JP2002508181A5 - - Google Patents
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- Publication number
- JP2002508181A5 JP2002508181A5 JP2000539135A JP2000539135A JP2002508181A5 JP 2002508181 A5 JP2002508181 A5 JP 2002508181A5 JP 2000539135 A JP2000539135 A JP 2000539135A JP 2000539135 A JP2000539135 A JP 2000539135A JP 2002508181 A5 JP2002508181 A5 JP 2002508181A5
- Authority
- JP
- Japan
- Prior art keywords
- troponin
- sequence
- polypeptide
- coli
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 24
- 229920001184 polypeptide Polymers 0.000 description 19
- 102000004196 processed proteins & peptides Human genes 0.000 description 19
- 108010065729 Troponin I Proteins 0.000 description 14
- 102000013394 Troponin I Human genes 0.000 description 14
- 108090000362 Lymphotoxin-beta Proteins 0.000 description 9
- 102000013534 Troponin C Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 7
- 101710128251 Troponin I, cardiac muscle Proteins 0.000 description 7
- 102100036859 Troponin I, cardiac muscle Human genes 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 7
- 230000000747 cardiac effect Effects 0.000 description 6
- 238000010367 cloning Methods 0.000 description 4
- 102000004903 Troponin Human genes 0.000 description 2
- 108090001027 Troponin Proteins 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 241000589877 Campylobacter coli Species 0.000 description 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 101000851330 Xenopus laevis Troponin I, cardiac muscle Proteins 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/993,380 US6077676A (en) | 1997-12-18 | 1997-12-18 | Single-chain polypeptides comprising troponin I and troponin C |
| US08/993,380 | 1997-12-18 | ||
| PCT/IB1998/002095 WO1999031235A1 (en) | 1997-12-18 | 1998-12-18 | Single-chain polypeptides comprising troponin i and troponin c |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508181A JP2002508181A (ja) | 2002-03-19 |
| JP2002508181A5 true JP2002508181A5 (https=) | 2006-01-05 |
| JP4328019B2 JP4328019B2 (ja) | 2009-09-09 |
Family
ID=25539476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000539135A Expired - Lifetime JP4328019B2 (ja) | 1997-12-18 | 1998-12-18 | トロポニンｉおよびトロポニンｃを含む一本鎖ポリペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6077676A (https=) |
| EP (1) | EP1037976B1 (https=) |
| JP (1) | JP4328019B2 (https=) |
| AT (1) | ATE309351T1 (https=) |
| AU (1) | AU1444699A (https=) |
| CA (1) | CA2315282C (https=) |
| DE (1) | DE69832299T2 (https=) |
| ES (1) | ES2253835T3 (https=) |
| WO (1) | WO1999031235A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2756827B1 (fr) * | 1996-12-05 | 1999-01-29 | Pasteur Sanofi Diagnostics | Composes synthetiques biepitopiques utilisables comme etalons dans les dosages biologiques de la troponine i |
| US6475785B1 (en) * | 1997-12-18 | 2002-11-05 | Spectral Diagnostics, Inc. | Single-chain polypeptides comprising troponin I N-terminal fragments and troponin C |
| AU6117099A (en) | 1998-10-21 | 2000-05-08 | Spectral Diagnostics Inc. | Cardiac troponin i polypeptide fragments and uses in diagnostics |
| US7078486B2 (en) * | 1999-12-10 | 2006-07-18 | Spectral Diagnostics, Inc. | Single-chain polypeptides comprising troponin I and troponin C |
| US20070141710A1 (en) * | 2005-12-20 | 2007-06-21 | Beckman Coulter, Inc. | Stable calibrators for immunoassays |
| US20110306148A1 (en) | 2010-06-14 | 2011-12-15 | Siemens Healthcare Diagnostics Inc. | Composition for use as an assay reagent |
| CN107245103A (zh) * | 2016-12-30 | 2017-10-13 | 广西壮族自治区药用植物园 | 抗肿瘤重组蛋白ifti及其编码基因与应用 |
| CN107245102A (zh) * | 2016-12-30 | 2017-10-13 | 广西壮族自治区药用植物园 | 抗肿瘤重组蛋白gpti及其编码基因与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4892827A (en) * | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| US5604105B1 (en) * | 1990-10-12 | 1999-08-24 | Spectral Diagnostics Inc | Method and device for diagnosingand distinguishing chest pain in early onset thereof |
| CA2027434C (en) * | 1990-10-12 | 1999-01-05 | George Jackowski | Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof |
| AU687010B2 (en) * | 1992-07-17 | 1998-02-19 | Dana-Farber Cancer Institute | Method of intracellular binding of target molecules |
| FR2701954B1 (fr) * | 1993-02-23 | 1995-07-07 | Pasteur Sanofi Diagnostics | Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais. |
| EP0805821A1 (en) * | 1995-11-29 | 1997-11-12 | Dade Behring Inc. | HUMAN HEART CNBr TROPONIN I ISOFORM AND USE OF SAME |
| FI104857B (fi) * | 1996-01-15 | 2000-04-14 | Hytest Oy | Sydänlihaksen soluvaurioiden asteen mittaus immunokemiallisella menetelmällä sisältäen menetelmään soveliaat vasta-aineet |
| WO1997039132A1 (en) * | 1996-04-16 | 1997-10-23 | University Of Miami | Stabilized preparations of human troponins and modifications thereof, diagnostic assay methods and assay kits |
| AU4981897A (en) * | 1996-10-15 | 1998-05-11 | Navix, Inc. | Stabilized conjugates of uncomplexed subunits of multimeric proteins |
| US5834210A (en) * | 1997-05-23 | 1998-11-10 | Spectral Diagnostics, Inc. | Stable troponin subunits and complexes |
| JP2002508839A (ja) * | 1997-05-29 | 2002-03-19 | メディカル アナリシス システムズ，インコーポレイテッド | 共有結合したトロポニン複合体 |
-
1997
- 1997-12-18 US US08/993,380 patent/US6077676A/en not_active Expired - Lifetime
-
1998
- 1998-12-18 EP EP98958383A patent/EP1037976B1/en not_active Expired - Lifetime
- 1998-12-18 CA CA2315282A patent/CA2315282C/en not_active Expired - Lifetime
- 1998-12-18 WO PCT/IB1998/002095 patent/WO1999031235A1/en not_active Ceased
- 1998-12-18 AU AU14446/99A patent/AU1444699A/en not_active Abandoned
- 1998-12-18 DE DE69832299T patent/DE69832299T2/de not_active Expired - Lifetime
- 1998-12-18 ES ES98958383T patent/ES2253835T3/es not_active Expired - Lifetime
- 1998-12-18 JP JP2000539135A patent/JP4328019B2/ja not_active Expired - Lifetime
- 1998-12-18 AT AT98958383T patent/ATE309351T1/de not_active IP Right Cessation
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