epotylonu B oraz środek leczniczy |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| EP0977563B1 (en) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
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| DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
| EP0975622B1 (de) | 1997-04-18 | 2002-10-09 | Studiengesellschaft Kohle mbH | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
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| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| ES2184307T3 (es) | 1997-07-16 | 2003-04-01 | Schering Ag | Derivados de tiazol, procedimiento para su preparacion y su utilizacion. |
| JP2001512723A (ja) | 1997-08-09 | 2001-08-28 | シエーリング アクチエンゲゼルシヤフト | 新規エポチロン誘導体、その製法およびその薬学的使用 |
| HUP0101564A3 (en) | 1998-02-05 | 2002-06-28 | Novartis Ag | Compositions containing epothilone |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
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| WO2000000485A1 (de) | 1998-06-30 | 2000-01-06 | Schering Aktiengesellschaft | Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung |
| EP1135470A2 (en) | 1998-11-20 | 2001-09-26 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| AU2795000A (en) | 1998-12-22 | 2000-07-12 | Novartis Ag | Epothilone derivatives and their use as antitumor agents |
| AU3156700A (en) | 1999-02-18 | 2000-09-04 | Schering Aktiengesellschaft | 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use |
| US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
| AR023792A1 (es) | 1999-04-30 | 2002-09-04 | Bayer Schering Pharma Ag | Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos |
-
1999
- 1999-03-29 US US09/280,192 patent/US6380395B1/en not_active Expired - Lifetime
- 1999-03-29 US US09/280,191 patent/US6399638B1/en not_active Expired - Lifetime
- 1999-04-05 ES ES05015236T patent/ES2400049T3/es not_active Expired - Lifetime
- 1999-04-05 ES ES99916383T patent/ES2273484T3/es not_active Expired - Lifetime
- 1999-04-05 EP EP99915273A patent/EP1073647B1/en not_active Expired - Lifetime
- 1999-04-05 PT PT99916383T patent/PT1073648E/pt unknown
- 1999-04-05 EP EP05015236A patent/EP1589017B1/en not_active Expired - Lifetime
- 1999-04-05 DK DK99916383T patent/DK1073648T3/da active
- 1999-04-05 WO PCT/US1999/007475 patent/WO1999054319A1/en not_active Ceased
- 1999-04-05 AU AU34716/99A patent/AU748526B2/en not_active Ceased
- 1999-04-05 JP JP2000544658A patent/JP4476483B2/ja not_active Expired - Fee Related
- 1999-04-05 PT PT99915273T patent/PT1073647E/pt unknown
- 1999-04-05 JP JP2000544657A patent/JP2002512238A/ja active Pending
- 1999-04-05 AU AU33827/99A patent/AU757733B2/en not_active Ceased
- 1999-04-05 AT AT99916383T patent/ATE340177T1/de active
- 1999-04-05 DK DK05015236.2T patent/DK1589017T3/da active
- 1999-04-05 CN CNB998052663A patent/CN1142923C/zh not_active Expired - Fee Related
- 1999-04-05 AT AT99915273T patent/ATE435861T1/de active
- 1999-04-05 DE DE69933287T patent/DE69933287T2/de not_active Expired - Lifetime
- 1999-04-05 BR BR9909795-8A patent/BR9909795A/pt not_active IP Right Cessation
- 1999-04-05 ES ES99915273T patent/ES2327803T3/es not_active Expired - Lifetime
- 1999-04-05 CA CA2329181A patent/CA2329181C/en not_active Expired - Fee Related
- 1999-04-05 PT PT50152362T patent/PT1589017E/pt unknown
- 1999-04-05 CA CA002323609A patent/CA2323609A1/en not_active Abandoned
- 1999-04-05 EP EP99916383A patent/EP1073648B1/en not_active Expired - Lifetime
- 1999-04-05 TR TR2000/03036T patent/TR200003036T2/xx unknown
- 1999-04-05 DE DE69941083T patent/DE69941083D1/de not_active Expired - Lifetime
- 1999-04-05 WO PCT/US1999/007448 patent/WO1999054318A1/en not_active Ceased
- 1999-04-05 DK DK99915273T patent/DK1073647T3/da active
- 1999-04-20 PE PE1999000331A patent/PE20000460A1/es not_active Application Discontinuation
- 1999-04-21 AR ARP990101833A patent/AR015007A1/es unknown
- 1999-04-21 AR ARP990101834A patent/AR015774A1/es unknown
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2006
- 2006-12-08 CY CY20061101766T patent/CY1105836T1/el unknown
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2009
- 2009-09-01 CY CY20091100911T patent/CY1109593T1/el unknown