CA2315282C - Single-chain polypeptides comprising troponin i and troponin c - Google Patents

Single-chain polypeptides comprising troponin i and troponin c Download PDF

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Publication number
CA2315282C
CA2315282C CA2315282A CA2315282A CA2315282C CA 2315282 C CA2315282 C CA 2315282C CA 2315282 A CA2315282 A CA 2315282A CA 2315282 A CA2315282 A CA 2315282A CA 2315282 C CA2315282 C CA 2315282C
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CA
Canada
Prior art keywords
troponin
glu
lys
ala
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2315282A
Other languages
English (en)
French (fr)
Other versions
CA2315282A1 (en
Inventor
Qinwei Shi
Qian-Li Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPECTRAL DIAGNOSTICS Inc
Original Assignee
SPECTRAL DIAGNOSTICS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SPECTRAL DIAGNOSTICS Inc filed Critical SPECTRAL DIAGNOSTICS Inc
Publication of CA2315282A1 publication Critical patent/CA2315282A1/en
Application granted granted Critical
Publication of CA2315282C publication Critical patent/CA2315282C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2315282A 1997-12-18 1998-12-18 Single-chain polypeptides comprising troponin i and troponin c Expired - Lifetime CA2315282C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/993,380 1997-12-18
US08/993,380 US6077676A (en) 1997-12-18 1997-12-18 Single-chain polypeptides comprising troponin I and troponin C
PCT/IB1998/002095 WO1999031235A1 (en) 1997-12-18 1998-12-18 Single-chain polypeptides comprising troponin i and troponin c

Publications (2)

Publication Number Publication Date
CA2315282A1 CA2315282A1 (en) 1999-06-24
CA2315282C true CA2315282C (en) 2012-10-23

Family

ID=25539476

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2315282A Expired - Lifetime CA2315282C (en) 1997-12-18 1998-12-18 Single-chain polypeptides comprising troponin i and troponin c

Country Status (9)

Country Link
US (1) US6077676A (https=)
EP (1) EP1037976B1 (https=)
JP (1) JP4328019B2 (https=)
AT (1) ATE309351T1 (https=)
AU (1) AU1444699A (https=)
CA (1) CA2315282C (https=)
DE (1) DE69832299T2 (https=)
ES (1) ES2253835T3 (https=)
WO (1) WO1999031235A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756827B1 (fr) * 1996-12-05 1999-01-29 Pasteur Sanofi Diagnostics Composes synthetiques biepitopiques utilisables comme etalons dans les dosages biologiques de la troponine i
US6475785B1 (en) * 1997-12-18 2002-11-05 Spectral Diagnostics, Inc. Single-chain polypeptides comprising troponin I N-terminal fragments and troponin C
AU6117099A (en) 1998-10-21 2000-05-08 Spectral Diagnostics Inc. Cardiac troponin i polypeptide fragments and uses in diagnostics
US7078486B2 (en) * 1999-12-10 2006-07-18 Spectral Diagnostics, Inc. Single-chain polypeptides comprising troponin I and troponin C
US20070141710A1 (en) * 2005-12-20 2007-06-21 Beckman Coulter, Inc. Stable calibrators for immunoassays
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
CN107245103A (zh) * 2016-12-30 2017-10-13 广西壮族自治区药用植物园 抗肿瘤重组蛋白ifti及其编码基因与应用
CN107245102A (zh) * 2016-12-30 2017-10-13 广西壮族自治区药用植物园 抗肿瘤重组蛋白gpti及其编码基因与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4892827A (en) * 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US5604105B1 (en) * 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
CA2027434C (en) * 1990-10-12 1999-01-05 George Jackowski Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof
DE69334095T2 (de) * 1992-07-17 2007-04-12 Dana-Farber Cancer Institute, Boston Verfahren zur intrazellulären Bindung von zielgerichteten Molekülen
FR2701954B1 (fr) * 1993-02-23 1995-07-07 Pasteur Sanofi Diagnostics Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais.
AU1274097A (en) * 1995-11-29 1997-06-19 Dade International Inc. Human heart cnbr troponin i isoform and use of same
FI104857B (fi) * 1996-01-15 2000-04-14 Hytest Oy Sydänlihaksen soluvaurioiden asteen mittaus immunokemiallisella menetelmällä sisältäen menetelmään soveliaat vasta-aineet
WO1997039132A1 (en) * 1996-04-16 1997-10-23 University Of Miami Stabilized preparations of human troponins and modifications thereof, diagnostic assay methods and assay kits
EP0946198B1 (en) * 1996-10-15 2002-06-19 Medical Analysis Systems, Inc. Method of stabilizing troponin I (cTnI) via conjugation with an active polymer
US5834210A (en) * 1997-05-23 1998-11-10 Spectral Diagnostics, Inc. Stable troponin subunits and complexes
EP0983299A1 (en) * 1997-05-29 2000-03-08 Medical Analysis Systems, Inc. Covalently coupled troponin complexes

Also Published As

Publication number Publication date
WO1999031235A1 (en) 1999-06-24
DE69832299D1 (de) 2005-12-15
EP1037976A1 (en) 2000-09-27
DE69832299T2 (de) 2006-08-10
ES2253835T3 (es) 2006-06-01
ATE309351T1 (de) 2005-11-15
EP1037976B1 (en) 2005-11-09
CA2315282A1 (en) 1999-06-24
JP2002508181A (ja) 2002-03-19
US6077676A (en) 2000-06-20
JP4328019B2 (ja) 2009-09-09
AU1444699A (en) 1999-07-05

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Effective date: 20181218